Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              20     390
XP_005262424                                                           20     390
NP_001138537                                                           18    1135
NP_997374                                                              18    1135
NP_001265596                                                           16    5631
NP_057361                                                              16    5631
NP_899050                                                              16    5631
NP_001265597                                                           16    5631
NP_001265595                                                           16    5631
XP_005252323                                                           16    5631
XP_005252322                                                           16    5631
XP_005252321                                                           16    5631
XP_005252320                                                           16    5631
NP_001092272                                                           16    5631
NP_115547                                                              16    5631
NP_006246                                                              16    7355
NP_660337                                                              16    7355
XP_006720926                                                           16    7355
XP_006720925                                                           16    7355
XP_006720924                                                           16    7355
XP_006720923                                                           16    7355
XP_005255218                                                           16    7355
XP_005255217                                                           16    7355
NP_008969                                                              15    9605
NP_001157281                                                           15    9605
NP_001157145                                                           15    9605
NP_689561                                                              15    9605
NP_001157283                                                           15    9605
NP_003310                                                              15    9605
NP_597676                                                              15    9605
NP_001243779                                                           15    9605
NP_596869                                                              15    9605
NP_001135797                                                           15    9605
NP_001135796                                                           15    9605
NP_003044                                                              15    9605
NP_001129163                                                           15    9605
XP_006713055                                                           15    9605
XP_005246888                                                           15    9605
XP_006712788                                                           15    9605
XP_006712787                                                           15    9605
XP_006712786                                                           15    9605
NP_001254479                                                           15    9605
NP_597681                                                              15    9605
>NP_722576
          Length = 3080

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TSSNRVGVH 9
            TSSN VGVH
Sbjct: 1344 TSSNTVGVH 1352
>XP_005262424
          Length = 2875

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TSSNRVGVH 9
            TSSN VGVH
Sbjct: 1139 TSSNTVGVH 1147
>NP_001138537
          Length = 900

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  TSSNRVGVH 9
          +SSN VGVH
Sbjct: 34 SSSNTVGVH 42
>NP_997374
          Length = 677

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  TSSNRVGVH 9
          +SSN VGVH
Sbjct: 34 SSSNTVGVH 42
>NP_001265596
          Length = 237

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TSSNRVGV 8
           +SSN++GV
Sbjct: 186 SSSNKIGV 193
>NP_057361
          Length = 237

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TSSNRVGV 8
           +SSN++GV
Sbjct: 186 SSSNKIGV 193
>NP_899050
          Length = 237

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TSSNRVGV 8
           +SSN++GV
Sbjct: 186 SSSNKIGV 193
>NP_001265597
          Length = 237

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TSSNRVGV 8
           +SSN++GV
Sbjct: 186 SSSNKIGV 193
>NP_001265595
          Length = 237

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TSSNRVGV 8
           +SSN++GV
Sbjct: 186 SSSNKIGV 193
>XP_005252323
          Length = 635

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TSSNRVGV 8
           TSSN +GV
Sbjct: 558 TSSNNLGV 565
>XP_005252322
          Length = 690

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TSSNRVGV 8
           TSSN +GV
Sbjct: 629 TSSNNLGV 636
>XP_005252321
          Length = 696

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TSSNRVGV 8
           TSSN +GV
Sbjct: 619 TSSNNLGV 626
>XP_005252320
          Length = 706

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TSSNRVGV 8
           TSSN +GV
Sbjct: 645 TSSNNLGV 652
>NP_001092272
          Length = 722

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TSSNRVGV 8
           TSSN +GV
Sbjct: 645 TSSNNLGV 652
>NP_115547
          Length = 706

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TSSNRVGV 8
           TSSN +GV
Sbjct: 629 TSSNNLGV 636
>NP_006246
          Length = 683

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SSNRVGV 8
           SSNR+G+
Sbjct: 346 SSNRLGI 352
>NP_660337
          Length = 1748

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   TSSNRVGV 8
           TSSNRV V
Sbjct: 904 TSSNRVVV 911
>XP_006720926
          Length = 1383

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   TSSNRVGV 8
           TSSNRV V
Sbjct: 905 TSSNRVVV 912
>XP_006720925
          Length = 1674

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   TSSNRVGV 8
           TSSNRV V
Sbjct: 905 TSSNRVVV 912
>XP_006720924
          Length = 1679

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   TSSNRVGV 8
           TSSNRV V
Sbjct: 833 TSSNRVVV 840
>XP_006720923
          Length = 1738

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   TSSNRVGV 8
           TSSNRV V
Sbjct: 905 TSSNRVVV 912
>XP_005255218
          Length = 1750

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   TSSNRVGV 8
           TSSNRV V
Sbjct: 904 TSSNRVVV 911
>XP_005255217
          Length = 1751

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   TSSNRVGV 8
           TSSNRV V
Sbjct: 905 TSSNRVVV 912
>NP_008969
          Length = 930

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   SNRVGVH 9
           SN+VG H
Sbjct: 867 SNKVGSH 873
>NP_001157281
          Length = 1941

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    TSSNRVGV 8
            T SN++GV
Sbjct: 1886 TVSNKIGV 1893
>NP_001157145
          Length = 738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TSSNRVGV 8
           T SN++GV
Sbjct: 683 TVSNKIGV 690
>NP_689561
          Length = 890

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TSSNRVGV 8
           T SN++GV
Sbjct: 835 TVSNKIGV 842
>NP_001157283
          Length = 714

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TSSNRVGV 8
           T SN++GV
Sbjct: 659 TVSNKIGV 666
>NP_003310
          Length = 26926

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    TSSNRVG 7
            T+SNR+G
Sbjct: 8981 TASNRLG 8987
>NP_597676
          Length = 27051

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    TSSNRVG 7
            T+SNR+G
Sbjct: 9106 TASNRLG 9112
>NP_001243779
          Length = 34350

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1     TSSNRVG 7
             T+SNR+G
Sbjct: 16405 TASNRLG 16411
>NP_596869
          Length = 33423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1     TSSNRVG 7
             T+SNR+G
Sbjct: 15478 TASNRLG 15484
>NP_001135797
          Length = 472

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   SNRVGVH 9
           +NR+G H
Sbjct: 161 TNRIGYH 167
>NP_001135796
          Length = 493

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   SNRVGVH 9
           +NR+G H
Sbjct: 161 TNRIGYH 167
>NP_003044
          Length = 525

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   SNRVGVH 9
           +NR+G H
Sbjct: 161 TNRIGYH 167
>NP_001129163
          Length = 525

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   SNRVGVH 9
           +NR+G H
Sbjct: 161 TNRIGYH 167
>XP_006713055
          Length = 195

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   TSSNRVGV 8
           TSS R GV
Sbjct: 123 TSSTRTGV 130
>XP_005246888
          Length = 22663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    TSSNRVG 7
            T+SNR+G
Sbjct: 4718 TASNRLG 4724
>XP_006712788
          Length = 24022

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    TSSNRVG 7
            T+SNR+G
Sbjct: 6077 TASNRLG 6083
>XP_006712787
          Length = 33978

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1     TSSNRVG 7
             T+SNR+G
Sbjct: 16033 TASNRLG 16039
>XP_006712786
          Length = 35484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1     TSSNRVG 7
             T+SNR+G
Sbjct: 17539 TASNRLG 17545
>NP_001254479
          Length = 35991

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1     TSSNRVG 7
             T+SNR+G
Sbjct: 18046 TASNRLG 18052
>NP_597681
          Length = 27118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    TSSNRVG 7
            T+SNR+G
Sbjct: 9173 TASNRLG 9179
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.308    0.118    0.326 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 420,965
Number of extensions: 539
Number of successful extensions: 43
Number of sequences better than 10000.0: 43
Number of HSP's gapped: 43
Number of HSP's successfully gapped: 43
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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