Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000236                                                              20     390
NP_001120972                                                           20     390
XP_006716054                                                           20     390
XP_006716053                                                           20     390
XP_006716052                                                           20     390
XP_006716051                                                           20     390
NP_060921                                                              17    2528
NP_002791                                                              17    2528
NP_699167                                                              17    3301
NP_004332                                                              16    5631
NP_067045                                                              16    5631
NP_001265321                                                           16    5631
XP_005264615                                                           16    5631
XP_006712164                                                           16    5631
XP_005264614                                                           16    5631
XP_005264613                                                           16    5631
XP_005264612                                                           16    5631
XP_005245451                                                           16    5631
XP_005245450                                                           16    5631
NP_001243599                                                           16    7355
NP_569710                                                              16    7355
NP_005691                                                              16    7355
NP_079140                                                              16    7355
NP_000192                                                              16    7355
NP_060876                                                              16    7355
NP_001138397                                                           16    7355
NP_001269849                                                           16    7355
NP_001171517                                                           16    7355
NP_002453                                                              16    7355
NP_001106853                                                           16    7355
NP_954634                                                              16    7355
NP_003390                                                              16    7355
XP_005261039                                                           16    7355
XP_005261038                                                           16    7355
XP_005261037                                                           16    7355
XP_005261036                                                           16    7355
XP_005261035                                                           16    7355
XP_006724068                                                           16    7355
XP_005273975                                                           16    7355
XP_006718567                                                           16    7355
XP_006718566                                                           16    7355
XP_006718565                                                           16    7355
XP_006712889                                                           16    7355
NP_001032302                                                           16    7355
NP_002175                                                              15    9605
NP_001177910                                                           15    9605
NP_057726                                                              15    9605
NP_003310                                                              15    9605
NP_597676                                                              15    9605
NP_056533                                                              15    9605
NP_001243779                                                           15    9605
NP_596869                                                              15    9605
NP_542415                                                              15    9605
NP_542416                                                              15    9605
NP_542414                                                              15    9605
NP_006255                                                              15    9605
NP_001438                                                              15    9605
NP_078964                                                              15    9605
NP_001186867                                                           15    9605
XP_005254495                                                           15    9605
XP_006719226                                                           15    9605
XP_005252650                                                           15    9605
XP_006717569                                                           15    9605
XP_006717568                                                           15    9605
XP_006717567                                                           15    9605
XP_006714824                                                           15    9605
XP_005263224                                                           15    9605
XP_005246888                                                           15    9605
XP_006712788                                                           15    9605
XP_006712787                                                           15    9605
XP_006712786                                                           15    9605
NP_001254479                                                           15    9605
NP_597681                                                              15    9605
>NP_000236
          Length = 1390

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TRVVLGNES 9
           TRV+LGNES
Sbjct: 601 TRVLLGNES 609
>NP_001120972
          Length = 1408

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TRVVLGNES 9
           TRV+LGNES
Sbjct: 601 TRVLLGNES 609
>XP_006716054
          Length = 960

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TRVVLGNES 9
           TRV+LGNES
Sbjct: 171 TRVLLGNES 179
>XP_006716053
          Length = 960

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TRVVLGNES 9
           TRV+LGNES
Sbjct: 171 TRVLLGNES 179
>XP_006716052
          Length = 1409

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TRVVLGNES 9
           TRV+LGNES
Sbjct: 620 TRVLLGNES 628
>XP_006716051
          Length = 1427

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TRVVLGNES 9
           TRV+LGNES
Sbjct: 620 TRVLLGNES 628
>NP_060921
          Length = 1338

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   VVLGNES 9
           VVLGNES
Sbjct: 811 VVLGNES 817
>NP_002791
          Length = 219

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RVVLGNE 8
           RV+LGNE
Sbjct: 206 RVILGNE 212
>NP_699167
          Length = 348

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RVVLGNE 8
           R++LGNE
Sbjct: 317 RIILGNE 323
>NP_004332
          Length = 2225

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    TRVVLGNE 8
            TRV++G E
Sbjct: 1239 TRVIMGEE 1246
>NP_067045
          Length = 453

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  VVLGNES 9
          VVLGNE+
Sbjct: 20 VVLGNEA 26
>NP_001265321
          Length = 374

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RVVLGNES 9
           RVV GNE+
Sbjct: 116 RVVAGNET 123
>XP_005264615
          Length = 2162

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    TRVVLGNE 8
            TRV++G E
Sbjct: 1176 TRVIMGEE 1183
>XP_006712164
          Length = 2179

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    TRVVLGNE 8
            TRV++G E
Sbjct: 1176 TRVIMGEE 1183
>XP_005264614
          Length = 2191

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    TRVVLGNE 8
            TRV++G E
Sbjct: 1239 TRVIMGEE 1246
>XP_005264613
          Length = 2208

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    TRVVLGNE 8
            TRV++G E
Sbjct: 1239 TRVIMGEE 1246
>XP_005264612
          Length = 2242

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    TRVVLGNE 8
            TRV++G E
Sbjct: 1239 TRVIMGEE 1246
>XP_005245451
          Length = 400

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  VVLGNES 9
          VVLGNE+
Sbjct: 20 VVLGNEA 26
>XP_005245450
          Length = 423

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  VVLGNES 9
          VVLGNE+
Sbjct: 20 VVLGNEA 26
>NP_001243599
          Length = 707

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RVVLGNES 9
           RV+LG+E+
Sbjct: 95  RVILGSEA 102
>NP_569710
          Length = 737

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RVVLGNES 9
           RV+LG+E+
Sbjct: 125 RVILGSEA 132
>NP_005691
          Length = 737

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RVVLGNES 9
           RV+LG+E+
Sbjct: 125 RVILGSEA 132
>NP_079140
          Length = 353

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TRVVLGNE 8
           T +VLGNE
Sbjct: 252 TLLVLGNE 259
>NP_000192
          Length = 532

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VVLGNES 9
           V+LGN+S
Sbjct: 292 VILGNQS 298
>NP_060876
          Length = 5412

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TRVVLGNES 9
           TR+V GN S
Sbjct: 514 TRLVTGNPS 522
>NP_001138397
          Length = 662

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRVVLGNE 8
           TRV +GN+
Sbjct: 183 TRVAVGNQ 190
>NP_001269849
          Length = 508

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRVVLGNE 8
           TRV +GN+
Sbjct: 183 TRVAVGNQ 190
>NP_001171517
          Length = 662

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRVVLGNE 8
           TRV +GN+
Sbjct: 183 TRVAVGNQ 190
>NP_002453
          Length = 662

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRVVLGNE 8
           TRV +GN+
Sbjct: 183 TRVAVGNQ 190
>NP_001106853
          Length = 2093

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  TRVVLGNE 8
          TRVV GN+
Sbjct: 34 TRVVEGND 41
>NP_954634
          Length = 500

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  TRVVLGNE 8
          TRV LG E
Sbjct: 68 TRVTLGEE 75
>NP_003390
          Length = 674

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TRVVLGN 7
           TRV++GN
Sbjct: 480 TRVLIGN 486
>XP_005261039
          Length = 662

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRVVLGNE 8
           TRV +GN+
Sbjct: 183 TRVAVGNQ 190
>XP_005261038
          Length = 662

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRVVLGNE 8
           TRV +GN+
Sbjct: 183 TRVAVGNQ 190
>XP_005261037
          Length = 662

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRVVLGNE 8
           TRV +GN+
Sbjct: 183 TRVAVGNQ 190
>XP_005261036
          Length = 662

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRVVLGNE 8
           TRV +GN+
Sbjct: 183 TRVAVGNQ 190
>XP_005261035
          Length = 662

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRVVLGNE 8
           TRV +GN+
Sbjct: 183 TRVAVGNQ 190
>XP_006724068
          Length = 685

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRVVLGNE 8
           TRV +GN+
Sbjct: 206 TRVAVGNQ 213
>XP_005273975
          Length = 254

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  RVVLGN 7
          RVVLGN
Sbjct: 53 RVVLGN 58
>XP_006718567
          Length = 255

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  RVVLGN 7
          RVVLGN
Sbjct: 53 RVVLGN 58
>XP_006718566
          Length = 293

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  RVVLGN 7
          RVVLGN
Sbjct: 53 RVVLGN 58
>XP_006718565
          Length = 293

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  RVVLGN 7
          RVVLGN
Sbjct: 53 RVVLGN 58
>XP_006712889
          Length = 2069

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  TRVVLGNE 8
          TRVV GN+
Sbjct: 34 TRVVEGND 41
>NP_001032302
          Length = 216

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  RVVLGN 7
          RVVLGN
Sbjct: 53 RVVLGN 58
>NP_002175
          Length = 918

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   RVVLGNES 9
           R ++GNE+
Sbjct: 559 RTIIGNET 566
>NP_001177910
          Length = 857

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   RVVLGNES 9
           R ++GNE+
Sbjct: 498 RTIIGNET 505
>NP_057726
          Length = 3674

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    TRVVLG 6
            TRVVLG
Sbjct: 2949 TRVVLG 2954
>NP_003310
          Length = 26926

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1     TRVVLGNE 8
             TR++ GNE
Sbjct: 11861 TRLIEGNE 11868
>NP_597676
          Length = 27051

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1     TRVVLGNE 8
             TR++ GNE
Sbjct: 11986 TRLIEGNE 11993
>NP_056533
          Length = 568

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TRVVLGN 7
          TRV+LG+
Sbjct: 43 TRVILGS 49
>NP_001243779
          Length = 34350

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1     TRVVLGNE 8
             TR++ GNE
Sbjct: 19285 TRLIEGNE 19292
>NP_596869
          Length = 33423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1     TRVVLGNE 8
             TR++ GNE
Sbjct: 18358 TRLIEGNE 18365
>NP_542415
          Length = 2294

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    TRVVLGNE 8
            TRV LG+E
Sbjct: 2061 TRVPLGDE 2068
>NP_542416
          Length = 2490

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    TRVVLGNE 8
            TRV LG+E
Sbjct: 2257 TRVPLGDE 2264
>NP_542414
          Length = 2485

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    TRVVLGNE 8
            TRV LG+E
Sbjct: 2252 TRVPLGDE 2259
>NP_006255
          Length = 2466

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    TRVVLGNE 8
            TRV LG+E
Sbjct: 2233 TRVPLGDE 2240
>NP_001438
          Length = 4349

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    RVVLGNE 8
            RVV GNE
Sbjct: 3254 RVVSGNE 3260
>NP_078964
          Length = 628

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TRVVLGNES 9
           TR+V+ NE+
Sbjct: 197 TRIVVPNEN 205
>NP_001186867
          Length = 366

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   TRVVLGNES 9
           + +V+GNE+
Sbjct: 102 SNIVIGNEN 110
>XP_005254495
          Length = 3694

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    TRVVLG 6
            TRVVLG
Sbjct: 2969 TRVVLG 2974
>XP_006719226
          Length = 968

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TRVVLGNES 9
          TRVV+G E+
Sbjct: 11 TRVVVGVEA 19
>XP_005252650
          Length = 692

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TRVVLGNES 9
           TR+V+ NE+
Sbjct: 197 TRIVVPNEN 205
>XP_006717569
          Length = 1278

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TRVVLGNES 9
           TR+V+ NE+
Sbjct: 783 TRIVVPNEN 791
>XP_006717568
          Length = 1314

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TRVVLGNES 9
           TR+V+ NE+
Sbjct: 819 TRIVVPNEN 827
>XP_006717567
          Length = 1385

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TRVVLGNES 9
           TR+V+ NE+
Sbjct: 890 TRIVVPNEN 898
>XP_006714824
          Length = 4349

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    RVVLGNE 8
            RVV GNE
Sbjct: 3254 RVVSGNE 3260
>XP_005263224
          Length = 2491

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    TRVVLGNE 8
            TRV LG+E
Sbjct: 2258 TRVPLGDE 2265
>XP_005246888
          Length = 22663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    TRVVLGNE 8
            TR++ GNE
Sbjct: 7598 TRLIEGNE 7605
>XP_006712788
          Length = 24022

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    TRVVLGNE 8
            TR++ GNE
Sbjct: 8957 TRLIEGNE 8964
>XP_006712787
          Length = 33978

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1     TRVVLGNE 8
             TR++ GNE
Sbjct: 18913 TRLIEGNE 18920
>XP_006712786
          Length = 35484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1     TRVVLGNE 8
             TR++ GNE
Sbjct: 20419 TRLIEGNE 20426
>NP_001254479
          Length = 35991

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1     TRVVLGNE 8
             TR++ GNE
Sbjct: 20926 TRLIEGNE 20933
>NP_597681
          Length = 27118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1     TRVVLGNE 8
             TR++ GNE
Sbjct: 12053 TRLIEGNE 12060
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.307    0.127    0.320 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 527,595
Number of extensions: 735
Number of successful extensions: 73
Number of sequences better than 10000.0: 73
Number of HSP's gapped: 73
Number of HSP's successfully gapped: 73
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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