Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001277144                                                           20     299
NP_001277143                                                           20     299
NP_001319                                                              20     299
NP_001012632                                                           20     299
NP_001077383                                                           20     299
NP_001320                                                              20     299
NP_073713                                                              20     299
XP_005269629                                                           20     299
XP_005269628                                                           20     299
XP_005269627                                                           20     299
XP_005269626                                                           20     299
XP_006717706                                                           20     299
XP_005269625                                                           20     299
XP_005269624                                                           20     299
XP_006717705                                                           20     299
XP_005269622                                                           20     299
XP_005269621                                                           20     299
XP_006717704                                                           20     299
XP_005269619                                                           20     299
XP_005269618                                                           20     299
XP_005272320                                                           20     299
XP_005272319                                                           20     299
XP_005272318                                                           20     299
XP_005276368                                                           18    1482
XP_005250138                                                           18    1482
XP_005276070                                                           18    1482
NP_001186017                                                           17    3301
NP_001186015                                                           17    3301
NP_001186016                                                           17    3301
NP_150278                                                              17    3301
NP_001002006                                                           17    3301
NP_001186032                                                           17    3301
NP_001186033                                                           17    3301
NP_055680                                                              17    4312
NP_689799                                                              17    4312
XP_005269639                                                           17    4312
XP_006717716                                                           17    4312
XP_006717715                                                           17    4312
XP_006717714                                                           17    4312
XP_006717713                                                           17    4312
XP_006717712                                                           17    4312
XP_006717711                                                           17    4312
XP_005269635                                                           17    4312
XP_006717710                                                           17    4312
XP_006717709                                                           17    4312
XP_006717708                                                           17    4312
NP_005888                                                              16    5631
NP_001138821                                                           16    5631
XP_006710686                                                           16    5631
XP_005270897                                                           16    5631
XP_005270896                                                           16    5631
XP_006710685                                                           16    5631
NP_208384                                                              16    7355
NP_001032412                                                           16    7355
NP_001009905                                                           16    7355
XP_006725352                                                           16    7355
XP_006722336                                                           16    7355
XP_006722335                                                           16    7355
NP_001003750                                                           16    7355
NP_079182                                                              15    9605
NP_005899                                                              15    9605
NP_001032671                                                           15    9605
>NP_001277144
          Length = 445

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VAFCDAQLT 9
          VAFCDAQ T
Sbjct: 57 VAFCDAQST 65
>NP_001277143
          Length = 445

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VAFCDAQLT 9
          VAFCDAQ T
Sbjct: 57 VAFCDAQST 65
>NP_001319
          Length = 440

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VAFCDAQLT 9
          VAFCDAQ T
Sbjct: 51 VAFCDAQST 59
>NP_001012632
          Length = 429

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VAFCDAQLT 9
          VAFCDAQ T
Sbjct: 40 VAFCDAQST 48
>NP_001077383
          Length = 445

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VAFCDAQLT 9
          VAFCDAQ T
Sbjct: 57 VAFCDAQST 65
>NP_001320
          Length = 445

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VAFCDAQLT 9
          VAFCDAQ T
Sbjct: 57 VAFCDAQST 65
>NP_073713
          Length = 985

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VAFCDAQLT 9
           VAFCDAQ T
Sbjct: 597 VAFCDAQST 605
>XP_005269629
          Length = 445

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VAFCDAQLT 9
          VAFCDAQ T
Sbjct: 57 VAFCDAQST 65
>XP_005269628
          Length = 445

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VAFCDAQLT 9
          VAFCDAQ T
Sbjct: 57 VAFCDAQST 65
>XP_005269627
          Length = 445

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VAFCDAQLT 9
          VAFCDAQ T
Sbjct: 57 VAFCDAQST 65
>XP_005269626
          Length = 445

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VAFCDAQLT 9
          VAFCDAQ T
Sbjct: 57 VAFCDAQST 65
>XP_006717706
          Length = 445

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VAFCDAQLT 9
          VAFCDAQ T
Sbjct: 57 VAFCDAQST 65
>XP_005269625
          Length = 445

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VAFCDAQLT 9
          VAFCDAQ T
Sbjct: 57 VAFCDAQST 65
>XP_005269624
          Length = 445

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VAFCDAQLT 9
          VAFCDAQ T
Sbjct: 57 VAFCDAQST 65
>XP_006717705
          Length = 445

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VAFCDAQLT 9
          VAFCDAQ T
Sbjct: 57 VAFCDAQST 65
>XP_005269622
          Length = 445

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VAFCDAQLT 9
          VAFCDAQ T
Sbjct: 57 VAFCDAQST 65
>XP_005269621
          Length = 445

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VAFCDAQLT 9
          VAFCDAQ T
Sbjct: 57 VAFCDAQST 65
>XP_006717704
          Length = 445

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VAFCDAQLT 9
          VAFCDAQ T
Sbjct: 57 VAFCDAQST 65
>XP_005269619
          Length = 445

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VAFCDAQLT 9
          VAFCDAQ T
Sbjct: 57 VAFCDAQST 65
>XP_005269618
          Length = 445

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VAFCDAQLT 9
          VAFCDAQ T
Sbjct: 57 VAFCDAQST 65
>XP_005272320
          Length = 430

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VAFCDAQLT 9
          VAFCDAQ T
Sbjct: 40 VAFCDAQST 48
>XP_005272319
          Length = 430

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VAFCDAQLT 9
          VAFCDAQ T
Sbjct: 40 VAFCDAQST 48
>XP_005272318
          Length = 441

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VAFCDAQLT 9
          VAFCDAQ T
Sbjct: 51 VAFCDAQST 59
>XP_005276368
          Length = 103

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  AFCDAQL 8
          A+CDAQL
Sbjct: 46 AYCDAQL 52
>XP_005250138
          Length = 103

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  AFCDAQL 8
          A+CDAQL
Sbjct: 46 AYCDAQL 52
>XP_005276070
          Length = 103

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  AFCDAQL 8
          A+CDAQL
Sbjct: 46 AYCDAQL 52
>NP_001186017
          Length = 612

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VAFCDAQL 8
           +A+CD QL
Sbjct: 457 MAYCDTQL 464
>NP_001186015
          Length = 593

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VAFCDAQL 8
           +A+CD QL
Sbjct: 438 MAYCDTQL 445
>NP_001186016
          Length = 627

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VAFCDAQL 8
           +A+CD QL
Sbjct: 472 MAYCDTQL 479
>NP_150278
          Length = 550

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VAFCDAQL 8
           +A+CD QL
Sbjct: 395 MAYCDTQL 402
>NP_001002006
          Length = 610

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VAFCDAQL 8
           +A+CD QL
Sbjct: 455 MAYCDTQL 462
>NP_001186032
          Length = 650

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VAFCDAQL 8
           +A+CD QL
Sbjct: 397 MAYCDTQL 404
>NP_001186033
          Length = 602

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VAFCDAQL 8
           +A+CD QL
Sbjct: 455 MAYCDTQL 462
>NP_055680
          Length = 1401

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    FCDAQL 8
            FCD+QL
Sbjct: 1051 FCDSQL 1056
>NP_689799
          Length = 1684

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    FCDAQL 8
            FCD+QL
Sbjct: 1269 FCDSQL 1274
>XP_005269639
          Length = 1580

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    FCDAQL 8
            FCD+QL
Sbjct: 1212 FCDSQL 1217
>XP_006717716
          Length = 1619

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    FCDAQL 8
            FCD+QL
Sbjct: 1251 FCDSQL 1256
>XP_006717715
          Length = 1660

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    FCDAQL 8
            FCD+QL
Sbjct: 1245 FCDSQL 1250
>XP_006717714
          Length = 1665

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    FCDAQL 8
            FCD+QL
Sbjct: 1302 FCDSQL 1307
>XP_006717713
          Length = 1666

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    FCDAQL 8
            FCD+QL
Sbjct: 1251 FCDSQL 1256
>XP_006717712
          Length = 1670

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    FCDAQL 8
            FCD+QL
Sbjct: 1302 FCDSQL 1307
>XP_006717711
          Length = 1677

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    FCDAQL 8
            FCD+QL
Sbjct: 1262 FCDSQL 1267
>XP_005269635
          Length = 1695

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    FCDAQL 8
            FCD+QL
Sbjct: 1280 FCDSQL 1285
>XP_006717710
          Length = 1706

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    FCDAQL 8
            FCD+QL
Sbjct: 1291 FCDSQL 1296
>XP_006717709
          Length = 1712

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    FCDAQL 8
            FCD+QL
Sbjct: 1302 FCDSQL 1307
>XP_006717708
          Length = 1717

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    FCDAQL 8
            FCD+QL
Sbjct: 1302 FCDSQL 1307
>NP_005888
          Length = 584

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3  FCDAQL 8
          FCD QL
Sbjct: 36 FCDVQL 41
>NP_001138821
          Length = 582

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3  FCDAQL 8
          FCD QL
Sbjct: 36 FCDVQL 41
>XP_006710686
          Length = 440

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3  FCDAQL 8
          FCD QL
Sbjct: 36 FCDVQL 41
>XP_005270897
          Length = 465

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3  FCDAQL 8
          FCD QL
Sbjct: 36 FCDVQL 41
>XP_005270896
          Length = 465

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3  FCDAQL 8
          FCD QL
Sbjct: 36 FCDVQL 41
>XP_006710685
          Length = 538

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3  FCDAQL 8
          FCD QL
Sbjct: 36 FCDVQL 41
>NP_208384
          Length = 2080

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    FCDAQLT 9
            FC+AQ T
Sbjct: 2057 FCEAQQT 2063
>NP_001032412
          Length = 2649

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    FCDAQLT 9
            FC+AQ T
Sbjct: 2626 FCEAQQT 2632
>NP_001009905
          Length = 361

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1   VAFCD 5
           VAFCD
Sbjct: 289 VAFCD 293
>XP_006725352
          Length = 332

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1   VAFCD 5
           VAFCD
Sbjct: 274 VAFCD 278
>XP_006722336
          Length = 332

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1   VAFCD 5
           VAFCD
Sbjct: 274 VAFCD 278
>XP_006722335
          Length = 361

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1   VAFCD 5
           VAFCD
Sbjct: 289 VAFCD 293
>NP_001003750
          Length = 310

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   VAFCDAQL 8
           +AFCD+ +
Sbjct: 166 LAFCDSSI 173
>NP_079182
          Length = 256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1  VAFCDAQ 7
          + FCDA+
Sbjct: 11 IPFCDAK 17
>NP_005899
          Length = 879

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   VAFCDAQLT 9
           V  C AQ+T
Sbjct: 797 VGLCKAQIT 805
>NP_001032671
          Length = 330

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1  VAFCDAQ 7
          + FCDA+
Sbjct: 11 IPFCDAK 17
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.336    0.135    0.439 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 516,294
Number of extensions: 482
Number of successful extensions: 62
Number of sequences better than 10000.0: 62
Number of HSP's gapped: 62
Number of HSP's successfully gapped: 62
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.5 bits)
S2: 28 (15.4 bits)

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