Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              19     869
NP_001075109                                                           19     869
NP_078961                                                              17    4312
XP_006719666                                                           17    4312
NP_004437                                                              16    5631
NP_000149                                                              16    7355
NP_001010904                                                           16    7355
NP_001136013                                                           16    7355
NP_057032                                                              16    7355
XP_006715167                                                           16    7355
XP_005249215                                                           16    7355
XP_006715166                                                           16    7355
XP_006715165                                                           16    7355
XP_005249214                                                           16    7355
XP_005249213                                                           16    7355
NP_001073920                                                           15    9605
NP_005015                                                              15    9605
>NP_008835
          Length = 4128

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TYMIIANAL 9
            TY IIANAL
Sbjct: 3333 TYRIIANAL 3341
>NP_001075109
          Length = 4097

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TYMIIANAL 9
            TY IIANAL
Sbjct: 3333 TYRIIANAL 3341
>NP_078961
          Length = 723

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   MIIANAL 9
           MIIANAL
Sbjct: 631 MIIANAL 637
>XP_006719666
          Length = 657

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   MIIANAL 9
           MIIANAL
Sbjct: 565 MIIANAL 571
>NP_004437
          Length = 1512

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    TYMIIANAL 9
            T+M++AN +
Sbjct: 1422 THMVVANTM 1430
>NP_000149
          Length = 702

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TYMIIANAL 9
           TY+++AN L
Sbjct: 391 TYLMLANHL 399
>NP_001010904
          Length = 288

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TYMIIANA 8
           TY+ +ANA
Sbjct: 155 TYLSVANA 162
>NP_001136013
          Length = 401

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TYMIIA 6
           TYMIIA
Sbjct: 145 TYMIIA 150
>NP_057032
          Length = 401

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TYMIIA 6
           TYMIIA
Sbjct: 145 TYMIIA 150
>XP_006715167
          Length = 285

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TYMIIA 6
           TYMIIA
Sbjct: 147 TYMIIA 152
>XP_005249215
          Length = 369

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TYMIIA 6
           TYMIIA
Sbjct: 113 TYMIIA 118
>XP_006715166
          Length = 372

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TYMIIA 6
           TYMIIA
Sbjct: 147 TYMIIA 152
>XP_006715165
          Length = 401

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TYMIIA 6
           TYMIIA
Sbjct: 145 TYMIIA 150
>XP_005249214
          Length = 401

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TYMIIA 6
           TYMIIA
Sbjct: 145 TYMIIA 150
>XP_005249213
          Length = 403

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TYMIIA 6
           TYMIIA
Sbjct: 147 TYMIIA 152
>NP_001073920
          Length = 422

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   TYMIIAN 7
           T+M++AN
Sbjct: 203 TFMVLAN 209
>NP_005015
          Length = 397

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TYMIIANAL 9
           T MI+ NAL
Sbjct: 179 TRMILVNAL 187
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.334    0.137    0.362 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 244,550
Number of extensions: 538
Number of successful extensions: 17
Number of sequences better than 10000.0: 17
Number of HSP's gapped: 17
Number of HSP's successfully gapped: 17
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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