Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004351                                                              18    1135
XP_006714542                                                           16    5631
NP_060826                                                              16    5631
NP_001240628                                                           16    7355
NP_001438                                                              16    7355
NP_057422                                                              16    7355
NP_001240630                                                           16    7355
NP_001006600                                                           16    7355
NP_061165                                                              16    7355
NP_001240627                                                           16    7355
NP_001240626                                                           16    7355
XP_006714824                                                           16    7355
XP_006714723                                                           16    7355
XP_005248613                                                           16    7355
XP_005248612                                                           16    7355
XP_005248611                                                           16    7355
NP_001128251                                                           16    7355
NP_003310                                                              15    9605
NP_597676                                                              15    9605
NP_001243779                                                           15    9605
NP_596869                                                              15    9605
NP_443164                                                              15    9605
XP_005246888                                                           15    9605
XP_006712788                                                           15    9605
XP_006712787                                                           15    9605
XP_006712786                                                           15    9605
NP_001254479                                                           15    9605
NP_597681                                                              15    9605
>NP_004351
          Length = 882

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TTLKVTAAD 9
           TTLKVT AD
Sbjct: 394 TTLKVTDAD 402
>XP_006714542
          Length = 358

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  TTLKVTAAD 9
          TT++VT+ D
Sbjct: 39 TTIRVTSTD 47
>NP_060826
          Length = 442

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TTLKVTAAD 9
           TT++VT+ D
Sbjct: 123 TTIRVTSTD 131
>NP_001240628
          Length = 1419

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TTLKVTAA 8
           TT+K+T+A
Sbjct: 897 TTVKITSA 904
>NP_001438
          Length = 4349

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TLKVTAAD 9
           +LK+TA+D
Sbjct: 637 SLKITASD 644
>NP_057422
          Length = 975

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TTLKVTAAD 9
           TTLK+T  D
Sbjct: 537 TTLKLTVDD 545
>NP_001240630
          Length = 1367

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TTLKVTAA 8
           TT+K+T+A
Sbjct: 893 TTVKITSA 900
>NP_001006600
          Length = 1302

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TTLKVTAA 8
           TT+K+T+A
Sbjct: 897 TTVKITSA 904
>NP_061165
          Length = 1371

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TTLKVTAA 8
           TT+K+T+A
Sbjct: 897 TTVKITSA 904
>NP_001240627
          Length = 1346

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TTLKVTAA 8
           TT+K+T+A
Sbjct: 897 TTVKITSA 904
>NP_001240626
          Length = 1412

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TTLKVTAA 8
           TT+K+T+A
Sbjct: 897 TTVKITSA 904
>XP_006714824
          Length = 4349

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TLKVTAAD 9
           +LK+TA+D
Sbjct: 637 SLKITASD 644
>XP_006714723
          Length = 1246

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TTLKVTAA 8
           TT+K+T+A
Sbjct: 897 TTVKITSA 904
>XP_005248613
          Length = 1391

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TTLKVTAA 8
           TT+K+T+A
Sbjct: 897 TTVKITSA 904
>XP_005248612
          Length = 1456

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TTLKVTAA 8
           TT+K+T+A
Sbjct: 893 TTVKITSA 900
>XP_005248611
          Length = 1460

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TTLKVTAA 8
           TT+K+T+A
Sbjct: 897 TTVKITSA 904
>NP_001128251
          Length = 1015

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TTLKVTAAD 9
           TTLK+T  D
Sbjct: 577 TTLKLTVDD 585
>NP_003310
          Length = 26926

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1     TTLKVT 6
             TTLKVT
Sbjct: 16883 TTLKVT 16888
>NP_597676
          Length = 27051

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1     TTLKVT 6
             TTLKVT
Sbjct: 17008 TTLKVT 17013
>NP_001243779
          Length = 34350

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1     TTLKVT 6
             TTLKVT
Sbjct: 24307 TTLKVT 24312
>NP_596869
          Length = 33423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1     TTLKVT 6
             TTLKVT
Sbjct: 23380 TTLKVT 23385
>NP_443164
          Length = 208

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  TTLKVTAA 8
          TT+K TAA
Sbjct: 87 TTMKPTAA 94
>XP_005246888
          Length = 22663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1     TTLKVT 6
             TTLKVT
Sbjct: 12620 TTLKVT 12625
>XP_006712788
          Length = 24022

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1     TTLKVT 6
             TTLKVT
Sbjct: 13979 TTLKVT 13984
>XP_006712787
          Length = 33978

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1     TTLKVT 6
             TTLKVT
Sbjct: 23935 TTLKVT 23940
>XP_006712786
          Length = 35484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1     TTLKVT 6
             TTLKVT
Sbjct: 25441 TTLKVT 25446
>NP_001254479
          Length = 35991

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1     TTLKVT 6
             TTLKVT
Sbjct: 25948 TTLKVT 25953
>NP_597681
          Length = 27118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1     TTLKVT 6
             TTLKVT
Sbjct: 17075 TTLKVT 17080
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.304    0.111    0.267 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 227,059
Number of extensions: 298
Number of successful extensions: 28
Number of sequences better than 10000.0: 28
Number of HSP's gapped: 28
Number of HSP's successfully gapped: 28
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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