Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001138389                                                           18    1482
NP_001138390                                                           18    1482
NP_001138386                                                           18    1482
NP_001138387                                                           18    1482
NP_000132                                                              18    1482
NP_075259                                                              18    1482
NP_001138388                                                           18    1482
NP_001138391                                                           18    1482
NP_001138385                                                           18    1482
NP_075418                                                              18    1482
NP_001156685                                                           18    1482
NP_000133                                                              18    1482
NP_075254                                                              18    1482
XP_006717776                                                           18    1482
XP_006717775                                                           18    1482
XP_006717774                                                           18    1482
XP_006717773                                                           18    1482
XP_006717772                                                           18    1482
XP_006717771                                                           18    1482
XP_006713936                                                           18    1482
XP_006713935                                                           18    1482
XP_006713934                                                           18    1482
XP_006713933                                                           18    1482
XP_006713932                                                           18    1482
XP_006713931                                                           18    1482
NP_000213                                                              17    3301
NP_001087241                                                           17    3301
XP_005265799                                                           17    3301
XP_005265798                                                           17    3301
XP_005265797                                                           17    3301
NP_002011                                                              17    4312
NP_891555                                                              17    4312
NP_065681                                                              17    4312
NP_066124                                                              17    4312
NP_002600                                                              17    4312
NP_002244                                                              17    4312
NP_075252                                                              17    4312
NP_998812                                                              17    4312
NP_002002                                                              17    4312
NP_002010                                                              17    4312
XP_006717999                                                           17    4312
XP_005265895                                                           17    4312
XP_005265894                                                           17    4312
XP_005268521                                                           17    4312
NP_001136245                                                           16    7355
NP_001136239                                                           16    7355
NP_001136236                                                           16    7355
NP_001136244                                                           16    7355
NP_001136238                                                           16    7355
NP_001136240                                                           16    7355
NP_001136243                                                           16    7355
NP_001136242                                                           16    7355
NP_001136235                                                           16    7355
NP_001136237                                                           16    7355
NP_001136241                                                           16    7355
NP_149045                                                              16    7355
NP_006173                                                              16    7355
NP_001014796                                                           16    7355
NP_004110                                                              16    7355
NP_006284                                                              16    7355
XP_006718013                                                           16    7355
XP_006711407                                                           16    7355
XP_005245278                                                           16    7355
NP_001161846                                                           15    9605
NP_001161849                                                           15    9605
NP_001161848                                                           15    9605
NP_001239257                                                           15    9605
NP_055624                                                              15    9605
NP_001161847                                                           15    9605
XP_006715351                                                           15    9605
XP_006715350                                                           15    9605
XP_006715349                                                           15    9605
XP_005249561                                                           15    9605
>NP_001138389
          Length = 705

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   VTVAVKML 9
           VTVAVKML
Sbjct: 396 VTVAVKML 403
>NP_001138390
          Length = 704

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   VTVAVKML 9
           VTVAVKML
Sbjct: 395 VTVAVKML 402
>NP_001138386
          Length = 709

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   VTVAVKML 9
           VTVAVKML
Sbjct: 400 VTVAVKML 407
>NP_001138387
          Length = 707

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   VTVAVKML 9
           VTVAVKML
Sbjct: 423 VTVAVKML 430
>NP_000132
          Length = 821

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   VTVAVKML 9
           VTVAVKML
Sbjct: 512 VTVAVKML 519
>NP_075259
          Length = 822

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   VTVAVKML 9
           VTVAVKML
Sbjct: 513 VTVAVKML 520
>NP_001138388
          Length = 706

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   VTVAVKML 9
           VTVAVKML
Sbjct: 397 VTVAVKML 404
>NP_001138391
          Length = 680

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   VTVAVKML 9
           VTVAVKML
Sbjct: 424 VTVAVKML 431
>NP_001138385
          Length = 769

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   VTVAVKML 9
           VTVAVKML
Sbjct: 513 VTVAVKML 520
>NP_075418
          Length = 732

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   VTVAVKML 9
           VTVAVKML
Sbjct: 423 VTVAVKML 430
>NP_001156685
          Length = 808

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   VTVAVKML 9
           VTVAVKML
Sbjct: 505 VTVAVKML 512
>NP_000133
          Length = 806

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   VTVAVKML 9
           VTVAVKML
Sbjct: 503 VTVAVKML 510
>NP_075254
          Length = 694

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   VTVAVKML 9
           VTVAVKML
Sbjct: 391 VTVAVKML 398
>XP_006717776
          Length = 806

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   VTVAVKML 9
           VTVAVKML
Sbjct: 531 VTVAVKML 538
>XP_006717775
          Length = 726

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   VTVAVKML 9
           VTVAVKML
Sbjct: 417 VTVAVKML 424
>XP_006717774
          Length = 752

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   VTVAVKML 9
           VTVAVKML
Sbjct: 443 VTVAVKML 450
>XP_006717773
          Length = 807

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   VTVAVKML 9
           VTVAVKML
Sbjct: 532 VTVAVKML 539
>XP_006717772
          Length = 838

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   VTVAVKML 9
           VTVAVKML
Sbjct: 529 VTVAVKML 536
>XP_006717771
          Length = 839

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   VTVAVKML 9
           VTVAVKML
Sbjct: 530 VTVAVKML 537
>XP_006713936
          Length = 807

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   VTVAVKML 9
           VTVAVKML
Sbjct: 503 VTVAVKML 510
>XP_006713935
          Length = 807

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   VTVAVKML 9
           VTVAVKML
Sbjct: 504 VTVAVKML 511
>XP_006713934
          Length = 809

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   VTVAVKML 9
           VTVAVKML
Sbjct: 505 VTVAVKML 512
>XP_006713933
          Length = 810

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   VTVAVKML 9
           VTVAVKML
Sbjct: 506 VTVAVKML 513
>XP_006713932
          Length = 810

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   VTVAVKML 9
           VTVAVKML
Sbjct: 507 VTVAVKML 514
>XP_006713931
          Length = 811

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   VTVAVKML 9
           VTVAVKML
Sbjct: 507 VTVAVKML 514
>NP_000213
          Length = 976

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   VTVAVKML 9
           +TVAVKML
Sbjct: 618 MTVAVKML 625
>NP_001087241
          Length = 972

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   VTVAVKML 9
           +TVAVKML
Sbjct: 614 MTVAVKML 621
>XP_005265799
          Length = 973

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   VTVAVKML 9
           +TVAVKML
Sbjct: 615 MTVAVKML 622
>XP_005265798
          Length = 976

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   VTVAVKML 9
           +TVAVKML
Sbjct: 619 MTVAVKML 626
>XP_005265797
          Length = 977

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   VTVAVKML 9
           +TVAVKML
Sbjct: 619 MTVAVKML 626
>NP_002011
          Length = 1298

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   TVAVKML 9
           TVAVKML
Sbjct: 875 TVAVKML 881
>NP_891555
          Length = 1363

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   TVAVKML 9
           TVAVKML
Sbjct: 875 TVAVKML 881
>NP_065681
          Length = 1072

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   TVAVKML 9
           TVAVKML
Sbjct: 754 TVAVKML 760
>NP_066124
          Length = 1114

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   TVAVKML 9
           TVAVKML
Sbjct: 754 TVAVKML 760
>NP_002600
          Length = 1106

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   TVTVAVKML 9
           T+ VAVKML
Sbjct: 628 TMKVAVKML 636
>NP_002244
          Length = 1356

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   TVAVKML 9
           TVAVKML
Sbjct: 864 TVAVKML 870
>NP_075252
          Length = 762

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   TVAVKML 9
           TVAVKML
Sbjct: 459 TVAVKML 465
>NP_998812
          Length = 802

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   TVAVKML 9
           TVAVKML
Sbjct: 499 TVAVKML 505
>NP_002002
          Length = 802

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   TVAVKML 9
           TVAVKML
Sbjct: 499 TVAVKML 505
>NP_002010
          Length = 1338

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   TVAVKML 9
           TVAVKML
Sbjct: 857 TVAVKML 863
>XP_006717999
          Length = 1207

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   TVAVKML 9
           TVAVKML
Sbjct: 847 TVAVKML 853
>XP_005265895
          Length = 802

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   TVAVKML 9
           TVAVKML
Sbjct: 499 TVAVKML 505
>XP_005265894
          Length = 834

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   TVAVKML 9
           TVAVKML
Sbjct: 531 TVAVKML 537
>XP_005268521
          Length = 1042

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   TVTVAVKML 9
           T+ VAVKML
Sbjct: 564 TMKVAVKML 572
>NP_001136245
          Length = 1932

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TVTVAVKML 9
           T+T+A+K+L
Sbjct: 780 TLTLAIKVL 788
>NP_001136239
          Length = 1915

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TVTVAVKML 9
           T+T+A+K+L
Sbjct: 765 TLTLAIKVL 773
>NP_001136236
          Length = 1957

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TVTVAVKML 9
           T+T+A+K+L
Sbjct: 802 TLTLAIKVL 810
>NP_001136244
          Length = 1677

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TVTVAVKML 9
           T+T+A+K+L
Sbjct: 802 TLTLAIKVL 810
>NP_001136238
          Length = 1952

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TVTVAVKML 9
           T+T+A+K+L
Sbjct: 802 TLTLAIKVL 810
>NP_001136240
          Length = 1935

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TVTVAVKML 9
           T+T+A+K+L
Sbjct: 780 TLTLAIKVL 788
>NP_001136243
          Length = 1682

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TVTVAVKML 9
           T+T+A+K+L
Sbjct: 807 TLTLAIKVL 815
>NP_001136242
          Length = 1539

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TVTVAVKML 9
           T+T+A+K+L
Sbjct: 802 TLTLAIKVL 810
>NP_001136235
          Length = 1962

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TVTVAVKML 9
           T+T+A+K+L
Sbjct: 807 TLTLAIKVL 815
>NP_001136237
          Length = 1886

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TVTVAVKML 9
           T+T+A+K+L
Sbjct: 731 TLTLAIKVL 739
>NP_001136241
          Length = 1790

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TVTVAVKML 9
           T+T+A+K+L
Sbjct: 814 TLTLAIKVL 822
>NP_149045
          Length = 1955

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TVTVAVKML 9
           T+T+A+K+L
Sbjct: 802 TLTLAIKVL 810
>NP_006173
          Length = 855

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   VTVAVKML 9
           V VAVKML
Sbjct: 603 VLVAVKML 610
>NP_001014796
          Length = 855

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   VTVAVKML 9
           V VAVKML
Sbjct: 603 VLVAVKML 610
>NP_004110
          Length = 993

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TVTVAVKML 9
           ++ VAVKML
Sbjct: 638 SIQVAVKML 646
>NP_006284
          Length = 890

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   VTVAVKML 9
           V VAVKML
Sbjct: 545 VKVAVKML 552
>XP_006718013
          Length = 1778

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TVTVAVKML 9
           T+T+A+K+L
Sbjct: 802 TLTLAIKVL 810
>XP_006711407
          Length = 855

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   VTVAVKML 9
           V VAVKML
Sbjct: 603 VLVAVKML 610
>XP_005245278
          Length = 867

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   VTVAVKML 9
           V VAVKML
Sbjct: 615 VLVAVKML 622
>NP_001161846
          Length = 1063

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TVTVAVK 7
           T+TVAVK
Sbjct: 697 TLTVAVK 703
>NP_001161849
          Length = 1011

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TVTVAVK 7
           T+TVAVK
Sbjct: 706 TLTVAVK 712
>NP_001161848
          Length = 1027

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TVTVAVK 7
           T+TVAVK
Sbjct: 661 TLTVAVK 667
>NP_001239257
          Length = 483

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TVTVAVK 7
           T+TVAVK
Sbjct: 117 TLTVAVK 123
>NP_055624
          Length = 1072

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TVTVAVK 7
           T+TVAVK
Sbjct: 706 TLTVAVK 712
>NP_001161847
          Length = 1072

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TVTVAVK 7
           T+TVAVK
Sbjct: 706 TLTVAVK 712
>XP_006715351
          Length = 920

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TVTVAVK 7
           T+TVAVK
Sbjct: 554 TLTVAVK 560
>XP_006715350
          Length = 1040

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TVTVAVK 7
           T+TVAVK
Sbjct: 768 TLTVAVK 774
>XP_006715349
          Length = 1101

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TVTVAVK 7
           T+TVAVK
Sbjct: 735 TLTVAVK 741
>XP_005249561
          Length = 1134

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TVTVAVK 7
           T+TVAVK
Sbjct: 768 TLTVAVK 774
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.328    0.127    0.296 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 215,591
Number of extensions: 283
Number of successful extensions: 73
Number of sequences better than 10000.0: 73
Number of HSP's gapped: 73
Number of HSP's successfully gapped: 73
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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