Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006715                                                              20     509
NP_005913                                                              20     509
XP_005267046                                                           20     509
XP_005267045                                                           20     509
NP_077719                                                              17    4312
XP_005270959                                                           17    4312
XP_005270958                                                           17    4312
XP_006710730                                                           17    4312
NP_714915                                                              16    5631
NP_001135773                                                           16    5631
XP_006716750                                                           16    5631
XP_006716749                                                           16    5631
XP_006716748                                                           16    5631
NP_001743                                                              16    7355
NP_004090                                                              16    7355
NP_001257456                                                           16    7355
NP_001257455                                                           16    7355
NP_001129334                                                           15    9605
NP_612424                                                              15    9605
NP_001229379                                                           15    9605
NP_057405                                                              15    9605
XP_006724185                                                           15    9605
XP_006724184                                                           15    9605
>NP_006715
          Length = 1558

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TVVGIKNLS 9
           TV+GIKNLS
Sbjct: 412 TVLGIKNLS 420
>NP_005913
          Length = 1608

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TVVGIKNLS 9
           TV+GIKNLS
Sbjct: 412 TVLGIKNLS 420
>XP_005267046
          Length = 1554

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TVVGIKNLS 9
           TV+GIKNLS
Sbjct: 412 TVLGIKNLS 420
>XP_005267045
          Length = 1604

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TVVGIKNLS 9
           TV+GIKNLS
Sbjct: 412 TVLGIKNLS 420
>NP_077719
          Length = 2471

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    VGIKNLS 9
            VG+KNLS
Sbjct: 1735 VGLKNLS 1741
>XP_005270959
          Length = 2432

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    VGIKNLS 9
            VG+KNLS
Sbjct: 1696 VGLKNLS 1702
>XP_005270958
          Length = 2432

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    VGIKNLS 9
            VG+KNLS
Sbjct: 1696 VGLKNLS 1702
>XP_006710730
          Length = 2432

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    VGIKNLS 9
            VG+KNLS
Sbjct: 1696 VGLKNLS 1702
>NP_714915
          Length = 995

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VVGIKNLS 9
           VVG KNL+
Sbjct: 701 VVGFKNLA 708
>NP_001135773
          Length = 914

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VVGIKNLS 9
           VVG KNL+
Sbjct: 620 VVGFKNLA 627
>XP_006716750
          Length = 795

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VVGIKNLS 9
           VVG KNL+
Sbjct: 501 VVGFKNLA 508
>XP_006716749
          Length = 894

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VVGIKNLS 9
           VVG KNL+
Sbjct: 600 VVGFKNLA 607
>XP_006716748
          Length = 980

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VVGIKNLS 9
           VVG KNL+
Sbjct: 686 VVGFKNLA 693
>NP_001743
          Length = 527

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GIKNLS 9
           GIKNLS
Sbjct: 241 GIKNLS 246
>NP_004090
          Length = 288

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VVGIKNLS 9
           V+G KNLS
Sbjct: 154 VLGTKNLS 161
>NP_001257456
          Length = 168

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VVGIKNLS 9
           V+G KNLS
Sbjct: 154 VLGTKNLS 161
>NP_001257455
          Length = 197

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VVGIKNLS 9
           V+G KNLS
Sbjct: 154 VLGTKNLS 161
>NP_001129334
          Length = 489

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TVVGIKNLS 9
           TVV +KN S
Sbjct: 102 TVVSVKNPS 110
>NP_612424
          Length = 531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TVVGIKNLS 9
           TVV +KN S
Sbjct: 102 TVVSVKNPS 110
>NP_001229379
          Length = 477

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  TVVGIKNLS 9
          TVV +KN S
Sbjct: 90 TVVSVKNPS 98
>NP_057405
          Length = 479

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VVGIKNL 8
           VVG++NL
Sbjct: 119 VVGVENL 125
>XP_006724185
          Length = 489

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TVVGIKNLS 9
           TVV +KN S
Sbjct: 102 TVVSVKNPS 110
>XP_006724184
          Length = 302

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TVVGIKNLS 9
           TVV +KN S
Sbjct: 102 TVVSVKNPS 110
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.313    0.132    0.332 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 407,525
Number of extensions: 598
Number of successful extensions: 23
Number of sequences better than 10000.0: 23
Number of HSP's gapped: 23
Number of HSP's successfully gapped: 23
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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