Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004324                                                              18    1135
XP_005250103                                                           18    1135
XP_005250102                                                           18    1135
NP_054742                                                              17    3301
NP_060341                                                              17    3301
NP_001243391                                                           17    3301
NP_001243389                                                           17    3301
NP_001243392                                                           17    3301
NP_001243385                                                           17    3301
XP_005244820                                                           17    3301
XP_006710778                                                           17    3301
NP_057132                                                              16    5631
NP_008880                                                              16    7355
NP_001258963                                                           16    7355
NP_001120868                                                           16    7355
NP_000050                                                              16    7355
NP_001013433                                                           16    7355
NP_060785                                                              16    7355
NP_361014                                                              16    7355
NP_115551                                                              16    7355
NP_001271359                                                           16    7355
NP_001271360                                                           16    7355
XP_005259076                                                           16    7355
XP_006722914                                                           16    7355
NP_060178                                                              16    7355
NP_008986                                                              15    9605
NP_940980                                                              15    9605
NP_001155178                                                           15    9605
NP_000135                                                              15    9605
NP_852090                                                              15    9605
NP_002401                                                              15    9605
NP_055599                                                              15    9605
NP_937879                                                              15    9605
XP_005268686                                                           15    9605
XP_006717660                                                           15    9605
XP_005263727                                                           15    9605
XP_005263726                                                           15    9605
XP_006712598                                                           15    9605
XP_005263725                                                           15    9605
XP_006712597                                                           15    9605
XP_005263723                                                           15    9605
XP_005245690                                                           15    9605
XP_006711728                                                           15    9605
XP_006711727                                                           15    9605
XP_006711726                                                           15    9605
XP_005245686                                                           15    9605
XP_006711725                                                           15    9605
XP_006711724                                                           15    9605
XP_006711723                                                           15    9605
XP_006711722                                                           15    9605
NP_000929                                                              15    9605
>NP_004324
          Length = 766

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TVGQRIVSG 9
           TVGQRI SG
Sbjct: 458 TVGQRIGSG 466
>XP_005250103
          Length = 758

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TVGQRIVSG 9
           TVGQRI SG
Sbjct: 458 TVGQRIGSG 466
>XP_005250102
          Length = 767

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TVGQRIVSG 9
           TVGQRI SG
Sbjct: 458 TVGQRIGSG 466
>NP_054742
          Length = 494

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TVGQRIVSG 9
           TVG  +VSG
Sbjct: 376 TVGDNVVSG 384
>NP_060341
          Length = 600

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TVGQRIVSG 9
           TVG +I+SG
Sbjct: 358 TVGHKILSG 366
>NP_001243391
          Length = 502

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TVGQRIVSG 9
           TVG +I+SG
Sbjct: 260 TVGHKILSG 268
>NP_001243389
          Length = 571

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TVGQRIVSG 9
           TVG +I+SG
Sbjct: 329 TVGHKILSG 337
>NP_001243392
          Length = 499

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TVGQRIVSG 9
           TVG +I+SG
Sbjct: 257 TVGHKILSG 265
>NP_001243385
          Length = 606

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TVGQRIVSG 9
           TVG +I+SG
Sbjct: 364 TVGHKILSG 372
>XP_005244820
          Length = 502

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TVGQRIVSG 9
           TVG +I+SG
Sbjct: 260 TVGHKILSG 268
>XP_006710778
          Length = 484

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TVGQRIVSG 9
           TVG +I+SG
Sbjct: 358 TVGHKILSG 366
>NP_057132
          Length = 298

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TVGQRIVSG 9
           +VGQR++ G
Sbjct: 138 SVGQRLLQG 146
>NP_008880
          Length = 593

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  VGQRIVSG 9
          VG++I+SG
Sbjct: 10 VGEKILSG 17
>NP_001258963
          Length = 604

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  VGQRIVSG 9
          VG++I+SG
Sbjct: 10 VGEKILSG 17
>NP_001120868
          Length = 590

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  VGQRIVSG 9
          VG++I+SG
Sbjct: 10 VGEKILSG 17
>NP_000050
          Length = 3418

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    TVGQRIV 7
            TVGQ+I+
Sbjct: 2746 TVGQKII 2752
>NP_001013433
          Length = 589

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   GQRIVSG 9
           G RIVSG
Sbjct: 273 GNRIVSG 279

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   GQRIVSG 9
           G+R+VSG
Sbjct: 393 GRRVVSG 399
>NP_060785
          Length = 627

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   GQRIVSG 9
           G RIVSG
Sbjct: 311 GNRIVSG 317

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   GQRIVSG 9
           G+R+VSG
Sbjct: 431 GRRVVSG 437
>NP_361014
          Length = 707

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   GQRIVSG 9
           G RIVSG
Sbjct: 391 GNRIVSG 397

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   GQRIVSG 9
           G+R+VSG
Sbjct: 511 GRRVVSG 517
>NP_115551
          Length = 518

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   GQRIVSG 9
           GQR++SG
Sbjct: 260 GQRLLSG 266
>NP_001271359
          Length = 499

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   GQRIVSG 9
           GQR++SG
Sbjct: 241 GQRLLSG 247
>NP_001271360
          Length = 328

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  GQRIVSG 9
          GQR++SG
Sbjct: 70 GQRLLSG 76
>XP_005259076
          Length = 478

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   GQRIVSG 9
           G+R++SG
Sbjct: 244 GERVISG 250
>XP_006722914
          Length = 566

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  VGQRIVSG 9
          VG++I+SG
Sbjct: 10 VGEKILSG 17
>NP_060178
          Length = 478

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   GQRIVSG 9
           G+R++SG
Sbjct: 244 GERVISG 250
>NP_008986
          Length = 1390

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VGQRIVSG 9
           VGQ+ +SG
Sbjct: 799 VGQQAISG 806
>NP_940980
          Length = 2527

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    TVGQRIVSG 9
            T G RIV G
Sbjct: 2068 TTGGRIVEG 2076
>NP_001155178
          Length = 171

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  TVGQRIVSG 9
          T+G+R V+G
Sbjct: 3  TLGRRAVAG 11
>NP_000135
          Length = 210

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  TVGQRIVSG 9
          T+G+R V+G
Sbjct: 3  TLGRRAVAG 11
>NP_852090
          Length = 196

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  TVGQRIVSG 9
          T+G+R V+G
Sbjct: 3  TLGRRAVAG 11
>NP_002401
          Length = 741

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TVGQRIV 7
           TVG RIV
Sbjct: 340 TVGDRIV 346
>NP_055599
          Length = 1522

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TVGQRIVSG 9
           TVG+ +V+G
Sbjct: 719 TVGKDVVAG 727
>NP_937879
          Length = 1562

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TVGQRIVSG 9
           TVG+ +V+G
Sbjct: 759 TVGKDVVAG 767
>XP_005268686
          Length = 2521

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    TVGQRIVSG 9
            T G RIV G
Sbjct: 2068 TTGGRIVEG 2076
>XP_006717660
          Length = 1369

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VGQRIVSG 9
           VGQ+ +SG
Sbjct: 778 VGQQAISG 785
>XP_005263727
          Length = 741

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TVGQRIV 7
           TVG RIV
Sbjct: 340 TVGDRIV 346
>XP_005263726
          Length = 741

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TVGQRIV 7
           TVG RIV
Sbjct: 340 TVGDRIV 346
>XP_006712598
          Length = 741

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TVGQRIV 7
           TVG RIV
Sbjct: 340 TVGDRIV 346
>XP_005263725
          Length = 741

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TVGQRIV 7
           TVG RIV
Sbjct: 340 TVGDRIV 346
>XP_006712597
          Length = 741

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TVGQRIV 7
           TVG RIV
Sbjct: 340 TVGDRIV 346
>XP_005263723
          Length = 741

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TVGQRIV 7
           TVG RIV
Sbjct: 340 TVGDRIV 346
>XP_005245690
          Length = 1141

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TVGQRIVSG 9
           TVG+ +V+G
Sbjct: 338 TVGKDVVAG 346
>XP_006711728
          Length = 1538

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TVGQRIVSG 9
           TVG+ +V+G
Sbjct: 735 TVGKDVVAG 743
>XP_006711727
          Length = 1547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TVGQRIVSG 9
           TVG+ +V+G
Sbjct: 776 TVGKDVVAG 784
>XP_006711726
          Length = 1559

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TVGQRIVSG 9
           TVG+ +V+G
Sbjct: 756 TVGKDVVAG 764
>XP_005245686
          Length = 1563

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TVGQRIVSG 9
           TVG+ +V+G
Sbjct: 760 TVGKDVVAG 768
>XP_006711725
          Length = 1568

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TVGQRIVSG 9
           TVG+ +V+G
Sbjct: 765 TVGKDVVAG 773
>XP_006711724
          Length = 1569

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TVGQRIVSG 9
           TVG+ +V+G
Sbjct: 766 TVGKDVVAG 774
>XP_006711723
          Length = 1578

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TVGQRIVSG 9
           TVG+ +V+G
Sbjct: 775 TVGKDVVAG 783
>XP_006711722
          Length = 1579

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TVGQRIVSG 9
           TVG+ +V+G
Sbjct: 776 TVGKDVVAG 784
>NP_000929
          Length = 1174

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VGQRIVS 8
           +GQRIV+
Sbjct: 252 IGQRIVA 258
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.317    0.136    0.363 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 469,939
Number of extensions: 912
Number of successful extensions: 54
Number of sequences better than 10000.0: 51
Number of HSP's gapped: 54
Number of HSP's successfully gapped: 54
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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