Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_443179                                                              20     509
XP_005266703                                                           20     509
NP_004250                                                              17    4312
XP_005257879                                                           17    4312
XP_006722249                                                           17    4312
XP_005257875                                                           17    4312
NP_002372                                                              16    5631
NP_775866                                                              16    7355
NP_001273700                                                           16    7355
NP_115593                                                              16    7355
NP_004228                                                              16    7355
NP_066277                                                              16    7355
NP_942592                                                              16    7355
XP_005256248                                                           16    7355
XP_005248445                                                           16    7355
XP_005265730                                                           16    7355
XP_005265729                                                           16    7355
XP_005265728                                                           16    7355
XP_005265724                                                           16    7355
XP_006710481                                                           16    7355
NP_113678                                                              16    7355
NP_003733                                                              15    9605
NP_001269810                                                           15    9605
NP_001093587                                                           15    9605
NP_055492                                                              15    9605
NP_001092284                                                           15    9605
XP_006716762                                                           15    9605
XP_006716758                                                           15    9605
XP_006716757                                                           15    9605
XP_006716756                                                           15    9605
XP_005251165                                                           15    9605
XP_005251164                                                           15    9605
XP_005251163                                                           15    9605
XP_006716755                                                           15    9605
XP_006716754                                                           15    9605
XP_006716753                                                           15    9605
XP_006712881                                                           15    9605
XP_006712880                                                           15    9605
NP_001276                                                              15    9605
>NP_443179
          Length = 2170

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TVDRADLRS 9
            TVDRAD RS
Sbjct: 1113 TVDRADFRS 1121
>XP_005266703
          Length = 1501

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TVDRADLRS 9
           TVDRAD RS
Sbjct: 444 TVDRADFRS 452
>NP_004250
          Length = 991

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TVDRADLRS 9
           T D ADLR+
Sbjct: 570 TADEADLRA 578
>XP_005257879
          Length = 586

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TVDRADLRS 9
           T D ADLR+
Sbjct: 165 TADEADLRA 173
>XP_006722249
          Length = 607

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TVDRADLRS 9
           T D ADLR+
Sbjct: 165 TADEADLRA 173
>XP_005257875
          Length = 1012

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TVDRADLRS 9
           T D ADLR+
Sbjct: 570 TADEADLRA 578
>NP_002372
          Length = 486

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VDRADLRS 9
           VDRAD+ S
Sbjct: 222 VDRADMAS 229
>NP_775866
          Length = 1076

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   TVDRADLR 8
           T D ADLR
Sbjct: 713 TADAADLR 720
>NP_001273700
          Length = 2490

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  TVDRADLRS 9
          T D ADLR+
Sbjct: 45 TADGADLRT 53
>NP_115593
          Length = 2603

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TVDRADLRS 9
           T D ADLR+
Sbjct: 158 TADGADLRT 166
>NP_004228
          Length = 432

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VDRADLR 8
           VDRAD++
Sbjct: 310 VDRADIK 316
>NP_066277
          Length = 366

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TVDRADL 7
          T+DRAD+
Sbjct: 42 TLDRADM 48
>NP_942592
          Length = 2352

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TVDRADLRS 9
           T D ADLR+
Sbjct: 158 TADGADLRT 166
>XP_005256248
          Length = 808

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TVDRADLRS 9
           T DR D+R+
Sbjct: 282 TTDRLDIRA 290
>XP_005248445
          Length = 417

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VDRADLR 8
           VDRAD++
Sbjct: 295 VDRADIK 301
>XP_005265730
          Length = 1480

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TVDRADLRS 9
           T D ADLR+
Sbjct: 158 TADGADLRT 166
>XP_005265729
          Length = 1543

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TVDRADLRS 9
           T D ADLR+
Sbjct: 158 TADGADLRT 166
>XP_005265728
          Length = 2351

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TVDRADLRS 9
           T D ADLR+
Sbjct: 158 TADGADLRT 166
>XP_005265724
          Length = 2602

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TVDRADLRS 9
           T D ADLR+
Sbjct: 158 TADGADLRT 166
>XP_006710481
          Length = 542

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TVDRADLRS 9
           ++ RADLRS
Sbjct: 460 SLTRADLRS 468
>NP_113678
          Length = 852

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TVDRADLRS 9
           T DR D+R+
Sbjct: 326 TTDRLDIRA 334
>NP_003733
          Length = 1321

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TVDRADLRS 9
           TVD  D+RS
Sbjct: 480 TVDGHDIRS 488
>NP_001269810
          Length = 1188

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VDRADLR 8
           +DR DLR
Sbjct: 251 IDRPDLR 257
>NP_001093587
          Length = 1349

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VDRADLR 8
           +DR DLR
Sbjct: 443 IDRPDLR 449
>NP_055492
          Length = 1163

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VDRADLR 8
           +DR DLR
Sbjct: 251 IDRPDLR 257
>NP_001092284
          Length = 473

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   VDRADL 7
           +DRADL
Sbjct: 215 IDRADL 220
>XP_006716762
          Length = 1571

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VDRADLR 8
           +DR DLR
Sbjct: 487 IDRPDLR 493
>XP_006716758
          Length = 1269

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VDRADLR 8
           +DR DLR
Sbjct: 487 IDRPDLR 493
>XP_006716757
          Length = 1356

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VDRADLR 8
           +DR DLR
Sbjct: 251 IDRPDLR 257
>XP_006716756
          Length = 1462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VDRADLR 8
           +DR DLR
Sbjct: 487 IDRPDLR 493
>XP_005251165
          Length = 1532

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VDRADLR 8
           +DR DLR
Sbjct: 483 IDRPDLR 489
>XP_005251164
          Length = 1552

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VDRADLR 8
           +DR DLR
Sbjct: 443 IDRPDLR 449
>XP_005251163
          Length = 1574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VDRADLR 8
           +DR DLR
Sbjct: 443 IDRPDLR 449
>XP_006716755
          Length = 1634

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VDRADLR 8
           +DR DLR
Sbjct: 487 IDRPDLR 493
>XP_006716754
          Length = 1655

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VDRADLR 8
           +DR DLR
Sbjct: 487 IDRPDLR 493
>XP_006716753
          Length = 1656

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VDRADLR 8
           +DR DLR
Sbjct: 487 IDRPDLR 493
>XP_006712881
          Length = 1335

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TVDRADLRS 9
           TVD  D+RS
Sbjct: 494 TVDGHDIRS 502
>XP_006712880
          Length = 1335

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TVDRADLRS 9
           TVD  D+RS
Sbjct: 494 TVDGHDIRS 502
>NP_001276
          Length = 914

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VDRADLRS 9
           VD+ DL+S
Sbjct: 847 VDKVDLKS 854
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.318    0.129    0.332 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 412,896
Number of extensions: 484
Number of successful extensions: 39
Number of sequences better than 10000.0: 39
Number of HSP's gapped: 39
Number of HSP's successfully gapped: 39
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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