Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001138389                                                           18    1135
NP_001138390                                                           18    1135
NP_001138386                                                           18    1135
NP_001138387                                                           18    1135
NP_000132                                                              18    1135
NP_075259                                                              18    1135
NP_001138388                                                           18    1135
NP_001138391                                                           18    1135
NP_001138385                                                           18    1135
NP_075418                                                              18    1135
XP_006717776                                                           18    1135
XP_006717775                                                           18    1135
XP_006717774                                                           18    1135
XP_006717773                                                           18    1135
XP_006717772                                                           18    1135
XP_006717771                                                           18    1135
NP_056073                                                              18    1935
XP_006717082                                                           18    1935
XP_006717081                                                           18    1935
NP_001158307                                                           16    5631
NP_061952                                                              16    5631
NP_114416                                                              16    5631
NP_003039                                                              16    5631
XP_006723775                                                           16    5631
XP_006723773                                                           16    5631
NP_001138822                                                           16    5631
NP_079043                                                              16    7355
NP_872584                                                              16    7355
XP_006719740                                                           16    7355
XP_005273431                                                           16    7355
NP_054878                                                              15    9605
NP_001007103                                                           15    9605
NP_115814                                                              15    9605
XP_005267218                                                           15    9605
XP_006715641                                                           15    9605
XP_006715640                                                           15    9605
XP_006715639                                                           15    9605
XP_005265151                                                           15    9605
XP_006713182                                                           15    9605
>NP_001138389
          Length = 705

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TRLSLTADT 9
           TRLS TADT
Sbjct: 333 TRLSSTADT 341
>NP_001138390
          Length = 704

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TRLSLTADT 9
           TRLS TADT
Sbjct: 332 TRLSSTADT 340
>NP_001138386
          Length = 709

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TRLSLTADT 9
           TRLS TADT
Sbjct: 337 TRLSSTADT 345
>NP_001138387
          Length = 707

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TRLSLTADT 9
           TRLS TADT
Sbjct: 360 TRLSSTADT 368
>NP_000132
          Length = 821

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TRLSLTADT 9
           TRLS TADT
Sbjct: 449 TRLSSTADT 457
>NP_075259
          Length = 822

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TRLSLTADT 9
           TRLS TADT
Sbjct: 450 TRLSSTADT 458
>NP_001138388
          Length = 706

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TRLSLTADT 9
           TRLS TADT
Sbjct: 334 TRLSSTADT 342
>NP_001138391
          Length = 680

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TRLSLTADT 9
           TRLS TADT
Sbjct: 361 TRLSSTADT 369
>NP_001138385
          Length = 769

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TRLSLTADT 9
           TRLS TADT
Sbjct: 450 TRLSSTADT 458
>NP_075418
          Length = 732

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TRLSLTADT 9
           TRLS TADT
Sbjct: 360 TRLSSTADT 368
>XP_006717776
          Length = 806

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TRLSLTADT 9
           TRLS TADT
Sbjct: 468 TRLSSTADT 476
>XP_006717775
          Length = 726

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TRLSLTADT 9
           TRLS TADT
Sbjct: 354 TRLSSTADT 362
>XP_006717774
          Length = 752

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TRLSLTADT 9
           TRLS TADT
Sbjct: 380 TRLSSTADT 388
>XP_006717773
          Length = 807

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TRLSLTADT 9
           TRLS TADT
Sbjct: 469 TRLSSTADT 477
>XP_006717772
          Length = 838

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TRLSLTADT 9
           TRLS TADT
Sbjct: 466 TRLSSTADT 474
>XP_006717771
          Length = 839

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TRLSLTADT 9
           TRLS TADT
Sbjct: 467 TRLSSTADT 475
>NP_056073
          Length = 1219

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1    TRLSLTAD 8
            TRLSLT+D
Sbjct: 1094 TRLSLTSD 1101
>XP_006717082
          Length = 1151

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1    TRLSLTAD 8
            TRLSLT+D
Sbjct: 1026 TRLSLTSD 1033
>XP_006717081
          Length = 1209

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1    TRLSLTAD 8
            TRLSLT+D
Sbjct: 1084 TRLSLTSD 1091
>NP_001158307
          Length = 865

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TRLSLTAD 8
           TR+ LTAD
Sbjct: 788 TRIRLTAD 795
>NP_061952
          Length = 865

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TRLSLTAD 8
           TR+ LTAD
Sbjct: 788 TRIRLTAD 795
>NP_114416
          Length = 207

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TRLSLTADT 9
           TRLS+T +T
Sbjct: 191 TRLSITNET 199
>NP_003039
          Length = 812

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   RLSLTADT 9
           R SLTADT
Sbjct: 621 RHSLTADT 628
>XP_006723775
          Length = 203

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TRLSLTADT 9
          TR S+T+DT
Sbjct: 90 TRESMTSDT 98
>XP_006723773
          Length = 203

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TRLSLTADT 9
          TR S+T+DT
Sbjct: 90 TRESMTSDT 98
>NP_001138822
          Length = 202

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TRLSLTADT 9
          TR S+T+DT
Sbjct: 90 TRESMTSDT 98
>NP_079043
          Length = 463

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TRLSLTADT 9
           TR++L++DT
Sbjct: 409 TRVNLSSDT 417
>NP_872584
          Length = 1528

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TRLSLTADT 9
           TR++L++DT
Sbjct: 409 TRVNLSSDT 417
>XP_006719740
          Length = 1863

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  TRLSLTAD 8
          T LSLT+D
Sbjct: 29 TNLSLTSD 36
>XP_005273431
          Length = 1528

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TRLSLTADT 9
           TR++L++DT
Sbjct: 409 TRVNLSSDT 417
>NP_054878
          Length = 2564

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TRLSLTADT 9
            T+LS  ADT
Sbjct: 1862 TKLSTEADT 1870
>NP_001007103
          Length = 755

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RLSLTADT 9
           +LSL ADT
Sbjct: 151 KLSLKADT 158
>NP_115814
          Length = 780

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RLSLTADT 9
           +LSL ADT
Sbjct: 176 KLSLKADT 183
>XP_005267218
          Length = 780

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RLSLTADT 9
           +LSL ADT
Sbjct: 176 KLSLKADT 183
>XP_006715641
          Length = 780

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RLSLTADT 9
           +LSL ADT
Sbjct: 176 KLSLKADT 183
>XP_006715640
          Length = 780

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RLSLTADT 9
           +LSL ADT
Sbjct: 176 KLSLKADT 183
>XP_006715639
          Length = 815

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RLSLTADT 9
           +LSL ADT
Sbjct: 211 KLSLKADT 218
>XP_005265151
          Length = 2058

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TRLSLTADT 9
            T+LS  ADT
Sbjct: 1862 TKLSTEADT 1870
>XP_006713182
          Length = 2422

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TRLSLTADT 9
            T+LS  ADT
Sbjct: 1862 TKLSTEADT 1870
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.310    0.117    0.285 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 292,885
Number of extensions: 489
Number of successful extensions: 39
Number of sequences better than 10000.0: 39
Number of HSP's gapped: 39
Number of HSP's successfully gapped: 39
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package