Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              19     869
NP_671714                                                              19     869
XP_006715890                                                           19     869
XP_005250160                                                           19     869
XP_005250159                                                           19     869
NP_071328                                                              17    3301
NP_058544                                                              17    4312
NP_001189788                                                           16    5631
NP_001123513                                                           16    5631
NP_003020                                                              16    5631
NP_001123512                                                           16    5631
NP_892113                                                              16    5631
XP_005259586                                                           16    5631
XP_005245509                                                           16    5631
XP_005245508                                                           16    5631
XP_005245507                                                           16    5631
XP_005245506                                                           16    5631
NP_036567                                                              16    5631
NP_001129947                                                           16    7355
NP_001129946                                                           16    7355
NP_848639                                                              16    7355
NP_001768                                                              16    7355
NP_942088                                                              16    7355
XP_005258911                                                           16    7355
XP_005258910                                                           16    7355
XP_005247966                                                           16    7355
XP_005247965                                                           16    7355
XP_006711604                                                           16    7355
NP_003990                                                              15    9605
NP_036443                                                              15    9605
XP_006717498                                                           15    9605
XP_006717497                                                           15    9605
XP_006714572                                                           15    9605
XP_005248442                                                           15    9605
XP_005248441                                                           15    9605
NP_061993                                                              15    9605
>NP_005742
          Length = 3907

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TQTELTRES 9
            TQTEL RES
Sbjct: 1874 TQTELMRES 1882
>NP_671714
          Length = 3899

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TQTELTRES 9
            TQTEL RES
Sbjct: 1874 TQTELMRES 1882
>XP_006715890
          Length = 3860

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TQTELTRES 9
            TQTEL RES
Sbjct: 1827 TQTELMRES 1835
>XP_005250160
          Length = 3939

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TQTELTRES 9
            TQTEL RES
Sbjct: 1906 TQTELMRES 1914
>XP_005250159
          Length = 3952

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TQTELTRES 9
            TQTEL RES
Sbjct: 1906 TQTELMRES 1914
>NP_071328
          Length = 904

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   TQTELTRES 9
           TQT  TRES
Sbjct: 687 TQTTCTRES 695
>NP_058544
          Length = 594

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TQTELTRES 9
           T+T++TRE+
Sbjct: 176 TRTQITREA 184
>NP_001189788
          Length = 428

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  TQTELTRES 9
          T+T++TRE+
Sbjct: 28 TRTQVTREA 36
>NP_001123513
          Length = 473

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  TQTELTRES 9
          T+T++TRE+
Sbjct: 73 TRTQVTREA 81
>NP_003020
          Length = 474

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  TQTELTRES 9
          T+T++TRE+
Sbjct: 73 TRTQVTREA 81
>NP_001123512
          Length = 584

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TQTELTRES 9
           T+T++TRE+
Sbjct: 183 TRTQVTREA 191
>NP_892113
          Length = 583

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TQTELTRES 9
           T+T++TRE+
Sbjct: 183 TRTQVTREA 191
>XP_005259586
          Length = 425

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  TQTELTRES 9
          T+T++TRE+
Sbjct: 17 TRTQVTREA 25
>XP_005245509
          Length = 456

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  TQTELTRES 9
          T+T++TRE+
Sbjct: 73 TRTQVTREA 81
>XP_005245508
          Length = 488

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  TQTELTRES 9
          T+T++TRE+
Sbjct: 73 TRTQVTREA 81
>XP_005245507
          Length = 566

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TQTELTRES 9
           T+T++TRE+
Sbjct: 183 TRTQVTREA 191
>XP_005245506
          Length = 598

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TQTELTRES 9
           T+T++TRE+
Sbjct: 183 TRTQVTREA 191
>NP_036567
          Length = 582

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TQTELTRES 9
           T+T++TRE+
Sbjct: 174 TRTQVTREA 182
>NP_001129947
          Length = 251

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  TQTELTRES 9
          T  E+TRES
Sbjct: 41 TAKEMTRES 49
>NP_001129946
          Length = 290

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  TQTELTRES 9
          T  E+TRES
Sbjct: 80 TAKEMTRES 88
>NP_848639
          Length = 836

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   QTELTR 7
           QTELTR
Sbjct: 453 QTELTR 458
>NP_001768
          Length = 323

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TELTRE 8
           TELTRE
Sbjct: 117 TELTRE 122
>NP_942088
          Length = 305

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TELTRE 8
           TELTRE
Sbjct: 117 TELTRE 122
>XP_005258911
          Length = 798

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   QTELTR 7
           QTELTR
Sbjct: 415 QTELTR 420
>XP_005258910
          Length = 810

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   QTELTR 7
           QTELTR
Sbjct: 427 QTELTR 432
>XP_005247966
          Length = 293

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TELTRE 8
           TELTRE
Sbjct: 117 TELTRE 122
>XP_005247965
          Length = 312

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TELTRE 8
           TELTRE
Sbjct: 117 TELTRE 122
>XP_006711604
          Length = 355

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TQTELTRES 9
           T  E+TRES
Sbjct: 145 TAKEMTRES 153
>NP_003990
          Length = 979

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TQTELTR 7
           T+TELT+
Sbjct: 828 TETELTK 834
>NP_036443
          Length = 393

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TQTELTRES 9
           T TEL+RE+
Sbjct: 190 TFTELSREN 198
>XP_006717498
          Length = 288

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TQTELTRES 9
          T TEL+RE+
Sbjct: 84 TFTELSREN 92
>XP_006717497
          Length = 394

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TQTELTRES 9
           T TEL+RE+
Sbjct: 190 TFTELSREN 198
>XP_006714572
          Length = 647

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TQTELTR 7
           T+TELT+
Sbjct: 496 TETELTK 502
>XP_005248442
          Length = 980

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TQTELTR 7
           T+TELT+
Sbjct: 829 TETELTK 835
>XP_005248441
          Length = 980

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TQTELTR 7
           T+TELT+
Sbjct: 829 TETELTK 835
>NP_061993
          Length = 801

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TQTELTRES 9
           T+T L RES
Sbjct: 406 TETPLDRES 414
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.288    0.101    0.228 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 407,204
Number of extensions: 667
Number of successful extensions: 36
Number of sequences better than 10000.0: 36
Number of HSP's gapped: 36
Number of HSP's successfully gapped: 36
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.9 bits)
S2: 28 (15.4 bits)

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