Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              19     665
XP_005262424                                                           19     665
NP_758519                                                              17    2528
NP_000751                                                              17    2528
NP_724781                                                              17    2528
NP_001094811                                                           17    2528
XP_005270552                                                           17    2528
XP_005270550                                                           17    2528
XP_005270549                                                           17    2528
NP_789743                                                              17    3301
NP_001005469                                                           17    3301
NP_631958                                                              17    4312
NP_631957                                                              17    4312
NP_115884                                                              17    4312
NP_001138932                                                           17    4312
NP_001138931                                                           17    4312
XP_006714116                                                           17    4312
XP_006714115                                                           17    4312
XP_005265840                                                           17    4312
XP_006714114                                                           17    4312
NP_001130010                                                           16    5631
NP_061141                                                              16    5631
XP_006726577                                                           16    5631
XP_005255020                                                           16    5631
XP_006709997                                                           16    5631
NP_001001923                                                           16    5631
NP_079523                                                              16    5631
NP_001034764                                                           16    5631
NP_004940                                                              16    7355
NP_077740                                                              16    7355
XP_005258263                                                           16    7355
XP_006720777                                                           16    7355
NP_001005278                                                           16    7355
NP_001004457                                                           16    7355
NP_001009899                                                           15    9605
NP_055873                                                              15    9605
NP_001009814                                                           15    9605
NP_004807                                                              15    9605
NP_001121080                                                           15    9605
NP_055737                                                              15    9605
NP_001028225                                                           15    9605
NP_127497                                                              15    9605
NP_542170                                                              15    9605
NP_127500                                                              15    9605
NP_127499                                                              15    9605
NP_054730                                                              15    9605
XP_005260667                                                           15    9605
XP_005260668                                                           15    9605
XP_006719855                                                           15    9605
XP_006719853                                                           15    9605
XP_005252366                                                           15    9605
XP_005252365                                                           15    9605
XP_005252364                                                           15    9605
XP_005247723                                                           15    9605
XP_005247266                                                           15    9605
XP_005247265                                                           15    9605
NP_002539                                                              15    9605
NP_001005284                                                           15    9605
NP_659198                                                              15    9605
>NP_722576
          Length = 3080

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TSMSTTLCL 9
           TSMSTT CL
Sbjct: 410 TSMSTTPCL 418
>XP_005262424
          Length = 2875

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TSMSTTLCL 9
           TSMSTT CL
Sbjct: 205 TSMSTTPCL 213
>NP_758519
          Length = 783

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   TSMSTTLCL 9
           TSMS  LCL
Sbjct: 211 TSMSPQLCL 219
>NP_000751
          Length = 836

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   TSMSTTLCL 9
           TSMS  LCL
Sbjct: 211 TSMSPQLCL 219
>NP_724781
          Length = 863

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   TSMSTTLCL 9
           TSMS  LCL
Sbjct: 211 TSMSPQLCL 219
>NP_001094811
          Length = 94

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  SMSTTLCL 9
          S STTLCL
Sbjct: 39 SESTTLCL 46
>XP_005270552
          Length = 731

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  TSMSTTLCL 9
          TSMS  LCL
Sbjct: 79 TSMSPQLCL 87
>XP_005270550
          Length = 835

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   TSMSTTLCL 9
           TSMS  LCL
Sbjct: 211 TSMSPQLCL 219
>XP_005270549
          Length = 841

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   TSMSTTLCL 9
           TSMS  LCL
Sbjct: 189 TSMSPQLCL 197
>NP_789743
          Length = 342

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SMSTTLCL 9
           S+STT CL
Sbjct: 165 SLSTTACL 172
>NP_001005469
          Length = 314

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TSMSTTLC 8
           T+M+TT+C
Sbjct: 132 TTMTTTVC 139
>NP_631958
          Length = 73

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  STTLCL 9
          STTLCL
Sbjct: 30 STTLCL 35
>NP_631957
          Length = 73

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  STTLCL 9
          STTLCL
Sbjct: 30 STTLCL 35
>NP_115884
          Length = 91

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  STTLCL 9
          STTLCL
Sbjct: 48 STTLCL 53
>NP_001138932
          Length = 112

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  STTLCL 9
          STTLCL
Sbjct: 48 STTLCL 53
>NP_001138931
          Length = 73

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  STTLCL 9
          STTLCL
Sbjct: 30 STTLCL 35
>XP_006714116
          Length = 108

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  STTLCL 9
          STTLCL
Sbjct: 45 STTLCL 50
>XP_006714115
          Length = 111

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  STTLCL 9
          STTLCL
Sbjct: 48 STTLCL 53
>XP_005265840
          Length = 111

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  STTLCL 9
          STTLCL
Sbjct: 68 STTLCL 73
>XP_006714114
          Length = 131

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  STTLCL 9
          STTLCL
Sbjct: 68 STTLCL 73
>NP_001130010
          Length = 1090

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TSMSTTLC 8
           T+M+T LC
Sbjct: 420 TAMNTVLC 427
>NP_061141
          Length = 944

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   TSMSTTLC 8
           TSM  TLC
Sbjct: 846 TSMRPTLC 853
>XP_006726577
          Length = 201

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SMSTTLCL 9
           +++TTLCL
Sbjct: 182 AVTTTLCL 189
>XP_005255020
          Length = 799

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   TSMSTTLC 8
           TSM  TLC
Sbjct: 701 TSMRPTLC 708
>XP_006709997
          Length = 201

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SMSTTLCL 9
           +++TTLCL
Sbjct: 182 AVTTTLCL 189
>NP_001001923
          Length = 320

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TSMSTTLCL 9
           T+MS  LCL
Sbjct: 138 TAMSQRLCL 146
>NP_079523
          Length = 1059

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TSMSTTLC 8
           T+M+T LC
Sbjct: 389 TAMNTVLC 396
>NP_001034764
          Length = 929

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   TSMSTTLC 8
           TSM  TLC
Sbjct: 831 TSMRPTLC 838
>NP_004940
          Length = 847

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   TSMSTTLC 8
           TS+  TLC
Sbjct: 662 TSLDVTLC 669
>NP_077740
          Length = 901

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   TSMSTTLC 8
           TS+  TLC
Sbjct: 662 TSLDVTLC 669
>XP_005258263
          Length = 758

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   TSMSTTLC 8
           TS+  TLC
Sbjct: 519 TSLDVTLC 526
>XP_006720777
          Length = 292

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3 MSTTLC 8
         M+TTLC
Sbjct: 1 MNTTLC 6
>NP_001005278
          Length = 317

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   MSTTLC 8
           M+TTLC
Sbjct: 136 MTTTLC 141
>NP_001004457
          Length = 330

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   TSMSTTLC 8
           TSMS  LC
Sbjct: 151 TSMSPQLC 158
>NP_001009899
          Length = 2245

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TSMSTTLCL 9
           +SM+T  CL
Sbjct: 779 SSMNTVACL 787
>NP_055873
          Length = 1905

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SMSTTLC 8
           S +TTLC
Sbjct: 295 SFATTLC 301
>NP_001009814
          Length = 1039

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SMSTTLC 8
           S +TTLC
Sbjct: 295 SFATTLC 301
>NP_004807
          Length = 450

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   SMSTTLCL 9
           +++TT+CL
Sbjct: 95  ALTTTVCL 102
>NP_001121080
          Length = 450

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   SMSTTLCL 9
           +++TT+CL
Sbjct: 95  ALTTTVCL 102
>NP_055737
          Length = 1429

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   STTLCL 9
           +TTLCL
Sbjct: 547 TTTLCL 552
>NP_001028225
          Length = 1375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   STTLCL 9
           +TTLCL
Sbjct: 547 TTTLCL 552
>NP_127497
          Length = 1473

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   STTLCL 9
           +TTLCL
Sbjct: 547 TTTLCL 552
>NP_542170
          Length = 485

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   TSMSTTLC 8
           TS+ +T+C
Sbjct: 196 TSLQSTMC 203
>NP_127500
          Length = 1399

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   STTLCL 9
           +TTLCL
Sbjct: 547 TTTLCL 552
>NP_127499
          Length = 1443

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   STTLCL 9
           +TTLCL
Sbjct: 547 TTTLCL 552
>NP_054730
          Length = 536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   STTLCL 9
           +TTLCL
Sbjct: 328 TTTLCL 333
>XP_005260667
          Length = 485

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   TSMSTTLC 8
           TS+ +T+C
Sbjct: 196 TSLQSTMC 203
>XP_005260668
          Length = 485

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   TSMSTTLC 8
           TS+ +T+C
Sbjct: 196 TSLQSTMC 203
>XP_006719855
          Length = 1046

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SMSTTLC 8
           S +TTLC
Sbjct: 295 SFATTLC 301
>XP_006719853
          Length = 1809

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SMSTTLC 8
           S +TTLC
Sbjct: 199 SFATTLC 205
>XP_005252366
          Length = 450

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   SMSTTLCL 9
           +++TT+CL
Sbjct: 95  ALTTTVCL 102
>XP_005252365
          Length = 522

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   SMSTTLCL 9
           +++TT+CL
Sbjct: 167 ALTTTVCL 174
>XP_005252364
          Length = 603

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   SMSTTLCL 9
           +++TT+CL
Sbjct: 248 ALTTTVCL 255
>XP_005247723
          Length = 1481

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TSMSTT 6
           TSMSTT
Sbjct: 582 TSMSTT 587
>XP_005247266
          Length = 2189

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TSMSTTLCL 9
           +SM+T  CL
Sbjct: 723 SSMNTVACL 731
>XP_005247265
          Length = 2211

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TSMSTTLCL 9
           +SM+T  CL
Sbjct: 745 SSMNTVACL 753
>NP_002539
          Length = 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TSMSTTLCL 9
           T+MS  LC+
Sbjct: 134 TAMSPKLCI 142
>NP_001005284
          Length = 327

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SMSTTLC 8
           +MST LC
Sbjct: 150 TMSTALC 156
>NP_659198
          Length = 536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   STTLCL 9
           +TTLCL
Sbjct: 328 TTTLCL 333
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.320    0.114    0.328 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 441,419
Number of extensions: 536
Number of successful extensions: 59
Number of sequences better than 10000.0: 59
Number of HSP's gapped: 59
Number of HSP's successfully gapped: 59
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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