Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              19     869
XP_005262424                                                           19     869
NP_849144                                                              18    1935
XP_006713662                                                           18    1935
XP_006713661                                                           18    1935
XP_006713660                                                           18    1935
XP_005247434                                                           18    1935
XP_006713659                                                           18    1935
NP_001027006                                                           17    2528
NP_065974                                                              17    3301
NP_001272478                                                           17    3301
XP_006712719                                                           17    3301
XP_005246770                                                           17    3301
XP_005246768                                                           17    3301
XP_005246769                                                           17    3301
NP_000564                                                              17    4312
NP_000642                                                              17    4312
XP_006711231                                                           17    4312
XP_005273121                                                           17    4312
XP_006711230                                                           17    4312
XP_006711229                                                           17    4312
NP_006173                                                              16    7355
NP_001014796                                                           16    7355
XP_006711408                                                           16    7355
XP_006711407                                                           16    7355
XP_005245278                                                           16    7355
NP_001093321                                                           15    9605
NP_001038945                                                           15    9605
NP_001230175                                                           15    9605
NP_001269683                                                           15    9605
NP_000435                                                              15    9605
NP_056049                                                              15    9605
NP_001091988                                                           15    9605
NP_002510                                                              15    9605
NP_775871                                                              15    9605
XP_005248952                                                           15    9605
XP_005248951                                                           15    9605
XP_005248950                                                           15    9605
XP_005248949                                                           15    9605
XP_001718723                                                           15    9605
>NP_722576
          Length = 3080

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TSTNALSFP 9
            TST ALSFP
Sbjct: 1180 TSTYALSFP 1188
>XP_005262424
          Length = 2875

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TSTNALSFP 9
           TST ALSFP
Sbjct: 975 TSTYALSFP 983
>NP_849144
          Length = 2623

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    TSTNALSFP 9
            T+T ALSFP
Sbjct: 1074 TATAALSFP 1082
>XP_006713662
          Length = 1846

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    TSTNALSFP 9
            T+T ALSFP
Sbjct: 1146 TATAALSFP 1154
>XP_006713661
          Length = 1860

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    TSTNALSFP 9
            T+T ALSFP
Sbjct: 1146 TATAALSFP 1154
>XP_006713660
          Length = 2623

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    TSTNALSFP 9
            T+T ALSFP
Sbjct: 1074 TATAALSFP 1082
>XP_005247434
          Length = 2623

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    TSTNALSFP 9
            T+T ALSFP
Sbjct: 1074 TATAALSFP 1082
>XP_006713659
          Length = 2695

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    TSTNALSFP 9
            T+T ALSFP
Sbjct: 1146 TATAALSFP 1154
>NP_001027006
          Length = 1149

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    TNALSFP 9
            TN+LSFP
Sbjct: 1096 TNSLSFP 1102
>NP_065974
          Length = 2354

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TSTNALSFP 9
            TS+N L FP
Sbjct: 2183 TSSNKLGFP 2191
>NP_001272478
          Length = 2352

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TSTNALSFP 9
            TS+N L FP
Sbjct: 2181 TSSNKLGFP 2189
>XP_006712719
          Length = 2354

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TSTNALSFP 9
            TS+N L FP
Sbjct: 2183 TSSNKLGFP 2191
>XP_005246770
          Length = 2354

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TSTNALSFP 9
            TS+N L FP
Sbjct: 2183 TSSNKLGFP 2191
>XP_005246768
          Length = 2354

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TSTNALSFP 9
            TS+N L FP
Sbjct: 2183 TSSNKLGFP 2191
>XP_005246769
          Length = 2354

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TSTNALSFP 9
            TS+N L FP
Sbjct: 2183 TSSNKLGFP 2191
>NP_000564
          Length = 2039

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   TSTNALSFP 9
           T TNA  FP
Sbjct: 506 TQTNASDFP 514

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   TSTNALSFP 9
           T TNA  FP
Sbjct: 956 TQTNASDFP 964
>NP_000642
          Length = 2489

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   TSTNALSFP 9
           T TNA  FP
Sbjct: 506 TQTNASDFP 514

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   TSTNALSFP 9
           T TNA  FP
Sbjct: 956 TQTNASDFP 964

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    TSTNALSFP 9
            T TNA  FP
Sbjct: 1406 TQTNASDFP 1414
>XP_006711231
          Length = 2044

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   TSTNALSFP 9
           T TNA  FP
Sbjct: 511 TQTNASDFP 519

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   TSTNALSFP 9
           T TNA  FP
Sbjct: 961 TQTNASDFP 969
>XP_005273121
          Length = 2361

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   TSTNALSFP 9
           T TNA  FP
Sbjct: 511 TQTNASDFP 519

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   TSTNALSFP 9
           T TNA  FP
Sbjct: 961 TQTNASDFP 969

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    TSTNALSFP 9
            T TNA  FP
Sbjct: 1278 TQTNASDFP 1286
>XP_006711230
          Length = 2361

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   TSTNALSFP 9
           T TNA  FP
Sbjct: 511 TQTNASDFP 519

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   TSTNALSFP 9
           T TNA  FP
Sbjct: 961 TQTNASDFP 969

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    TSTNALSFP 9
            T TNA  FP
Sbjct: 1411 TQTNASDFP 1419
>XP_006711229
          Length = 2459

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   TSTNALSFP 9
           T TNA  FP
Sbjct: 511 TQTNASDFP 519

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   TSTNALSFP 9
           T TNA  FP
Sbjct: 961 TQTNASDFP 969

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    TSTNALSFP 9
            T TNA  FP
Sbjct: 1411 TQTNASDFP 1419
>NP_006173
          Length = 855

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NALSFP 9
           NA+SFP
Sbjct: 316 NAISFP 321
>NP_001014796
          Length = 855

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NALSFP 9
           NA+SFP
Sbjct: 316 NAISFP 321
>XP_006711408
          Length = 571

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NALSFP 9
           NA+SFP
Sbjct: 328 NAISFP 333
>XP_006711407
          Length = 855

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NALSFP 9
           NA+SFP
Sbjct: 316 NAISFP 321
>XP_005245278
          Length = 867

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NALSFP 9
           NA+SFP
Sbjct: 328 NAISFP 333
>NP_001093321
          Length = 474

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TSTNAL 6
           TSTNAL
Sbjct: 389 TSTNAL 394
>NP_001038945
          Length = 474

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TSTNAL 6
           TSTNAL
Sbjct: 389 TSTNAL 394
>NP_001230175
          Length = 804

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TSTNALS 7
           TS+NALS
Sbjct: 729 TSSNALS 735
>NP_001269683
          Length = 695

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   STNALSFP 9
           STN + FP
Sbjct: 544 STNQIRFP 551
>NP_000435
          Length = 749

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   STNALSFP 9
           STN + FP
Sbjct: 544 STNQIRFP 551
>NP_056049
          Length = 1346

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  NALSFP 9
          N+LSFP
Sbjct: 85 NSLSFP 90
>NP_001091988
          Length = 1346

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  NALSFP 9
          N+LSFP
Sbjct: 85 NSLSFP 90
>NP_002510
          Length = 1427

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    NALSFP 9
            NA+SFP
Sbjct: 1091 NAVSFP 1096
>NP_775871
          Length = 8384

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    TSTNALS 7
            T TNALS
Sbjct: 5250 TGTNALS 5256
>XP_005248952
          Length = 1380

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  NALSFP 9
          N+LSFP
Sbjct: 85 NSLSFP 90
>XP_005248951
          Length = 1381

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  NALSFP 9
          N+LSFP
Sbjct: 85 NSLSFP 90
>XP_005248950
          Length = 1386

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  NALSFP 9
          N+LSFP
Sbjct: 85 NSLSFP 90
>XP_005248949
          Length = 1386

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  NALSFP 9
          N+LSFP
Sbjct: 85 NSLSFP 90
>XP_001718723
          Length = 1091

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  TSTNALSFP 9
          TST+ ++FP
Sbjct: 50 TSTSHVTFP 58
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.306    0.114    0.311 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 405,608
Number of extensions: 532
Number of successful extensions: 50
Number of sequences better than 10000.0: 40
Number of HSP's gapped: 50
Number of HSP's successfully gapped: 50
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package