Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000537                                                              19     869
NP_001263689                                                           19     869
NP_001119584                                                           19     869
NP_001119586                                                           19     869
NP_001263625                                                           19     869
NP_001119590                                                           19     869
NP_001263690                                                           19     869
NP_001119585                                                           19     869
NP_001263624                                                           19     869
NP_001119588                                                           19     869
NP_001119587                                                           19     869
NP_001119589                                                           19     869
NP_660350                                                              17    2528
NP_001361                                                              17    2528
XP_006717758                                                           17    2528
XP_006712019                                                           17    2528
NP_059111                                                              17    4312
NP_001244123                                                           17    4312
NP_001244124                                                           17    4312
NP_680474                                                              17    4312
NP_079183                                                              17    4312
NP_444256                                                              16    5631
NP_444254                                                              16    5631
NP_444253                                                              16    5631
NP_444255                                                              16    5631
NP_001013680                                                           16    5631
NP_060009                                                              16    5631
XP_006721125                                                           16    5631
XP_005247551                                                           16    5631
XP_005247550                                                           16    5631
XP_006713712                                                           16    5631
XP_005247549                                                           16    5631
NP_060649                                                              16    7355
NP_001273443                                                           16    7355
NP_851997                                                              16    7355
NP_597998                                                              16    7355
NP_065928                                                              16    7355
XP_005256527                                                           16    7355
XP_005256489                                                           16    7355
XP_006721497                                                           16    7355
XP_006719172                                                           16    7355
XP_006719171                                                           16    7355
XP_005253481                                                           16    7355
XP_006714302                                                           16    7355
XP_005263127                                                           16    7355
NP_061908                                                              16    7355
NP_001245258                                                           15    9605
NP_001153777                                                           15    9605
NP_001245260                                                           15    9605
NP_004282                                                              15    9605
NP_079136                                                              15    9605
NP_001243040                                                           15    9605
NP_001243035                                                           15    9605
NP_004249                                                              15    9605
NP_001243038                                                           15    9605
NP_001245259                                                           15    9605
NP_818932                                                              15    9605
NP_036288                                                              15    9605
XP_005260382                                                           15    9605
XP_005260381                                                           15    9605
XP_006723804                                                           15    9605
XP_005260380                                                           15    9605
XP_006723803                                                           15    9605
XP_005260379                                                           15    9605
XP_005260378                                                           15    9605
XP_005260377                                                           15    9605
XP_006723802                                                           15    9605
XP_005260376                                                           15    9605
XP_006723801                                                           15    9605
XP_006723800                                                           15    9605
XP_006723799                                                           15    9605
XP_006723798                                                           15    9605
XP_006721335                                                           15    9605
XP_006721334                                                           15    9605
>NP_000537
          Length = 393

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TRVRAMDIY 9
           TRVRAM IY
Sbjct: 155 TRVRAMAIY 163
>NP_001263689
          Length = 354

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TRVRAMDIY 9
           TRVRAM IY
Sbjct: 116 TRVRAMAIY 124
>NP_001119584
          Length = 393

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TRVRAMDIY 9
           TRVRAM IY
Sbjct: 155 TRVRAMAIY 163
>NP_001119586
          Length = 341

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TRVRAMDIY 9
           TRVRAM IY
Sbjct: 155 TRVRAMAIY 163
>NP_001263625
          Length = 302

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TRVRAMDIY 9
           TRVRAM IY
Sbjct: 116 TRVRAMAIY 124
>NP_001119590
          Length = 354

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TRVRAMDIY 9
           TRVRAM IY
Sbjct: 116 TRVRAMAIY 124
>NP_001263690
          Length = 354

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TRVRAMDIY 9
           TRVRAM IY
Sbjct: 116 TRVRAMAIY 124
>NP_001119585
          Length = 346

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TRVRAMDIY 9
           TRVRAM IY
Sbjct: 155 TRVRAMAIY 163
>NP_001263624
          Length = 307

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TRVRAMDIY 9
           TRVRAM IY
Sbjct: 116 TRVRAMAIY 124
>NP_001119588
          Length = 209

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  TRVRAMDIY 9
          TRVRAM IY
Sbjct: 23 TRVRAMAIY 31
>NP_001119587
          Length = 261

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  TRVRAMDIY 9
          TRVRAM IY
Sbjct: 23 TRVRAMAIY 31
>NP_001119589
          Length = 214

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  TRVRAMDIY 9
          TRVRAM IY
Sbjct: 23 TRVRAMAIY 31
>NP_660350
          Length = 609

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TRVRAMD 7
           TR+RAMD
Sbjct: 342 TRIRAMD 348
>NP_001361
          Length = 4158

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    VRAMDIY 9
            VRAMD+Y
Sbjct: 2885 VRAMDLY 2891
>XP_006717758
          Length = 630

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TRVRAMD 7
           TR+RAMD
Sbjct: 363 TRIRAMD 369
>XP_006712019
          Length = 4158

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    VRAMDIY 9
            VRAMD+Y
Sbjct: 2885 VRAMDLY 2891
>NP_059111
          Length = 587

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RVRAMDIY 9
           RVR +D+Y
Sbjct: 360 RVRTVDVY 367
>NP_001244123
          Length = 555

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RVRAMDIY 9
           RVR +D+Y
Sbjct: 328 RVRTVDVY 335
>NP_001244124
          Length = 505

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RVRAMDIY 9
           RVR +D+Y
Sbjct: 278 RVRTVDVY 285
>NP_680474
          Length = 287

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RVRAMDIY 9
           RVR +D+Y
Sbjct: 209 RVRLLDVY 216
>NP_079183
          Length = 278

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RVRAMDIY 9
           RVR +D+Y
Sbjct: 200 RVRLLDVY 207
>NP_444256
          Length = 1794

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    RVRAMDIY 9
            RVRA+++Y
Sbjct: 1334 RVRAINVY 1341
>NP_444254
          Length = 1845

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    RVRAMDIY 9
            RVRA+++Y
Sbjct: 1334 RVRAINVY 1341
>NP_444253
          Length = 1914

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    RVRAMDIY 9
            RVRA+++Y
Sbjct: 1403 RVRAINVY 1410
>NP_444255
          Length = 1863

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    RVRAMDIY 9
            RVRA+++Y
Sbjct: 1403 RVRAINVY 1410
>NP_001013680
          Length = 473

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   TRVRAMDI 8
           TR+RA+D+
Sbjct: 115 TRLRALDL 122
>NP_060009
          Length = 4116

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    VRAMDIY 9
            VRAM++Y
Sbjct: 2888 VRAMEVY 2894
>XP_006721125
          Length = 4070

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    VRAMDIY 9
            VRAM++Y
Sbjct: 2842 VRAMEVY 2848
>XP_005247551
          Length = 1855

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    RVRAMDIY 9
            RVRA+++Y
Sbjct: 1344 RVRAINVY 1351
>XP_005247550
          Length = 1856

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    RVRAMDIY 9
            RVRA+++Y
Sbjct: 1413 RVRAINVY 1420
>XP_006713712
          Length = 1923

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    RVRAMDIY 9
            RVRA+++Y
Sbjct: 1413 RVRAINVY 1420
>XP_005247549
          Length = 1924

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    RVRAMDIY 9
            RVRA+++Y
Sbjct: 1413 RVRAINVY 1420
>NP_060649
          Length = 1270

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    VRAMDIY 9
            VRA DIY
Sbjct: 1243 VRAKDIY 1249
>NP_001273443
          Length = 1269

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    VRAMDIY 9
            VRA DIY
Sbjct: 1242 VRAKDIY 1248
>NP_851997
          Length = 1278

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    VRAMDIY 9
            VRA DIY
Sbjct: 1251 VRAKDIY 1257
>NP_597998
          Length = 170

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RAMDIY 9
           RAMD+Y
Sbjct: 135 RAMDLY 140
>NP_065928
          Length = 4427

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    VRAMDIY 9
            VRAM++Y
Sbjct: 3200 VRAMELY 3206
>XP_005256527
          Length = 4427

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    VRAMDIY 9
            VRAM++Y
Sbjct: 3200 VRAMELY 3206
>XP_005256489
          Length = 136

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RAMDIY 9
           RAMD+Y
Sbjct: 101 RAMDLY 106
>XP_006721497
          Length = 215

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RAMDIY 9
           RAMD+Y
Sbjct: 180 RAMDLY 185
>XP_006719172
          Length = 1270

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    VRAMDIY 9
            VRA DIY
Sbjct: 1243 VRAKDIY 1249
>XP_006719171
          Length = 1270

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    VRAMDIY 9
            VRA DIY
Sbjct: 1243 VRAKDIY 1249
>XP_005253481
          Length = 1277

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    VRAMDIY 9
            VRA DIY
Sbjct: 1250 VRAKDIY 1256
>XP_006714302
          Length = 916

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TRVRAMD 7
           TR+RA+D
Sbjct: 601 TRIRAID 607
>XP_005263127
          Length = 1134

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TRVRAMD 7
           TR+RA+D
Sbjct: 601 TRIRAID 607
>NP_061908
          Length = 1135

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TRVRAMD 7
           TR+RA+D
Sbjct: 601 TRIRAID 607
>NP_001245258
          Length = 880

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TRVRAMD 7
           TRV AMD
Sbjct: 719 TRVSAMD 725
>NP_001153777
          Length = 473

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   RVRAMDIY 9
           RVR++++Y
Sbjct: 206 RVRSLELY 213
>NP_001245260
          Length = 779

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TRVRAMD 7
           TRV AMD
Sbjct: 645 TRVSAMD 651
>NP_004282
          Length = 116

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  RAMDIY 9
          RA+DIY
Sbjct: 36 RALDIY 41
>NP_079136
          Length = 449

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   RVRAMDIY 9
           RVR++++Y
Sbjct: 182 RVRSLELY 189
>NP_001243040
          Length = 959

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  RVRAMDIY 9
          RVR+ D+Y
Sbjct: 88 RVRSGDVY 95
>NP_001243035
          Length = 1021

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  RVRAMDIY 9
          RVR+ D+Y
Sbjct: 88 RVRSGDVY 95
>NP_004249
          Length = 1021

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  RVRAMDIY 9
          RVR+ D+Y
Sbjct: 88 RVRSGDVY 95
>NP_001243038
          Length = 1021

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  RVRAMDIY 9
          RVR+ D+Y
Sbjct: 88 RVRSGDVY 95
>NP_001245259
          Length = 701

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TRVRAMD 7
           TRV AMD
Sbjct: 539 TRVSAMD 545
>NP_818932
          Length = 779

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TRVRAMD 7
           TRV AMD
Sbjct: 645 TRVSAMD 651
>NP_036288
          Length = 881

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TRVRAMD 7
           TRV AMD
Sbjct: 719 TRVSAMD 725
>XP_005260382
          Length = 732

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TRVRAMD 7
           TRV AMD
Sbjct: 570 TRVSAMD 576
>XP_005260381
          Length = 744

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TRVRAMD 7
           TRV AMD
Sbjct: 582 TRVSAMD 588
>XP_006723804
          Length = 819

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TRVRAMD 7
           TRV AMD
Sbjct: 657 TRVSAMD 663
>XP_005260380
          Length = 841

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TRVRAMD 7
           TRV AMD
Sbjct: 707 TRVSAMD 713
>XP_006723803
          Length = 853

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TRVRAMD 7
           TRV AMD
Sbjct: 719 TRVSAMD 725
>XP_005260379
          Length = 867

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TRVRAMD 7
           TRV AMD
Sbjct: 706 TRVSAMD 712
>XP_005260378
          Length = 868

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TRVRAMD 7
           TRV AMD
Sbjct: 707 TRVSAMD 713
>XP_005260377
          Length = 869

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TRVRAMD 7
           TRV AMD
Sbjct: 707 TRVSAMD 713
>XP_006723802
          Length = 880

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TRVRAMD 7
           TRV AMD
Sbjct: 718 TRVSAMD 724
>XP_005260376
          Length = 880

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TRVRAMD 7
           TRV AMD
Sbjct: 719 TRVSAMD 725
>XP_006723801
          Length = 881

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TRVRAMD 7
           TRV AMD
Sbjct: 719 TRVSAMD 725
>XP_006723800
          Length = 881

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TRVRAMD 7
           TRV AMD
Sbjct: 719 TRVSAMD 725
>XP_006723799
          Length = 881

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TRVRAMD 7
           TRV AMD
Sbjct: 719 TRVSAMD 725
>XP_006723798
          Length = 916

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   TRVRAMD 7
           TRV AMD
Sbjct: 782 TRVSAMD 788
>XP_006721335
          Length = 275

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   RVRAMDIY 9
           RVR++++Y
Sbjct: 209 RVRSLELY 216
>XP_006721334
          Length = 476

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   RVRAMDIY 9
           RVR++++Y
Sbjct: 209 RVRSLELY 216
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.339    0.142    0.400 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 335,051
Number of extensions: 554
Number of successful extensions: 74
Number of sequences better than 10000.0: 74
Number of HSP's gapped: 74
Number of HSP's successfully gapped: 74
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.5 bits)
S2: 28 (15.4 bits)

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