Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006209                                                              18    1135
XP_006713721                                                           18    1135
NP_056069                                                              17    4312
XP_006716380                                                           17    4312
XP_006716379                                                           17    4312
XP_005273516                                                           17    4312
XP_005273515                                                           17    4312
NP_055633                                                              16    5631
NP_038477                                                              16    5631
NP_002855                                                              16    5631
NP_997254                                                              16    5631
XP_006719271                                                           16    5631
XP_005268661                                                           16    5631
XP_005268660                                                           16    5631
XP_005268659                                                           16    5631
XP_005268657                                                           16    5631
XP_006719270                                                           16    5631
XP_005268656                                                           16    5631
XP_005268654                                                           16    5631
XP_005268653                                                           16    5631
XP_006718461                                                           16    5631
XP_006718460                                                           16    5631
XP_005252508                                                           16    5631
XP_006717511                                                           16    5631
XP_005252507                                                           16    5631
XP_005270463                                                           16    5631
XP_005270462                                                           16    5631
XP_006710373                                                           16    5631
XP_005270461                                                           16    5631
NP_443724                                                              16    5631
NP_001026                                                              16    7355
NP_001191957                                                           16    7355
NP_059136                                                              16    7355
NP_116162                                                              16    7355
NP_001193856                                                           16    7355
XP_005269084                                                           16    7355
XP_005269083                                                           16    7355
XP_006715067                                                           16    7355
XP_006713856                                                           16    7355
XP_005269424                                                           16    7355
XP_006713855                                                           16    7355
XP_005269422                                                           16    7355
XP_006713854                                                           16    7355
XP_005269420                                                           16    7355
XP_005269419                                                           16    7355
XP_006711873                                                           16    7355
XP_006711871                                                           16    7355
XP_006711870                                                           16    7355
XP_006711869                                                           16    7355
XP_006711868                                                           16    7355
XP_006711867                                                           16    7355
XP_006711866                                                           16    7355
XP_006711865                                                           16    7355
NP_000072                                                              15    9605
NP_112503                                                              15    9605
NP_000094                                                              15    9605
NP_689914                                                              15    9605
XP_006724601                                                           15    9605
XP_006720469                                                           15    9605
XP_005254248                                                           15    9605
XP_005254247                                                           15    9605
XP_006711794                                                           15    9605
XP_005273085                                                           15    9605
XP_005273084                                                           15    9605
>NP_006209
          Length = 1068

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TRDRLSEIT 9
           TRD LSEIT
Sbjct: 536 TRDPLSEIT 544
>XP_006713721
          Length = 1068

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TRDRLSEIT 9
           TRD LSEIT
Sbjct: 536 TRDPLSEIT 544
>NP_056069
          Length = 1826

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RDRLSEIT 9
           RDR SE+T
Sbjct: 979 RDRWSEVT 986
>XP_006716380
          Length = 1762

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RDRLSEIT 9
           RDR SE+T
Sbjct: 915 RDRWSEVT 922
>XP_006716379
          Length = 1762

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RDRLSEIT 9
           RDR SE+T
Sbjct: 915 RDRWSEVT 922
>XP_005273516
          Length = 1762

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RDRLSEIT 9
           RDR SE+T
Sbjct: 915 RDRWSEVT 922
>XP_005273515
          Length = 1805

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RDRLSEIT 9
           RDR SE+T
Sbjct: 979 RDRWSEVT 986
>NP_055633
          Length = 1216

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TRDRLSEIT 9
           ++DRLSE T
Sbjct: 911 SQDRLSEAT 919
>NP_038477
          Length = 1905

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TRDRLSEI 8
           TRD +SEI
Sbjct: 933 TRDNVSEI 940
>NP_002855
          Length = 1482

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TRDRLSEIT 9
           T +R+SEIT
Sbjct: 332 TANRISEIT 340
>NP_997254
          Length = 908

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   DRLSEIT 9
           DR+SEIT
Sbjct: 548 DRVSEIT 554
>XP_006719271
          Length = 1555

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TRDRLSEI 8
           TRD +SEI
Sbjct: 952 TRDNVSEI 959
>XP_005268661
          Length = 1657

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TRDRLSEI 8
           TRD +SEI
Sbjct: 685 TRDNVSEI 692
>XP_005268660
          Length = 1875

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TRDRLSEI 8
           TRD +SEI
Sbjct: 903 TRDNVSEI 910
>XP_005268659
          Length = 1894

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TRDRLSEI 8
           TRD +SEI
Sbjct: 922 TRDNVSEI 929
>XP_005268657
          Length = 1903

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TRDRLSEI 8
           TRD +SEI
Sbjct: 931 TRDNVSEI 938
>XP_006719270
          Length = 1903

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TRDRLSEI 8
           TRD +SEI
Sbjct: 931 TRDNVSEI 938
>XP_005268656
          Length = 1903

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TRDRLSEI 8
           TRD +SEI
Sbjct: 931 TRDNVSEI 938
>XP_005268654
          Length = 1923

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TRDRLSEI 8
           TRD +SEI
Sbjct: 952 TRDNVSEI 959
>XP_005268653
          Length = 1924

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TRDRLSEI 8
           TRD +SEI
Sbjct: 952 TRDNVSEI 959
>XP_006718461
          Length = 1247

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TRDRLSEIT 9
           ++DRLSE T
Sbjct: 942 SQDRLSEAT 950
>XP_006718460
          Length = 1392

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TRDRLSEIT 9
            ++DRLSE T
Sbjct: 1087 SQDRLSEAT 1095
>XP_005252508
          Length = 908

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   DRLSEIT 9
           DR+SEIT
Sbjct: 548 DRVSEIT 554
>XP_006717511
          Length = 908

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   DRLSEIT 9
           DR+SEIT
Sbjct: 548 DRVSEIT 554
>XP_005252507
          Length = 908

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   DRLSEIT 9
           DR+SEIT
Sbjct: 548 DRVSEIT 554
>XP_005270463
          Length = 402

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  TRDRLSEIT 9
          TRD L E+T
Sbjct: 19 TRDLLKELT 27
>XP_005270462
          Length = 460

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  TRDRLSEIT 9
          TRD L E+T
Sbjct: 19 TRDLLKELT 27
>XP_006710373
          Length = 460

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  TRDRLSEIT 9
          TRD L E+T
Sbjct: 19 TRDLLKELT 27
>XP_005270461
          Length = 460

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  TRDRLSEIT 9
          TRD L E+T
Sbjct: 19 TRDLLKELT 27
>NP_443724
          Length = 460

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  TRDRLSEIT 9
          TRD L E+T
Sbjct: 19 TRDLLKELT 27
>NP_001026
          Length = 4967

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    RDRLSEI 8
            RDR+SE+
Sbjct: 4663 RDRISEL 4669
>NP_001191957
          Length = 679

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   DRLSEIT 9
           DRLSEI+
Sbjct: 645 DRLSEIS 651
>NP_059136
          Length = 714

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   DRLSEIT 9
           DRLSEI+
Sbjct: 680 DRLSEIS 686
>NP_116162
          Length = 712

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  TRDRLSEI 8
          +R+RLSEI
Sbjct: 90 SRNRLSEI 97
>NP_001193856
          Length = 4707

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    DRLSEIT 9
            DR+SE+T
Sbjct: 1580 DRISELT 1586
>XP_005269084
          Length = 622

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   DRLSEIT 9
           DRLSEI+
Sbjct: 588 DRLSEIS 594
>XP_005269083
          Length = 724

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   DRLSEIT 9
           DRLSEI+
Sbjct: 690 DRLSEIS 696
>XP_006715067
          Length = 4707

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    DRLSEIT 9
            DR+SE+T
Sbjct: 1580 DRISELT 1586
>XP_006713856
          Length = 741

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  TRDRLSEI 8
          +R+RLSEI
Sbjct: 90 SRNRLSEI 97
>XP_005269424
          Length = 743

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  TRDRLSEI 8
          +R+RLSEI
Sbjct: 90 SRNRLSEI 97
>XP_006713855
          Length = 753

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  TRDRLSEI 8
          +R+RLSEI
Sbjct: 90 SRNRLSEI 97
>XP_005269422
          Length = 767

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  TRDRLSEI 8
          +R+RLSEI
Sbjct: 90 SRNRLSEI 97
>XP_006713854
          Length = 777

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  TRDRLSEI 8
          +R+RLSEI
Sbjct: 90 SRNRLSEI 97
>XP_005269420
          Length = 779

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  TRDRLSEI 8
          +R+RLSEI
Sbjct: 90 SRNRLSEI 97
>XP_005269419
          Length = 803

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  TRDRLSEI 8
          +R+RLSEI
Sbjct: 90 SRNRLSEI 97
>XP_006711873
          Length = 4954

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    RDRLSEI 8
            RDR+SE+
Sbjct: 4650 RDRISEL 4656
>XP_006711871
          Length = 4906

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    RDRLSEI 8
            RDR+SE+
Sbjct: 4602 RDRISEL 4608
>XP_006711870
          Length = 4965

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    RDRLSEI 8
            RDR+SE+
Sbjct: 4661 RDRISEL 4667
>XP_006711869
          Length = 4973

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    RDRLSEI 8
            RDR+SE+
Sbjct: 4669 RDRISEL 4675
>XP_006711868
          Length = 4975

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    RDRLSEI 8
            RDR+SE+
Sbjct: 4671 RDRISEL 4677
>XP_006711867
          Length = 4977

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    RDRLSEI 8
            RDR+SE+
Sbjct: 4673 RDRISEL 4679
>XP_006711866
          Length = 4984

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    RDRLSEI 8
            RDR+SE+
Sbjct: 4680 RDRISEL 4686
>XP_006711865
          Length = 4985

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    RDRLSEI 8
            RDR+SE+
Sbjct: 4681 RDRISEL 4687
>NP_000072
          Length = 3801

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    TRDRLSEIT 9
            TR+++ EIT
Sbjct: 3448 TREQVKEIT 3456
>NP_112503
          Length = 503

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   DRLSEIT 9
           DRL E+T
Sbjct: 173 DRLEEVT 179
>NP_000094
          Length = 503

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   DRLSEIT 9
           DRL E+T
Sbjct: 173 DRLEEVT 179
>NP_689914
          Length = 5058

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    TRDRLSEI 8
            TRD +SE+
Sbjct: 1935 TRDSISEL 1942
>XP_006724601
          Length = 1020

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   DRLSEI 8
           DRLSEI
Sbjct: 786 DRLSEI 791
>XP_006720469
          Length = 401

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  DRLSEIT 9
          DRL E+T
Sbjct: 71 DRLEEVT 77
>XP_005254248
          Length = 503

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   DRLSEIT 9
           DRL E+T
Sbjct: 173 DRLEEVT 179
>XP_005254247
          Length = 503

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   DRLSEIT 9
           DRL E+T
Sbjct: 173 DRLEEVT 179
>XP_006711794
          Length = 3022

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    TRDRLSEIT 9
            TR+++ EIT
Sbjct: 2669 TREQVKEIT 2677
>XP_005273085
          Length = 3755

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    TRDRLSEIT 9
            TR+++ EIT
Sbjct: 3402 TREQVKEIT 3410
>XP_005273084
          Length = 3801

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    TRDRLSEIT 9
            TR+++ EIT
Sbjct: 3448 TREQVKEIT 3456
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.314    0.128    0.317 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 405,769
Number of extensions: 676
Number of successful extensions: 64
Number of sequences better than 10000.0: 64
Number of HSP's gapped: 64
Number of HSP's successfully gapped: 64
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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