Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005091                                                              19     869
NP_653080                                                              19     869
XP_005267292                                                           19     869
XP_005267291                                                           19     869
XP_005267290                                                           19     869
NP_060569                                                              17    4312
NP_001258713                                                           17    4312
NP_001258712                                                           17    4312
NP_004361                                                              16    5631
XP_006715397                                                           16    5631
NP_066933                                                              16    7355
NP_982284                                                              16    7355
XP_005251116                                                           16    7355
XP_006716714                                                           16    7355
XP_005245099                                                           16    7355
XP_005245098                                                           16    7355
XP_005245097                                                           16    7355
NP_001013725                                                           15    9605
NP_775740                                                              15    9605
NP_001138807                                                           15    9605
NP_001271311                                                           15    9605
NP_055869                                                              15    9605
NP_001001671                                                           15    9605
XP_006720833                                                           15    9605
XP_005254845                                                           15    9605
XP_005254844                                                           15    9605
XP_005254450                                                           15    9605
XP_005254449                                                           15    9605
XP_006719360                                                           15    9605
XP_005268797                                                           15    9605
XP_005268796                                                           15    9605
XP_005268795                                                           15    9605
XP_005268794                                                           15    9605
XP_006715518                                                           15    9605
XP_006715517                                                           15    9605
>NP_005091
          Length = 1782

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    TEMLTSEL 9
            TEMLTSEL
Sbjct: 1569 TEMLTSEL 1576
>NP_653080
          Length = 1684

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    TEMLTSEL 9
            TEMLTSEL
Sbjct: 1471 TEMLTSEL 1478
>XP_005267292
          Length = 1677

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    TEMLTSEL 9
            TEMLTSEL
Sbjct: 1464 TEMLTSEL 1471
>XP_005267291
          Length = 1684

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    TEMLTSEL 9
            TEMLTSEL
Sbjct: 1471 TEMLTSEL 1478
>XP_005267290
          Length = 1782

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    TEMLTSEL 9
            TEMLTSEL
Sbjct: 1569 TEMLTSEL 1576
>NP_060569
          Length = 515

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TEMLTSEL 9
           TEML SEL
Sbjct: 406 TEMLMSEL 413
>NP_001258713
          Length = 418

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TEMLTSEL 9
           TEML SEL
Sbjct: 309 TEMLMSEL 316
>NP_001258712
          Length = 515

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TEMLTSEL 9
           TEML SEL
Sbjct: 406 TEMLMSEL 413
>NP_004361
          Length = 3063

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  TTEMLTSEL 9
          TTE L SEL
Sbjct: 76 TTETLLSEL 84
>XP_006715397
          Length = 2972

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  TTEMLTSEL 9
          TTE L SEL
Sbjct: 76 TTETLLSEL 84
>NP_066933
          Length = 1796

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TEMLTSEL 9
           TE++TSE+
Sbjct: 357 TELITSEV 364
>NP_982284
          Length = 1478

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TTEMLTSEL 9
           TT++L SE+
Sbjct: 742 TTQLLASEM 750
>XP_005251116
          Length = 1780

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TEMLTSEL 9
           TE++TSE+
Sbjct: 357 TELITSEV 364
>XP_006716714
          Length = 1796

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TEMLTSEL 9
           TE++TSE+
Sbjct: 357 TELITSEV 364
>XP_005245099
          Length = 1462

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TTEMLTSEL 9
           TT++L SE+
Sbjct: 726 TTQLLASEM 734
>XP_005245098
          Length = 1473

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TTEMLTSEL 9
           TT++L SE+
Sbjct: 737 TTQLLASEM 745
>XP_005245097
          Length = 1489

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TTEMLTSEL 9
           TT++L SE+
Sbjct: 753 TTQLLASEM 761
>NP_001013725
          Length = 1649

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    TEMLTSEL 9
            TE+L SEL
Sbjct: 993  TELLKSEL 1000
>NP_775740
          Length = 375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TTEMLTSE 8
           TTE +TSE
Sbjct: 132 TTEEVTSE 139
>NP_001138807
          Length = 359

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TTEMLTSE 8
           TTE +TSE
Sbjct: 116 TTEEVTSE 123
>NP_001271311
          Length = 340

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TTEMLTSE 8
           TTE +TSE
Sbjct: 97  TTEEVTSE 104
>NP_055869
          Length = 1464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TTEMLTSEL 9
            +TE LTS L
Sbjct: 1286 STEFLTSSL 1294
>NP_001001671
          Length = 1313

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TEMLTSEL 9
           TE+LTS++
Sbjct: 277 TEVLTSDI 284
>XP_006720833
          Length = 235

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TTEMLTSE 8
           TTE +TSE
Sbjct: 132 TTEEVTSE 139
>XP_005254845
          Length = 296

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TTEMLTSE 8
           TTE +TSE
Sbjct: 132 TTEEVTSE 139
>XP_005254844
          Length = 314

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TTEMLTSE 8
           TTE +TSE
Sbjct: 132 TTEEVTSE 139
>XP_005254450
          Length = 1505

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    TEMLTSEL 9
            TE+L SEL
Sbjct: 993  TELLKSEL 1000
>XP_005254449
          Length = 1626

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    TEMLTSEL 9
            TE+L SEL
Sbjct: 993  TELLKSEL 1000
>XP_006719360
          Length = 1011

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TTEMLTSEL 9
           +TE LTS L
Sbjct: 833 STEFLTSSL 841
>XP_005268797
          Length = 1384

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TTEMLTSEL 9
            +TE LTS L
Sbjct: 1286 STEFLTSSL 1294
>XP_005268796
          Length = 1403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TTEMLTSEL 9
            +TE LTS L
Sbjct: 1225 STEFLTSSL 1233
>XP_005268795
          Length = 1416

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TTEMLTSEL 9
            +TE LTS L
Sbjct: 1238 STEFLTSSL 1246
>XP_005268794
          Length = 1443

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TTEMLTSEL 9
            +TE LTS L
Sbjct: 1286 STEFLTSSL 1294
>XP_006715518
          Length = 1338

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    TTEMLTSE 8
            +TE+LTS+
Sbjct: 1007 STELLTSD 1014
>XP_006715517
          Length = 1379

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    TTEMLTSE 8
            +TE+LTS+
Sbjct: 1007 STELLTSD 1014
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.296    0.108    0.243 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 333,913
Number of extensions: 646
Number of successful extensions: 35
Number of sequences better than 10000.0: 35
Number of HSP's gapped: 35
Number of HSP's successfully gapped: 35
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.2 bits)
S2: 28 (15.4 bits)

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