Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001092757                                                           16    5631
NP_000522                                                              16    5631
NP_000512                                                              16    5631
NP_056998                                                              16    5631
NP_003310                                                              16    5631
NP_001165763                                                           16    5631
NP_597676                                                              16    5631
NP_001243779                                                           16    5631
NP_596869                                                              16    5631
NP_054790                                                              16    5631
XP_006723818                                                           16    5631
XP_006723817                                                           16    5631
XP_006723816                                                           16    5631
XP_006723815                                                           16    5631
XP_006723814                                                           16    5631
XP_006723813                                                           16    5631
XP_005260405                                                           16    5631
XP_005255403                                                           16    5631
XP_005246888                                                           16    5631
XP_006712788                                                           16    5631
XP_006712787                                                           16    5631
XP_006712786                                                           16    5631
NP_001254479                                                           16    5631
NP_597681                                                              16    5631
NP_001265611                                                           16    7355
NP_775299                                                              16    7355
NP_003235                                                              16    7355
NP_775303                                                              16    7355
NP_775302                                                              16    7355
NP_689957                                                              16    7355
NP_060814                                                              16    7355
NP_775301                                                              16    7355
NP_001265615                                                           16    7355
NP_777480                                                              16    7355
NP_733796                                                              16    7355
NP_001265613                                                           16    7355
NP_775300                                                              16    7355
XP_005258192                                                           16    7355
XP_006717973                                                           16    7355
NP_057629                                                              16    7355
NP_060496                                                              15    9605
NP_001438                                                              15    9605
NP_689870                                                              15    9605
NP_001273548                                                           15    9605
NP_064537                                                              15    9605
NP_001085                                                              15    9605
NP_835258                                                              15    9605
NP_055379                                                              15    9605
NP_001273563                                                           15    9605
NP_001273547                                                           15    9605
NP_001273546                                                           15    9605
NP_001273551                                                           15    9605
NP_001273549                                                           15    9605
XP_005258676                                                           15    9605
XP_005274154                                                           15    9605
XP_005263467                                                           15    9605
XP_005249952                                                           15    9605
XP_005249951                                                           15    9605
XP_006714824                                                           15    9605
>NP_001092757
          Length = 466

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TSLVFP 6
           TSLVFP
Sbjct: 353 TSLVFP 358
>NP_000522
          Length = 354

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SLVFPE 7
           SLVFPE
Sbjct: 321 SLVFPE 326
>NP_000512
          Length = 556

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SLVFPEIS 9
           S+ FPE+S
Sbjct: 248 SITFPELS 255
>NP_056998
          Length = 958

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TSLVFP 6
           TSLVFP
Sbjct: 300 TSLVFP 305
>NP_003310
          Length = 26926

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1     TSLVFP 6
             TSLVFP
Sbjct: 24586 TSLVFP 24591
>NP_001165763
          Length = 447

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TSLVFP 6
           TSLVFP
Sbjct: 334 TSLVFP 339
>NP_597676
          Length = 27051

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1     TSLVFP 6
             TSLVFP
Sbjct: 24711 TSLVFP 24716
>NP_001243779
          Length = 34350

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1     TSLVFP 6
             TSLVFP
Sbjct: 32010 TSLVFP 32015
>NP_596869
          Length = 33423

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1     TSLVFP 6
             TSLVFP
Sbjct: 31083 TSLVFP 31088
>NP_054790
          Length = 2063

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TSLVFPEIS 9
            +SLV PE+S
Sbjct: 1557 SSLVHPELS 1565
>XP_006723818
          Length = 1975

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TSLVFPEIS 9
            +SLV PE+S
Sbjct: 1557 SSLVHPELS 1565
>XP_006723817
          Length = 2020

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TSLVFPEIS 9
            +SLV PE+S
Sbjct: 1514 SSLVHPELS 1522
>XP_006723816
          Length = 2034

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TSLVFPEIS 9
            +SLV PE+S
Sbjct: 1557 SSLVHPELS 1565
>XP_006723815
          Length = 2051

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TSLVFPEIS 9
            +SLV PE+S
Sbjct: 1545 SSLVHPELS 1553
>XP_006723814
          Length = 2052

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TSLVFPEIS 9
            +SLV PE+S
Sbjct: 1546 SSLVHPELS 1554
>XP_006723813
          Length = 2062

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TSLVFPEIS 9
            +SLV PE+S
Sbjct: 1557 SSLVHPELS 1565
>XP_005260405
          Length = 2063

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TSLVFPEIS 9
            +SLV PE+S
Sbjct: 1557 SSLVHPELS 1565
>XP_005255403
          Length = 744

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  TSLVFP 6
          TSLVFP
Sbjct: 86 TSLVFP 91
>XP_005246888
          Length = 22663

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1     TSLVFP 6
             TSLVFP
Sbjct: 20323 TSLVFP 20328
>XP_006712788
          Length = 24022

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1     TSLVFP 6
             TSLVFP
Sbjct: 21682 TSLVFP 21687
>XP_006712787
          Length = 33978

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1     TSLVFP 6
             TSLVFP
Sbjct: 31638 TSLVFP 31643
>XP_006712786
          Length = 35484

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1     TSLVFP 6
             TSLVFP
Sbjct: 33144 TSLVFP 33149
>NP_001254479
          Length = 35991

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1     TSLVFP 6
             TSLVFP
Sbjct: 33651 TSLVFP 33656
>NP_597681
          Length = 27118

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1     TSLVFP 6
             TSLVFP
Sbjct: 24778 TSLVFP 24783
>NP_001265611
          Length = 275

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TSLVFPE 7
           TSL++PE
Sbjct: 214 TSLMYPE 220
>NP_775299
          Length = 286

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TSLVFPE 7
           TSL++PE
Sbjct: 225 TSLMYPE 231
>NP_003235
          Length = 272

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TSLVFPE 7
           TSL++PE
Sbjct: 211 TSLMYPE 217
>NP_775303
          Length = 252

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TSLVFPE 7
           TSL++PE
Sbjct: 191 TSLMYPE 197
>NP_775302
          Length = 252

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TSLVFPE 7
           TSL++PE
Sbjct: 191 TSLMYPE 197
>NP_689957
          Length = 2213

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    LVFPEI 8
            LVFPE+
Sbjct: 1384 LVFPEV 1389
>NP_060814
          Length = 475

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TSLVFPEI 8
           TSL++P I
Sbjct: 319 TSLIYPAI 326
>NP_775301
          Length = 252

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TSLVFPE 7
           TSL++PE
Sbjct: 191 TSLMYPE 197
>NP_001265615
          Length = 252

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TSLVFPE 7
           TSL++PE
Sbjct: 191 TSLMYPE 197
>NP_777480
          Length = 252

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TSLVFPE 7
           TSL++PE
Sbjct: 191 TSLMYPE 197
>NP_733796
          Length = 401

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TSLVFPE 7
           TSL++PE
Sbjct: 340 TSLMYPE 346
>NP_001265613
          Length = 272

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TSLVFPE 7
           TSL++PE
Sbjct: 211 TSLMYPE 217
>NP_775300
          Length = 272

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TSLVFPE 7
           TSL++PE
Sbjct: 211 TSLMYPE 217
>XP_005258192
          Length = 252

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TSLVFPE 7
           TSL++PE
Sbjct: 191 TSLMYPE 197
>XP_006717973
          Length = 397

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TSLVFPEI 8
           TSL++P I
Sbjct: 241 TSLIYPAI 248
>NP_057629
          Length = 327

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VFPEIS 9
           VFPE+S
Sbjct: 164 VFPEVS 169
>NP_060496
          Length = 963

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TSLVFPE 7
           TSLV PE
Sbjct: 471 TSLVVPE 477
>NP_001438
          Length = 4349

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    TSLVFPE 7
            TSLV PE
Sbjct: 3874 TSLVVPE 3880
>NP_689870
          Length = 652

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TSLVFPEIS 9
          TSLV PE++
Sbjct: 29 TSLVEPEMT 37
>NP_001273548
          Length = 142

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  LVFPEI 8
          LVFPE+
Sbjct: 34 LVFPEL 39
>NP_064537
          Length = 242

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   LVFPEI 8
           LVFPE+
Sbjct: 134 LVFPEL 139
>NP_001085
          Length = 512

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  SLVFPEIS 9
          SLVFP ++
Sbjct: 83 SLVFPAVT 90
>NP_835258
          Length = 397

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TSLVFPEIS 9
           +SLV+P+ S
Sbjct: 335 SSLVYPDTS 343
>NP_055379
          Length = 402

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TSLVFPEIS 9
           +SLV+P+ S
Sbjct: 340 SSLVYPDTS 348
>NP_001273563
          Length = 242

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   LVFPEI 8
           LVFPE+
Sbjct: 134 LVFPEL 139
>NP_001273547
          Length = 142

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  LVFPEI 8
          LVFPE+
Sbjct: 34 LVFPEL 39
>NP_001273546
          Length = 142

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  LVFPEI 8
          LVFPE+
Sbjct: 34 LVFPEL 39
>NP_001273551
          Length = 136

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  LVFPEI 8
          LVFPE+
Sbjct: 28 LVFPEL 33
>NP_001273549
          Length = 142

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  LVFPEI 8
          LVFPE+
Sbjct: 34 LVFPEL 39
>XP_005258676
          Length = 652

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TSLVFPEIS 9
          TSLV PE++
Sbjct: 29 TSLVEPEMT 37
>XP_005274154
          Length = 630

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TSLVFPE 7
           TSLV PE
Sbjct: 471 TSLVVPE 477
>XP_005263467
          Length = 386

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TSLVFPEIS 9
           +SLV+P+ S
Sbjct: 324 SSLVYPDTS 332
>XP_005249952
          Length = 406

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LVFPEIS 9
           LV PEIS
Sbjct: 345 LVIPEIS 351
>XP_005249951
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LVFPEIS 9
           LV PEIS
Sbjct: 345 LVIPEIS 351
>XP_006714824
          Length = 4349

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    TSLVFPE 7
            TSLV PE
Sbjct: 3874 TSLVVPE 3880
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.317    0.133    0.353 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 587,496
Number of extensions: 786
Number of successful extensions: 59
Number of sequences better than 10000.0: 59
Number of HSP's gapped: 59
Number of HSP's successfully gapped: 59
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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