Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              19     665
NP_671714                                                              19     665
XP_006715890                                                           19     665
XP_005250160                                                           19     665
XP_005250159                                                           19     665
XP_006721522                                                           16    5631
NP_653282                                                              16    5631
NP_001151733                                                           16    5631
NP_065782                                                              16    7355
NP_001229341                                                           16    7355
NP_588616                                                              16    7355
NP_001137160                                                           16    7355
NP_002430                                                              16    7355
NP_003269                                                              16    7355
NP_001245240                                                           16    7355
XP_005254204                                                           16    7355
XP_005254202                                                           16    7355
XP_005254201                                                           16    7355
XP_005265483                                                           16    7355
NP_001360                                                              15    9605
NP_689590                                                              15    9605
NP_113584                                                              15    9605
NP_003743                                                              15    9605
NP_001254503                                                           15    9605
NP_001273407                                                           15    9605
NP_001032897                                                           15    9605
NP_001186071                                                           15    9605
NP_001093131                                                           15    9605
XP_005262029                                                           15    9605
XP_005262028                                                           15    9605
XP_005262026                                                           15    9605
XP_006724637                                                           15    9605
XP_005262025                                                           15    9605
XP_005262024                                                           15    9605
XP_005262023                                                           15    9605
XP_005262022                                                           15    9605
XP_005255592                                                           15    9605
XP_005248319                                                           15    9605
NP_116558                                                              15    9605
>NP_005742
          Length = 3907

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TQTELMHES 9
            TQTELM ES
Sbjct: 1874 TQTELMRES 1882
>NP_671714
          Length = 3899

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TQTELMHES 9
            TQTELM ES
Sbjct: 1874 TQTELMRES 1882
>XP_006715890
          Length = 3860

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TQTELMHES 9
            TQTELM ES
Sbjct: 1827 TQTELMRES 1835
>XP_005250160
          Length = 3939

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TQTELMHES 9
            TQTELM ES
Sbjct: 1906 TQTELMRES 1914
>XP_005250159
          Length = 3952

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TQTELMHES 9
            TQTELM ES
Sbjct: 1906 TQTELMRES 1914
>XP_006721522
          Length = 316

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2  QTELMHES 9
          +TE+MH++
Sbjct: 50 ETEIMHQT 57
>NP_653282
          Length = 316

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2  QTELMHES 9
          +TE+MH++
Sbjct: 50 ETEIMHQT 57
>NP_001151733
          Length = 242

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2  QTELMHES 9
          +TE+MH++
Sbjct: 50 ETEIMHQT 57
>NP_065782
          Length = 719

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   QTELMHES 9
           QT++MH++
Sbjct: 151 QTDVMHQN 158
>NP_001229341
          Length = 701

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   QTELMHES 9
           QT++MH++
Sbjct: 151 QTDVMHQN 158
>NP_588616
          Length = 971

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   TELMHES 9
           TEL+H+S
Sbjct: 899 TELIHQS 905
>NP_001137160
          Length = 1054

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   TELMHES 9
           TEL+H+S
Sbjct: 982 TELIHQS 988
>NP_002430
          Length = 1137

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    TQTELMH 7
            TQT L+H
Sbjct: 1131 TQTSLLH 1137
>NP_003269
          Length = 202

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  TQTELMHES 9
          TQT+  HE+
Sbjct: 86 TQTKTFHEA 94
>NP_001245240
          Length = 524

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   TQTELMHE 8
           +QT+++HE
Sbjct: 250 SQTQVLHE 257
>XP_005254204
          Length = 971

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   TELMHES 9
           TEL+H+S
Sbjct: 899 TELIHQS 905
>XP_005254202
          Length = 971

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   TELMHES 9
           TEL+H+S
Sbjct: 899 TELIHQS 905
>XP_005254201
          Length = 1037

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   TELMHES 9
           TEL+H+S
Sbjct: 965 TELIHQS 971
>XP_005265483
          Length = 160

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  TQTELMHES 9
          TQT+  HE+
Sbjct: 44 TQTKTFHEA 52
>NP_001360
          Length = 4624

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    QTELMHES 9
            +TEL+H++
Sbjct: 4118 ETELVHDA 4125
>NP_689590
          Length = 546

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  TQTELMHE 8
          T+T+ MH+
Sbjct: 44 TETQTMHQ 51
>NP_113584
          Length = 4374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    QTELMHE 8
            Q +LMHE
Sbjct: 3104 QRQLMHE 3110
>NP_003743
          Length = 913

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TQTELMHES 9
           TQT +MH +
Sbjct: 839 TQTVVMHRT 847
>NP_001254503
          Length = 913

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TQTELMHES 9
           TQT +MH +
Sbjct: 839 TQTVVMHRT 847
>NP_001273407
          Length = 903

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TQTELMHES 9
           TQT +MH +
Sbjct: 829 TQTVVMHRT 837
>NP_001032897
          Length = 913

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TQTELMHES 9
           TQT +MH +
Sbjct: 839 TQTVVMHRT 847
>NP_001186071
          Length = 913

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TQTELMHES 9
           TQT +MH +
Sbjct: 839 TQTVVMHRT 847
>NP_001093131
          Length = 914

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TQTELMHES 9
           TQT +MH +
Sbjct: 840 TQTVVMHRT 848
>XP_005262029
          Length = 4240

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    QTELMHE 8
            Q +LMHE
Sbjct: 2970 QRQLMHE 2976
>XP_005262028
          Length = 4341

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    QTELMHE 8
            Q +LMHE
Sbjct: 3071 QRQLMHE 3077
>XP_005262026
          Length = 4359

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    QTELMHE 8
            Q +LMHE
Sbjct: 3104 QRQLMHE 3110
>XP_006724637
          Length = 4365

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    QTELMHE 8
            Q +LMHE
Sbjct: 3095 QRQLMHE 3101
>XP_005262025
          Length = 4373

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    QTELMHE 8
            Q +LMHE
Sbjct: 3103 QRQLMHE 3109
>XP_005262024
          Length = 4374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    QTELMHE 8
            Q +LMHE
Sbjct: 3104 QRQLMHE 3110
>XP_005262023
          Length = 4374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    QTELMHE 8
            Q +LMHE
Sbjct: 3104 QRQLMHE 3110
>XP_005262022
          Length = 4374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    QTELMHE 8
            Q +LMHE
Sbjct: 3104 QRQLMHE 3110
>XP_005255592
          Length = 914

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TQTELMHES 9
           TQT +MH +
Sbjct: 840 TQTVVMHRT 848
>XP_005248319
          Length = 4609

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    QTELMHES 9
            +TEL+H++
Sbjct: 4103 ETELVHDA 4110
>NP_116558
          Length = 275

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   QTELMHE 8
           QT+L HE
Sbjct: 260 QTQLSHE 266
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.298    0.106    0.264 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 597,584
Number of extensions: 835
Number of successful extensions: 39
Number of sequences better than 10000.0: 39
Number of HSP's gapped: 39
Number of HSP's successfully gapped: 39
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package