Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_002083                                                              17    3301
XP_006712841                                                           17    3301
XP_006712840                                                           17    3301
NP_006346                                                              17    4312
XP_005248857                                                           17    4312
XP_005248856                                                           17    4312
NP_076951                                                              16    5631
NP_114102                                                              16    5631
NP_057624                                                              16    5631
XP_005259182                                                           16    5631
XP_005265535                                                           16    5631
NP_072047                                                              16    7355
NP_001276103                                                           16    7355
NP_001276105                                                           16    7355
NP_001276104                                                           16    7355
NP_056993                                                              16    7355
NP_036355                                                              16    7355
NP_001155291                                                           16    7355
NP_001123630                                                           16    7355
NP_002283                                                              16    7355
NP_857596                                                              16    7355
XP_005273859                                                           16    7355
XP_005265184                                                           16    7355
XP_005246634                                                           16    7355
XP_006712600                                                           16    7355
XP_005246632                                                           16    7355
XP_006712599                                                           16    7355
XP_005246629                                                           16    7355
XP_005246626                                                           16    7355
NP_001125                                                              15    9605
NP_689829                                                              15    9605
NP_852004                                                              15    9605
NP_001193795                                                           15    9605
NP_000556                                                              15    9605
NP_001244289                                                           15    9605
NP_001167448                                                           15    9605
NP_060110                                                              15    9605
NP_958784                                                              15    9605
NP_981949                                                              15    9605
NP_631895                                                              15    9605
NP_001244290                                                           15    9605
NP_004028                                                              15    9605
NP_005986                                                              15    9605
XP_005251036                                                           15    9605
XP_006715203                                                           15    9605
XP_006715202                                                           15    9605
XP_006715201                                                           15    9605
XP_006715200                                                           15    9605
XP_005249275                                                           15    9605
XP_006715199                                                           15    9605
XP_006713671                                                           15    9605
XP_005245197                                                           15    9605
XP_005245196                                                           15    9605
XP_006711362                                                           15    9605
XP_006711361                                                           15    9605
XP_006710639                                                           15    9605
XP_005270809                                                           15    9605
>NP_002083
          Length = 480

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TRRYAQESQ 9
           TR Y+QES+
Sbjct: 114 TRSYSQESK 122
>XP_006712841
          Length = 1696

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  TRRYAQES 8
          TRR++QES
Sbjct: 28 TRRHSQES 35
>XP_006712840
          Length = 1725

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  TRRYAQES 8
          TRR++QES
Sbjct: 28 TRRHSQES 35
>NP_006346
          Length = 465

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TRRYAQESQ 9
           TR Y QE+Q
Sbjct: 315 TRGYTQENQ 323
>XP_005248857
          Length = 465

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TRRYAQESQ 9
           TR Y QE+Q
Sbjct: 315 TRGYTQENQ 323
>XP_005248856
          Length = 465

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TRRYAQESQ 9
           TR Y QE+Q
Sbjct: 315 TRGYTQENQ 323
>NP_076951
          Length = 501

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   YAQESQ 9
           YAQESQ
Sbjct: 491 YAQESQ 496
>NP_114102
          Length = 275

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TRRYAQE 7
           T+RYA+E
Sbjct: 201 TKRYAEE 207
>NP_057624
          Length = 423

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  RRYAQESQ 9
          RRY  ESQ
Sbjct: 59 RRYGAESQ 66
>XP_005259182
          Length = 275

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TRRYAQE 7
           T+RYA+E
Sbjct: 201 TKRYAEE 207
>XP_005265535
          Length = 470

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   YAQESQ 9
           YAQESQ
Sbjct: 460 YAQESQ 465
>NP_072047
          Length = 723

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TRRYAQES 8
           TRRYA+ S
Sbjct: 510 TRRYAEFS 517
>NP_001276103
          Length = 656

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TRRYAQES 8
           TRRYA+ S
Sbjct: 443 TRRYAEFS 450
>NP_001276105
          Length = 534

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TRRYAQES 8
           TRRYA+ S
Sbjct: 321 TRRYAEFS 328
>NP_001276104
          Length = 598

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TRRYAQES 8
           TRRYA+ S
Sbjct: 385 TRRYAEFS 392
>NP_056993
          Length = 2371

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   RRYAQES 8
           R YAQES
Sbjct: 730 RTYAQES 736
>NP_036355
          Length = 1078

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RRYAQESQ 9
           RRYAQ+ +
Sbjct: 739 RRYAQQKR 746
>NP_001155291
          Length = 1136

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RRYAQESQ 9
           RRYAQ+ +
Sbjct: 739 RRYAQQKR 746
>NP_001123630
          Length = 1136

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RRYAQESQ 9
           RRYAQ+ +
Sbjct: 739 RRYAQQKR 746
>NP_002283
          Length = 1798

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TRRYAQESQ 9
            TRR A E+Q
Sbjct: 1480 TRRQASEAQ 1488
>NP_857596
          Length = 604

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TRRYAQESQ 9
           T RYA +SQ
Sbjct: 491 TGRYAYQSQ 499
>XP_005273859
          Length = 604

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TRRYAQESQ 9
           T RYA +SQ
Sbjct: 491 TGRYAYQSQ 499
>XP_005265184
          Length = 1798

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TRRYAQESQ 9
            TRR A E+Q
Sbjct: 1480 TRRQASEAQ 1488
>XP_005246634
          Length = 1098

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RRYAQESQ 9
           RRYAQ+ +
Sbjct: 759 RRYAQQKR 766
>XP_006712600
          Length = 1127

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RRYAQESQ 9
           RRYAQ+ +
Sbjct: 759 RRYAQQKR 766
>XP_005246632
          Length = 1127

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RRYAQESQ 9
           RRYAQ+ +
Sbjct: 759 RRYAQQKR 766
>XP_006712599
          Length = 1136

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RRYAQESQ 9
           RRYAQ+ +
Sbjct: 739 RRYAQQKR 746
>XP_005246629
          Length = 1136

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RRYAQESQ 9
           RRYAQ+ +
Sbjct: 739 RRYAQQKR 746
>XP_005246626
          Length = 1156

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RRYAQESQ 9
           RRYAQ+ +
Sbjct: 759 RRYAQQKR 766
>NP_001125
          Length = 609

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RRYAQESQ 9
           ++Y QESQ
Sbjct: 402 QKYIQESQ 409
>NP_689829
          Length = 723

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TRRYAQE 7
           T+RY QE
Sbjct: 215 TKRYMQE 221
>NP_852004
          Length = 365

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RYAQESQ 9
           +Y+QESQ
Sbjct: 166 QYSQESQ 172
>NP_001193795
          Length = 352

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RYAQESQ 9
           +Y+QESQ
Sbjct: 166 QYSQESQ 172
>NP_000556
          Length = 468

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RYAQESQ 9
           +Y+QESQ
Sbjct: 166 QYSQESQ 172
>NP_001244289
          Length = 879

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TRRYAQE 7
           TRRY Q+
Sbjct: 266 TRRYLQQ 272
>NP_001167448
          Length = 1365

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TRRYAQE 7
           TR+Y QE
Sbjct: 667 TRKYLQE 673
>NP_060110
          Length = 1371

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TRRYAQE 7
           TR+Y QE
Sbjct: 667 TRKYLQE 673
>NP_958784
          Length = 4547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  RRYAQESQ 9
          RR+AQ+ Q
Sbjct: 30 RRWAQDEQ 37
>NP_981949
          Length = 760

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TRRYAQE 7
           TRRY Q+
Sbjct: 147 TRRYLQQ 153
>NP_631895
          Length = 798

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TRRYAQE 7
           TRRY Q+
Sbjct: 185 TRRYLQQ 191
>NP_001244290
          Length = 761

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TRRYAQE 7
           TRRY Q+
Sbjct: 148 TRRYLQQ 154
>NP_004028
          Length = 879

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TRRYAQE 7
           TRRY Q+
Sbjct: 266 TRRYLQQ 272
>NP_005986
          Length = 385

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRRYAQES 8
           + RYAQE+
Sbjct: 207 SERYAQEN 214
>XP_005251036
          Length = 4552

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  RRYAQESQ 9
          RR+AQ+ Q
Sbjct: 30 RRWAQDEQ 37
>XP_006715203
          Length = 949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TRRYAQE 7
           TR+Y QE
Sbjct: 671 TRKYLQE 677
>XP_006715202
          Length = 966

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TRRYAQE 7
           TR+Y QE
Sbjct: 671 TRKYLQE 677
>XP_006715201
          Length = 1375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TRRYAQE 7
           TR+Y QE
Sbjct: 671 TRKYLQE 677
>XP_006715200
          Length = 1419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TRRYAQE 7
           TR+Y QE
Sbjct: 671 TRKYLQE 677
>XP_005249275
          Length = 1421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TRRYAQE 7
           TR+Y QE
Sbjct: 667 TRKYLQE 673
>XP_006715199
          Length = 1425

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TRRYAQE 7
           TR+Y QE
Sbjct: 671 TRKYLQE 677
>XP_006713671
          Length = 576

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  TRRYAQE 7
          T+RY QE
Sbjct: 68 TKRYMQE 74
>XP_005245197
          Length = 338

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RYAQESQ 9
           +Y+QESQ
Sbjct: 166 QYSQESQ 172
>XP_005245196
          Length = 360

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RYAQESQ 9
           +Y+QESQ
Sbjct: 166 QYSQESQ 172
>XP_006711362
          Length = 381

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RYAQESQ 9
           +Y+QESQ
Sbjct: 166 QYSQESQ 172
>XP_006711361
          Length = 484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RYAQESQ 9
           +Y+QESQ
Sbjct: 166 QYSQESQ 172
>XP_006710639
          Length = 523

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TRRYAQE 7
           TRRY Q+
Sbjct: 266 TRRYLQQ 272
>XP_005270809
          Length = 804

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TRRYAQE 7
           TRRY Q+
Sbjct: 191 TRRYLQQ 197
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.307    0.111    0.278 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 500,937
Number of extensions: 922
Number of successful extensions: 57
Number of sequences better than 10000.0: 57
Number of HSP's gapped: 57
Number of HSP's successfully gapped: 57
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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