Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001277144                                                           21     229
NP_001277143                                                           21     229
NP_001319                                                              21     229
NP_001012632                                                           21     229
NP_001077383                                                           21     229
NP_001320                                                              21     229
NP_073713                                                              21     229
XP_005269629                                                           21     229
XP_005269628                                                           21     229
XP_005269627                                                           21     229
XP_005269626                                                           21     229
XP_006717706                                                           21     229
XP_005269625                                                           21     229
XP_005269624                                                           21     229
XP_006717705                                                           21     229
XP_005269622                                                           21     229
XP_005269621                                                           21     229
XP_006717704                                                           21     229
XP_005269619                                                           21     229
XP_005269618                                                           21     229
XP_005272320                                                           21     229
XP_005272319                                                           21     229
XP_005272318                                                           21     229
XP_005276368                                                           17    4312
XP_005250138                                                           17    4312
XP_005276070                                                           17    4312
NP_001009905                                                           16    7355
XP_006725352                                                           16    7355
XP_006722336                                                           16    7355
XP_006722335                                                           16    7355
NP_003059                                                              15    9605
NP_699193                                                              15    9605
NP_001163894                                                           15    9605
NP_848519                                                              15    9605
NP_079182                                                              15    9605
NP_001164111                                                           15    9605
NP_036251                                                              15    9605
NP_001032671                                                           15    9605
NP_001164110                                                           15    9605
NP_001034892                                                           15    9605
NP_001186017                                                           15    9605
NP_001186015                                                           15    9605
NP_001186016                                                           15    9605
NP_150278                                                              15    9605
NP_001002006                                                           15    9605
NP_001186032                                                           15    9605
NP_001186033                                                           15    9605
NP_001012977                                                           15    9605
NP_001180473                                                           15    9605
NP_001146                                                              15    9605
XP_005251917                                                           15    9605
XP_005268489                                                           15    9605
>NP_001277144
          Length = 445

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  VAFCDAQS 8
          VAFCDAQS
Sbjct: 57 VAFCDAQS 64
>NP_001277143
          Length = 445

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  VAFCDAQS 8
          VAFCDAQS
Sbjct: 57 VAFCDAQS 64
>NP_001319
          Length = 440

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  VAFCDAQS 8
          VAFCDAQS
Sbjct: 51 VAFCDAQS 58
>NP_001012632
          Length = 429

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  VAFCDAQS 8
          VAFCDAQS
Sbjct: 40 VAFCDAQS 47
>NP_001077383
          Length = 445

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  VAFCDAQS 8
          VAFCDAQS
Sbjct: 57 VAFCDAQS 64
>NP_001320
          Length = 445

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  VAFCDAQS 8
          VAFCDAQS
Sbjct: 57 VAFCDAQS 64
>NP_073713
          Length = 985

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   VAFCDAQS 8
           VAFCDAQS
Sbjct: 597 VAFCDAQS 604
>XP_005269629
          Length = 445

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  VAFCDAQS 8
          VAFCDAQS
Sbjct: 57 VAFCDAQS 64
>XP_005269628
          Length = 445

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  VAFCDAQS 8
          VAFCDAQS
Sbjct: 57 VAFCDAQS 64
>XP_005269627
          Length = 445

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  VAFCDAQS 8
          VAFCDAQS
Sbjct: 57 VAFCDAQS 64
>XP_005269626
          Length = 445

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  VAFCDAQS 8
          VAFCDAQS
Sbjct: 57 VAFCDAQS 64
>XP_006717706
          Length = 445

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  VAFCDAQS 8
          VAFCDAQS
Sbjct: 57 VAFCDAQS 64
>XP_005269625
          Length = 445

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  VAFCDAQS 8
          VAFCDAQS
Sbjct: 57 VAFCDAQS 64
>XP_005269624
          Length = 445

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  VAFCDAQS 8
          VAFCDAQS
Sbjct: 57 VAFCDAQS 64
>XP_006717705
          Length = 445

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  VAFCDAQS 8
          VAFCDAQS
Sbjct: 57 VAFCDAQS 64
>XP_005269622
          Length = 445

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  VAFCDAQS 8
          VAFCDAQS
Sbjct: 57 VAFCDAQS 64
>XP_005269621
          Length = 445

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  VAFCDAQS 8
          VAFCDAQS
Sbjct: 57 VAFCDAQS 64
>XP_006717704
          Length = 445

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  VAFCDAQS 8
          VAFCDAQS
Sbjct: 57 VAFCDAQS 64
>XP_005269619
          Length = 445

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  VAFCDAQS 8
          VAFCDAQS
Sbjct: 57 VAFCDAQS 64
>XP_005269618
          Length = 445

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  VAFCDAQS 8
          VAFCDAQS
Sbjct: 57 VAFCDAQS 64
>XP_005272320
          Length = 430

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  VAFCDAQS 8
          VAFCDAQS
Sbjct: 40 VAFCDAQS 47
>XP_005272319
          Length = 430

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  VAFCDAQS 8
          VAFCDAQS
Sbjct: 40 VAFCDAQS 47
>XP_005272318
          Length = 441

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  VAFCDAQS 8
          VAFCDAQS
Sbjct: 51 VAFCDAQS 58
>XP_005276368
          Length = 103

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  AFCDAQ 7
          A+CDAQ
Sbjct: 46 AYCDAQ 51
>XP_005250138
          Length = 103

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  AFCDAQ 7
          A+CDAQ
Sbjct: 46 AYCDAQ 51
>XP_005276070
          Length = 103

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  AFCDAQ 7
          A+CDAQ
Sbjct: 46 AYCDAQ 51
>NP_001009905
          Length = 361

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1   VAFCD 5
           VAFCD
Sbjct: 289 VAFCD 293
>XP_006725352
          Length = 332

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1   VAFCD 5
           VAFCD
Sbjct: 274 VAFCD 278
>XP_006722336
          Length = 332

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1   VAFCD 5
           VAFCD
Sbjct: 274 VAFCD 278
>XP_006722335
          Length = 361

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1   VAFCD 5
           VAFCD
Sbjct: 289 VAFCD 293
>NP_003059
          Length = 268

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   CDAQS 8
           CDAQS
Sbjct: 151 CDAQS 155
>NP_699193
          Length = 413

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   FCDAQS 8
           +CDA+S
Sbjct: 338 YCDAES 343
>NP_001163894
          Length = 413

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   FCDAQS 8
           +CDA+S
Sbjct: 338 YCDAES 343
>NP_848519
          Length = 338

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VAFCDAQSM 9
           VAFC A ++
Sbjct: 128 VAFCHANNI 136
>NP_079182
          Length = 256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1  VAFCDAQ 7
          + FCDA+
Sbjct: 11 IPFCDAK 17
>NP_001164111
          Length = 243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VAFCDAQSM 9
           VAFC A ++
Sbjct: 115 VAFCHANNI 123
>NP_036251
          Length = 325

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VAFCDAQSM 9
           VAFC A ++
Sbjct: 115 VAFCHANNI 123
>NP_001032671
          Length = 330

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1  VAFCDAQ 7
          + FCDA+
Sbjct: 11 IPFCDAK 17
>NP_001164110
          Length = 275

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VAFCDAQSM 9
           VAFC A ++
Sbjct: 115 VAFCHANNI 123
>NP_001034892
          Length = 346

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VAFCDAQSM 9
           VAFC A ++
Sbjct: 115 VAFCHANNI 123
>NP_001186017
          Length = 612

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   VAFCDAQ 7
           +A+CD Q
Sbjct: 457 MAYCDTQ 463
>NP_001186015
          Length = 593

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   VAFCDAQ 7
           +A+CD Q
Sbjct: 438 MAYCDTQ 444
>NP_001186016
          Length = 627

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   VAFCDAQ 7
           +A+CD Q
Sbjct: 472 MAYCDTQ 478
>NP_150278
          Length = 550

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   VAFCDAQ 7
           +A+CD Q
Sbjct: 395 MAYCDTQ 401
>NP_001002006
          Length = 610

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   VAFCDAQ 7
           +A+CD Q
Sbjct: 455 MAYCDTQ 461
>NP_001186032
          Length = 650

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   VAFCDAQ 7
           +A+CD Q
Sbjct: 397 MAYCDTQ 403
>NP_001186033
          Length = 602

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   VAFCDAQ 7
           +A+CD Q
Sbjct: 455 MAYCDTQ 461
>NP_001012977
          Length = 678

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   FCDAQS 8
           +CDA+S
Sbjct: 664 YCDAES 669
>NP_001180473
          Length = 641

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  AFCDAQSM 9
          A+CDA+ +
Sbjct: 62 AYCDAKEI 69
>NP_001146
          Length = 673

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   AFCDAQSM 9
           A+CDA+ +
Sbjct: 94  AYCDAKEI 101
>XP_005251917
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VAFCDAQSM 9
           VAFC A ++
Sbjct: 115 VAFCHANNI 123
>XP_005268489
          Length = 667

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   AFCDAQSM 9
           A+CDA+ +
Sbjct: 94  AYCDAKEI 101
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.336    0.127    0.407 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 492,846
Number of extensions: 425
Number of successful extensions: 52
Number of sequences better than 10000.0: 52
Number of HSP's gapped: 52
Number of HSP's successfully gapped: 52
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.5 bits)
S2: 28 (15.4 bits)

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