Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004110                                                              20     509
NP_005559                                                              16    5631
NP_055893                                                              16    5631
NP_001002913                                                           16    5631
XP_006717018                                                           16    5631
NP_001159743                                                           16    7355
NP_001273721                                                           16    7355
NP_001138498                                                           16    7355
NP_001273723                                                           16    7355
NP_001273724                                                           16    7355
NP_001273722                                                           16    7355
NP_694568                                                              16    7355
NP_079357                                                              16    7355
NP_071758                                                              16    7355
NP_004963                                                              15    9605
NP_776297                                                              15    9605
NP_115921                                                              15    9605
NP_005447                                                              15    9605
NP_001095939                                                           15    9605
XP_005253283                                                           15    9605
XP_006718009                                                           15    9605
XP_005270106                                                           15    9605
XP_005251512                                                           15    9605
XP_005267222                                                           15    9605
XP_005262783                                                           15    9605
>NP_004110
          Length = 993

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   TEEIYIIM 9
           TEEIYIIM
Sbjct: 915 TEEIYIIM 922
>NP_005559
          Length = 406

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TTEEIYII 8
           T EE+YII
Sbjct: 100 TGEELYII 107
>NP_055893
          Length = 1114

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   TEEIYI 7
           TEEIYI
Sbjct: 630 TEEIYI 635
>NP_001002913
          Length = 214

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   TTEEIYII 8
           T EE+Y++
Sbjct: 112 TAEEVYLV 119
>XP_006717018
          Length = 196

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   TTEEIYII 8
           T EE+Y++
Sbjct: 125 TAEEVYLV 132
>NP_001159743
          Length = 1277

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    TTEEIYI 7
            TT+E+Y+
Sbjct: 1159 TTDEVYL 1165
>NP_001273721
          Length = 1339

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    TTEEIYI 7
            TT+E+Y+
Sbjct: 1221 TTDEVYL 1227
>NP_001138498
          Length = 2299

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    EEIYII 8
            EEIYII
Sbjct: 1839 EEIYII 1844
>NP_001273723
          Length = 596

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   TTEEIYI 7
           TT+E+Y+
Sbjct: 478 TTDEVYL 484
>NP_001273724
          Length = 574

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   TTEEIYI 7
           TT+E+Y+
Sbjct: 456 TTDEVYL 462
>NP_001273722
          Length = 512

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   TTEEIYI 7
           TT+E+Y+
Sbjct: 394 TTDEVYL 400
>NP_694568
          Length = 652

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   TTEEIYI 7
           TT+E+Y+
Sbjct: 534 TTDEVYL 540
>NP_079357
          Length = 1898

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TTEEIYIIM 9
           T E+I+I+M
Sbjct: 896 TNEQIHILM 904
>NP_071758
          Length = 402

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TTEEIYII 8
           T EE+Y+I
Sbjct: 101 TGEELYVI 108
>NP_004963
          Length = 1132

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    EEIYIIM 9
            +EIY+IM
Sbjct: 1096 DEIYMIM 1102
>NP_776297
          Length = 866

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   TTEEIYII 8
           T EE+Y++
Sbjct: 854 TEEEVYLL 861
>NP_115921
          Length = 1894

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    TEEIYII 8
            TEE Y+I
Sbjct: 1554 TEEAYVI 1560
>NP_005447
          Length = 711

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   TEEIYI 7
           TEEIY+
Sbjct: 278 TEEIYL 283
>NP_001095939
          Length = 398

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  TTEEIYIIM 9
          TTE+ YI++
Sbjct: 53 TTEDGYILL 61
>XP_005253283
          Length = 701

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   TEEIYI 7
           TEEIY+
Sbjct: 268 TEEIYL 273
>XP_006718009
          Length = 249

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  TTEEIYIIM 9
          TTE+ YI++
Sbjct: 58 TTEDGYILL 66
>XP_005270106
          Length = 398

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  TTEEIYIIM 9
          TTE+ YI++
Sbjct: 53 TTEDGYILL 61
>XP_005251512
          Length = 1132

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    EEIYIIM 9
            +EIY+IM
Sbjct: 1096 DEIYMIM 1102
>XP_005267222
          Length = 1819

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    TEEIYII 8
            TEE Y+I
Sbjct: 1479 TEEAYVI 1485
>XP_005262783
          Length = 839

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   TTEEIYII 8
           T EE+Y++
Sbjct: 827 TEEEVYLL 834
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.323    0.139    0.352 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 505,791
Number of extensions: 652
Number of successful extensions: 25
Number of sequences better than 10000.0: 25
Number of HSP's gapped: 25
Number of HSP's successfully gapped: 25
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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