Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_036462                                                              20     509
NP_001243397                                                           20     509
XP_005269721                                                           20     509
NP_001575                                                              18    1482
XP_005253170                                                           18    1482
XP_006718367                                                           18    1482
XP_005253169                                                           18    1482
XP_005253168                                                           18    1482
XP_005253167                                                           18    1482
NP_001037835                                                           18    1935
XP_006718462                                                           16    5631
NP_001244067                                                           16    7355
NP_113671                                                              16    7355
NP_001244066                                                           16    7355
NP_060603                                                              16    7355
NP_001138889                                                           16    7355
NP_620145                                                              16    7355
NP_612504                                                              16    7355
NP_065776                                                              16    7355
NP_775871                                                              16    7355
XP_005260627                                                           16    7355
XP_006723945                                                           16    7355
XP_006723944                                                           16    7355
XP_006720088                                                           16    7355
XP_006720087                                                           16    7355
XP_005250278                                                           16    7355
XP_006715966                                                           16    7355
XP_005250277                                                           16    7355
XP_006715965                                                           16    7355
XP_005250276                                                           16    7355
XP_006715964                                                           16    7355
XP_006715963                                                           16    7355
XP_005266069                                                           16    7355
XP_006713747                                                           16    7355
XP_005247629                                                           16    7355
XP_005247628                                                           16    7355
NP_073591                                                              16    7355
NP_112233                                                              16    7355
NP_115495                                                              15    9605
NP_073577                                                              15    9605
NP_001106710                                                           15    9605
NP_001185744                                                           15    9605
NP_001273700                                                           15    9605
NP_115593                                                              15    9605
NP_942592                                                              15    9605
XP_005275558                                                           15    9605
XP_005275391                                                           15    9605
XP_005275259                                                           15    9605
XP_005274965                                                           15    9605
XP_005272815                                                           15    9605
XP_005274885                                                           15    9605
XP_006715999                                                           15    9605
XP_006715998                                                           15    9605
XP_006715997                                                           15    9605
XP_005248836                                                           15    9605
XP_005265728                                                           15    9605
XP_005265724                                                           15    9605
>NP_036462
          Length = 2073

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TTTYISAST 9
           T+TYISAST
Sbjct: 416 TSTYISAST 424
>NP_001243397
          Length = 1890

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TTTYISAST 9
           T+TYISAST
Sbjct: 416 TSTYISAST 424
>XP_005269721
          Length = 2073

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TTTYISAST 9
           T+TYISAST
Sbjct: 416 TSTYISAST 424
>NP_001575
          Length = 294

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   TTYISAST 9
           TTYI+AST
Sbjct: 265 TTYINAST 272
>XP_005253170
          Length = 196

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   TTYISAST 9
           TTYI+AST
Sbjct: 167 TTYINAST 174
>XP_006718367
          Length = 220

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   TTYISAST 9
           TTYI+AST
Sbjct: 191 TTYINAST 198
>XP_005253169
          Length = 294

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   TTYISAST 9
           TTYI+AST
Sbjct: 265 TTYINAST 272
>XP_005253168
          Length = 294

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   TTYISAST 9
           TTYI+AST
Sbjct: 265 TTYINAST 272
>XP_005253167
          Length = 294

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   TTYISAST 9
           TTYI+AST
Sbjct: 265 TTYINAST 272
>NP_001037835
          Length = 326

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   TTTYISAS 8
           TTTY++AS
Sbjct: 296 TTTYVNAS 303
>XP_006718462
          Length = 4966

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    TTTYISAST 9
            TT+ ISAST
Sbjct: 3486 TTSTISAST 3494
>NP_001244067
          Length = 752

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   TTTYISAST 9
           TTTYI   T
Sbjct: 352 TTTYIDPRT 360
>NP_113671
          Length = 862

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   TTTYISAST 9
           TTTYI   T
Sbjct: 462 TTTYIDPRT 470
>NP_001244066
          Length = 903

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   TTTYISAST 9
           TTTYI   T
Sbjct: 503 TTTYIDPRT 511
>NP_060603
          Length = 577

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TTYISAST 9
           TT+++AST
Sbjct: 554 TTFLAAST 561
>NP_001138889
          Length = 503

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TTYISAST 9
           TT+++AST
Sbjct: 480 TTFLAAST 487
>NP_620145
          Length = 506

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   TTTYISAS 8
           TT Y SAS
Sbjct: 301 TTAYFSAS 308
>NP_612504
          Length = 738

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TTTYISAST 9
           TTT +SAS+
Sbjct: 97  TTTAVSASS 105
>NP_065776
          Length = 861

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TTTYISAST 9
           TTT +SAS+
Sbjct: 221 TTTAVSASS 229
>NP_775871
          Length = 8384

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    TTTYISAS 8
            TTTYI  S
Sbjct: 6499 TTTYIGES 6506
>XP_005260627
          Length = 692

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   TTTYISAST 9
           TTTYI   T
Sbjct: 292 TTTYIDPRT 300
>XP_006723945
          Length = 752

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   TTTYISAST 9
           TTTYI   T
Sbjct: 352 TTTYIDPRT 360
>XP_006723944
          Length = 862

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   TTTYISAST 9
           TTTYI   T
Sbjct: 462 TTTYIDPRT 470
>XP_006720088
          Length = 455

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   TTTYISAS 8
           TT Y SAS
Sbjct: 301 TTAYFSAS 308
>XP_006720087
          Length = 513

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   TTTYISAS 8
           TT Y SAS
Sbjct: 308 TTAYFSAS 315
>XP_005250278
          Length = 657

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TTTYISAST 9
          TTT +SAS+
Sbjct: 5  TTTAVSASS 13
>XP_006715966
          Length = 856

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TTTYISAST 9
           TTT +SAS+
Sbjct: 221 TTTAVSASS 229
>XP_005250277
          Length = 862

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TTTYISAST 9
           TTT +SAS+
Sbjct: 221 TTTAVSASS 229
>XP_006715965
          Length = 872

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TTTYISAST 9
           TTT +SAS+
Sbjct: 221 TTTAVSASS 229
>XP_005250276
          Length = 873

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TTTYISAST 9
           TTT +SAS+
Sbjct: 221 TTTAVSASS 229
>XP_006715964
          Length = 964

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TTTYISAST 9
           TTT +SAS+
Sbjct: 221 TTTAVSASS 229
>XP_006715963
          Length = 975

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TTTYISAST 9
           TTT +SAS+
Sbjct: 221 TTTAVSASS 229
>XP_005266069
          Length = 261

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  TTYISAST 9
          T Y+SA+T
Sbjct: 88 TAYVSATT 95
>XP_006713747
          Length = 503

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TTYISAST 9
           TT+++AST
Sbjct: 480 TTFLAAST 487
>XP_005247629
          Length = 503

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TTYISAST 9
           TT+++AST
Sbjct: 480 TTFLAAST 487
>XP_005247628
          Length = 503

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TTYISAST 9
           TT+++AST
Sbjct: 480 TTFLAAST 487
>NP_073591
          Length = 322

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TTYISAST 9
           T Y+SA+T
Sbjct: 149 TAYVSATT 156
>NP_112233
          Length = 325

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TTYISAST 9
           T Y+SA+T
Sbjct: 152 TAYVSATT 159
>NP_115495
          Length = 6306

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    TTTYISAS 8
            +TTY+S S
Sbjct: 5157 STTYLSTS 5164
>NP_073577
          Length = 1198

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    TYISAS 8
            TYISAS
Sbjct: 1171 TYISAS 1176
>NP_001106710
          Length = 1171

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    TYISAS 8
            TYISAS
Sbjct: 1144 TYISAS 1149
>NP_001185744
          Length = 1773

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TTTYISAST 9
           TTT+  AST
Sbjct: 138 TTTFTIAST 146
>NP_001273700
          Length = 2490

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    TTTYISAST 9
            TTT  SAST
Sbjct: 1858 TTTSSSAST 1866
>NP_115593
          Length = 2603

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    TTTYISAST 9
            TTT  SAST
Sbjct: 1971 TTTSSSAST 1979
>NP_942592
          Length = 2352

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    TTTYISAST 9
            TTT  SAST
Sbjct: 1720 TTTSSSAST 1728
>XP_005275558
          Length = 1776

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TTTYISAST 9
           TTT+  AST
Sbjct: 141 TTTFTIAST 149
>XP_005275391
          Length = 1776

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TTTYISAST 9
           TTT+  AST
Sbjct: 141 TTTFTIAST 149
>XP_005275259
          Length = 1776

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TTTYISAST 9
           TTT+  AST
Sbjct: 141 TTTFTIAST 149
>XP_005274965
          Length = 1776

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TTTYISAST 9
           TTT+  AST
Sbjct: 141 TTTFTIAST 149
>XP_005272815
          Length = 1776

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TTTYISAST 9
           TTT+  AST
Sbjct: 141 TTTFTIAST 149
>XP_005274885
          Length = 1776

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TTTYISAST 9
           TTT+  AST
Sbjct: 141 TTTFTIAST 149
>XP_006715999
          Length = 1170

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    TYISAS 8
            TYISAS
Sbjct: 1143 TYISAS 1148
>XP_006715998
          Length = 1191

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    TYISAS 8
            TYISAS
Sbjct: 1164 TYISAS 1169
>XP_006715997
          Length = 1197

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    TYISAS 8
            TYISAS
Sbjct: 1170 TYISAS 1175
>XP_005248836
          Length = 1776

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TTTYISAST 9
           TTT+  AST
Sbjct: 141 TTTFTIAST 149
>XP_005265728
          Length = 2351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    TTTYISAST 9
            TTT  SAST
Sbjct: 1719 TTTSSSAST 1727
>XP_005265724
          Length = 2602

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    TTTYISAST 9
            TTT  SAST
Sbjct: 1970 TTTSSSAST 1978
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.295   0.0983    0.235 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 357,626
Number of extensions: 356
Number of successful extensions: 57
Number of sequences better than 10000.0: 57
Number of HSP's gapped: 57
Number of HSP's successfully gapped: 57
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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