Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_115803                                                              20     509
NP_663696                                                              19     869
XP_006720785                                                           17    3301
NP_115821                                                              17    3301
XP_006726900                                                           17    4312
XP_006724474                                                           17    4312
XP_006710184                                                           17    4312
NP_001278350                                                           16    5631
NP_001278347                                                           16    5631
NP_001278346                                                           16    5631
NP_066963                                                              16    5631
NP_001278345                                                           16    5631
NP_001278344                                                           16    5631
NP_001157916                                                           16    5631
XP_005272716                                                           16    5631
XP_005272715                                                           16    5631
XP_005272713                                                           16    5631
XP_006714976                                                           16    5631
NP_002987                                                              16    7355
NP_078966                                                              16    7355
NP_653252                                                              16    7355
NP_778228                                                              16    7355
XP_006723004                                                           16    7355
XP_005253069                                                           16    7355
XP_005253068                                                           16    7355
XP_006718322                                                           16    7355
XP_005253066                                                           16    7355
XP_005252859                                                           16    7355
XP_006718216                                                           16    7355
XP_006718215                                                           16    7355
XP_006718214                                                           16    7355
XP_006718213                                                           16    7355
XP_006718212                                                           16    7355
XP_005251225                                                           16    7355
XP_006716483                                                           16    7355
XP_005251224                                                           16    7355
NP_055273                                                              15    9605
NP_005206                                                              15    9605
NP_001123553                                                           15    9605
NP_694997                                                              15    9605
NP_001091059                                                           15    9605
NP_071733                                                              15    9605
NP_066383                                                              15    9605
NP_001252530                                                           15    9605
NP_002653                                                              15    9605
NP_061862                                                              15    9605
NP_892117                                                              15    9605
NP_001254526                                                           15    9605
NP_006405                                                              15    9605
XP_005276776                                                           15    9605
XP_006726859                                                           15    9605
XP_005262564                                                           15    9605
XP_006723959                                                           15    9605
XP_005258261                                                           15    9605
XP_005274110                                                           15    9605
XP_005273935                                                           15    9605
XP_006718554                                                           15    9605
XP_006718553                                                           15    9605
XP_006717549                                                           15    9605
XP_006717548                                                           15    9605
XP_006717547                                                           15    9605
XP_006717427                                                           15    9605
XP_006717426                                                           15    9605
XP_005268525                                                           15    9605
XP_005268524                                                           15    9605
XP_006714850                                                           15    9605
XP_005268523                                                           15    9605
XP_005247591                                                           15    9605
XP_005247590                                                           15    9605
XP_005245150                                                           15    9605
XP_006711340                                                           15    9605
XP_006710324                                                           15    9605
>NP_115803
          Length = 1156

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TRVPSLSTA 9
           TR+PSLSTA
Sbjct: 855 TRMPSLSTA 863
>NP_663696
          Length = 615

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   RVPSLSTA 9
           RVPSLSTA
Sbjct: 557 RVPSLSTA 564
>XP_006720785
          Length = 1079

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    TRVPSLSTA 9
            T VPSLST+
Sbjct: 1011 TDVPSLSTS 1019
>NP_115821
          Length = 1044

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   TRVPSLSTA 9
           T VPSLST+
Sbjct: 976 TDVPSLSTS 984
>XP_006726900
          Length = 258

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TRVPSLST 8
           TR+P LST
Sbjct: 140 TRLPGLST 147
>XP_006724474
          Length = 278

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TRVPSLST 8
           TR+P LST
Sbjct: 140 TRLPGLST 147
>XP_006710184
          Length = 258

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TRVPSLST 8
           TR+P LST
Sbjct: 140 TRLPGLST 147
>NP_001278350
          Length = 1105

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TRVPSLS 7
           TRVPS+S
Sbjct: 252 TRVPSVS 258
>NP_001278347
          Length = 1322

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TRVPSLS 7
           TRVPS+S
Sbjct: 469 TRVPSVS 475
>NP_001278346
          Length = 1356

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TRVPSLS 7
           TRVPS+S
Sbjct: 503 TRVPSVS 509
>NP_066963
          Length = 1401

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TRVPSLS 7
           TRVPS+S
Sbjct: 548 TRVPSVS 554
>NP_001278345
          Length = 1408

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TRVPSLS 7
           TRVPS+S
Sbjct: 555 TRVPSVS 561
>NP_001278344
          Length = 1453

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TRVPSLS 7
           TRVPS+S
Sbjct: 600 TRVPSVS 606
>NP_001157916
          Length = 242

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RVPSLST 8
           R+PSLST
Sbjct: 97  RMPSLST 103
>XP_005272716
          Length = 1367

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TRVPSLS 7
           TRVPS+S
Sbjct: 514 TRVPSVS 520
>XP_005272715
          Length = 1374

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TRVPSLS 7
           TRVPS+S
Sbjct: 521 TRVPSVS 527
>XP_005272713
          Length = 1419

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TRVPSLS 7
           TRVPS+S
Sbjct: 566 TRVPSVS 572
>XP_006714976
          Length = 241

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RVPSLST 8
           R+PSLST
Sbjct: 96  RMPSLST 102
>NP_002987
          Length = 397

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RVPSLSTA 9
           RVP +STA
Sbjct: 187 RVPPVSTA 194
>NP_078966
          Length = 14507

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2     RVPSLST 8
             +VPSLST
Sbjct: 10415 QVPSLST 10421
>NP_653252
          Length = 1463

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VPSLSTA 9
           VP+LSTA
Sbjct: 818 VPALSTA 824
>NP_778228
          Length = 1121

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VPSLSTA 9
           VPSLST+
Sbjct: 852 VPSLSTS 858
>XP_006723004
          Length = 6443

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    RVPSLST 8
            +VPSLST
Sbjct: 2329 QVPSLST 2335
>XP_005253069
          Length = 1238

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TRVPSL 6
           TRVPSL
Sbjct: 317 TRVPSL 322
>XP_005253068
          Length = 1269

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TRVPSL 6
           TRVPSL
Sbjct: 317 TRVPSL 322
>XP_006718322
          Length = 1298

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TRVPSL 6
           TRVPSL
Sbjct: 317 TRVPSL 322
>XP_005253066
          Length = 1298

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TRVPSL 6
           TRVPSL
Sbjct: 317 TRVPSL 322
>XP_005252859
          Length = 1272

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VPSLSTA 9
           VPSLST+
Sbjct: 852 VPSLSTS 858
>XP_006718216
          Length = 1298

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VPSLSTA 9
           VPSLST+
Sbjct: 852 VPSLSTS 858
>XP_006718215
          Length = 1325

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VPSLSTA 9
           VPSLST+
Sbjct: 879 VPSLSTS 885
>XP_006718214
          Length = 1338

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VPSLSTA 9
           VPSLST+
Sbjct: 892 VPSLSTS 898
>XP_006718213
          Length = 1339

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VPSLSTA 9
           VPSLST+
Sbjct: 919 VPSLSTS 925
>XP_006718212
          Length = 1365

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VPSLSTA 9
           VPSLST+
Sbjct: 919 VPSLSTS 925
>XP_005251225
          Length = 848

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VPSLSTA 9
           VP+LSTA
Sbjct: 203 VPALSTA 209
>XP_006716483
          Length = 1367

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VPSLSTA 9
           VP+LSTA
Sbjct: 722 VPALSTA 728
>XP_005251224
          Length = 1439

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VPSLSTA 9
           VP+LSTA
Sbjct: 794 VPALSTA 800
>NP_055273
          Length = 609

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TRVPSLST 8
           TRV S+ST
Sbjct: 441 TRVASMST 448
>NP_005206
          Length = 1447

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   TRVPSLST 8
           T VP LST
Sbjct: 835 TSVPDLST 842
>NP_001123553
          Length = 1036

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TRVPSLS 7
           TRVPS++
Sbjct: 95  TRVPSIN 101
>NP_694997
          Length = 896

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TRVPSLSTA 9
           +R PSLS A
Sbjct: 883 SRTPSLSPA 891
>NP_001091059
          Length = 283

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   RVPSLS 7
           RVPSLS
Sbjct: 199 RVPSLS 204
>NP_071733
          Length = 449

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   PSLSTA 9
           PSLSTA
Sbjct: 186 PSLSTA 191
>NP_066383
          Length = 579

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TRVPSLSTA 9
           TRV +LST+
Sbjct: 571 TRVKALSTS 579
>NP_001252530
          Length = 283

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   RVPSLS 7
           RVPSLS
Sbjct: 199 RVPSLS 204
>NP_002653
          Length = 1074

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TRVPSLS 7
           TRVPS++
Sbjct: 95  TRVPSIN 101
>NP_061862
          Length = 1060

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    RVPSLST 8
            +VPS+ST
Sbjct: 1017 KVPSIST 1023
>NP_892117
          Length = 283

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   RVPSLS 7
           RVPSLS
Sbjct: 199 RVPSLS 204
>NP_001254526
          Length = 579

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TRVPSLSTA 9
           TRV +LST+
Sbjct: 571 TRVKALSTS 579
>NP_006405
          Length = 283

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   RVPSLS 7
           RVPSLS
Sbjct: 199 RVPSLS 204
>XP_005276776
          Length = 991

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRVPSLST 8
           T +PS+ST
Sbjct: 952 TGIPSMST 959
>XP_006726859
          Length = 336

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  RVPSLSTA 9
          R PSLS+A
Sbjct: 35 RCPSLSSA 42

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  RVPSLSTA 9
          R PSLS+A
Sbjct: 75 RCPSLSSA 82

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RVPSLSTA 9
           R PSLS+A
Sbjct: 95  RCPSLSSA 102
>XP_005262564
          Length = 991

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRVPSLST 8
           T +PS+ST
Sbjct: 952 TGIPSMST 959
>XP_006723959
          Length = 336

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  RVPSLSTA 9
          R PSLS+A
Sbjct: 75 RCPSLSSA 82

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RVPSLSTA 9
           R PSLS+A
Sbjct: 95  RCPSLSSA 102
>XP_005258261
          Length = 1447

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   TRVPSLST 8
           T VP LST
Sbjct: 835 TSVPDLST 842
>XP_005274110
          Length = 449

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   PSLSTA 9
           PSLSTA
Sbjct: 186 PSLSTA 191
>XP_005273935
          Length = 897

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TRVPSLSTA 9
           +R PSLS A
Sbjct: 884 SRTPSLSPA 892
>XP_006718554
          Length = 946

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TRVPSLSTA 9
           +R PSLS A
Sbjct: 933 SRTPSLSPA 941
>XP_006718553
          Length = 947

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TRVPSLSTA 9
           +R PSLS A
Sbjct: 934 SRTPSLSPA 942
>XP_006717549
          Length = 579

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TRVPSLSTA 9
           TRV +LST+
Sbjct: 571 TRVKALSTS 579
>XP_006717548
          Length = 579

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TRVPSLSTA 9
           TRV +LST+
Sbjct: 571 TRVKALSTS 579
>XP_006717547
          Length = 579

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TRVPSLSTA 9
           TRV +LST+
Sbjct: 571 TRVKALSTS 579
>XP_006717427
          Length = 283

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   RVPSLS 7
           RVPSLS
Sbjct: 199 RVPSLS 204
>XP_006717426
          Length = 283

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   RVPSLS 7
           RVPSLS
Sbjct: 199 RVPSLS 204
>XP_005268525
          Length = 1005

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RVPSLST 8
           +VPS+ST
Sbjct: 962 KVPSIST 968
>XP_005268524
          Length = 1006

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RVPSLST 8
           +VPS+ST
Sbjct: 963 KVPSIST 969
>XP_006714850
          Length = 1049

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    RVPSLST 8
            +VPS+ST
Sbjct: 1006 KVPSIST 1012
>XP_005268523
          Length = 1061

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    RVPSLST 8
            +VPS+ST
Sbjct: 1018 KVPSIST 1024
>XP_005247591
          Length = 1036

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TRVPSLS 7
           TRVPS++
Sbjct: 95  TRVPSIN 101
>XP_005247590
          Length = 1074

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TRVPSLS 7
           TRVPS++
Sbjct: 95  TRVPSIN 101
>XP_005245150
          Length = 609

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TRVPSLST 8
           TRV S+ST
Sbjct: 441 TRVASMST 448
>XP_006711340
          Length = 684

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TRVPSLST 8
           TRV S+ST
Sbjct: 516 TRVASMST 523
>XP_006710324
          Length = 943

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRVPSLST 8
           T +PS+ST
Sbjct: 904 TGIPSMST 911
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.305    0.111    0.283 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 598,303
Number of extensions: 685
Number of successful extensions: 75
Number of sequences better than 10000.0: 72
Number of HSP's gapped: 75
Number of HSP's successfully gapped: 75
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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