Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_002515                                                              21     175
NP_004976                                                              18    1935
NP_203524                                                              18    1935
XP_006719132                                                           18    1935
NP_001159635                                                           17    2528
NP_001159632                                                           17    2528
NP_001159634                                                           17    2528
NP_001159633                                                           17    2528
XP_006716110                                                           17    2528
XP_005250542                                                           17    2528
XP_006716109                                                           17    2528
NP_060120                                                              17    2528
NP_037407                                                              16    5631
NP_001243112                                                           16    5631
NP_001243111                                                           16    5631
XP_006721247                                                           16    5631
XP_006721246                                                           16    5631
XP_006721245                                                           16    5631
XP_006721244                                                           16    5631
NP_001276834                                                           16    7355
NP_055154                                                              16    7355
NP_722516                                                              16    7355
NP_001268421                                                           15    9605
NP_597677                                                              15    9605
NP_005742                                                              15    9605
NP_055313                                                              15    9605
NP_000170                                                              15    9605
NP_671714                                                              15    9605
NP_056199                                                              15    9605
NP_001268422                                                           15    9605
NP_001268423                                                           15    9605
NP_006536                                                              15    9605
NP_002283                                                              15    9605
XP_006721506                                                           15    9605
XP_005256500                                                           15    9605
XP_006721505                                                           15    9605
XP_006721504                                                           15    9605
XP_006717159                                                           15    9605
XP_006715890                                                           15    9605
XP_005250160                                                           15    9605
XP_005250159                                                           15    9605
XP_005248340                                                           15    9605
XP_005248339                                                           15    9605
XP_005248337                                                           15    9605
XP_006714531                                                           15    9605
XP_006714530                                                           15    9605
XP_005247421                                                           15    9605
XP_005265184                                                           15    9605
XP_006713000                                                           15    9605
XP_005264865                                                           15    9605
XP_005264863                                                           15    9605
XP_005264328                                                           15    9605
NP_061979                                                              15    9605
NP_998762                                                              15    9605
>NP_002515
          Length = 189

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TVDTKQAHK 9
           TVDTKQAH+
Sbjct: 124 TVDTKQAHE 132
>NP_004976
          Length = 188

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   TVDTKQA 7
           TVDTKQA
Sbjct: 124 TVDTKQA 130
>NP_203524
          Length = 189

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   TVDTKQA 7
           TVDTKQA
Sbjct: 124 TVDTKQA 130
>XP_006719132
          Length = 189

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   TVDTKQA 7
           TVDTKQA
Sbjct: 124 TVDTKQA 130
>NP_001159635
          Length = 1090

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VDTKQAHK 9
           VDT+ AHK
Sbjct: 266 VDTEDAHK 273
>NP_001159632
          Length = 1374

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VDTKQAHK 9
           VDT+ AHK
Sbjct: 266 VDTEDAHK 273
>NP_001159634
          Length = 1253

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VDTKQAHK 9
           VDT+ AHK
Sbjct: 266 VDTEDAHK 273
>NP_001159633
          Length = 1296

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VDTKQAHK 9
           VDT+ AHK
Sbjct: 266 VDTEDAHK 273
>XP_006716110
          Length = 1141

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VDTKQAHK 9
           VDT+ AHK
Sbjct: 266 VDTEDAHK 273
>XP_005250542
          Length = 1357

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VDTKQAHK 9
           VDT+ AHK
Sbjct: 266 VDTEDAHK 273
>XP_006716109
          Length = 1365

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VDTKQAHK 9
           VDT+ AHK
Sbjct: 266 VDTEDAHK 273
>NP_060120
          Length = 1098

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VDTKQAHK 9
           VDT+ AHK
Sbjct: 266 VDTEDAHK 273
>NP_037407
          Length = 2663

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    DTKQAHK 9
            DTK+ HK
Sbjct: 1061 DTKEKHK 1067
>NP_001243112
          Length = 2663

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    DTKQAHK 9
            DTK+ HK
Sbjct: 1061 DTKEKHK 1067
>NP_001243111
          Length = 2663

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    DTKQAHK 9
            DTK+ HK
Sbjct: 1061 DTKEKHK 1067
>XP_006721247
          Length = 2564

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   DTKQAHK 9
           DTK+ HK
Sbjct: 962 DTKEKHK 968
>XP_006721246
          Length = 2620

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    DTKQAHK 9
            DTK+ HK
Sbjct: 1018 DTKEKHK 1024
>XP_006721245
          Length = 2629

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    DTKQAHK 9
            DTK+ HK
Sbjct: 1027 DTKEKHK 1033
>XP_006721244
          Length = 2629

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    DTKQAHK 9
            DTK+ HK
Sbjct: 1027 DTKEKHK 1033
>NP_001276834
          Length = 832

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TVDTKQAHK 9
           TV+T +AH+
Sbjct: 208 TVETLEAHQ 216
>NP_055154
          Length = 866

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TVDTKQAHK 9
           TV+T +AH+
Sbjct: 208 TVETLEAHQ 216
>NP_722516
          Length = 1826

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    TVDTKQAH 8
            T+ T+QAH
Sbjct: 1050 TMSTEQAH 1057
>NP_001268421
          Length = 1230

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    TVDTKQAHK 9
            TVD +  HK
Sbjct: 1214 TVDAEAVHK 1222
>NP_597677
          Length = 2804

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VDTKQAH 8
           VDT +AH
Sbjct: 928 VDTNKAH 934
>NP_005742
          Length = 3907

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    TVDTKQAH 8
            T  +KQAH
Sbjct: 1471 TASSKQAH 1478
>NP_055313
          Length = 696

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   DTKQAHK 9
           D KQ HK
Sbjct: 198 DVKQQHK 204
>NP_000170
          Length = 1360

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    TVDTKQAHK 9
            TVD +  HK
Sbjct: 1344 TVDAEAVHK 1352
>NP_671714
          Length = 3899

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    TVDTKQAH 8
            T  +KQAH
Sbjct: 1471 TASSKQAH 1478
>NP_056199
          Length = 2697

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VDTKQAH 8
           VDT +AH
Sbjct: 928 VDTNKAH 934
>NP_001268422
          Length = 1058

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    TVDTKQAHK 9
            TVD +  HK
Sbjct: 1042 TVDAEAVHK 1050
>NP_001268423
          Length = 1058

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    TVDTKQAHK 9
            TVD +  HK
Sbjct: 1042 TVDAEAVHK 1050
>NP_006536
          Length = 380

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   TKQAHK 9
           TKQ HK
Sbjct: 269 TKQGHK 274
>NP_002283
          Length = 1798

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2    VDTKQAHK 9
            +DT Q H+
Sbjct: 1150 IDTPQCHR 1157
>XP_006721506
          Length = 410

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TKQAHK 9
           TKQAH+
Sbjct: 217 TKQAHE 222
>XP_005256500
          Length = 458

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TKQAHK 9
           TKQAH+
Sbjct: 265 TKQAHE 270
>XP_006721505
          Length = 492

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TKQAHK 9
           TKQAH+
Sbjct: 299 TKQAHE 304
>XP_006721504
          Length = 492

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TKQAHK 9
           TKQAH+
Sbjct: 299 TKQAHE 304
>XP_006717159
          Length = 2293

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3    DTKQAH 8
            D KQAH
Sbjct: 1580 DAKQAH 1585
>XP_006715890
          Length = 3860

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    TVDTKQAH 8
            T  +KQAH
Sbjct: 1471 TASSKQAH 1478
>XP_005250160
          Length = 3939

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    TVDTKQAH 8
            T  +KQAH
Sbjct: 1471 TASSKQAH 1478
>XP_005250159
          Length = 3952

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    TVDTKQAH 8
            T  +KQAH
Sbjct: 1471 TASSKQAH 1478
>XP_005248340
          Length = 2265

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VDTKQAH 8
           VDT +AH
Sbjct: 389 VDTNKAH 395
>XP_005248339
          Length = 2584

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VDTKQAH 8
           VDT +AH
Sbjct: 708 VDTNKAH 714
>XP_005248337
          Length = 2698

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VDTKQAH 8
           VDT +AH
Sbjct: 928 VDTNKAH 934
>XP_006714531
          Length = 2738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VDTKQAH 8
           VDT +AH
Sbjct: 928 VDTNKAH 934
>XP_006714530
          Length = 2755

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VDTKQAH 8
           VDT +AH
Sbjct: 928 VDTNKAH 934
>XP_005247421
          Length = 697

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   DTKQAHK 9
           D KQ HK
Sbjct: 198 DVKQQHK 204
>XP_005265184
          Length = 1798

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2    VDTKQAHK 9
            +DT Q H+
Sbjct: 1150 IDTPQCHR 1157
>XP_006713000
          Length = 260

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   TKQAHK 9
           TKQ HK
Sbjct: 149 TKQGHK 154
>XP_005264865
          Length = 260

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   TKQAHK 9
           TKQ HK
Sbjct: 149 TKQGHK 154
>XP_005264863
          Length = 321

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   TKQAHK 9
           TKQ HK
Sbjct: 210 TKQGHK 215
>XP_005264328
          Length = 1261

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    TVDTKQAHK 9
            TVD +  HK
Sbjct: 1245 TVDAEAVHK 1253
>NP_061979
          Length = 350

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   TVDTKQAH 8
           +VDT+++H
Sbjct: 339 SVDTEESH 346
>NP_998762
          Length = 492

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TKQAHK 9
           TKQAH+
Sbjct: 299 TKQAHE 304
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.304    0.111    0.297 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 518,977
Number of extensions: 1019
Number of successful extensions: 54
Number of sequences better than 10000.0: 54
Number of HSP's gapped: 54
Number of HSP's successfully gapped: 54
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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