Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_892006                                                              18    1135
NP_149062                                                              18    1135
NP_722576                                                              18    1135
XP_005262424                                                           18    1135
XP_006715488                                                           18    1135
XP_006715487                                                           18    1135
XP_006715486                                                           18    1135
XP_006715485                                                           18    1135
XP_006715484                                                           18    1135
XP_006715483                                                           18    1135
XP_006715482                                                           18    1135
XP_006715481                                                           18    1135
XP_006715480                                                           18    1135
XP_006715479                                                           18    1135
XP_006715478                                                           18    1135
XP_006715477                                                           18    1135
XP_006715476                                                           18    1135
XP_006715475                                                           18    1135
XP_006715474                                                           18    1135
XP_006715473                                                           18    1135
XP_006715472                                                           18    1135
XP_006715471                                                           18    1135
XP_006715470                                                           18    1135
NP_001191676                                                           17    2528
NP_002904                                                              17    2528
NP_000114                                                              17    3301
NP_001191354                                                           17    3301
NP_060823                                                              17    4312
XP_005267890                                                           17    4312
NP_612144                                                              17    4312
NP_003189                                                              16    5631
XP_005264824                                                           16    7355
NP_938012                                                              16    7355
NP_001010892                                                           15    9605
NP_001130033                                                           15    9605
NP_001013653                                                           15    9605
NP_001161693                                                           15    9605
XP_006715532                                                           15    9605
XP_005246404                                                           15    9605
>NP_892006
          Length = 8797

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    TNSMKKNE 9
            TNSM KNE
Sbjct: 1894 TNSMNKNE 1901
>NP_149062
          Length = 8749

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    TNSMKKNE 9
            TNSM KNE
Sbjct: 1901 TNSMNKNE 1908
>NP_722576
          Length = 3080

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   TTNSMKKNE 9
           TTNSMKK +
Sbjct: 336 TTNSMKKTK 344
>XP_005262424
          Length = 2875

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   TTNSMKKNE 9
           TTNSMKK +
Sbjct: 131 TTNSMKKTK 139
>XP_006715488
          Length = 8721

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    TNSMKKNE 9
            TNSM KNE
Sbjct: 1901 TNSMNKNE 1908
>XP_006715487
          Length = 8744

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    TNSMKKNE 9
            TNSM KNE
Sbjct: 1901 TNSMNKNE 1908
>XP_006715486
          Length = 8758

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    TNSMKKNE 9
            TNSM KNE
Sbjct: 1901 TNSMNKNE 1908
>XP_006715485
          Length = 8793

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    TNSMKKNE 9
            TNSM KNE
Sbjct: 1848 TNSMNKNE 1855
>XP_006715484
          Length = 8794

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    TNSMKKNE 9
            TNSM KNE
Sbjct: 1901 TNSMNKNE 1908
>XP_006715483
          Length = 8795

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    TNSMKKNE 9
            TNSM KNE
Sbjct: 1901 TNSMNKNE 1908
>XP_006715482
          Length = 8797

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    TNSMKKNE 9
            TNSM KNE
Sbjct: 1894 TNSMNKNE 1901
>XP_006715481
          Length = 8799

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    TNSMKKNE 9
            TNSM KNE
Sbjct: 1854 TNSMNKNE 1861
>XP_006715480
          Length = 8799

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    TNSMKKNE 9
            TNSM KNE
Sbjct: 1901 TNSMNKNE 1908
>XP_006715479
          Length = 8804

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    TNSMKKNE 9
            TNSM KNE
Sbjct: 1901 TNSMNKNE 1908
>XP_006715478
          Length = 8809

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    TNSMKKNE 9
            TNSM KNE
Sbjct: 1901 TNSMNKNE 1908
>XP_006715477
          Length = 8822

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    TNSMKKNE 9
            TNSM KNE
Sbjct: 1877 TNSMNKNE 1884
>XP_006715476
          Length = 8823

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    TNSMKKNE 9
            TNSM KNE
Sbjct: 1901 TNSMNKNE 1908
>XP_006715475
          Length = 8827

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    TNSMKKNE 9
            TNSM KNE
Sbjct: 1901 TNSMNKNE 1908
>XP_006715474
          Length = 8829

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    TNSMKKNE 9
            TNSM KNE
Sbjct: 1884 TNSMNKNE 1891
>XP_006715473
          Length = 8832

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    TNSMKKNE 9
            TNSM KNE
Sbjct: 1901 TNSMNKNE 1908
>XP_006715472
          Length = 8839

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    TNSMKKNE 9
            TNSM KNE
Sbjct: 1894 TNSMNKNE 1901
>XP_006715471
          Length = 8842

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    TNSMKKNE 9
            TNSM KNE
Sbjct: 1901 TNSMNKNE 1908
>XP_006715470
          Length = 8846

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    TNSMKKNE 9
            TNSM KNE
Sbjct: 1901 TNSMNKNE 1908
>NP_001191676
          Length = 1148

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   TNSMKKNE 9
           T++MKKNE
Sbjct: 138 TSNMKKNE 145
>NP_002904
          Length = 1147

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   TNSMKKNE 9
           T++MKKNE
Sbjct: 138 TSNMKKNE 145
>NP_000114
          Length = 1186

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TNSMKKNE 9
           TNS+ KNE
Sbjct: 530 TNSVSKNE 537
>NP_001191354
          Length = 1640

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TNSMKKNE 9
           TNS+ KNE
Sbjct: 984 TNSVSKNE 991
>NP_060823
          Length = 1132

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TNSMKKNE 9
           TN +KKN+
Sbjct: 374 TNGLKKNQ 381
>XP_005267890
          Length = 1132

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TNSMKKNE 9
           TN +KKN+
Sbjct: 374 TNGLKKNQ 381
>NP_612144
          Length = 740

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  TTNSMKKN 8
          T NS+KKN
Sbjct: 89 TENSIKKN 96
>NP_003189
          Length = 798

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  TTNSMKKNE 9
          T NS++K+E
Sbjct: 77 TVNSLRKHE 85
>XP_005264824
          Length = 560

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NSMKKNE 9
           N+MKKN+
Sbjct: 276 NAMKKNK 282
>NP_938012
          Length = 560

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NSMKKNE 9
           N+MKKN+
Sbjct: 276 NAMKKNK 282
>NP_001010892
          Length = 716

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NSMKKNE 9
           NS++KNE
Sbjct: 561 NSIQKNE 567
>NP_001130033
          Length = 293

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TTNSMKKNE 9
           +++SMKK+E
Sbjct: 225 SSSSMKKDE 233
>NP_001013653
          Length = 293

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TTNSMKKNE 9
           +++SMKK+E
Sbjct: 225 SSSSMKKDE 233
>NP_001161693
          Length = 1820

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TTNSMKKN 8
           T NS+K+N
Sbjct: 623 TKNSLKEN 630
>XP_006715532
          Length = 632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NSMKKNE 9
           NS++KNE
Sbjct: 561 NSIQKNE 567
>XP_005246404
          Length = 1821

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TTNSMKKN 8
           T NS+K+N
Sbjct: 624 TKNSLKEN 631
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.279   0.0939    0.218 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 496,284
Number of extensions: 995
Number of successful extensions: 39
Number of sequences better than 10000.0: 39
Number of HSP's gapped: 39
Number of HSP's successfully gapped: 39
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 18 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.7 bits)
S2: 28 (15.4 bits)

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