Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000537                                                              19     869
NP_001263689                                                           19     869
NP_001119584                                                           19     869
NP_001119586                                                           19     869
NP_001263625                                                           19     869
NP_001119590                                                           19     869
NP_001263690                                                           19     869
NP_001119585                                                           19     869
NP_001263624                                                           19     869
NP_001119588                                                           19     869
NP_001119587                                                           19     869
NP_001119589                                                           19     869
NP_055178                                                              16    5631
NP_001264984                                                           16    5631
XP_006726697                                                           16    5631
XP_005266395                                                           16    5631
NP_660344                                                              16    5631
NP_114127                                                              16    7355
NP_112181                                                              16    7355
NP_060658                                                              16    7355
NP_001164007                                                           16    7355
NP_001164006                                                           16    7355
XP_005244865                                                           16    7355
XP_005244863                                                           16    7355
XP_006710514                                                           16    7355
NP_001034300                                                           16    7355
NP_060021                                                              15    9605
NP_001013860                                                           15    9605
NP_001004753                                                           15    9605
XP_006721205                                                           15    9605
XP_005255864                                                           15    9605
XP_006721204                                                           15    9605
XP_006721203                                                           15    9605
XP_006721202                                                           15    9605
XP_006721201                                                           15    9605
XP_005269821                                                           15    9605
XP_006717867                                                           15    9605
NP_001121687                                                           15    9605
>NP_000537
          Length = 393

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TRVRDMAIY 9
           TRVR MAIY
Sbjct: 155 TRVRAMAIY 163
>NP_001263689
          Length = 354

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TRVRDMAIY 9
           TRVR MAIY
Sbjct: 116 TRVRAMAIY 124
>NP_001119584
          Length = 393

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TRVRDMAIY 9
           TRVR MAIY
Sbjct: 155 TRVRAMAIY 163
>NP_001119586
          Length = 341

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TRVRDMAIY 9
           TRVR MAIY
Sbjct: 155 TRVRAMAIY 163
>NP_001263625
          Length = 302

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TRVRDMAIY 9
           TRVR MAIY
Sbjct: 116 TRVRAMAIY 124
>NP_001119590
          Length = 354

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TRVRDMAIY 9
           TRVR MAIY
Sbjct: 116 TRVRAMAIY 124
>NP_001263690
          Length = 354

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TRVRDMAIY 9
           TRVR MAIY
Sbjct: 116 TRVRAMAIY 124
>NP_001119585
          Length = 346

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TRVRDMAIY 9
           TRVR MAIY
Sbjct: 155 TRVRAMAIY 163
>NP_001263624
          Length = 307

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TRVRDMAIY 9
           TRVR MAIY
Sbjct: 116 TRVRAMAIY 124
>NP_001119588
          Length = 209

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  TRVRDMAIY 9
          TRVR MAIY
Sbjct: 23 TRVRAMAIY 31
>NP_001119587
          Length = 261

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  TRVRDMAIY 9
          TRVR MAIY
Sbjct: 23 TRVRAMAIY 31
>NP_001119589
          Length = 214

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  TRVRDMAIY 9
          TRVR MAIY
Sbjct: 23 TRVRAMAIY 31
>NP_055178
          Length = 4579

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    VRDMAIY 9
            VRD+A+Y
Sbjct: 3902 VRDLALY 3908
>NP_001264984
          Length = 4432

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    VRDMAIY 9
            VRD+A+Y
Sbjct: 3755 VRDLALY 3761
>XP_006726697
          Length = 359

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   RVRDMAIY 9
           R  DMA+Y
Sbjct: 317 RAEDMAVY 324
>XP_005266395
          Length = 4588

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    VRDMAIY 9
            VRD+A+Y
Sbjct: 3911 VRDLALY 3917
>NP_660344
          Length = 276

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TRVRDMAIY 9
           TR+ D A+Y
Sbjct: 206 TRITDRALY 214
>NP_114127
          Length = 648

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RVRDMAI 8
           RVRD+AI
Sbjct: 327 RVRDIAI 333
>NP_112181
          Length = 615

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VRDMAIY 9
           VRD+A+Y
Sbjct: 605 VRDVALY 611
>NP_060658
          Length = 634

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RVRDMAI 8
           RVRD+AI
Sbjct: 375 RVRDIAI 381
>NP_001164007
          Length = 507

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RVRDMAI 8
           RVRD+AI
Sbjct: 248 RVRDIAI 254
>NP_001164006
          Length = 586

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RVRDMAI 8
           RVRD+AI
Sbjct: 327 RVRDIAI 333
>XP_005244865
          Length = 407

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RVRDMAI 8
           RVRD+AI
Sbjct: 327 RVRDIAI 333
>XP_005244863
          Length = 586

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RVRDMAI 8
           RVRD+AI
Sbjct: 327 RVRDIAI 333
>XP_006710514
          Length = 410

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RVRDMAI 8
           RVRD+AI
Sbjct: 151 RVRDIAI 157
>NP_001034300
          Length = 411

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RVRDMAI 8
           RVRD+AI
Sbjct: 152 RVRDIAI 158
>NP_060021
          Length = 1009

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VRDMAIY 9
           VRD A+Y
Sbjct: 682 VRDSAVY 688
>NP_001013860
          Length = 1435

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRVRDMAI 8
           TR+RDM +
Sbjct: 860 TRLRDMRL 867
>NP_001004753
          Length = 342

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VRDMAIY 9
           +RD AIY
Sbjct: 335 IRDKAIY 341
>XP_006721205
          Length = 1441

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRVRDMAI 8
           TR+RDM +
Sbjct: 860 TRLRDMRL 867
>XP_005255864
          Length = 1372

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRVRDMAI 8
           TR+RDM +
Sbjct: 824 TRLRDMRL 831
>XP_006721204
          Length = 1405

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRVRDMAI 8
           TR+RDM +
Sbjct: 824 TRLRDMRL 831
>XP_006721203
          Length = 1408

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRVRDMAI 8
           TR+RDM +
Sbjct: 860 TRLRDMRL 867
>XP_006721202
          Length = 1424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRVRDMAI 8
           TR+RDM +
Sbjct: 860 TRLRDMRL 867
>XP_006721201
          Length = 1430

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRVRDMAI 8
           TR+RDM +
Sbjct: 860 TRLRDMRL 867
>XP_005269821
          Length = 398

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RVRDMAI 8
           RVRDM +
Sbjct: 316 RVRDMTV 322
>XP_006717867
          Length = 896

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VRDMAIY 9
           VRD A+Y
Sbjct: 682 VRDSAVY 688
>NP_001121687
          Length = 423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RVRDMAI 8
           RVRDM +
Sbjct: 341 RVRDMTV 347
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.339    0.142    0.400 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 338,723
Number of extensions: 363
Number of successful extensions: 38
Number of sequences better than 10000.0: 38
Number of HSP's gapped: 38
Number of HSP's successfully gapped: 38
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.5 bits)
S2: 28 (15.4 bits)

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