Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              17    2528
XP_005262424                                                           17    2528
NP_620129                                                              17    3301
NP_055576                                                              17    4312
NP_055645                                                              16    5631
NP_001286                                                              16    7355
NP_066013                                                              16    7355
XP_006720685                                                           16    7355
XP_005273109                                                           16    7355
NP_620151                                                              16    7355
NP_000085                                                              15    9605
NP_001003698                                                           15    9605
NP_001161816                                                           15    9605
NP_001003699                                                           15    9605
NP_001003700                                                           15    9605
NP_001099038                                                           15    9605
NP_001099037                                                           15    9605
NP_001099036                                                           15    9605
NP_071396                                                              15    9605
XP_006715230                                                           15    9605
XP_006715229                                                           15    9605
XP_005249350                                                           15    9605
XP_005249349                                                           15    9605
XP_005249348                                                           15    9605
XP_005249347                                                           15    9605
XP_005249346                                                           15    9605
XP_006715224                                                           15    9605
XP_005249329                                                           15    9605
XP_006715223                                                           15    9605
XP_006715222                                                           15    9605
XP_005249333                                                           15    9605
XP_006715221                                                           15    9605
XP_006715220                                                           15    9605
XP_005249332                                                           15    9605
XP_006715219                                                           15    9605
XP_006711228                                                           15    9605
>NP_722576
          Length = 3080

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TQYQLTLLV 9
            TQ QLTLLV
Sbjct: 2363 TQDQLTLLV 2371
>XP_005262424
          Length = 2875

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TQYQLTLLV 9
            TQ QLTLLV
Sbjct: 2158 TQDQLTLLV 2166
>NP_620129
          Length = 268

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1  TQYQLTLL 8
          TQY LTLL
Sbjct: 76 TQYLLTLL 83
>NP_055576
          Length = 360

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   TQYQLTLLV 9
           T YQL LLV
Sbjct: 332 THYQLHLLV 340
>NP_055645
          Length = 712

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TQYQLTL 7
           TQ+QLTL
Sbjct: 411 TQWQLTL 417
>NP_001286
          Length = 355

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TQYQLTLLV 9
           T Y LT+L+
Sbjct: 253 TPYNLTILI 261
>NP_066013
          Length = 1250

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QYQLTLLV 9
           QY+LT LV
Sbjct: 701 QYELTQLV 708
>XP_006720685
          Length = 665

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QYQLTLLV 9
           QY+LT LV
Sbjct: 115 QYELTQLV 122
>XP_005273109
          Length = 361

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  QYQLTLLV 9
          QYQLT+ V
Sbjct: 74 QYQLTVQV 81
>NP_620151
          Length = 361

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  QYQLTLLV 9
          QYQLT+ V
Sbjct: 74 QYQLTVQV 81
>NP_000085
          Length = 2944

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   TQYQLTLL 8
           T+YQ+T++
Sbjct: 301 TEYQVTVI 308

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TQYQLTL 7
           T+Y+LTL
Sbjct: 478 TEYRLTL 484
>NP_001003698
          Length = 1687

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TQYQLTL 7
          TQ+QLT+
Sbjct: 77 TQHQLTM 83
>NP_001161816
          Length = 1687

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TQYQLTL 7
          TQ+QLT+
Sbjct: 77 TQHQLTM 83
>NP_001003699
          Length = 1742

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TQYQLTL 7
          TQ+QLT+
Sbjct: 77 TQHQLTM 83
>NP_001003700
          Length = 1476

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TQYQLTL 7
          TQ+QLT+
Sbjct: 77 TQHQLTM 83
>NP_001099038
          Length = 1749

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TQYQLTLLV 9
           T YQ+TL +
Sbjct: 703 TDYQVTLQI 711
>NP_001099037
          Length = 1757

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TQYQLTLLV 9
           T YQ+TL +
Sbjct: 703 TDYQVTLQI 711
>NP_001099036
          Length = 1770

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TQYQLTLLV 9
           T YQ+TL +
Sbjct: 703 TDYQVTLQI 711
>NP_071396
          Length = 1805

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TQYQLTLLV 9
           T YQ+TL +
Sbjct: 703 TDYQVTLQI 711
>XP_006715230
          Length = 1734

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TQYQLTLLV 9
           T YQ+TL +
Sbjct: 632 TDYQVTLQI 640
>XP_006715229
          Length = 1782

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TQYQLTLLV 9
           T YQ+TL +
Sbjct: 680 TDYQVTLQI 688
>XP_005249350
          Length = 1810

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TQYQLTLLV 9
           T YQ+TL +
Sbjct: 743 TDYQVTLQI 751
>XP_005249349
          Length = 1824

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TQYQLTLLV 9
           T YQ+TL +
Sbjct: 743 TDYQVTLQI 751
>XP_005249348
          Length = 1832

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TQYQLTLLV 9
           T YQ+TL +
Sbjct: 743 TDYQVTLQI 751
>XP_005249347
          Length = 1837

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TQYQLTLLV 9
           T YQ+TL +
Sbjct: 743 TDYQVTLQI 751
>XP_005249346
          Length = 1845

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TQYQLTLLV 9
           T YQ+TL +
Sbjct: 743 TDYQVTLQI 751
>XP_006715224
          Length = 1742

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TQYQLTL 7
          TQ+QLT+
Sbjct: 77 TQHQLTM 83
>XP_005249329
          Length = 1742

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TQYQLTL 7
          TQ+QLT+
Sbjct: 77 TQHQLTM 83
>XP_006715223
          Length = 1742

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TQYQLTL 7
          TQ+QLT+
Sbjct: 77 TQHQLTM 83
>XP_006715222
          Length = 1742

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TQYQLTL 7
          TQ+QLT+
Sbjct: 77 TQHQLTM 83
>XP_005249333
          Length = 1742

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TQYQLTL 7
          TQ+QLT+
Sbjct: 77 TQHQLTM 83
>XP_006715221
          Length = 1742

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TQYQLTL 7
          TQ+QLT+
Sbjct: 77 TQHQLTM 83
>XP_006715220
          Length = 1742

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TQYQLTL 7
          TQ+QLT+
Sbjct: 77 TQHQLTM 83
>XP_005249332
          Length = 1742

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TQYQLTL 7
          TQ+QLT+
Sbjct: 77 TQHQLTM 83
>XP_006715219
          Length = 1742

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TQYQLTL 7
          TQ+QLT+
Sbjct: 77 TQHQLTM 83
>XP_006711228
          Length = 344

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  QYQLTLLV 9
          QYQLT+ +
Sbjct: 74 QYQLTVQI 81
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.327    0.136    0.351 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 437,004
Number of extensions: 570
Number of successful extensions: 37
Number of sequences better than 10000.0: 36
Number of HSP's gapped: 37
Number of HSP's successfully gapped: 37
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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