Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_055288                                                              18    1482
NP_005742                                                              18    1935
NP_671714                                                              18    1935
XP_006715890                                                           18    1935
XP_005250160                                                           18    1935
XP_005250159                                                           18    1935
NP_001072                                                              17    4312
NP_001098677                                                           15    9605
NP_002281                                                              15    9605
NP_001098676                                                           15    9605
NP_001274324                                                           15    9605
XP_006715544                                                           15    9605
XP_005267041                                                           15    9605
XP_006715543                                                           15    9605
XP_005267040                                                           15    9605
XP_006712547                                                           15    9605
>NP_055288
          Length = 313

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   VASKLQVLL 9
           VASKLQVL+
Sbjct: 103 VASKLQVLV 111
>NP_005742
          Length = 3907

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    VASKLQVL 8
            VASKLQVL
Sbjct: 3522 VASKLQVL 3529
>NP_671714
          Length = 3899

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    VASKLQVL 8
            VASKLQVL
Sbjct: 3514 VASKLQVL 3521
>XP_006715890
          Length = 3860

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    VASKLQVL 8
            VASKLQVL
Sbjct: 3475 VASKLQVL 3482
>XP_005250160
          Length = 3939

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    VASKLQVL 8
            VASKLQVL
Sbjct: 3554 VASKLQVL 3561
>XP_005250159
          Length = 3952

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    VASKLQVL 8
            VASKLQVL
Sbjct: 3567 VASKLQVL 3574
>NP_001072
          Length = 3623

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    ASKLQVLL 9
            +SKLQVLL
Sbjct: 1363 SSKLQVLL 1370
>NP_001098677
          Length = 1816

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   VASKLQV 7
           VASK+QV
Sbjct: 821 VASKIQV 827
>NP_002281
          Length = 1816

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   VASKLQV 7
           VASK+QV
Sbjct: 821 VASKIQV 827
>NP_001098676
          Length = 1823

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   VASKLQV 7
           VASK+QV
Sbjct: 828 VASKIQV 834
>NP_001274324
          Length = 1688

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ASKLQVLL 9
           ASK++VLL
Sbjct: 704 ASKVEVLL 711
>XP_006715544
          Length = 1810

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   VASKLQV 7
           VASK+QV
Sbjct: 815 VASKIQV 821
>XP_005267041
          Length = 1823

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   VASKLQV 7
           VASK+QV
Sbjct: 828 VASKIQV 834
>XP_006715543
          Length = 1823

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   VASKLQV 7
           VASK+QV
Sbjct: 828 VASKIQV 834
>XP_005267040
          Length = 1823

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   VASKLQV 7
           VASK+QV
Sbjct: 828 VASKIQV 834
>XP_006712547
          Length = 1674

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ASKLQVLL 9
           ASK++VLL
Sbjct: 701 ASKVEVLL 708
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.325    0.135    0.301 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 252,006
Number of extensions: 238
Number of successful extensions: 16
Number of sequences better than 10000.0: 16
Number of HSP's gapped: 16
Number of HSP's successfully gapped: 16
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package