Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_002430                                                              20     509
NP_001005476                                                           18    1935
NP_003619                                                              18    1935
NP_001138424                                                           16    5631
NP_001257903                                                           16    7355
NP_001257628                                                           16    7355
NP_001257625                                                           16    7355
NP_001257626                                                           16    7355
NP_001257627                                                           16    7355
NP_001257624                                                           16    7355
NP_060757                                                              16    7355
NP_056272                                                              16    7355
XP_005260155                                                           16    7355
XP_006721269                                                           16    7355
XP_005252701                                                           16    7355
XP_006717604                                                           16    7355
XP_006717603                                                           16    7355
NP_115809                                                              16    7355
NP_001104026                                                           15    9605
NP_001122302                                                           15    9605
NP_001122303                                                           15    9605
NP_001158302                                                           15    9605
NP_001122301                                                           15    9605
NP_001729                                                              15    9605
NP_001447                                                              15    9605
NP_005338                                                              15    9605
NP_001157790                                                           15    9605
NP_001888                                                              15    9605
NP_001157791                                                           15    9605
NP_001157789                                                           15    9605
NP_001448                                                              15    9605
NP_001123633                                                           15    9605
NP_001129737                                                           15    9605
NP_612490                                                              15    9605
XP_005261428                                                           15    9605
XP_005261427                                                           15    9605
XP_006717757                                                           15    9605
XP_006717756                                                           15    9605
XP_006713130                                                           15    9605
XP_005265039                                                           15    9605
XP_005265038                                                           15    9605
XP_005265035                                                           15    9605
XP_005265034                                                           15    9605
NP_689922                                                              15    9605
>NP_002430
          Length = 1137

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   TVDIKGSQ 8
           TVDIKGSQ
Sbjct: 480 TVDIKGSQ 487
>NP_001005476
          Length = 1149

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   TVDIKGSQT 9
           TV+++GSQT
Sbjct: 432 TVELQGSQT 440
>NP_003619
          Length = 1192

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   TVDIKGSQT 9
           TV+++GSQT
Sbjct: 432 TVELQGSQT 440
>NP_001138424
          Length = 2172

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    TVDIKGS 7
            TVD+KG+
Sbjct: 1775 TVDVKGN 1781
>NP_001257903
          Length = 5121

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TVDIKGSQT 9
            TV+IKG  T
Sbjct: 4403 TVEIKGKGT 4411
>NP_001257628
          Length = 794

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TVDIKGS 7
           TVD+KG+
Sbjct: 469 TVDLKGA 475
>NP_001257625
          Length = 816

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TVDIKGS 7
           TVD+KG+
Sbjct: 491 TVDLKGA 497
>NP_001257626
          Length = 799

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TVDIKGS 7
           TVD+KG+
Sbjct: 474 TVDLKGA 480
>NP_001257627
          Length = 769

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TVDIKGS 7
           TVD+KG+
Sbjct: 444 TVDLKGA 450
>NP_001257624
          Length = 841

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TVDIKGS 7
           TVD+KG+
Sbjct: 516 TVDLKGA 522
>NP_060757
          Length = 846

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TVDIKGS 7
           TVD+KG+
Sbjct: 521 TVDLKGA 527
>NP_056272
          Length = 715

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TVDIKGSQ 8
           TV+IKG Q
Sbjct: 93  TVEIKGIQ 100
>XP_005260155
          Length = 556

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   TVDIKGSQ 8
           ++D+KG Q
Sbjct: 186 SIDVKGEQ 193
>XP_006721269
          Length = 5138

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TVDIKGSQT 9
            TV+IKG  T
Sbjct: 4420 TVEIKGKGT 4428
>XP_005252701
          Length = 794

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TVDIKGS 7
           TVD+KG+
Sbjct: 469 TVDLKGA 475
>XP_006717604
          Length = 820

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TVDIKGS 7
           TVD+KG+
Sbjct: 521 TVDLKGA 527
>XP_006717603
          Length = 846

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TVDIKGS 7
           TVD+KG+
Sbjct: 521 TVDLKGA 527
>NP_115809
          Length = 665

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   TVDIKGSQ 8
           ++D+KG Q
Sbjct: 295 SIDVKGEQ 302
>NP_001104026
          Length = 2647

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    TVDIKGSQT 9
            T+D KG+ T
Sbjct: 1089 TIDTKGAGT 1097
>NP_001122302
          Length = 261

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  VDIKGSQT 9
          VDIK S+T
Sbjct: 32 VDIKTSET 39
>NP_001122303
          Length = 261

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  VDIKGSQT 9
          VDIK S+T
Sbjct: 32 VDIKTSET 39
>NP_001158302
          Length = 261

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  VDIKGSQT 9
          VDIK S+T
Sbjct: 32 VDIKTSET 39
>NP_001122301
          Length = 261

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  VDIKGSQT 9
          VDIK S+T
Sbjct: 32 VDIKTSET 39
>NP_001729
          Length = 261

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  VDIKGSQT 9
          VDIK S+T
Sbjct: 32 VDIKTSET 39
>NP_001447
          Length = 2639

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    TVDIKGSQT 9
            T+D KG+ T
Sbjct: 1089 TIDTKGAGT 1097
>NP_005338
          Length = 654

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   VDIKGSQT 9
           VDI G QT
Sbjct: 130 VDIGGGQT 137
>NP_001157790
          Length = 2591

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    TVDIKGSQT 9
            T+D KG+ T
Sbjct: 1062 TIDTKGAGT 1070
>NP_001888
          Length = 2322

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VDIKGSQT 9
            + +KGSQT
Sbjct: 1582 LSLKGSQT 1589
>NP_001157791
          Length = 2578

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    TVDIKGSQT 9
            T+D KG+ T
Sbjct: 1062 TIDTKGAGT 1070
>NP_001157789
          Length = 2633

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    TVDIKGSQT 9
            T+D KG+ T
Sbjct: 1062 TIDTKGAGT 1070
>NP_001448
          Length = 2602

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    TVDIKGSQT 9
            T+D KG+ T
Sbjct: 1062 TIDTKGAGT 1070
>NP_001123633
          Length = 989

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TVDIKGSQT 9
           T D+K SQT
Sbjct: 516 TSDLKPSQT 524
>NP_001129737
          Length = 517

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   TVDIKGSQ 8
           T+D++G Q
Sbjct: 402 TIDLQGEQ 409
>NP_612490
          Length = 762

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   TVDIKGSQ 8
           T+D++G+Q
Sbjct: 282 TLDLRGNQ 289
>XP_005261428
          Length = 757

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   TVDIKGSQ 8
           T+D++G+Q
Sbjct: 282 TLDLRGNQ 289
>XP_005261427
          Length = 771

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   TVDIKGSQ 8
           T+D++G+Q
Sbjct: 282 TLDLRGNQ 289
>XP_006717757
          Length = 879

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TVDIKGSQT 9
           T D+K SQT
Sbjct: 406 TSDLKPSQT 414
>XP_006717756
          Length = 879

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TVDIKGSQT 9
           T D+K SQT
Sbjct: 406 TSDLKPSQT 414
>XP_006713130
          Length = 2109

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    TVDIKGSQT 9
            T+D KG+ T
Sbjct: 1062 TIDTKGAGT 1070
>XP_005265039
          Length = 2177

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    TVDIKGSQT 9
            T+D KG+ T
Sbjct: 1062 TIDTKGAGT 1070
>XP_005265038
          Length = 2181

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    TVDIKGSQT 9
            T+D KG+ T
Sbjct: 1062 TIDTKGAGT 1070
>XP_005265035
          Length = 2609

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    TVDIKGSQT 9
            T+D KG+ T
Sbjct: 1062 TIDTKGAGT 1070
>XP_005265034
          Length = 2622

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    TVDIKGSQT 9
            T+D KG+ T
Sbjct: 1062 TIDTKGAGT 1070
>NP_689922
          Length = 989

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TVDIKGSQT 9
           T D+K SQT
Sbjct: 516 TSDLKPSQT 524
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.301    0.120    0.303 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 544,516
Number of extensions: 1039
Number of successful extensions: 44
Number of sequences better than 10000.0: 44
Number of HSP's gapped: 44
Number of HSP's successfully gapped: 44
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.2 bits)
S2: 28 (15.4 bits)

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