Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000312                                                              19     665
NP_060798                                                              16    5631
XP_005263769                                                           16    5631
XP_005263768                                                           16    5631
NP_001127854                                                           16    7355
NP_001171811                                                           16    7355
NP_055684                                                              16    7355
NP_001171808                                                           16    7355
NP_003865                                                              16    7355
NP_001171810                                                           16    7355
NP_055840                                                              15    9605
NP_005406                                                              15    9605
NP_149038                                                              15    9605
NP_057191                                                              15    9605
NP_003957                                                              15    9605
NP_001243275                                                           15    9605
NP_757385                                                              15    9605
NP_115807                                                              15    9605
NP_722576                                                              15    9605
NP_001018054                                                           15    9605
NP_079328                                                              15    9605
NP_001026872                                                           15    9605
NP_001243277                                                           15    9605
NP_001243276                                                           15    9605
XP_005262424                                                           15    9605
XP_005255623                                                           15    9605
XP_006714571                                                           15    9605
XP_006714570                                                           15    9605
XP_006714569                                                           15    9605
XP_006714540                                                           15    9605
XP_006712837                                                           15    9605
XP_006712775                                                           15    9605
XP_005263800                                                           15    9605
XP_006711931                                                           15    9605
XP_006711930                                                           15    9605
XP_006711929                                                           15    9605
XP_006711928                                                           15    9605
XP_006711927                                                           15    9605
XP_006711926                                                           15    9605
XP_006711925                                                           15    9605
NP_076936                                                              15    9605
>NP_000312
          Length = 928

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TTSVNSTAN 9
           TT VNSTAN
Sbjct: 619 TTRVNSTAN 627
>NP_060798
          Length = 1494

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    TTSVNST 7
            TT+VNST
Sbjct: 1105 TTAVNST 1111
>XP_005263769
          Length = 1727

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    TTSVNST 7
            TT+VNST
Sbjct: 1338 TTAVNST 1344
>XP_005263768
          Length = 1727

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    TTSVNST 7
            TT+VNST
Sbjct: 1338 TTAVNST 1344
>NP_001127854
          Length = 1114

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   SVNSTAN 9
           S+NST+N
Sbjct: 458 SINSTSN 464
>NP_001171811
          Length = 214

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  SVNSTAN 9
          SVNST N
Sbjct: 30 SVNSTCN 36
>NP_055684
          Length = 963

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   SVNSTAN 9
           S+NST+N
Sbjct: 472 SINSTSN 478
>NP_001171808
          Length = 345

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SVNSTAN 9
           SVNST N
Sbjct: 144 SVNSTCN 150
>NP_003865
          Length = 328

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SVNSTAN 9
           SVNST N
Sbjct: 144 SVNSTCN 150
>NP_001171810
          Length = 272

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SVNSTAN 9
           SVNST N
Sbjct: 144 SVNSTCN 150
>NP_055840
          Length = 1184

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TTSVNS 6
           TTSVNS
Sbjct: 412 TTSVNS 417
>NP_005406
          Length = 679

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TSVNSTAN 9
           TS++ST N
Sbjct: 342 TSIDSTVN 349
>NP_149038
          Length = 512

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TTSVNSTA 8
           TT+VNS A
Sbjct: 109 TTNVNSLA 116
>NP_057191
          Length = 1074

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TSVNSTAN 9
           +S+NST+N
Sbjct: 475 SSLNSTSN 482
>NP_003957
          Length = 1074

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TTSVNSTA 8
           TT+VNS A
Sbjct: 308 TTNVNSIA 315
>NP_001243275
          Length = 1151

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TTSVNSTA 8
           TT+VNS A
Sbjct: 376 TTNVNSIA 383
>NP_757385
          Length = 617

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   TSVNST 7
           TSVNST
Sbjct: 538 TSVNST 543
>NP_115807
          Length = 616

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   TSVNST 7
           TSVNST
Sbjct: 537 TSVNST 542
>NP_722576
          Length = 3080

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    TTSVNS 6
            TTSVNS
Sbjct: 1224 TTSVNS 1229
>NP_001018054
          Length = 1215

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VNSTAN 9
           +NSTAN
Sbjct: 540 INSTAN 545
>NP_079328
          Length = 1328

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VNSTAN 9
           +NSTAN
Sbjct: 653 INSTAN 658
>NP_001026872
          Length = 1151

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TTSVNSTA 8
           TT+VNS A
Sbjct: 376 TTNVNSIA 383
>NP_001243277
          Length = 1057

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TTSVNSTA 8
           TT+VNS A
Sbjct: 318 TTNVNSIA 325
>NP_001243276
          Length = 1205

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TTSVNSTA 8
           TT+VNS A
Sbjct: 430 TTNVNSIA 437
>XP_005262424
          Length = 2875

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    TTSVNS 6
            TTSVNS
Sbjct: 1019 TTSVNS 1024
>XP_005255623
          Length = 585

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TTSVNSTAN 9
           TTS +STA+
Sbjct: 397 TTSCSSTAS 405
>XP_006714571
          Length = 917

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TTSVNSTA 8
           TT+VNS A
Sbjct: 151 TTNVNSIA 158
>XP_006714570
          Length = 1074

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TTSVNSTA 8
           TT+VNS A
Sbjct: 308 TTNVNSIA 315
>XP_006714569
          Length = 1074

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TTSVNSTA 8
           TT+VNS A
Sbjct: 308 TTNVNSIA 315
>XP_006714540
          Length = 1030

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TSVNSTAN 9
           +S+NST+N
Sbjct: 431 SSLNSTSN 438
>XP_006712837
          Length = 1328

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VNSTAN 9
           +NSTAN
Sbjct: 653 INSTAN 658
>XP_006712775
          Length = 426

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  TSVNSTAN 9
          TS++ST N
Sbjct: 89 TSIDSTVN 96
>XP_005263800
          Length = 426

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  TSVNSTAN 9
          TS++ST N
Sbjct: 89 TSIDSTVN 96
>XP_006711931
          Length = 1162

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TTSVNS 6
           TTSVNS
Sbjct: 412 TTSVNS 417
>XP_006711930
          Length = 1186

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TTSVNS 6
           TTSVNS
Sbjct: 412 TTSVNS 417
>XP_006711929
          Length = 1186

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TTSVNS 6
           TTSVNS
Sbjct: 412 TTSVNS 417
>XP_006711928
          Length = 1188

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TTSVNS 6
           TTSVNS
Sbjct: 412 TTSVNS 417
>XP_006711927
          Length = 1207

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TTSVNS 6
           TTSVNS
Sbjct: 412 TTSVNS 417
>XP_006711926
          Length = 1207

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TTSVNS 6
           TTSVNS
Sbjct: 412 TTSVNS 417
>XP_006711925
          Length = 1209

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TTSVNS 6
           TTSVNS
Sbjct: 412 TTSVNS 417
>NP_076936
          Length = 585

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TTSVNSTAN 9
           TTS +STA+
Sbjct: 397 TTSCSSTAS 405
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.276   0.0859    0.194 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 287,905
Number of extensions: 388
Number of successful extensions: 41
Number of sequences better than 10000.0: 41
Number of HSP's gapped: 41
Number of HSP's successfully gapped: 41
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 18 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.7 bits)
S2: 28 (15.4 bits)

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