Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001245200                                                           19     665
NP_000240                                                              19     665
NP_001161089                                                           19     665
XP_005265218                                                           19     665
NP_001171953                                                           17    4312
XP_006724302                                                           17    4312
NP_037505                                                              17    4312
NP_001018051                                                           16    5631
NP_005661                                                              16    5631
NP_001120867                                                           16    5631
NP_660323                                                              16    5631
XP_006715628                                                           16    5631
XP_005246398                                                           16    5631
XP_005246397                                                           16    5631
XP_006712392                                                           16    5631
XP_005246396                                                           16    5631
XP_006712391                                                           16    5631
XP_006712390                                                           16    5631
XP_005246395                                                           16    5631
XP_005246394                                                           16    5631
XP_005246393                                                           16    5631
NP_055782                                                              16    7355
NP_835229                                                              16    7355
NP_001177716                                                           16    7355
XP_006725604                                                           16    7355
XP_006725603                                                           16    7355
XP_006725602                                                           16    7355
XP_006725601                                                           16    7355
XP_006725600                                                           16    7355
XP_006721883                                                           16    7355
XP_005257281                                                           16    7355
XP_005254293                                                           16    7355
XP_005254289                                                           16    7355
XP_005254292                                                           16    7355
XP_005254291                                                           16    7355
XP_005254290                                                           16    7355
NP_002205                                                              15    9605
NP_003310                                                              15    9605
NP_597676                                                              15    9605
NP_660350                                                              15    9605
NP_596870                                                              15    9605
NP_001243779                                                           15    9605
NP_596869                                                              15    9605
NP_078928                                                              15    9605
XP_005255036                                                           15    9605
XP_006717758                                                           15    9605
XP_005249809                                                           15    9605
XP_005249808                                                           15    9605
XP_005264950                                                           15    9605
XP_006713056                                                           15    9605
XP_005264949                                                           15    9605
XP_006712787                                                           15    9605
XP_006712786                                                           15    9605
NP_001035522                                                           15    9605
NP_001004730                                                           15    9605
NP_001254479                                                           15    9605
NP_597681                                                              15    9605
>NP_001245200
          Length = 687

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VAHVTITMK 9
           VAHVTIT K
Sbjct: 110 VAHVTITTK 118
>NP_000240
          Length = 756

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VAHVTITMK 9
           VAHVTIT K
Sbjct: 110 VAHVTITTK 118
>NP_001161089
          Length = 658

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VAHVTITMK 9
          VAHVTIT K
Sbjct: 12 VAHVTITTK 20
>XP_005265218
          Length = 687

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VAHVTITMK 9
           VAHVTIT K
Sbjct: 110 VAHVTITTK 118
>NP_001171953
          Length = 778

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   AHVTITM 8
           AH TITM
Sbjct: 181 AHTTITM 187
>XP_006724302
          Length = 778

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   AHVTITM 8
           AH TITM
Sbjct: 181 AHTTITM 187
>NP_037505
          Length = 765

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   AHVTITM 8
           AH TITM
Sbjct: 181 AHTTITM 187
>NP_001018051
          Length = 317

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VAHVTITMK 9
           V HVTI +K
Sbjct: 173 VEHVTIKLK 181
>NP_005661
          Length = 331

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VAHVTITMK 9
           V HVTI +K
Sbjct: 173 VEHVTIKLK 181
>NP_001120867
          Length = 218

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  AHVTIT 7
          AHVTIT
Sbjct: 88 AHVTIT 93
>NP_660323
          Length = 218

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  AHVTIT 7
          AHVTIT
Sbjct: 88 AHVTIT 93
>XP_006715628
          Length = 177

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  VAHVTITMK 9
          V HVTI +K
Sbjct: 19 VEHVTIKLK 27
>XP_005246398
          Length = 218

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  AHVTIT 7
          AHVTIT
Sbjct: 88 AHVTIT 93
>XP_005246397
          Length = 218

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  AHVTIT 7
          AHVTIT
Sbjct: 88 AHVTIT 93
>XP_006712392
          Length = 218

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  AHVTIT 7
          AHVTIT
Sbjct: 88 AHVTIT 93
>XP_005246396
          Length = 218

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  AHVTIT 7
          AHVTIT
Sbjct: 88 AHVTIT 93
>XP_006712391
          Length = 236

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   AHVTIT 7
           AHVTIT
Sbjct: 106 AHVTIT 111
>XP_006712390
          Length = 236

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   AHVTIT 7
           AHVTIT
Sbjct: 106 AHVTIT 111
>XP_005246395
          Length = 236

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   AHVTIT 7
           AHVTIT
Sbjct: 106 AHVTIT 111
>XP_005246394
          Length = 236

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   AHVTIT 7
           AHVTIT
Sbjct: 106 AHVTIT 111
>XP_005246393
          Length = 236

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   AHVTIT 7
           AHVTIT
Sbjct: 106 AHVTIT 111
>NP_055782
          Length = 1017

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VAHVTIT 7
           V HVTIT
Sbjct: 777 VKHVTIT 783
>NP_835229
          Length = 350

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  VAHVTITMK 9
          V H T+T+K
Sbjct: 85 VCHYTLTVK 93
>NP_001177716
          Length = 385

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   HVTITMK 9
           HVT+T K
Sbjct: 204 HVTLTQK 210
>XP_006725604
          Length = 904

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VAHVTIT 7
           V HVTIT
Sbjct: 777 VKHVTIT 783
>XP_006725603
          Length = 1017

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VAHVTIT 7
           V HVTIT
Sbjct: 777 VKHVTIT 783
>XP_006725602
          Length = 1017

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VAHVTIT 7
           V HVTIT
Sbjct: 777 VKHVTIT 783
>XP_006725601
          Length = 1017

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VAHVTIT 7
           V HVTIT
Sbjct: 777 VKHVTIT 783
>XP_006725600
          Length = 1017

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VAHVTIT 7
           V HVTIT
Sbjct: 777 VKHVTIT 783
>XP_006721883
          Length = 368

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VAHVTITMK 9
           V H T+T+K
Sbjct: 103 VCHYTLTVK 111
>XP_005257281
          Length = 382

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VAHVTITMK 9
           V H T+T+K
Sbjct: 103 VCHYTLTVK 111
>XP_005254293
          Length = 904

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VAHVTIT 7
           V HVTIT
Sbjct: 777 VKHVTIT 783
>XP_005254289
          Length = 1017

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VAHVTIT 7
           V HVTIT
Sbjct: 777 VKHVTIT 783
>XP_005254292
          Length = 1017

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VAHVTIT 7
           V HVTIT
Sbjct: 777 VKHVTIT 783
>XP_005254291
          Length = 1017

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VAHVTIT 7
           V HVTIT
Sbjct: 777 VKHVTIT 783
>XP_005254290
          Length = 1017

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VAHVTIT 7
           V HVTIT
Sbjct: 777 VKHVTIT 783
>NP_002205
          Length = 769

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   HVTITMK 9
           +VT+TMK
Sbjct: 431 NVTVTMK 437
>NP_003310
          Length = 26926

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    HVTITMK 9
            H+T TMK
Sbjct: 2837 HITKTMK 2843
>NP_597676
          Length = 27051

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    HVTITMK 9
            H+T TMK
Sbjct: 2837 HITKTMK 2843
>NP_660350
          Length = 609

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VAHVTITMK 9
           +AH T+T++
Sbjct: 236 LAHTTLTLE 244
>NP_596870
          Length = 5604

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    HVTITMK 9
            H+T TMK
Sbjct: 2883 HITKTMK 2889
>NP_001243779
          Length = 34350

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    HVTITMK 9
            H+T TMK
Sbjct: 2883 HITKTMK 2889
>NP_596869
          Length = 33423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    HVTITMK 9
            H+T TMK
Sbjct: 2883 HITKTMK 2889
>NP_078928
          Length = 2015

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VAHVTITMK 9
           + HVT +MK
Sbjct: 819 IFHVTCSMK 827
>XP_005255036
          Length = 1310

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VAHVTITMK 9
           + HVT +MK
Sbjct: 114 IFHVTCSMK 122
>XP_006717758
          Length = 630

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VAHVTITMK 9
           +AH T+T++
Sbjct: 236 LAHTTLTLE 244
>XP_005249809
          Length = 634

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   HVTITMK 9
           +VT+TMK
Sbjct: 296 NVTVTMK 302
>XP_005249808
          Length = 634

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   HVTITMK 9
           +VT+TMK
Sbjct: 296 NVTVTMK 302
>XP_005264950
          Length = 377

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VAHVTITMK 9
           V H +IT+K
Sbjct: 239 VGHYSITLK 247
>XP_006713056
          Length = 384

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VAHVTITMK 9
           V H +IT+K
Sbjct: 239 VGHYSITLK 247
>XP_005264949
          Length = 439

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VAHVTITMK 9
           V H +IT+K
Sbjct: 239 VGHYSITLK 247
>XP_006712787
          Length = 33978

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    HVTITMK 9
            H+T TMK
Sbjct: 2884 HITKTMK 2890
>XP_006712786
          Length = 35484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    HVTITMK 9
            H+T TMK
Sbjct: 2884 HITKTMK 2890
>NP_001035522
          Length = 356

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VAHVTITMK 9
           V H +IT+K
Sbjct: 156 VGHYSITLK 164
>NP_001004730
          Length = 310

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   VAHVTIT 7
           VAH T+T
Sbjct: 157 VAHTTLT 163
>NP_001254479
          Length = 35991

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    HVTITMK 9
            H+T TMK
Sbjct: 2883 HITKTMK 2889
>NP_597681
          Length = 27118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    HVTITMK 9
            H+T TMK
Sbjct: 2837 HITKTMK 2843
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.329    0.125    0.337 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 471,816
Number of extensions: 674
Number of successful extensions: 57
Number of sequences better than 10000.0: 57
Number of HSP's gapped: 57
Number of HSP's successfully gapped: 57
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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