Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001123914                                                           20     509
NP_005334                                                              20     509
NP_004976                                                              20     509
NP_002515                                                              20     509
NP_853510                                                              20     509
NP_002126                                                              16    5631
NP_001189162                                                           16    5631
NP_775180                                                              16    5631
NP_056374                                                              16    5631
NP_006755                                                              16    5631
NP_001624                                                              16    5631
NP_066278                                                              16    5631
NP_001258662                                                           16    5631
XP_006722501                                                           16    5631
XP_005258301                                                           16    5631
XP_005258300                                                           16    5631
XP_006719427                                                           16    5631
XP_005268881                                                           16    5631
XP_006719426                                                           16    5631
XP_005268880                                                           16    5631
XP_005268879                                                           16    5631
XP_006713232                                                           16    5631
XP_006713231                                                           16    5631
XP_006713230                                                           16    5631
XP_006713229                                                           16    5631
NP_005805                                                              16    7355
NP_849188                                                              16    7355
NP_036473                                                              16    7355
NP_001265238                                                           16    7355
NP_006413                                                              16    7355
XP_006725006                                                           16    7355
XP_005253722                                                           16    7355
XP_005253721                                                           16    7355
XP_006719014                                                           16    7355
XP_006717500                                                           16    7355
NP_004031                                                              15    9605
NP_078911                                                              15    9605
NP_001138923                                                           15    9605
NP_786886                                                              15    9605
NP_001036143                                                           15    9605
NP_003076                                                              15    9605
NP_001036144                                                           15    9605
NP_001001502                                                           15    9605
XP_005252185                                                           15    9605
XP_006717294                                                           15    9605
XP_005252184                                                           15    9605
XP_005252183                                                           15    9605
XP_006714979                                                           15    9605
XP_006714978                                                           15    9605
XP_006714977                                                           15    9605
>NP_001123914
          Length = 189

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TSTKTRQGV 9
           TS KTRQGV
Sbjct: 144 TSAKTRQGV 152
>NP_005334
          Length = 189

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TSTKTRQGV 9
           TS KTRQGV
Sbjct: 144 TSAKTRQGV 152
>NP_004976
          Length = 188

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TSTKTRQGV 9
           TS KTRQGV
Sbjct: 144 TSAKTRQGV 152
>NP_002515
          Length = 189

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TSTKTRQGV 9
           TS KTRQGV
Sbjct: 144 TSAKTRQGV 152
>NP_853510
          Length = 233

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TSTKTRQGV 9
           TS KTRQGV
Sbjct: 180 TSAKTRQGV 188
>NP_002126
          Length = 598

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   TSTKTRQG 8
           TSTK R G
Sbjct: 251 TSTKARSG 258
>NP_001189162
          Length = 611

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   TSTKTRQG 8
           TSTK R G
Sbjct: 264 TSTKARSG 271
>NP_775180
          Length = 598

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   TSTKTRQG 8
           TSTK R G
Sbjct: 251 TSTKARSG 258
>NP_056374
          Length = 1596

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   TSTKTRQG 8
           TSTK R G
Sbjct: 909 TSTKNRHG 916
>NP_006755
          Length = 506

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   STKTRQG 8
           S KTRQG
Sbjct: 152 SAKTRQG 158
>NP_001624
          Length = 352

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TSTKTRQGV 9
          TST+ R+GV
Sbjct: 82 TSTRWRKGV 90
>NP_066278
          Length = 725

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TSTKTRQGV 9
           T +KTR+GV
Sbjct: 395 TVSKTRKGV 403
>NP_001258662
          Length = 689

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TSTKTRQGV 9
           T +KTR+GV
Sbjct: 365 TVSKTRKGV 373
>XP_006722501
          Length = 1403

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   TSTKTRQG 8
           TSTK R G
Sbjct: 909 TSTKNRHG 916
>XP_005258301
          Length = 1539

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   TSTKTRQG 8
           TSTK R G
Sbjct: 909 TSTKNRHG 916
>XP_005258300
          Length = 1596

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   TSTKTRQG 8
           TSTK R G
Sbjct: 909 TSTKNRHG 916
>XP_006719427
          Length = 598

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   TSTKTRQG 8
           TSTK R G
Sbjct: 251 TSTKARSG 258
>XP_005268881
          Length = 598

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   TSTKTRQG 8
           TSTK R G
Sbjct: 251 TSTKARSG 258
>XP_006719426
          Length = 598

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   TSTKTRQG 8
           TSTK R G
Sbjct: 251 TSTKARSG 258
>XP_005268880
          Length = 652

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   TSTKTRQG 8
           TSTK R G
Sbjct: 305 TSTKARSG 312
>XP_005268879
          Length = 670

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   TSTKTRQG 8
           TSTK R G
Sbjct: 323 TSTKARSG 330
>XP_006713232
          Length = 519

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TSTKTRQGV 9
           T +KTR+GV
Sbjct: 395 TVSKTRKGV 403
>XP_006713231
          Length = 625

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TSTKTRQGV 9
           T +KTR+GV
Sbjct: 295 TVSKTRKGV 303
>XP_006713230
          Length = 655

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TSTKTRQGV 9
           T +KTR+GV
Sbjct: 395 TVSKTRKGV 403
>XP_006713229
          Length = 680

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TSTKTRQGV 9
           T +KTR+GV
Sbjct: 350 TVSKTRKGV 358
>NP_005805
          Length = 319

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  TSTKTRQGV 9
          TST +R+G+
Sbjct: 47 TSTSSREGL 55
>NP_849188
          Length = 2400

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    TSTKTRQG 8
            TST+T QG
Sbjct: 1718 TSTRTVQG 1725
>NP_036473
          Length = 634

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TSTKTRQGV 9
           TST T +GV
Sbjct: 320 TSTLTEEGV 328
>NP_001265238
          Length = 853

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   STKTRQG 8
           STK RQG
Sbjct: 223 STKERQG 229
>NP_006413
          Length = 853

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   STKTRQG 8
           STK RQG
Sbjct: 223 STKERQG 229
>XP_006725006
          Length = 570

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TSTKTRQGV 9
           TST T +GV
Sbjct: 273 TSTLTEEGV 281
>XP_005253722
          Length = 853

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   STKTRQG 8
           STK RQG
Sbjct: 223 STKERQG 229
>XP_005253721
          Length = 853

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   STKTRQG 8
           STK RQG
Sbjct: 223 STKERQG 229
>XP_006719014
          Length = 853

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   STKTRQG 8
           STK RQG
Sbjct: 223 STKERQG 229
>XP_006717500
          Length = 539

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TSTKTRQGV 9
           TST T +GV
Sbjct: 225 TSTLTEEGV 233
>NP_004031
          Length = 196

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   STKTRQGV 9
           S KT++GV
Sbjct: 160 SAKTKEGV 167
>NP_078911
          Length = 725

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   STKTRQG 8
           ST++RQG
Sbjct: 210 STRSRQG 216
>NP_001138923
          Length = 870

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3 TKTRQG 8
         TKT+QG
Sbjct: 4 TKTKQG 9
>NP_786886
          Length = 193

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   STKTRQGV 9
           S KT++GV
Sbjct: 160 SAKTKEGV 167
>NP_001036143
          Length = 193

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   STKTRQGV 9
           S KT++GV
Sbjct: 160 SAKTKEGV 167
>NP_003076
          Length = 134

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  TKTRQGV 9
          +KTR+GV
Sbjct: 42 SKTREGV 48
>NP_001036144
          Length = 193

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   STKTRQGV 9
           S KT++GV
Sbjct: 160 SAKTKEGV 167
>NP_001001502
          Length = 134

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  TKTRQGV 9
          +KTR+GV
Sbjct: 42 SKTREGV 48
>XP_005252185
          Length = 569

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  STKTRQG 8
          ST++RQG
Sbjct: 54 STRSRQG 60
>XP_006717294
          Length = 692

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   STKTRQG 8
           ST++RQG
Sbjct: 210 STRSRQG 216
>XP_005252184
          Length = 725

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   STKTRQG 8
           ST++RQG
Sbjct: 210 STRSRQG 216
>XP_005252183
          Length = 725

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   STKTRQG 8
           ST++RQG
Sbjct: 210 STRSRQG 216
>XP_006714979
          Length = 134

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  TKTRQGV 9
          +KTR+GV
Sbjct: 42 SKTREGV 48
>XP_006714978
          Length = 152

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  TKTRQGV 9
          +KTR+GV
Sbjct: 42 SKTREGV 48
>XP_006714977
          Length = 152

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  TKTRQGV 9
          +KTR+GV
Sbjct: 42 SKTREGV 48
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.299    0.109    0.271 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 422,121
Number of extensions: 685
Number of successful extensions: 50
Number of sequences better than 10000.0: 50
Number of HSP's gapped: 50
Number of HSP's successfully gapped: 50
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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