Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000305                                                              20     390
XP_006717989                                                           20     390
NP_055811                                                              18    1935
XP_005247296                                                           18    1935
XP_006713604                                                           18    1935
XP_005247295                                                           18    1935
NP_001124432                                                           18    1935
NP_001276324                                                           17    2528
NP_003313                                                              17    2528
NP_813977                                                              17    2528
NP_003311                                                              17    2528
XP_006718366                                                           17    2528
XP_005253166                                                           17    2528
NP_004915                                                              16    5631
NP_001093                                                              16    5631
NP_001123477                                                           16    5631
NP_001123476                                                           16    5631
XP_005259339                                                           16    5631
XP_005259338                                                           16    5631
XP_006723469                                                           16    5631
NP_001136068                                                           16    7355
NP_000908                                                              16    7355
NP_001136067                                                           16    7355
NP_001017962                                                           16    7355
NP_001161710                                                           16    7355
NP_001161709                                                           16    7355
NP_001161708                                                           16    7355
NP_001265273                                                           16    7355
NP_001094                                                              16    7355
NP_001265272                                                           16    7355
NP_006548                                                              16    7355
NP_009298                                                              16    7355
NP_870987                                                              16    7355
NP_005149                                                              16    7355
NP_001161711                                                           16    7355
NP_001124337                                                           16    7355
XP_005251411                                                           16    7355
XP_005251409                                                           16    7355
XP_005251408                                                           16    7355
XP_006716780                                                           16    7355
XP_005245145                                                           16    7355
NP_001129472                                                           16    7355
NP_000375                                                              15    9605
NP_001245300                                                           15    9605
NP_001095                                                              15    9605
NP_001001331                                                           15    9605
NP_065078                                                              15    9605
XP_006718528                                                           15    9605
XP_006713243                                                           15    9605
XP_006713242                                                           15    9605
XP_006713239                                                           15    9605
XP_005265236                                                           15    9605
XP_006713238                                                           15    9605
XP_005265134                                                           15    9605
XP_005265135                                                           15    9605
XP_005265133                                                           15    9605
>NP_000305
          Length = 403

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TRDKKGVAI 9
           TRDKKGV I
Sbjct: 160 TRDKKGVTI 168
>XP_006717989
          Length = 388

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TRDKKGVAI 9
           TRDKKGV I
Sbjct: 145 TRDKKGVTI 153
>NP_055811
          Length = 1655

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    RDKKGVAI 9
            RDKKGV +
Sbjct: 1486 RDKKGVTV 1493
>XP_005247296
          Length = 1673

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    RDKKGVAI 9
            RDKKGV +
Sbjct: 1504 RDKKGVTV 1511
>XP_006713604
          Length = 1685

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    RDKKGVAI 9
            RDKKGV +
Sbjct: 1516 RDKKGVTV 1523
>XP_005247295
          Length = 1705

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    RDKKGVAI 9
            RDKKGV +
Sbjct: 1536 RDKKGVTV 1543
>NP_001124432
          Length = 1693

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    RDKKGVAI 9
            RDKKGV +
Sbjct: 1524 RDKKGVTV 1531
>NP_001276324
          Length = 489

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TRDKKGV 7
           TRDKKG+
Sbjct: 257 TRDKKGM 263
>NP_003313
          Length = 542

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TRDKKGV 7
           TRDKKG+
Sbjct: 310 TRDKKGM 316
>NP_813977
          Length = 506

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TRDKKGV 7
           TRDKKG+
Sbjct: 270 TRDKKGM 276
>NP_003311
          Length = 561

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TRDKKGV 7
           TRDKKG+
Sbjct: 325 TRDKKGM 331
>XP_006718366
          Length = 451

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TRDKKGV 7
           TRDKKG+
Sbjct: 312 TRDKKGM 318
>XP_005253166
          Length = 548

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TRDKKGV 7
           TRDKKG+
Sbjct: 312 TRDKKGM 318
>NP_004915
          Length = 911

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRDKKGVA 8
           TRD KG++
Sbjct: 756 TRDAKGIS 763
>NP_001093
          Length = 892

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRDKKGVA 8
           TRD KG++
Sbjct: 737 TRDAKGIS 744
>NP_001123477
          Length = 887

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRDKKGVA 8
           TRD KG++
Sbjct: 737 TRDAKGIS 744
>NP_001123476
          Length = 914

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRDKKGVA 8
           TRD KG++
Sbjct: 737 TRDAKGIS 744
>XP_005259339
          Length = 906

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRDKKGVA 8
           TRD KG++
Sbjct: 756 TRDAKGIS 763
>XP_005259338
          Length = 906

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRDKKGVA 8
           TRD KG++
Sbjct: 756 TRDAKGIS 763
>XP_006723469
          Length = 911

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRDKKGVA 8
           TRD KG++
Sbjct: 756 TRDAKGIS 763
>NP_001136068
          Length = 516

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TRDKKGVAI 9
           T  KKGVA+
Sbjct: 272 TPKKKGVAV 280
>NP_000908
          Length = 534

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TRDKKGVAI 9
           T  KKGVA+
Sbjct: 272 TPKKKGVAV 280
>NP_001136067
          Length = 534

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TRDKKGVAI 9
           T  KKGVA+
Sbjct: 272 TPKKKGVAV 280
>NP_001017962
          Length = 534

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TRDKKGVAI 9
           T  KKGVA+
Sbjct: 272 TPKKKGVAV 280
>NP_001161710
          Length = 1058

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   TRDKKG 6
           TRD+KG
Sbjct: 624 TRDRKG 629
>NP_001161709
          Length = 1079

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   TRDKKG 6
           TRD+KG
Sbjct: 645 TRDRKG 650
>NP_001161708
          Length = 1161

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   TRDKKG 6
           TRD+KG
Sbjct: 624 TRDRKG 629
>NP_001265273
          Length = 686

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TRDKKGV 7
           TRD KG+
Sbjct: 536 TRDAKGI 542
>NP_001094
          Length = 894

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TRDKKGV 7
           TRD KG+
Sbjct: 744 TRDAKGI 750
>NP_001265272
          Length = 894

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TRDKKGV 7
           TRD KG+
Sbjct: 744 TRDAKGI 750
>NP_006548
          Length = 226

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRDKKGVA 8
           T DKKG++
Sbjct: 174 TEDKKGLS 181
>NP_009298
          Length = 1182

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   TRDKKG 6
           TRD+KG
Sbjct: 645 TRDRKG 650
>NP_870987
          Length = 561

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRDKKGVA 8
           T DKKG++
Sbjct: 174 TEDKKGLS 181
>NP_005149
          Length = 1167

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   TRDKKG 6
           TRD+KG
Sbjct: 630 TRDRKG 635
>NP_001161711
          Length = 1043

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   TRDKKG 6
           TRD+KG
Sbjct: 609 TRDRKG 614
>NP_001124337
          Length = 226

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRDKKGVA 8
           T DKKG++
Sbjct: 174 TEDKKGLS 181
>XP_005251411
          Length = 226

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRDKKGVA 8
           T DKKG++
Sbjct: 174 TEDKKGLS 181
>XP_005251409
          Length = 561

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRDKKGVA 8
           T DKKG++
Sbjct: 174 TEDKKGLS 181
>XP_005251408
          Length = 561

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRDKKGVA 8
           T DKKG++
Sbjct: 174 TEDKKGLS 181
>XP_006716780
          Length = 561

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRDKKGVA 8
           T DKKG++
Sbjct: 174 TEDKKGLS 181
>XP_005245145
          Length = 1146

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   TRDKKG 6
           TRD+KG
Sbjct: 609 TRDRKG 614
>NP_001129472
          Length = 1064

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   TRDKKG 6
           TRD+KG
Sbjct: 630 TRDRKG 635
>NP_000375
          Length = 4563

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2    RDKKGVA 8
            +DKKG++
Sbjct: 3992 KDKKGIS 3998
>NP_001245300
          Length = 944

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRDKKGVA 8
           TRD KG++
Sbjct: 794 TRDAKGLS 801
>NP_001095
          Length = 901

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TRDKKGVA 8
           TRD KG++
Sbjct: 751 TRDAKGLS 758
>NP_001001331
          Length = 1243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   RDKKGV 7
           +DKKGV
Sbjct: 299 KDKKGV 304
>NP_065078
          Length = 192

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RDKKGVAI 9
           +DKK VAI
Sbjct: 108 KDKKEVAI 115
>XP_006718528
          Length = 161

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   TRDKKG 6
           TRDK+G
Sbjct: 146 TRDKQG 151
>XP_006713243
          Length = 1199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   RDKKGV 7
           +DKKGV
Sbjct: 299 KDKKGV 304
>XP_006713242
          Length = 1205

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   RDKKGV 7
           +DKKGV
Sbjct: 299 KDKKGV 304
>XP_006713239
          Length = 1243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   RDKKGV 7
           +DKKGV
Sbjct: 299 KDKKGV 304
>XP_005265236
          Length = 1243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   RDKKGV 7
           +DKKGV
Sbjct: 299 KDKKGV 304
>XP_006713238
          Length = 1243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   RDKKGV 7
           +DKKGV
Sbjct: 299 KDKKGV 304
>XP_005265134
          Length = 192

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RDKKGVAI 9
           +DKK VAI
Sbjct: 108 KDKKEVAI 115
>XP_005265135
          Length = 192

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RDKKGVAI 9
           +DKK VAI
Sbjct: 108 KDKKEVAI 115
>XP_005265133
          Length = 192

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RDKKGVAI 9
           +DKK VAI
Sbjct: 108 KDKKEVAI 115
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.315    0.134    0.352 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 538,736
Number of extensions: 774
Number of successful extensions: 56
Number of sequences better than 10000.0: 56
Number of HSP's gapped: 56
Number of HSP's successfully gapped: 56
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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