Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_443179                                                              22     134
NP_001188254                                                           17    3301
NP_002605                                                              17    3301
NP_001188255                                                           17    3301
XP_005273026                                                           17    3301
XP_005273025                                                           17    3301
NP_114111                                                              16    5631
NP_001154485                                                           16    5631
NP_001154483                                                           16    5631
NP_001154482                                                           16    5631
NP_001154481                                                           16    5631
NP_001154484                                                           16    5631
XP_005250681                                                           16    5631
XP_006716210                                                           16    5631
XP_005250680                                                           16    5631
XP_005250679                                                           16    5631
XP_005250678                                                           16    5631
NP_001139320                                                           16    7355
NP_001139321                                                           16    7355
NP_001139323                                                           16    7355
NP_006008                                                              16    7355
NP_001139322                                                           16    7355
NP_001139324                                                           16    7355
NP_056385                                                              16    7355
NP_001120703                                                           16    7355
NP_001139319                                                           16    7355
NP_998765                                                              16    7355
NP_056195                                                              16    7355
XP_005254329                                                           16    7355
XP_006719245                                                           16    7355
XP_006719244                                                           16    7355
XP_005250314                                                           16    7355
XP_005248253                                                           16    7355
XP_005248252                                                           16    7355
XP_006714036                                                           16    7355
NP_005471                                                              16    7355
NP_976035                                                              15    9605
NP_001080                                                              15    9605
NP_079279                                                              15    9605
NP_003741                                                              15    9605
NP_002559                                                              15    9605
NP_001338                                                              15    9605
NP_036549                                                              15    9605
NP_858057                                                              15    9605
NP_006211                                                              15    9605
NP_005291                                                              15    9605
XP_003960359                                                           15    9605
XP_005272654                                                           15    9605
XP_005257273                                                           15    9605
XP_005269023                                                           15    9605
XP_005269022                                                           15    9605
XP_005269021                                                           15    9605
XP_006719516                                                           15    9605
XP_005269019                                                           15    9605
XP_006719515                                                           15    9605
XP_005250918                                                           15    9605
XP_006716283                                                           15    9605
XP_005249548                                                           15    9605
XP_001724294                                                           15    9605
XP_002345622                                                           15    9605
NP_057572                                                              15    9605
NP_001137260                                                           15    9605
NP_001137261                                                           15    9605
NP_001137259                                                           15    9605
NP_958847                                                              15    9605
NP_001091048                                                           15    9605
NP_958923                                                              15    9605
NP_958846                                                              15    9605
NP_958848                                                              15    9605
NP_112241                                                              15    9605
>NP_443179
          Length = 2170

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TRDSHQAKE 9
           TRDSHQA+E
Sbjct: 469 TRDSHQARE 477
>NP_001188254
          Length = 519

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DSHQAKE 9
           DSH AKE
Sbjct: 495 DSHMAKE 501
>NP_002605
          Length = 519

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DSHQAKE 9
           DSH AKE
Sbjct: 495 DSHMAKE 501
>NP_001188255
          Length = 408

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DSHQAKE 9
           DSH AKE
Sbjct: 384 DSHMAKE 390
>XP_005273026
          Length = 508

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DSHQAKE 9
           DSH AKE
Sbjct: 495 DSHMAKE 501
>XP_005273025
          Length = 508

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DSHQAKE 9
           DSH AKE
Sbjct: 495 DSHMAKE 501
>NP_114111
          Length = 343

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DSHQAKE 9
           DSH AKE
Sbjct: 269 DSHVAKE 275
>NP_001154485
          Length = 225

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DSHQAKE 9
           DSH AKE
Sbjct: 151 DSHVAKE 157
>NP_001154483
          Length = 284

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DSHQAKE 9
           DSH AKE
Sbjct: 210 DSHVAKE 216
>NP_001154482
          Length = 284

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DSHQAKE 9
           DSH AKE
Sbjct: 210 DSHVAKE 216
>NP_001154481
          Length = 308

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DSHQAKE 9
           DSH AKE
Sbjct: 234 DSHVAKE 240
>NP_001154484
          Length = 249

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DSHQAKE 9
           DSH AKE
Sbjct: 175 DSHVAKE 181
>XP_005250681
          Length = 271

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DSHQAKE 9
           DSH AKE
Sbjct: 197 DSHVAKE 203
>XP_006716210
          Length = 291

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DSHQAKE 9
           DSH AKE
Sbjct: 217 DSHVAKE 223
>XP_005250680
          Length = 295

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DSHQAKE 9
           DSH AKE
Sbjct: 221 DSHVAKE 227
>XP_005250679
          Length = 319

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DSHQAKE 9
           DSH AKE
Sbjct: 245 DSHVAKE 251
>XP_005250678
          Length = 354

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DSHQAKE 9
           DSH AKE
Sbjct: 280 DSHVAKE 286
>NP_001139320
          Length = 856

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TRDSHQA 7
          T+DSH+A
Sbjct: 43 TQDSHKA 49
>NP_001139321
          Length = 842

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TRDSHQA 7
          T+DSH+A
Sbjct: 43 TQDSHKA 49
>NP_001139323
          Length = 833

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TRDSHQA 7
          T+DSH+A
Sbjct: 43 TQDSHKA 49
>NP_006008
          Length = 865

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TRDSHQA 7
          T+DSH+A
Sbjct: 43 TQDSHKA 49
>NP_001139322
          Length = 834

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TRDSHQA 7
          T+DSH+A
Sbjct: 43 TQDSHKA 49
>NP_001139324
          Length = 825

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TRDSHQA 7
          T+DSH+A
Sbjct: 43 TQDSHKA 49
>NP_056385
          Length = 1259

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   DSHQAKE 9
           D H+AKE
Sbjct: 907 DEHKAKE 913
>NP_001120703
          Length = 1235

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   DSHQAKE 9
           D H+AKE
Sbjct: 883 DEHKAKE 889
>NP_001139319
          Length = 856

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TRDSHQA 7
          T+DSH+A
Sbjct: 43 TQDSHKA 49
>NP_998765
          Length = 849

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   DSHQAKE 9
           D HQA+E
Sbjct: 839 DRHQARE 845
>NP_056195
          Length = 469

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  RDSHQAKE 9
          R SH+A+E
Sbjct: 81 RKSHEARE 88
>XP_005254329
          Length = 481

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   DSHQAKE 9
           D HQA+E
Sbjct: 471 DRHQARE 477
>XP_006719245
          Length = 776

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TRDSHQA 7
           TRDSH +
Sbjct: 296 TRDSHDS 302
>XP_006719244
          Length = 868

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TRDSHQA 7
           TRDSH +
Sbjct: 296 TRDSHDS 302
>XP_005250314
          Length = 808

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   DSHQAKE 9
           D H+AKE
Sbjct: 456 DEHKAKE 462
>XP_005248253
          Length = 825

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TRDSHQA 7
          T+DSH+A
Sbjct: 43 TQDSHKA 49
>XP_005248252
          Length = 833

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TRDSHQA 7
          T+DSH+A
Sbjct: 43 TQDSHKA 49
>XP_006714036
          Length = 856

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TRDSHQA 7
          T+DSH+A
Sbjct: 43 TQDSHKA 49
>NP_005471
          Length = 778

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TRDSHQA 7
           TRDSH +
Sbjct: 296 TRDSHDS 302
>NP_976035
          Length = 346

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TRDSHQAKE 9
           TR+ H AK+
Sbjct: 147 TRNPHAAKD 155
>NP_001080
          Length = 1704

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1    TRDSHQA 7
            TRD H A
Sbjct: 1173 TRDGHMA 1179
>NP_079279
          Length = 1910

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    RDSHQAKE 9
            +DSHQ  E
Sbjct: 1550 KDSHQRME 1557
>NP_003741
          Length = 1382

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  RDSHQAKE 9
          R SH AKE
Sbjct: 62 RKSHLAKE 69
>NP_002559
          Length = 636

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   SHQAKE 9
           +HQAKE
Sbjct: 616 AHQAKE 621
>NP_001338
          Length = 942

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   DSHQAKE 9
           D HQA+E
Sbjct: 757 DFHQARE 763
>NP_036549
          Length = 332

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   RDSHQ 6
           RDSHQ
Sbjct: 174 RDSHQ 178
>NP_858057
          Length = 268

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   RDSHQ 6
           RDSHQ
Sbjct: 174 RDSHQ 178
>NP_006211
          Length = 421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RDSHQAKE 9
           RD+ +AKE
Sbjct: 175 RDTEEAKE 182
>NP_005291
          Length = 381

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 2   RDSHQAK 8
           RD H AK
Sbjct: 208 RDKHNAK 214
>XP_003960359
          Length = 589

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   TRDSHQAKE 9
           +RD H+++E
Sbjct: 188 SRDHHESQE 196
>XP_005272654
          Length = 381

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 2   RDSHQAK 8
           RD H AK
Sbjct: 208 RDKHNAK 214
>XP_005257273
          Length = 309

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   RDSHQ 6
           RDSHQ
Sbjct: 151 RDSHQ 155
>XP_005269023
          Length = 300

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1  TRDSHQA 7
          TRD H A
Sbjct: 39 TRDDHSA 45
>XP_005269022
          Length = 340

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1  TRDSHQA 7
          TRD H A
Sbjct: 32 TRDDHSA 38
>XP_005269021
          Length = 355

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   TRDSHQA 7
           TRD H A
Sbjct: 94  TRDDHSA 100
>XP_006719516
          Length = 366

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   TRDSHQA 7
           TRD H A
Sbjct: 94  TRDDHSA 100
>XP_005269019
          Length = 409

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1  TRDSHQA 7
          TRD H A
Sbjct: 32 TRDDHSA 38
>XP_006719515
          Length = 423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   TRDSHQA 7
           TRD H A
Sbjct: 94  TRDDHSA 100
>XP_005250918
          Length = 636

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   SHQAKE 9
           +HQAKE
Sbjct: 616 AHQAKE 621
>XP_006716283
          Length = 298

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  SHQAKE 9
          SHQAK+
Sbjct: 64 SHQAKQ 69
>XP_005249548
          Length = 342

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TRDSHQAKE 9
           TR+ H AK+
Sbjct: 147 TRNPHAAKD 155
>XP_001724294
          Length = 589

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   TRDSHQAKE 9
           +RD H+++E
Sbjct: 188 SRDHHESQE 196
>XP_002345622
          Length = 613

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   TRDSHQAKE 9
           +RD H+++E
Sbjct: 212 SRDHHESQE 220
>NP_057572
          Length = 458

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1  TRDSHQA 7
          TRD H A
Sbjct: 87 TRDDHSA 93
>NP_001137260
          Length = 348

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1  TRDSHQA 7
          TRD H A
Sbjct: 87 TRDDHSA 93
>NP_001137261
          Length = 293

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1  TRDSHQA 7
          TRD H A
Sbjct: 32 TRDDHSA 38
>NP_001137259
          Length = 434

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1  TRDSHQA 7
          TRD H A
Sbjct: 32 TRDDHSA 38
>NP_958847
          Length = 367

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1  TRDSHQA 7
          TRD H A
Sbjct: 87 TRDDHSA 93
>NP_001091048
          Length = 381

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 2   RDSHQAK 8
           RD H AK
Sbjct: 208 RDKHNAK 214
>NP_958923
          Length = 374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   TRDSHQA 7
           TRD H A
Sbjct: 94  TRDDHSA 100
>NP_958846
          Length = 258

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1  TRDSHQA 7
          TRD H A
Sbjct: 39 TRDDHSA 45
>NP_958848
          Length = 319

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1  TRDSHQA 7
          TRD H A
Sbjct: 39 TRDDHSA 45
>NP_112241
          Length = 631

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   SHQAKE 9
           +HQAKE
Sbjct: 611 AHQAKE 616
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.298    0.107    0.280 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 661,015
Number of extensions: 1034
Number of successful extensions: 70
Number of sequences better than 10000.0: 70
Number of HSP's gapped: 70
Number of HSP's successfully gapped: 70
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.2 bits)
S2: 28 (15.4 bits)

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