Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              20     509
NP_001075109                                                           20     509
NP_899243                                                              17    3301
NP_001099010                                                           17    3301
NP_001186197                                                           17    3301
NP_001186195                                                           17    3301
NP_963291                                                              17    3301
NP_963290                                                              17    3301
XP_006720135                                                           17    3301
XP_006720134                                                           17    3301
XP_006720133                                                           17    3301
XP_006718418                                                           17    3301
XP_005253239                                                           17    3301
XP_005253238                                                           17    3301
XP_006718417                                                           17    3301
XP_005253237                                                           17    3301
XP_005253236                                                           17    3301
NP_001186196                                                           17    3301
NP_003637                                                              17    3301
NP_002323                                                              16    5631
NP_001265122                                                           16    5631
NP_001265123                                                           16    5631
NP_938148                                                              16    5631
NP_001609                                                              16    7355
NP_076924                                                              16    7355
NP_001186711                                                           15    9605
XP_006726477                                                           15    9605
XP_006726476                                                           15    9605
XP_003960392                                                           15    9605
XP_005260625                                                           15    9605
XP_005271706                                                           15    9605
XP_006718960                                                           15    9605
XP_006718959                                                           15    9605
XP_006714494                                                           15    9605
XP_006714493                                                           15    9605
XP_373030                                                              15    9605
XP_006710222                                                           15    9605
XP_006710221                                                           15    9605
XP_001717475                                                           15    9605
>NP_008835
          Length = 4128

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    VAVSRGSKD 9
            VAV+RGSKD
Sbjct: 4078 VAVARGSKD 4086
>NP_001075109
          Length = 4097

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    VAVSRGSKD 9
            VAV+RGSKD
Sbjct: 4047 VAVARGSKD 4055
>NP_899243
          Length = 1977

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VAVSRGSKD 9
           ++++RGSKD
Sbjct: 809 LSIARGSKD 817
>NP_001099010
          Length = 1117

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    AVSRGSKD 9
            AVS GSKD
Sbjct: 1019 AVSTGSKD 1026
>NP_001186197
          Length = 906

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   AVSRGSKD 9
           AVS GSKD
Sbjct: 808 AVSTGSKD 815
>NP_001186195
          Length = 934

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   AVSRGSKD 9
           AVS GSKD
Sbjct: 831 AVSTGSKD 838
>NP_963291
          Length = 933

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   AVSRGSKD 9
           AVS GSKD
Sbjct: 835 AVSTGSKD 842
>NP_963290
          Length = 945

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   AVSRGSKD 9
           AVS GSKD
Sbjct: 847 AVSTGSKD 854
>XP_006720135
          Length = 1454

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VAVSRGSKD 9
           ++++RGSKD
Sbjct: 809 LSIARGSKD 817
>XP_006720134
          Length = 1579

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VAVSRGSKD 9
           ++++RGSKD
Sbjct: 809 LSIARGSKD 817
>XP_006720133
          Length = 1969

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VAVSRGSKD 9
           ++++RGSKD
Sbjct: 809 LSIARGSKD 817
>XP_006718418
          Length = 933

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   AVSRGSKD 9
           AVS GSKD
Sbjct: 835 AVSTGSKD 842
>XP_005253239
          Length = 934

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   AVSRGSKD 9
           AVS GSKD
Sbjct: 836 AVSTGSKD 843
>XP_005253238
          Length = 946

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   AVSRGSKD 9
           AVS GSKD
Sbjct: 848 AVSTGSKD 855
>XP_006718417
          Length = 1118

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    AVSRGSKD 9
            AVS GSKD
Sbjct: 1020 AVSTGSKD 1027
>XP_005253237
          Length = 1160

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    AVSRGSKD 9
            AVS GSKD
Sbjct: 1062 AVSTGSKD 1069
>XP_005253236
          Length = 1161

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    AVSRGSKD 9
            AVS GSKD
Sbjct: 1063 AVSTGSKD 1070
>NP_001186196
          Length = 928

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   AVSRGSKD 9
           AVS GSKD
Sbjct: 830 AVSTGSKD 837
>NP_003637
          Length = 929

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   AVSRGSKD 9
           AVS GSKD
Sbjct: 831 AVSTGSKD 838
>NP_002323
          Length = 4544

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    AVSRGSKD 9
            ++ RGSKD
Sbjct: 2119 SIKRGSKD 2126
>NP_001265122
          Length = 830

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  VSRGSKD 9
          VS+GSKD
Sbjct: 72 VSQGSKD 78
>NP_001265123
          Length = 847

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  VSRGSKD 9
          VS+GSKD
Sbjct: 89 VSQGSKD 95
>NP_938148
          Length = 944

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VSRGSKD 9
           VS+GSKD
Sbjct: 186 VSQGSKD 192
>NP_001609
          Length = 1014

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AVSRGSKD 9
           AVS+GS D
Sbjct: 719 AVSQGSSD 726
>NP_076924
          Length = 272

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   AVSRGSK 8
           AVSRG+K
Sbjct: 95  AVSRGAK 101
>NP_001186711
          Length = 406

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  VAVSRGS 7
          +AVSRGS
Sbjct: 21 LAVSRGS 27
>XP_006726477
          Length = 1793

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VAVSRGSKD 9
           +A S+GS+D
Sbjct: 350 IAKSQGSRD 358
>XP_006726476
          Length = 1793

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VAVSRGSKD 9
           +A S+GS+D
Sbjct: 350 IAKSQGSRD 358
>XP_003960392
          Length = 1826

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VAVSRGSKD 9
           +A S+GS+D
Sbjct: 383 IAKSQGSRD 391
>XP_005260625
          Length = 121

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VSRGSK 8
           VSRGSK
Sbjct: 111 VSRGSK 116
>XP_005271706
          Length = 352

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  VSRGSKD 9
          V+RGS+D
Sbjct: 4  VARGSRD 10
>XP_006718960
          Length = 354

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3 VSRGSKD 9
         V+RGS+D
Sbjct: 2 VARGSRD 8
>XP_006718959
          Length = 356

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  VSRGSKD 9
          V+RGS+D
Sbjct: 4  VARGSRD 10
>XP_006714494
          Length = 1793

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VAVSRGSKD 9
           +A S+GS+D
Sbjct: 350 IAKSQGSRD 358
>XP_006714493
          Length = 1793

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VAVSRGSKD 9
           +A S+GS+D
Sbjct: 350 IAKSQGSRD 358
>XP_373030
          Length = 1826

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VAVSRGSKD 9
           +A S+GS+D
Sbjct: 383 IAKSQGSRD 391
>XP_006710222
          Length = 1793

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VAVSRGSKD 9
           +A S+GS+D
Sbjct: 350 IAKSQGSRD 358
>XP_006710221
          Length = 1793

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VAVSRGSKD 9
           +A S+GS+D
Sbjct: 350 IAKSQGSRD 358
>XP_001717475
          Length = 1826

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VAVSRGSKD 9
           +A S+GS+D
Sbjct: 383 IAKSQGSRD 391
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.304    0.120    0.296 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 571,357
Number of extensions: 845
Number of successful extensions: 39
Number of sequences better than 10000.0: 39
Number of HSP's gapped: 39
Number of HSP's successfully gapped: 39
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package