Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001073883                                                           19     869
NP_000258                                                              19     869
NP_001035957                                                           19     869
XP_006721990                                                           19     869
XP_006721989                                                           19     869
XP_005258041                                                           19     869
XP_006721988                                                           19     869
XP_006721987                                                           19     869
XP_006721986                                                           19     869
XP_005258040                                                           19     869
XP_006721985                                                           19     869
XP_005267748                                                           19     869
NP_065910                                                              16    5631
XP_005263222                                                           16    5631
XP_005263221                                                           16    5631
XP_005263220                                                           16    5631
XP_006714345                                                           16    5631
XP_005263219                                                           16    5631
XP_006710300                                                           16    5631
NP_005364                                                              16    7355
NP_001186028                                                           16    7355
NP_001186026                                                           16    7355
NP_001186027                                                           16    7355
NP_001186025                                                           16    7355
NP_003924                                                              16    7355
NP_056073                                                              16    7355
NP_001273393                                                           16    7355
XP_006717082                                                           16    7355
XP_006717081                                                           16    7355
NP_065914                                                              15    9605
NP_001167628                                                           15    9605
NP_001276323                                                           15    9605
NP_001025110                                                           15    9605
NP_001161055                                                           15    9605
NP_060469                                                              15    9605

>NP_001073883
          Length = 2028

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   TSLETATE 8
           TSLETATE
Sbjct: 652 TSLETATE 659



>NP_000258
          Length = 2818

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TSLETATEA 9
            TSLET TEA
Sbjct: 2179 TSLETVTEA 2187



>NP_001035957
          Length = 2839

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TSLETATEA 9
            TSLET TEA
Sbjct: 2200 TSLETVTEA 2208



>XP_006721990
          Length = 2823

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TSLETATEA 9
            TSLET TEA
Sbjct: 2210 TSLETVTEA 2218



>XP_006721989
          Length = 2823

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TSLETATEA 9
            TSLET TEA
Sbjct: 2210 TSLETVTEA 2218



>XP_005258041
          Length = 2836

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TSLETATEA 9
            TSLET TEA
Sbjct: 2179 TSLETVTEA 2187



>XP_006721988
          Length = 2846

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TSLETATEA 9
            TSLET TEA
Sbjct: 2189 TSLETVTEA 2197



>XP_006721987
          Length = 2849

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TSLETATEA 9
            TSLET TEA
Sbjct: 2210 TSLETVTEA 2218



>XP_006721986
          Length = 2854

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TSLETATEA 9
            TSLET TEA
Sbjct: 2197 TSLETVTEA 2205



>XP_005258040
          Length = 2857

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TSLETATEA 9
            TSLET TEA
Sbjct: 2200 TSLETVTEA 2208



>XP_006721985
          Length = 2867

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TSLETATEA 9
            TSLET TEA
Sbjct: 2210 TSLETVTEA 2218



>XP_005267748
          Length = 1535

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   TSLETATE 8
           TSLETATE
Sbjct: 652 TSLETATE 659



>NP_065910
          Length = 1996

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   TSLETATE 8
           +SLETAT+
Sbjct: 367 SSLETATD 374



>XP_005263222
          Length = 1820

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   TSLETATE 8
           +SLETAT+
Sbjct: 191 SSLETATD 198



>XP_005263221
          Length = 1820

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   TSLETATE 8
           +SLETAT+
Sbjct: 191 SSLETATD 198



>XP_005263220
          Length = 1820

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   TSLETATE 8
           +SLETAT+
Sbjct: 191 SSLETATD 198



>XP_006714345
          Length = 1961

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   TSLETATE 8
           +SLETAT+
Sbjct: 332 SSLETATD 339



>XP_005263219
          Length = 1996

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   TSLETATE 8
           +SLETAT+
Sbjct: 367 SSLETATD 374



>XP_006710300
          Length = 1116

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   TSLETATEA 9
           TSL TATE+
Sbjct: 340 TSLITATES 348



>NP_005364
          Length = 635

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TSLETATE 8
           T +ETATE
Sbjct: 481 TRVETATE 488



>NP_001186028
          Length = 1124

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   TSLETATEA 9
           TSLE  TEA
Sbjct: 112 TSLEEHTEA 120



>NP_001186026
          Length = 1152

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   TSLETATEA 9
           TSLE  TEA
Sbjct: 140 TSLEEHTEA 148



>NP_001186027
          Length = 1129

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   TSLETATEA 9
           TSLE  TEA
Sbjct: 117 TSLEEHTEA 125



>NP_001186025
          Length = 1116

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   TSLETATEA 9
           TSLE  TEA
Sbjct: 140 TSLEEHTEA 148



>NP_003924
          Length = 1187

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   TSLETATEA 9
           TSLE  TEA
Sbjct: 175 TSLEEHTEA 183



>NP_056073
          Length = 1219

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SLETATE 8
           SL+TATE
Sbjct: 619 SLQTATE 625



>NP_001273393
          Length = 1169

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   TSLETATEA 9
           TSLE  TEA
Sbjct: 157 TSLEEHTEA 165



>XP_006717082
          Length = 1151

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SLETATE 8
           SL+TATE
Sbjct: 551 SLQTATE 557



>XP_006717081
          Length = 1209

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SLETATE 8
           SL+TATE
Sbjct: 619 SLQTATE 625



>NP_065914
          Length = 1243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    ETATEA 9
            ETATEA
Sbjct: 1078 ETATEA 1083



>NP_001167628
          Length = 1181

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    ETATEA 9
            ETATEA
Sbjct: 1016 ETATEA 1021



>NP_001276323
          Length = 1231

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    ETATEA 9
            ETATEA
Sbjct: 1066 ETATEA 1071



>NP_001025110
          Length = 1231

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    ETATEA 9
            ETATEA
Sbjct: 1066 ETATEA 1071



>NP_001161055
          Length = 1231

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    ETATEA 9
            ETATEA
Sbjct: 1066 ETATEA 1071



>NP_060469
          Length = 1072

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    LETATE 8
            LETATE
Sbjct: 1026 LETATE 1031



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.278   0.0916    0.196 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 282,685
Number of extensions: 477
Number of successful extensions: 35
Number of sequences better than 10000.0: 35
Number of HSP's gapped: 35
Number of HSP's successfully gapped: 35
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 18 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.7 bits)
S2: 28 (15.4 bits)