Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005912                                                              20     509
XP_005248577                                                           20     509
XP_005248576                                                           20     509
XP_006716762                                                           18    1935
XP_006716761                                                           18    1935
XP_006716760                                                           18    1935
XP_006716759                                                           18    1935
XP_006716757                                                           18    1935
XP_005251165                                                           18    1935
XP_005251164                                                           18    1935
XP_005251163                                                           18    1935
XP_006716755                                                           18    1935
XP_006716754                                                           18    1935
XP_006716753                                                           18    1935
NP_001006620                                                           17    3301
NP_958441                                                              17    4312
NP_958439                                                              17    4312
NP_958440                                                              17    4312
NP_005219                                                              17    4312
NP_001193900                                                           17    4312
NP_002828                                                              17    4312
NP_001103224                                                           17    4312
NP_001193901                                                           17    4312
XP_006719593                                                           17    4312
XP_006719592                                                           17    4312
XP_006719591                                                           17    4312
NP_057205                                                              16    5631
NP_001077058                                                           16    5631
NP_001942                                                              16    5631
NP_001077057                                                           16    5631
NP_079225                                                              16    5631
XP_006716497                                                           16    5631
XP_006714376                                                           16    5631
XP_006714375                                                           16    5631
XP_005273215                                                           16    5631
XP_005273214                                                           16    5631
XP_005273213                                                           16    5631
NP_001161879                                                           16    7355
NP_055804                                                              16    7355
NP_001018088                                                           16    7355
NP_004948                                                              16    7355
NP_001275732                                                           16    7355
XP_005251921                                                           16    7355
XP_006715455                                                           16    7355
XP_006715452                                                           16    7355
XP_006715451                                                           16    7355
XP_006715450                                                           16    7355
XP_005248745                                                           16    7355
XP_005248744                                                           16    7355
XP_005248743                                                           16    7355
XP_005248742                                                           16    7355
XP_006715449                                                           16    7355
XP_006715448                                                           16    7355
XP_006715447                                                           16    7355
XP_006715446                                                           16    7355
NP_009123                                                              15    9605
NP_775105                                                              15    9605
NP_001096078                                                           15    9605
NP_001036148                                                           15    9605
NP_006558                                                              15    9605
XP_006715506                                                           15    9605
XP_006715505                                                           15    9605
XP_006715504                                                           15    9605
XP_006715503                                                           15    9605
XP_006715502                                                           15    9605
XP_005248868                                                           15    9605
XP_005248869                                                           15    9605
XP_005247178                                                           15    9605
>NP_005912
          Length = 1512

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TSISGDMVE 9
           TSISGD+VE
Sbjct: 625 TSISGDVVE 633
>XP_005248577
          Length = 1349

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TSISGDMVE 9
           TSISGD+VE
Sbjct: 462 TSISGDVVE 470
>XP_005248576
          Length = 1375

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TSISGDMVE 9
           TSISGD+VE
Sbjct: 488 TSISGDVVE 496
>XP_006716762
          Length = 1571

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1    TSISGDM 7
            TSISGDM
Sbjct: 1275 TSISGDM 1281
>XP_006716761
          Length = 313

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1  TSISGDM 7
          TSISGDM
Sbjct: 17 TSISGDM 23
>XP_006716760
          Length = 428

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   TSISGDM 7
           TSISGDM
Sbjct: 132 TSISGDM 138
>XP_006716759
          Length = 444

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   TSISGDM 7
           TSISGDM
Sbjct: 148 TSISGDM 154
>XP_006716757
          Length = 1356

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1    TSISGDM 7
            TSISGDM
Sbjct: 1060 TSISGDM 1066
>XP_005251165
          Length = 1532

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1    TSISGDM 7
            TSISGDM
Sbjct: 1236 TSISGDM 1242
>XP_005251164
          Length = 1552

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1    TSISGDM 7
            TSISGDM
Sbjct: 1256 TSISGDM 1262
>XP_005251163
          Length = 1574

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1    TSISGDM 7
            TSISGDM
Sbjct: 1278 TSISGDM 1284
>XP_006716755
          Length = 1634

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1    TSISGDM 7
            TSISGDM
Sbjct: 1338 TSISGDM 1344
>XP_006716754
          Length = 1655

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1    TSISGDM 7
            TSISGDM
Sbjct: 1359 TSISGDM 1365
>XP_006716753
          Length = 1656

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1    TSISGDM 7
            TSISGDM
Sbjct: 1360 TSISGDM 1366
>NP_001006620
          Length = 475

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SISGDMVE 9
           SISGD VE
Sbjct: 356 SISGDKVE 363
>NP_958441
          Length = 705

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TSISGDM 7
           TSISGD+
Sbjct: 363 TSISGDL 369
>NP_958439
          Length = 628

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TSISGDM 7
           TSISGD+
Sbjct: 363 TSISGDL 369
>NP_958440
          Length = 405

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TSISGDM 7
           TSISGD+
Sbjct: 363 TSISGDL 369
>NP_005219
          Length = 1210

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TSISGDM 7
           TSISGD+
Sbjct: 363 TSISGDL 369
>NP_001193900
          Length = 1907

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TSISGDM 7
           TSISGD+
Sbjct: 446 TSISGDL 452
>NP_002828
          Length = 1997

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TSISGDM 7
           TSISGD+
Sbjct: 536 TSISGDL 542
>NP_001103224
          Length = 2215

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TSISGDM 7
           TSISGD+
Sbjct: 754 TSISGDL 760
>NP_001193901
          Length = 1907

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TSISGDM 7
           TSISGD+
Sbjct: 536 TSISGDL 542
>XP_006719593
          Length = 1304

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TSISGDM 7
           TSISGD+
Sbjct: 754 TSISGDL 760
>XP_006719592
          Length = 2012

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TSISGDM 7
           TSISGD+
Sbjct: 536 TSISGDL 542
>XP_006719591
          Length = 2230

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TSISGDM 7
           TSISGD+
Sbjct: 754 TSISGDL 760
>NP_057205
          Length = 815

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TSISGDMVE 9
           TS+SG+ +E
Sbjct: 379 TSVSGNWIE 387
>NP_001077058
          Length = 185

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SISGDMVE 9
           SISGD+++
Sbjct: 136 SISGDIID 143
>NP_001942
          Length = 346

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SISGDMVE 9
           SISGD+++
Sbjct: 297 SISGDIID 304
>NP_001077057
          Length = 345

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SISGDMVE 9
           SISGD+++
Sbjct: 296 SISGDIID 303
>NP_079225
          Length = 1192

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TSISGDM 7
           TSISGD+
Sbjct: 288 TSISGDI 294
>XP_006716497
          Length = 185

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SISGDMVE 9
           SISGD+++
Sbjct: 136 SISGDIID 143
>XP_006714376
          Length = 815

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TSISGDM 7
           TSISGD+
Sbjct: 288 TSISGDI 294
>XP_006714375
          Length = 1208

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TSISGDM 7
           TSISGD+
Sbjct: 288 TSISGDI 294
>XP_005273215
          Length = 713

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TSISGDMVE 9
           TS+SG+ +E
Sbjct: 277 TSVSGNWIE 285
>XP_005273214
          Length = 788

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TSISGDMVE 9
           TS+SG+ +E
Sbjct: 352 TSVSGNWIE 360
>XP_005273213
          Length = 813

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TSISGDMVE 9
           TS+SG+ +E
Sbjct: 379 TSVSGNWIE 387
>NP_001161879
          Length = 1012

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TSISGDM 7
           TS+SG+M
Sbjct: 719 TSVSGEM 725
>NP_055804
          Length = 1692

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    TSISGDM 7
            TS+SG+M
Sbjct: 1399 TSVSGEM 1405
>NP_001018088
          Length = 537

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TSISGDMVE 9
           TS+ GD VE
Sbjct: 179 TSLLGDTVE 187
>NP_004948
          Length = 587

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TSISGDMVE 9
           TS+ GD VE
Sbjct: 229 TSLLGDTVE 237
>NP_001275732
          Length = 561

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TSISGDMVE 9
           TS+ GD VE
Sbjct: 203 TSLLGDTVE 211
>XP_005251921
          Length = 500

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TSISGDMVE 9
           TS+ GD VE
Sbjct: 229 TSLLGDTVE 237
>XP_006715455
          Length = 474

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TSISGDM 7
           TS+SG+M
Sbjct: 181 TSVSGEM 187
>XP_006715452
          Length = 1474

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    TSISGDM 7
            TS+SG+M
Sbjct: 1181 TSVSGEM 1187
>XP_006715451
          Length = 1475

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    TSISGDM 7
            TS+SG+M
Sbjct: 1182 TSVSGEM 1188
>XP_006715450
          Length = 1498

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    TSISGDM 7
            TS+SG+M
Sbjct: 1205 TSVSGEM 1211
>XP_005248745
          Length = 1515

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    TSISGDM 7
            TS+SG+M
Sbjct: 1222 TSVSGEM 1228
>XP_005248744
          Length = 1519

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    TSISGDM 7
            TS+SG+M
Sbjct: 1226 TSVSGEM 1232
>XP_005248743
          Length = 1525

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    TSISGDM 7
            TS+SG+M
Sbjct: 1232 TSVSGEM 1238
>XP_005248742
          Length = 1535

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    TSISGDM 7
            TS+SG+M
Sbjct: 1242 TSVSGEM 1248
>XP_006715449
          Length = 1539

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    TSISGDM 7
            TS+SG+M
Sbjct: 1246 TSVSGEM 1252
>XP_006715448
          Length = 1549

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    TSISGDM 7
            TS+SG+M
Sbjct: 1256 TSVSGEM 1262
>XP_006715447
          Length = 1574

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    TSISGDM 7
            TS+SG+M
Sbjct: 1281 TSVSGEM 1287
>XP_006715446
          Length = 1574

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    TSISGDM 7
            TS+SG+M
Sbjct: 1281 TSVSGEM 1287
>NP_009123
          Length = 1047

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TSISGDMVE 9
           TS+ GD V+
Sbjct: 690 TSVRGDKVD 698
>NP_775105
          Length = 1659

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TSISGDMVE 9
           +S SG+M+E
Sbjct: 179 SSFSGEMLE 187
>NP_001096078
          Length = 2263

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    TSISGDMV 8
            TS++GD V
Sbjct: 2003 TSVTGDRV 2010
>NP_001036148
          Length = 1683

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TSISGDMVE 9
           +S SG+M+E
Sbjct: 179 SSFSGEMLE 187
>NP_006558
          Length = 451

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SISGDMVE 9
           +I GD+VE
Sbjct: 387 TIGGDLVE 394
>XP_006715506
          Length = 1507

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TSISGDMVE 9
           +S SG+M+E
Sbjct: 179 SSFSGEMLE 187
>XP_006715505
          Length = 1673

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TSISGDMVE 9
           +S SG+M+E
Sbjct: 179 SSFSGEMLE 187
>XP_006715504
          Length = 1683

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TSISGDMVE 9
           +S SG+M+E
Sbjct: 179 SSFSGEMLE 187
>XP_006715503
          Length = 1707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TSISGDMVE 9
           +S SG+M+E
Sbjct: 179 SSFSGEMLE 187
>XP_006715502
          Length = 1707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TSISGDMVE 9
           +S SG+M+E
Sbjct: 179 SSFSGEMLE 187
>XP_005248868
          Length = 451

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SISGDMVE 9
           +I GD+VE
Sbjct: 387 TIGGDLVE 394
>XP_005248869
          Length = 451

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SISGDMVE 9
           +I GD+VE
Sbjct: 387 TIGGDLVE 394
>XP_005247178
          Length = 2263

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    TSISGDMV 8
            TS++GD V
Sbjct: 2003 TSVTGDRV 2010
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.301    0.120    0.292 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 504,795
Number of extensions: 693
Number of successful extensions: 68
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.2 bits)
S2: 28 (15.4 bits)

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