Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              19     869
XP_005262424                                                           19     869
NP_001167569                                                           17    3301
NP_060814                                                              17    3301
NP_056098                                                              17    3301
NP_776173                                                              17    3301
XP_006719419                                                           17    3301
XP_006719416                                                           17    3301
XP_006719415                                                           17    3301
XP_006719414                                                           17    3301
XP_006719413                                                           17    3301
XP_006719411                                                           17    3301
XP_006717973                                                           17    3301
NP_001121084                                                           16    5631
NP_000271                                                              16    5631
NP_001245394                                                           16    5631
NP_001165405                                                           16    5631
NP_001245393                                                           16    5631
NP_001165404                                                           16    5631
NP_071407                                                              16    5631
NP_001245391                                                           16    5631
NP_001245392                                                           16    5631
NP_001595                                                              16    5631
XP_005253015                                                           16    5631
XP_006718309                                                           16    5631
XP_006718308                                                           16    5631
XP_006718307                                                           16    5631
XP_005253014                                                           16    5631
XP_005253013                                                           16    5631
XP_005253012                                                           16    5631
XP_005253011                                                           16    5631
XP_006718005                                                           16    5631
XP_006718004                                                           16    5631
XP_006718003                                                           16    5631
XP_005275746                                                           16    5631
XP_003403671                                                           16    5631
XP_006710003                                                           16    5631
NP_004516                                                              16    7355
NP_001036064                                                           16    7355
NP_005226                                                              16    7355
NP_078966                                                              16    7355
NP_001159632                                                           16    7355
NP_001159634                                                           16    7355
NP_001159633                                                           16    7355
XP_006716111                                                           16    7355
XP_005250542                                                           16    7355
XP_006716109                                                           16    7355
XP_006712591                                                           16    7355
XP_006712590                                                           16    7355
XP_006712589                                                           16    7355
XP_005246434                                                           16    7355
XP_005246433                                                           16    7355
XP_005246432                                                           16    7355
XP_006712427                                                           16    7355
NP_004942                                                              15    9605
NP_694996                                                              15    9605
NP_001265227                                                           15    9605
NP_060899                                                              15    9605
XP_006726589                                                           15    9605
XP_006725524                                                           15    9605
XP_006725523                                                           15    9605
XP_005276828                                                           15    9605
XP_006726279                                                           15    9605
XP_005268693                                                           15    9605
XP_005268692                                                           15    9605
XP_006719296                                                           15    9605
XP_006719295                                                           15    9605
XP_006718462                                                           15    9605
XP_006714722                                                           15    9605
XP_006714721                                                           15    9605
XP_006710010                                                           15    9605
NP_689532                                                              15    9605
>NP_722576
          Length = 3080

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    TTLFSTSV 8
            TTLFSTSV
Sbjct: 1126 TTLFSTSV 1133
>XP_005262424
          Length = 2875

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   TTLFSTSV 8
           TTLFSTSV
Sbjct: 921 TTLFSTSV 928
>NP_001167569
          Length = 258

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TTLFSTSVY 9
           +T+FS+S+Y
Sbjct: 179 STVFSSSIY 187
>NP_060814
          Length = 475

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TTLFSTSVY 9
           +T+FS+S+Y
Sbjct: 179 STVFSSSIY 187
>NP_056098
          Length = 675

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TTLFSTSVY 9
           TT+F  SVY
Sbjct: 659 TTVFQNSVY 667
>NP_776173
          Length = 758

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TTLFSTSVY 9
           TT+F  SVY
Sbjct: 744 TTVFQNSVY 752
>XP_006719419
          Length = 443

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TTLFSTSVY 9
           TT+F  SVY
Sbjct: 429 TTVFQNSVY 437
>XP_006719416
          Length = 615

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TTLFSTSVY 9
           TT+F  SVY
Sbjct: 601 TTVFQNSVY 609
>XP_006719415
          Length = 615

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TTLFSTSVY 9
           TT+F  SVY
Sbjct: 601 TTVFQNSVY 609
>XP_006719414
          Length = 708

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TTLFSTSVY 9
           TT+F  SVY
Sbjct: 694 TTVFQNSVY 702
>XP_006719413
          Length = 716

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TTLFSTSVY 9
           TT+F  SVY
Sbjct: 702 TTVFQNSVY 710
>XP_006719411
          Length = 738

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TTLFSTSVY 9
           TT+F  SVY
Sbjct: 724 TTVFQNSVY 732
>XP_006717973
          Length = 397

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TTLFSTSVY 9
           +T+FS+S+Y
Sbjct: 101 STVFSSSIY 109
>NP_001121084
          Length = 422

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   FSTSVY 9
           FSTSVY
Sbjct: 291 FSTSVY 296
>NP_000271
          Length = 422

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   FSTSVY 9
           FSTSVY
Sbjct: 291 FSTSVY 296
>NP_001245394
          Length = 422

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   FSTSVY 9
           FSTSVY
Sbjct: 291 FSTSVY 296
>NP_001165405
          Length = 1079

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   FSTSVY 9
           FSTSVY
Sbjct: 274 FSTSVY 279
>NP_001245393
          Length = 422

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   FSTSVY 9
           FSTSVY
Sbjct: 291 FSTSVY 296
>NP_001165404
          Length = 1114

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   FSTSVY 9
           FSTSVY
Sbjct: 274 FSTSVY 279
>NP_071407
          Length = 3354

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    FSTSVY 9
            FSTSVY
Sbjct: 2514 FSTSVY 2519
>NP_001245391
          Length = 436

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   FSTSVY 9
           FSTSVY
Sbjct: 305 FSTSVY 310
>NP_001245392
          Length = 436

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   FSTSVY 9
           FSTSVY
Sbjct: 305 FSTSVY 310
>NP_001595
          Length = 436

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   FSTSVY 9
           FSTSVY
Sbjct: 305 FSTSVY 310
>XP_005253015
          Length = 286

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   FSTSVY 9
           FSTSVY
Sbjct: 155 FSTSVY 160
>XP_006718309
          Length = 355

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   FSTSVY 9
           FSTSVY
Sbjct: 224 FSTSVY 229
>XP_006718308
          Length = 369

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   FSTSVY 9
           FSTSVY
Sbjct: 238 FSTSVY 243
>XP_006718307
          Length = 377

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   FSTSVY 9
           FSTSVY
Sbjct: 246 FSTSVY 251
>XP_005253014
          Length = 415

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   FSTSVY 9
           FSTSVY
Sbjct: 305 FSTSVY 310
>XP_005253013
          Length = 422

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   FSTSVY 9
           FSTSVY
Sbjct: 291 FSTSVY 296
>XP_005253012
          Length = 422

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   FSTSVY 9
           FSTSVY
Sbjct: 291 FSTSVY 296
>XP_005253011
          Length = 436

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   FSTSVY 9
           FSTSVY
Sbjct: 305 FSTSVY 310
>XP_006718005
          Length = 3397

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    FSTSVY 9
            FSTSVY
Sbjct: 2557 FSTSVY 2562
>XP_006718004
          Length = 3399

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    FSTSVY 9
            FSTSVY
Sbjct: 2559 FSTSVY 2564
>XP_006718003
          Length = 3419

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    FSTSVY 9
            FSTSVY
Sbjct: 2579 FSTSVY 2584
>XP_005275746
          Length = 3352

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    FSTSVY 9
            FSTSVY
Sbjct: 2512 FSTSVY 2517
>XP_003403671
          Length = 3354

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    FSTSVY 9
            FSTSVY
Sbjct: 2514 FSTSVY 2519
>XP_006710003
          Length = 3374

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    FSTSVY 9
            FSTSVY
Sbjct: 2534 FSTSVY 2539
>NP_004516
          Length = 4655

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    TLFSTSVY 9
            TLF  SVY
Sbjct: 1649 TLFEDSVY 1656
>NP_001036064
          Length = 1292

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TTLFST 6
           TTLFST
Sbjct: 475 TTLFST 480
>NP_005226
          Length = 1308

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TTLFST 6
           TTLFST
Sbjct: 475 TTLFST 480
>NP_078966
          Length = 14507

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   TTLFSTSV 8
           TTL STSV
Sbjct: 886 TTLASTSV 893

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    TTLFST 6
            TTLFST
Sbjct: 3014 TTLFST 3019
>NP_001159632
          Length = 1374

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    TTLFSTS 7
            T+LFSTS
Sbjct: 1011 TSLFSTS 1017
>NP_001159634
          Length = 1253

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TTLFSTS 7
           T+LFSTS
Sbjct: 989 TSLFSTS 995
>NP_001159633
          Length = 1296

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TTLFSTS 7
           T+LFSTS
Sbjct: 971 TSLFSTS 977
>XP_006716111
          Length = 701

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TTLFSTS 7
           T+LFSTS
Sbjct: 338 TSLFSTS 344
>XP_005250542
          Length = 1357

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    TTLFSTS 7
            T+LFSTS
Sbjct: 1032 TSLFSTS 1038
>XP_006716109
          Length = 1365

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    TTLFSTS 7
            T+LFSTS
Sbjct: 1032 TSLFSTS 1038
>XP_006712591
          Length = 3308

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    TLFSTSVY 9
            TLF  SVY
Sbjct: 1654 TLFEDSVY 1661
>XP_006712590
          Length = 3897

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   TLFSTSVY 9
           TLF  SVY
Sbjct: 891 TLFEDSVY 898
>XP_006712589
          Length = 4660

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    TLFSTSVY 9
            TLF  SVY
Sbjct: 1654 TLFEDSVY 1661
>XP_005246434
          Length = 1282

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TTLFST 6
           TTLFST
Sbjct: 475 TTLFST 480
>XP_005246433
          Length = 1298

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TTLFST 6
           TTLFST
Sbjct: 475 TTLFST 480
>XP_005246432
          Length = 1307

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TTLFST 6
           TTLFST
Sbjct: 475 TTLFST 480
>XP_006712427
          Length = 1323

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TTLFST 6
           TTLFST
Sbjct: 475 TTLFST 480
>NP_004942
          Length = 361

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  TTLFSTSV 8
          TTL+ST++
Sbjct: 66 TTLYSTNL 73
>NP_694996
          Length = 2526

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   TLFSTSVY 9
           T+FS  VY
Sbjct: 757 TIFSVGVY 764
>NP_001265227
          Length = 2614

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   TLFSTSVY 9
           T+FS  VY
Sbjct: 757 TIFSVGVY 764
>NP_060899
          Length = 2624

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TTLFSTSVY 9
            TT+ STS Y
Sbjct: 1815 TTISSTSEY 1823
>XP_006726589
          Length = 931

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   TLFSTS 7
           TLFSTS
Sbjct: 538 TLFSTS 543
>XP_006725524
          Length = 2584

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TTLFSTSVY 9
            TT+ STS Y
Sbjct: 1815 TTISSTSEY 1823
>XP_006725523
          Length = 2623

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TTLFSTSVY 9
            TT+ STS Y
Sbjct: 1815 TTISSTSEY 1823
>XP_005276828
          Length = 2584

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TTLFSTSVY 9
            TT+ STS Y
Sbjct: 1815 TTISSTSEY 1823
>XP_006726279
          Length = 2623

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TTLFSTSVY 9
            TT+ STS Y
Sbjct: 1815 TTISSTSEY 1823
>XP_005268693
          Length = 99

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  TTLFSTSVY 9
          T LFS S Y
Sbjct: 87 TQLFSQSAY 95
>XP_005268692
          Length = 116

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   TTLFSTSVY 9
           T LFS S Y
Sbjct: 104 TQLFSQSAY 112
>XP_006719296
          Length = 117

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   TTLFSTSVY 9
           T LFS S Y
Sbjct: 105 TQLFSQSAY 113
>XP_006719295
          Length = 127

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   TTLFSTSVY 9
           T LFS S Y
Sbjct: 115 TQLFSQSAY 123
>XP_006718462
          Length = 4966

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    TLFSTS 7
            TLFSTS
Sbjct: 4573 TLFSTS 4578
>XP_006714722
          Length = 2584

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TTLFSTSVY 9
            TT+ STS Y
Sbjct: 1815 TTISSTSEY 1823
>XP_006714721
          Length = 2623

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TTLFSTSVY 9
            TT+ STS Y
Sbjct: 1815 TTISSTSEY 1823
>XP_006710010
          Length = 1103

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   TLFSTS 7
           TLFSTS
Sbjct: 710 TLFSTS 715
>NP_689532
          Length = 127

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   TTLFSTSVY 9
           T LFS S Y
Sbjct: 115 TQLFSQSAY 123
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.318    0.121    0.318 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 328,406
Number of extensions: 582
Number of successful extensions: 73
Number of sequences better than 10000.0: 72
Number of HSP's gapped: 73
Number of HSP's successfully gapped: 73
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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