Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000213                                                              19     665
NP_001087241                                                           19     665
XP_006714101                                                           19     665
XP_005265799                                                           19     665
XP_005265798                                                           19     665
XP_005265797                                                           19     665
NP_036466                                                              16    5631
NP_002882                                                              16    5631
NP_001139120                                                           16    5631
NP_056484                                                              16    5631
XP_006720692                                                           16    5631
XP_006720691                                                           16    5631
XP_006720690                                                           16    5631
XP_005254635                                                           16    5631
XP_005248364                                                           16    5631
XP_005248363                                                           16    5631
XP_006714538                                                           16    5631
NP_001077377                                                           16    7355
NP_060609                                                              16    7355
NP_062541                                                              16    7355
NP_671494                                                              16    7355
NP_006268                                                              16    7355
NP_878918                                                              15    9605
NP_055995                                                              15    9605
NP_056099                                                              15    9605
NP_001007103                                                           15    9605
NP_115814                                                              15    9605
NP_001277060                                                           15    9605
NP_001028733                                                           15    9605
NP_065940                                                              15    9605
NP_775735                                                              15    9605
NP_443173                                                              15    9605
NP_113676                                                              15    9605
XP_006722429                                                           15    9605
XP_006722428                                                           15    9605
XP_006722427                                                           15    9605
XP_006722426                                                           15    9605
XP_005258225                                                           15    9605
XP_006722425                                                           15    9605
XP_005258223                                                           15    9605
XP_005258073                                                           15    9605
XP_005258072                                                           15    9605
XP_006720147                                                           15    9605
XP_005267517                                                           15    9605
XP_005267516                                                           15    9605
XP_005267515                                                           15    9605
XP_005267514                                                           15    9605
XP_005267513                                                           15    9605
XP_005267512                                                           15    9605
XP_005267511                                                           15    9605
XP_005267218                                                           15    9605
XP_006715641                                                           15    9605
XP_006715640                                                           15    9605
XP_006715639                                                           15    9605
XP_006710565                                                           15    9605
XP_006710564                                                           15    9605
XP_005270743                                                           15    9605
>NP_000213
          Length = 976

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TTALEVVDK 9
           TT LEVVDK
Sbjct: 302 TTTLEVVDK 310
>NP_001087241
          Length = 972

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TTALEVVDK 9
           TT LEVVDK
Sbjct: 302 TTTLEVVDK 310
>XP_006714101
          Length = 526

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TTALEVVDK 9
           TT LEVVDK
Sbjct: 303 TTTLEVVDK 311
>XP_005265799
          Length = 973

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TTALEVVDK 9
           TT LEVVDK
Sbjct: 303 TTTLEVVDK 311
>XP_005265798
          Length = 976

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TTALEVVDK 9
           TT LEVVDK
Sbjct: 303 TTTLEVVDK 311
>XP_005265797
          Length = 977

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TTALEVVDK 9
           TT LEVVDK
Sbjct: 303 TTTLEVVDK 311
>NP_036466
          Length = 2058

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    TTALEVVDK 9
            TTA EVV+K
Sbjct: 1720 TTAGEVVEK 1728
>NP_002882
          Length = 1273

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TTALEVVDK 9
           TTA+ V+DK
Sbjct: 682 TTAIVVLDK 690
>NP_001139120
          Length = 1257

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TTALEVVDK 9
           TTA+ V+DK
Sbjct: 669 TTAIVVLDK 677
>NP_056484
          Length = 795

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TTALEVVD 8
           T A+EVVD
Sbjct: 331 TVAIEVVD 338
>XP_006720692
          Length = 1270

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TTALEVVDK 9
           TTA+ V+DK
Sbjct: 682 TTAIVVLDK 690
>XP_006720691
          Length = 1182

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TTALEVVDK 9
           TTA+ V+DK
Sbjct: 669 TTAIVVLDK 677
>XP_006720690
          Length = 1245

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TTALEVVDK 9
           TTA+ V+DK
Sbjct: 669 TTAIVVLDK 677
>XP_005254635
          Length = 1280

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TTALEVVDK 9
           TTA+ V+DK
Sbjct: 669 TTAIVVLDK 677
>XP_005248364
          Length = 1415

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    TTALEVVDK 9
            TTA EVV+K
Sbjct: 1077 TTAGEVVEK 1085
>XP_005248363
          Length = 1416

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    TTALEVVDK 9
            TTA EVV+K
Sbjct: 1078 TTAGEVVEK 1086
>XP_006714538
          Length = 2035

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    TTALEVVDK 9
            TTA EVV+K
Sbjct: 1697 TTAGEVVEK 1705
>NP_001077377
          Length = 789

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TALEVVDK 9
           TALE V+K
Sbjct: 167 TALEAVEK 174
>NP_060609
          Length = 837

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TALEVVDK 9
           TALE V+K
Sbjct: 167 TALEAVEK 174
>NP_062541
          Length = 1670

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TALEVVDK 9
           T LEV+DK
Sbjct: 521 TELEVLDK 528
>NP_671494
          Length = 1249

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TALEVVDK 9
           T LEV+DK
Sbjct: 521 TELEVLDK 528
>NP_006268
          Length = 1697

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TALEVVDK 9
           T LEV+DK
Sbjct: 521 TELEVLDK 528
>NP_878918
          Length = 6907

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    LEVVDK 9
            LEVVDK
Sbjct: 1588 LEVVDK 1593
>NP_055995
          Length = 6885

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    LEVVDK 9
            LEVVDK
Sbjct: 1588 LEVVDK 1593
>NP_056099
          Length = 3375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    LEVVDK 9
            LEVVDK
Sbjct: 2595 LEVVDK 2600
>NP_001007103
          Length = 755

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LEVVDK 9
           LEVVDK
Sbjct: 456 LEVVDK 461
>NP_115814
          Length = 780

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LEVVDK 9
           LEVVDK
Sbjct: 481 LEVVDK 486
>NP_001277060
          Length = 849

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TTALEVVDK 9
           TT+L+  DK
Sbjct: 477 TTSLQTADK 485
>NP_001028733
          Length = 1004

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TTALEVVDK 9
           TT+L+  DK
Sbjct: 477 TTSLQTADK 485
>NP_065940
          Length = 704

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TTALEVVDK 9
           TT+L+  DK
Sbjct: 477 TTSLQTADK 485
>NP_775735
          Length = 623

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LEVVDK 9
           LEVVDK
Sbjct: 302 LEVVDK 307
>NP_443173
          Length = 640

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  ALEVVDK 9
          ALE++DK
Sbjct: 42 ALEILDK 48
>NP_113676
          Length = 705

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LEVVDK 9
           LEVVDK
Sbjct: 329 LEVVDK 334
>XP_006722429
          Length = 331

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LEVVDK 9
           LEVVDK
Sbjct: 302 LEVVDK 307
>XP_006722428
          Length = 370

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LEVVDK 9
           LEVVDK
Sbjct: 302 LEVVDK 307
>XP_006722427
          Length = 485

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LEVVDK 9
           LEVVDK
Sbjct: 302 LEVVDK 307
>XP_006722426
          Length = 527

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LEVVDK 9
           LEVVDK
Sbjct: 215 LEVVDK 220
>XP_005258225
          Length = 534

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LEVVDK 9
           LEVVDK
Sbjct: 302 LEVVDK 307
>XP_006722425
          Length = 593

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LEVVDK 9
           LEVVDK
Sbjct: 302 LEVVDK 307
>XP_005258223
          Length = 614

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LEVVDK 9
           LEVVDK
Sbjct: 302 LEVVDK 307
>XP_005258073
          Length = 787

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TTALEVVDK 9
           TT+L+  DK
Sbjct: 260 TTSLQTADK 268
>XP_005258072
          Length = 914

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TTALEVVDK 9
           TT+L+  DK
Sbjct: 387 TTSLQTADK 395
>XP_006720147
          Length = 4788

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    LEVVDK 9
            LEVVDK
Sbjct: 1588 LEVVDK 1593
>XP_005267517
          Length = 6883

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    LEVVDK 9
            LEVVDK
Sbjct: 1588 LEVVDK 1593
>XP_005267516
          Length = 6884

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    LEVVDK 9
            LEVVDK
Sbjct: 1588 LEVVDK 1593
>XP_005267515
          Length = 6899

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    LEVVDK 9
            LEVVDK
Sbjct: 1588 LEVVDK 1593
>XP_005267514
          Length = 6908

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    LEVVDK 9
            LEVVDK
Sbjct: 1588 LEVVDK 1593
>XP_005267513
          Length = 6921

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    LEVVDK 9
            LEVVDK
Sbjct: 1588 LEVVDK 1593
>XP_005267512
          Length = 6922

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    LEVVDK 9
            LEVVDK
Sbjct: 1588 LEVVDK 1593
>XP_005267511
          Length = 6922

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    LEVVDK 9
            LEVVDK
Sbjct: 1588 LEVVDK 1593
>XP_005267218
          Length = 780

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LEVVDK 9
           LEVVDK
Sbjct: 481 LEVVDK 486
>XP_006715641
          Length = 780

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LEVVDK 9
           LEVVDK
Sbjct: 481 LEVVDK 486
>XP_006715640
          Length = 780

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LEVVDK 9
           LEVVDK
Sbjct: 481 LEVVDK 486
>XP_006715639
          Length = 815

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LEVVDK 9
           LEVVDK
Sbjct: 516 LEVVDK 521
>XP_006710565
          Length = 3140

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    LEVVDK 9
            LEVVDK
Sbjct: 2360 LEVVDK 2365
>XP_006710564
          Length = 3432

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    LEVVDK 9
            LEVVDK
Sbjct: 2652 LEVVDK 2657
>XP_005270743
          Length = 3453

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    LEVVDK 9
            LEVVDK
Sbjct: 2673 LEVVDK 2678
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.305    0.120    0.286 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 315,105
Number of extensions: 353
Number of successful extensions: 57
Number of sequences better than 10000.0: 57
Number of HSP's gapped: 57
Number of HSP's successfully gapped: 57
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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