Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              19     869
XP_005262424                                                           19     869
NP_115785                                                              16    7355
NP_598193                                                              16    7355
NP_598194                                                              16    7355
NP_002868                                                              16    7355
XP_005268020                                                           16    7355
XP_005268019                                                           16    7355
XP_005268018                                                           16    7355
NP_004685                                                              15    9605
NP_001167637                                                           15    9605
NP_055401                                                              15    9605
XP_006722232                                                           15    9605
XP_005257846                                                           15    9605
NP_543146                                                              15    9605
>NP_722576
          Length = 3080

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    TVLSNRITT 9
            TVLS+RITT
Sbjct: 1479 TVLSDRITT 1487
>XP_005262424
          Length = 2875

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    TVLSNRITT 9
            TVLS+RITT
Sbjct: 1274 TVLSDRITT 1282
>NP_115785
          Length = 581

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TVLSNRIT 8
           T+L+NR+T
Sbjct: 538 TLLANRLT 545
>NP_598193
          Length = 384

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VLSNRITT 9
           +L+N+ITT
Sbjct: 254 ILTNQITT 261
>NP_598194
          Length = 350

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VLSNRITT 9
           +L+N+ITT
Sbjct: 254 ILTNQITT 261
>NP_002868
          Length = 350

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VLSNRITT 9
           +L+N+ITT
Sbjct: 254 ILTNQITT 261
>XP_005268020
          Length = 347

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VLSNRITT 9
           +L+N+ITT
Sbjct: 254 ILTNQITT 261
>XP_005268019
          Length = 351

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VLSNRITT 9
           +L+N+ITT
Sbjct: 254 ILTNQITT 261
>XP_005268018
          Length = 372

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VLSNRITT 9
           +L+N+ITT
Sbjct: 254 ILTNQITT 261
>NP_004685
          Length = 523

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  TVLSNR 6
          TVLSNR
Sbjct: 82 TVLSNR 87
>NP_001167637
          Length = 523

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  TVLSNR 6
          TVLSNR
Sbjct: 82 TVLSNR 87
>NP_055401
          Length = 714

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TVLSNR 6
           TVLSNR
Sbjct: 365 TVLSNR 370
>XP_006722232
          Length = 523

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  TVLSNR 6
          TVLSNR
Sbjct: 82 TVLSNR 87
>XP_005257846
          Length = 523

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  TVLSNR 6
          TVLSNR
Sbjct: 82 TVLSNR 87
>NP_543146
          Length = 1393

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TVLSNRITT 9
           T L+N ITT
Sbjct: 928 TPLANEITT 936
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.314    0.120    0.292 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 290,983
Number of extensions: 298
Number of successful extensions: 15
Number of sequences better than 10000.0: 15
Number of HSP's gapped: 15
Number of HSP's successfully gapped: 15
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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