Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              18    1135
NP_671714                                                              18    1135
XP_006715890                                                           18    1135
XP_005250160                                                           18    1135
XP_005250159                                                           18    1135
NP_114426                                                              16    5631
NP_061821                                                              16    7355
NP_001128119                                                           16    7355
NP_940997                                                              16    7355
XP_006713973                                                           16    7355
XP_006713972                                                           16    7355
XP_006713971                                                           16    7355
XP_005263534                                                           16    7355
XP_006710760                                                           16    7355
NP_001707                                                              15    9605
NP_116743                                                              15    9605
NP_775837                                                              15    9605
NP_071451                                                              15    9605
NP_056164                                                              15    9605
XP_006724284                                                           15    9605
XP_006724283                                                           15    9605
XP_006724282                                                           15    9605
XP_005261537                                                           15    9605
XP_005249030                                                           15    9605
XP_005249029                                                           15    9605
>NP_005742
          Length = 3907

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    AEGSVSKV 9
            AEGSVSKV
Sbjct: 1031 AEGSVSKV 1038
>NP_671714
          Length = 3899

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    AEGSVSKV 9
            AEGSVSKV
Sbjct: 1031 AEGSVSKV 1038
>XP_006715890
          Length = 3860

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    AEGSVSKV 9
            AEGSVSKV
Sbjct: 1031 AEGSVSKV 1038
>XP_005250160
          Length = 3939

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    AEGSVSKV 9
            AEGSVSKV
Sbjct: 1031 AEGSVSKV 1038
>XP_005250159
          Length = 3952

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    AEGSVSKV 9
            AEGSVSKV
Sbjct: 1031 AEGSVSKV 1038
>NP_114426
          Length = 273

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  VAEGSVSKV 9
          + EGS SKV
Sbjct: 18 IGEGSYSKV 26
>NP_061821
          Length = 462

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AEGSVSKV 9
           +EGS SKV
Sbjct: 369 SEGSASKV 376
>NP_001128119
          Length = 814

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   AEGSVSKV 9
           A+G+VSKV
Sbjct: 312 AKGTVSKV 319
>NP_940997
          Length = 730

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   AEGSVSKV 9
           A+G+VSKV
Sbjct: 312 AKGTVSKV 319
>XP_006713973
          Length = 558

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   AEGSVSKV 9
           A+G+VSKV
Sbjct: 333 AKGTVSKV 340
>XP_006713972
          Length = 751

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   AEGSVSKV 9
           A+G+VSKV
Sbjct: 333 AKGTVSKV 340
>XP_006713971
          Length = 835

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   AEGSVSKV 9
           A+G+VSKV
Sbjct: 333 AKGTVSKV 340
>XP_005263534
          Length = 411

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AEGSVSKV 9
           +EGS SKV
Sbjct: 318 SEGSASKV 325
>XP_006710760
          Length = 462

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AEGSVSKV 9
           +EGS SKV
Sbjct: 369 SEGSASKV 376
>NP_001707
          Length = 372

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   VAEGSVSKV 9
           VAEGSV  V
Sbjct: 108 VAEGSVGWV 116
>NP_116743
          Length = 327

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  VAEGSVSKV 9
          VAEGSV  V
Sbjct: 63 VAEGSVGWV 71
>NP_775837
          Length = 2151

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    VAEGSVSKV 9
            VAE +VSK+
Sbjct: 1958 VAESAVSKL 1966
>NP_071451
          Length = 1025

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   VAEGSVS 7
           +AEGSVS
Sbjct: 262 LAEGSVS 268
>NP_056164
          Length = 1079

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   AEGSVSK 8
           AEG++SK
Sbjct: 889 AEGNISK 895
>XP_006724284
          Length = 1989

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    VAEGSVSKV 9
            VAE +VSK+
Sbjct: 1796 VAESAVSKL 1804
>XP_006724283
          Length = 2151

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    VAEGSVSKV 9
            VAE +VSK+
Sbjct: 1958 VAESAVSKL 1966
>XP_006724282
          Length = 2151

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    VAEGSVSKV 9
            VAE +VSK+
Sbjct: 1958 VAESAVSKL 1966
>XP_005261537
          Length = 2151

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    VAEGSVSKV 9
            VAE +VSK+
Sbjct: 1958 VAESAVSKL 1966
>XP_005249030
          Length = 1079

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   AEGSVSK 8
           AEG++SK
Sbjct: 889 AEGNISK 895
>XP_005249029
          Length = 1079

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   AEGSVSK 8
           AEG++SK
Sbjct: 889 AEGNISK 895
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.295    0.113    0.258 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 435,499
Number of extensions: 399
Number of successful extensions: 25
Number of sequences better than 10000.0: 25
Number of HSP's gapped: 25
Number of HSP's successfully gapped: 25
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.1 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package