Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_002941                                                              16    5631
NP_055177                                                              16    7355
NP_932164                                                              16    7355
NP_001137469                                                           16    7355
NP_001137468                                                           16    7355
NP_060715                                                              16    7355
NP_006332                                                              16    7355
XP_005263480                                                           16    7355
NP_001120797                                                           16    7355
NP_001001915                                                           16    7355
NP_001018098                                                           15    9605
NP_060154                                                              15    9605
NP_001265247                                                           15    9605
NP_060550                                                              15    9605
NP_006854                                                              15    9605
NP_065872                                                              15    9605
NP_937817                                                              15    9605
NP_705618                                                              15    9605
NP_055640                                                              15    9605
NP_004289                                                              15    9605
NP_001265248                                                           15    9605
NP_001158508                                                           15    9605
NP_002532                                                              15    9605
NP_001265241                                                           15    9605
XP_006726237                                                           15    9605
XP_006726236                                                           15    9605
XP_006726235                                                           15    9605
XP_006726234                                                           15    9605
XP_006726360                                                           15    9605
XP_006726359                                                           15    9605
XP_006726358                                                           15    9605
XP_006726357                                                           15    9605
XP_006726324                                                           15    9605
XP_006726323                                                           15    9605
XP_006726322                                                           15    9605
XP_006726321                                                           15    9605
XP_006723045                                                           15    9605
XP_006723044                                                           15    9605
XP_006723043                                                           15    9605
XP_006723042                                                           15    9605
XP_005249816                                                           15    9605
XP_005249818                                                           15    9605
>NP_002941
          Length = 607

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   TVLIHVRL 8
           TV+I+VRL
Sbjct: 452 TVIIYVRL 459
>NP_055177
          Length = 386

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  TVLIHVRLS 9
          T+L H+R+S
Sbjct: 21 TILHHLRMS 29
>NP_932164
          Length = 338

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  TVLIHVRLS 9
          T+L H+R+S
Sbjct: 21 TILHHLRMS 29
>NP_001137469
          Length = 801

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   IHVRLS 9
           IHVRLS
Sbjct: 447 IHVRLS 452
>NP_001137468
          Length = 953

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   IHVRLS 9
           IHVRLS
Sbjct: 599 IHVRLS 604
>NP_060715
          Length = 1010

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   IHVRLS 9
           IHVRLS
Sbjct: 656 IHVRLS 661
>NP_006332
          Length = 211

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TVLIHVR 7
           TVL+H R
Sbjct: 147 TVLVHTR 153
>XP_005263480
          Length = 276

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TVLIHVR 7
           TVL+H R
Sbjct: 212 TVLVHTR 218
>NP_001120797
          Length = 211

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TVLIHVR 7
           TVL+H R
Sbjct: 147 TVLVHTR 153
>NP_001001915
          Length = 317

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TVLIHVRL 8
           TVL+H+ L
Sbjct: 136 TVLMHIHL 143
>NP_001018098
          Length = 3628

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LIHVRLS 9
           L+HVR+S
Sbjct: 812 LMHVRIS 818
>NP_060154
          Length = 3710

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LIHVRLS 9
           L+HVR+S
Sbjct: 769 LMHVRIS 775
>NP_001265247
          Length = 289

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  TVLIHVRLS 9
          TVLI +RLS
Sbjct: 6  TVLICLRLS 14
>NP_060550
          Length = 3585

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LIHVRLS 9
           L+HVR+S
Sbjct: 769 LMHVRIS 775
>NP_006854
          Length = 489

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  TVLIHVRLS 9
          TVLI +RLS
Sbjct: 6  TVLICLRLS 14
>NP_065872
          Length = 3753

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LIHVRLS 9
           L+HVR+S
Sbjct: 812 LMHVRIS 818
>NP_937817
          Length = 626

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TVLIHVRLS 9
           T L+H RLS
Sbjct: 567 TSLLHPRLS 575
>NP_705618
          Length = 1391

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   LIHVRL 8
           L+HVRL
Sbjct: 387 LVHVRL 392
>NP_055640
          Length = 2271

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    TVLIHVRL 8
            T+L HVR+
Sbjct: 2234 TLLTHVRM 2241
>NP_004289
          Length = 1332

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   LIHVRL 8
           L+HVRL
Sbjct: 328 LVHVRL 333
>NP_001265248
          Length = 439

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  TVLIHVRLS 9
          TVLI +RLS
Sbjct: 6  TVLICLRLS 14
>NP_001158508
          Length = 1019

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   IHVRLS 9
           IH+RLS
Sbjct: 665 IHIRLS 670
>NP_002532
          Length = 1023

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   IHVRLS 9
           IH+RLS
Sbjct: 669 IHIRLS 674
>NP_001265241
          Length = 1327

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   LIHVRL 8
           L+HVRL
Sbjct: 387 LVHVRL 392
>XP_006726237
          Length = 270

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  TVLIHVRLS 9
          TVLI +RLS
Sbjct: 23 TVLICLRLS 31
>XP_006726236
          Length = 273

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  TVLIHVRLS 9
          TVLI +RLS
Sbjct: 23 TVLICLRLS 31
>XP_006726235
          Length = 333

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  TVLIHVRLS 9
          TVLI +RLS
Sbjct: 23 TVLICLRLS 31
>XP_006726234
          Length = 474

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  TVLIHVRLS 9
          TVLI +RLS
Sbjct: 23 TVLICLRLS 31
>XP_006726360
          Length = 270

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  TVLIHVRLS 9
          TVLI +RLS
Sbjct: 23 TVLICLRLS 31
>XP_006726359
          Length = 273

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  TVLIHVRLS 9
          TVLI +RLS
Sbjct: 23 TVLICLRLS 31
>XP_006726358
          Length = 333

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  TVLIHVRLS 9
          TVLI +RLS
Sbjct: 23 TVLICLRLS 31
>XP_006726357
          Length = 474

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  TVLIHVRLS 9
          TVLI +RLS
Sbjct: 23 TVLICLRLS 31
>XP_006726324
          Length = 270

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  TVLIHVRLS 9
          TVLI +RLS
Sbjct: 23 TVLICLRLS 31
>XP_006726323
          Length = 273

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  TVLIHVRLS 9
          TVLI +RLS
Sbjct: 23 TVLICLRLS 31
>XP_006726322
          Length = 333

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  TVLIHVRLS 9
          TVLI +RLS
Sbjct: 23 TVLICLRLS 31
>XP_006726321
          Length = 474

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  TVLIHVRLS 9
          TVLI +RLS
Sbjct: 23 TVLICLRLS 31
>XP_006723045
          Length = 270

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  TVLIHVRLS 9
          TVLI +RLS
Sbjct: 23 TVLICLRLS 31
>XP_006723044
          Length = 273

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  TVLIHVRLS 9
          TVLI +RLS
Sbjct: 23 TVLICLRLS 31
>XP_006723043
          Length = 333

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  TVLIHVRLS 9
          TVLI +RLS
Sbjct: 23 TVLICLRLS 31
>XP_006723042
          Length = 474

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  TVLIHVRLS 9
          TVLI +RLS
Sbjct: 23 TVLICLRLS 31
>XP_005249816
          Length = 1038

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   IHVRLS 9
           IH+RLS
Sbjct: 684 IHIRLS 689
>XP_005249818
          Length = 1034

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   IHVRLS 9
           IH+RLS
Sbjct: 680 IHIRLS 685
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.339    0.144    0.386 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 464,198
Number of extensions: 466
Number of successful extensions: 42
Number of sequences better than 10000.0: 42
Number of HSP's gapped: 42
Number of HSP's successfully gapped: 42
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.5 bits)
S2: 28 (15.4 bits)

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