Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001244299                                                           17    2528
XP_005255219                                                           17    2528
NP_003310                                                              17    3301
NP_597676                                                              17    3301
NP_001243779                                                           17    3301
NP_596869                                                              17    3301
XP_005246888                                                           17    3301
XP_006712788                                                           17    3301
XP_006712787                                                           17    3301
XP_006712786                                                           17    3301
XP_006712418                                                           17    3301
XP_006712417                                                           17    3301
XP_006712415                                                           17    3301
XP_006712414                                                           17    3301
XP_006712413                                                           17    3301
XP_006712412                                                           17    3301
NP_001254479                                                           17    3301
NP_597681                                                              17    3301
NP_036377                                                              17    4312
NP_001123292                                                           17    4312
XP_005258025                                                           17    4312
XP_005267471                                                           17    4312
XP_005267470                                                           17    4312
NP_733751                                                              16    5631
XP_006716142                                                           16    5631
XP_005250088                                                           16    5631
XP_006716141                                                           16    5631
XP_005250085                                                           16    5631
XP_006716140                                                           16    5631
XP_005250084                                                           16    5631
XP_005250083                                                           16    5631
XP_005250082                                                           16    5631
NP_899199                                                              16    7355
NP_001171547                                                           16    7355
NP_001171548                                                           16    7355
NP_001171546                                                           16    7355
NP_001664                                                              16    7355
NP_597680                                                              16    7355
NP_996809                                                              16    7355
NP_065184                                                              16    7355
NP_004546                                                              16    7355
NP_775186                                                              16    7355
NP_775188                                                              16    7355
NP_005566                                                              16    7355
NP_787116                                                              16    7355
NP_003704                                                              16    7355
NP_775922                                                              16    7355
NP_060735                                                              16    7355
NP_001136041                                                           16    7355
XP_006711508                                                           16    7355
NP_000305                                                              15    9605
NP_057532                                                              15    9605
XP_006717990                                                           15    9605
XP_006717989                                                           15    9605
XP_005248355                                                           15    9605
NP_872438                                                              15    9605
>NP_001244299
          Length = 379

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   VAQYPLK 7
           +AQYPLK
Sbjct: 254 LAQYPLK 260
>XP_005255219
          Length = 351

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   VAQYPLK 7
           +AQYPLK
Sbjct: 226 LAQYPLK 232
>NP_003310
          Length = 26926

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1     VAQYPLK 7
             VAQYP K
Sbjct: 15836 VAQYPFK 15842

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1     VAQYPLK 7
             VAQYP K
Sbjct: 16918 VAQYPYK 16924
>NP_597676
          Length = 27051

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1     VAQYPLK 7
             VAQYP K
Sbjct: 15961 VAQYPFK 15967

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1     VAQYPLK 7
             VAQYP K
Sbjct: 17043 VAQYPYK 17049
>NP_001243779
          Length = 34350

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1     VAQYPLK 7
             VAQYP K
Sbjct: 23260 VAQYPFK 23266

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1     VAQYPLK 7
             VAQYP K
Sbjct: 24342 VAQYPYK 24348
>NP_596869
          Length = 33423

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1     VAQYPLK 7
             VAQYP K
Sbjct: 22333 VAQYPFK 22339

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1     VAQYPLK 7
             VAQYP K
Sbjct: 23415 VAQYPYK 23421
>XP_005246888
          Length = 22663

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1     VAQYPLK 7
             VAQYP K
Sbjct: 11573 VAQYPFK 11579

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1     VAQYPLK 7
             VAQYP K
Sbjct: 12655 VAQYPYK 12661
>XP_006712788
          Length = 24022

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1     VAQYPLK 7
             VAQYP K
Sbjct: 12932 VAQYPFK 12938

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1     VAQYPLK 7
             VAQYP K
Sbjct: 14014 VAQYPYK 14020
>XP_006712787
          Length = 33978

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1     VAQYPLK 7
             VAQYP K
Sbjct: 22888 VAQYPFK 22894

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1     VAQYPLK 7
             VAQYP K
Sbjct: 23970 VAQYPYK 23976
>XP_006712786
          Length = 35484

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1     VAQYPLK 7
             VAQYP K
Sbjct: 24394 VAQYPFK 24400

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1     VAQYPLK 7
             VAQYP K
Sbjct: 25476 VAQYPYK 25482
>XP_006712418
          Length = 611

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VAQYPLKTI 9
           V+ +PLKT+
Sbjct: 547 VSHFPLKTV 555
>XP_006712417
          Length = 735

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VAQYPLKTI 9
           V+ +PLKT+
Sbjct: 671 VSHFPLKTV 679
>XP_006712415
          Length = 894

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VAQYPLKTI 9
           V+ +PLKT+
Sbjct: 830 VSHFPLKTV 838
>XP_006712414
          Length = 896

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VAQYPLKTI 9
           V+ +PLKT+
Sbjct: 832 VSHFPLKTV 840
>XP_006712413
          Length = 896

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VAQYPLKTI 9
           V+ +PLKT+
Sbjct: 832 VSHFPLKTV 840
>XP_006712412
          Length = 896

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VAQYPLKTI 9
           V+ +PLKT+
Sbjct: 832 VSHFPLKTV 840
>NP_001254479
          Length = 35991

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1     VAQYPLK 7
             VAQYP K
Sbjct: 24901 VAQYPFK 24907

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1     VAQYPLK 7
             VAQYP K
Sbjct: 25983 VAQYPYK 25989
>NP_597681
          Length = 27118

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1     VAQYPLK 7
             VAQYP K
Sbjct: 16028 VAQYPFK 16034

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1     VAQYPLK 7
             VAQYP K
Sbjct: 17110 VAQYPYK 17116
>NP_036377
          Length = 536

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  VAQYPL 6
          VAQYPL
Sbjct: 69 VAQYPL 74
>NP_001123292
          Length = 912

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AQYPLKTI 9
           AQ+P KTI
Sbjct: 721 AQFPRKTI 728
>XP_005258025
          Length = 912

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AQYPLKTI 9
           AQ+P KTI
Sbjct: 721 AQFPRKTI 728
>XP_005267471
          Length = 571

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  VAQYPL 6
          VAQYPL
Sbjct: 69 VAQYPL 74
>XP_005267470
          Length = 430

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  VAQYPL 6
          VAQYPL
Sbjct: 69 VAQYPL 74
>NP_733751
          Length = 4911

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VAQYPLKT 8
            +AQ P+KT
Sbjct: 3355 IAQLPIKT 3362
>XP_006716142
          Length = 4927

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VAQYPLKT 8
            +AQ P+KT
Sbjct: 3372 IAQLPIKT 3379
>XP_005250088
          Length = 4928

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VAQYPLKT 8
            +AQ P+KT
Sbjct: 3372 IAQLPIKT 3379
>XP_006716141
          Length = 4959

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VAQYPLKT 8
            +AQ P+KT
Sbjct: 3372 IAQLPIKT 3379
>XP_005250085
          Length = 4979

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VAQYPLKT 8
            +AQ P+KT
Sbjct: 3372 IAQLPIKT 3379
>XP_006716140
          Length = 4982

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VAQYPLKT 8
            +AQ P+KT
Sbjct: 3372 IAQLPIKT 3379
>XP_005250084
          Length = 4982

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VAQYPLKT 8
            +AQ P+KT
Sbjct: 3372 IAQLPIKT 3379
>XP_005250083
          Length = 4982

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VAQYPLKT 8
            +AQ P+KT
Sbjct: 3371 IAQLPIKT 3378
>XP_005250082
          Length = 4983

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VAQYPLKT 8
            +AQ P+KT
Sbjct: 3372 IAQLPIKT 3379
>NP_899199
          Length = 561

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   QYPLKT 8
           QYPL+T
Sbjct: 280 QYPLQT 285
>NP_001171547
          Length = 478

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   QYPLKT 8
           QYPL+T
Sbjct: 197 QYPLQT 202
>NP_001171548
          Length = 478

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   QYPLKT 8
           QYPL+T
Sbjct: 197 QYPLQT 202
>NP_001171546
          Length = 540

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   QYPLKT 8
           QYPL+T
Sbjct: 259 QYPLQT 264
>NP_001664
          Length = 561

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   QYPLKT 8
           QYPL+T
Sbjct: 280 QYPLQT 285
>NP_597680
          Length = 561

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   QYPLKT 8
           QYPL+T
Sbjct: 280 QYPLQT 285
>NP_996809
          Length = 556

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   VAQYPLKTI 9
           VA YP K +
Sbjct: 386 VAMYPFKKV 394
>NP_065184
          Length = 590

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   VAQYPLKTI 9
           VA YP K +
Sbjct: 420 VAMYPFKKV 428
>NP_004546
          Length = 1068

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   AQYPLK 7
           +QYPLK
Sbjct: 379 SQYPLK 384
>NP_775186
          Length = 1065

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   AQYPLK 7
           +QYPLK
Sbjct: 379 SQYPLK 384
>NP_775188
          Length = 1075

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   AQYPLK 7
           +QYPLK
Sbjct: 379 SQYPLK 384
>NP_005566
          Length = 1025

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   QYPLKTI 9
           QYPLK +
Sbjct: 411 QYPLKKL 417
>NP_787116
          Length = 1011

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   QYPLKTI 9
           QYPLK +
Sbjct: 397 QYPLKKL 403
>NP_003704
          Length = 311

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  QYPLKT 8
          +YPLKT
Sbjct: 74 KYPLKT 79
>NP_775922
          Length = 6996

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    QYPLKT 8
            +YPLKT
Sbjct: 1306 KYPLKT 1311
>NP_060735
          Length = 677

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   AQYPLK 7
           A+YPLK
Sbjct: 167 AEYPLK 172
>NP_001136041
          Length = 578

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  AQYPLK 7
          A+YPLK
Sbjct: 68 AEYPLK 73
>XP_006711508
          Length = 662

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   AQYPLK 7
           A+YPLK
Sbjct: 153 AEYPLK 158
>NP_000305
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  VAQYPLK 7
          VAQYP +
Sbjct: 85 VAQYPFE 91
>NP_057532
          Length = 730

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2  AQYPLKTI 9
          +QYPL+++
Sbjct: 21 SQYPLQSL 28
>XP_006717990
          Length = 175

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  VAQYPLK 7
          VAQYP +
Sbjct: 70 VAQYPFE 76
>XP_006717989
          Length = 388

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  VAQYPLK 7
          VAQYP +
Sbjct: 70 VAQYPFE 76
>XP_005248355
          Length = 433

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VAQYPLK 7
           VAQ PLK
Sbjct: 166 VAQLPLK 172
>NP_872438
          Length = 628

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VAQYPLK 7
           VAQ PLK
Sbjct: 361 VAQLPLK 367
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.322    0.136    0.384 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 528,634
Number of extensions: 512
Number of successful extensions: 66
Number of sequences better than 10000.0: 56
Number of HSP's gapped: 66
Number of HSP's successfully gapped: 66
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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