Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004351                                                              21     229
NP_001106995                                                           18    1935
XP_005247216                                                           18    1935
NP_004791                                                              17    2528
NP_060625                                                              17    3301
XP_006713748                                                           17    3301
XP_005247632                                                           17    3301
NP_001098117                                                           17    3301
NP_056414                                                              17    4312
NP_001186846                                                           17    4312
NP_001186848                                                           17    4312
XP_005248785                                                           17    4312
XP_006715567                                                           17    4312
NP_001186847                                                           17    4312
NP_056224                                                              16    5631
NP_056986                                                              16    5631
NP_001269802                                                           16    5631
XP_005251017                                                           16    5631
XP_005251016                                                           16    5631
XP_005251014                                                           16    5631
XP_005251013                                                           16    5631
NP_055318                                                              16    7355
NP_001431                                                              16    7355
XP_005276395                                                           16    7355
XP_006726551                                                           16    7355
XP_005256701                                                           16    7355
XP_005256700                                                           16    7355
XP_006719406                                                           16    7355
XP_003403594                                                           16    7355
XP_005273756                                                           16    7355
XP_006716365                                                           16    7355
NP_065908                                                              16    7355
NP_004131                                                              16    7355
NP_443723                                                              15    9605
NP_001517                                                              15    9605
NP_001138501                                                           15    9605
NP_689612                                                              15    9605
NP_001107859                                                           15    9605
NP_001092275                                                           15    9605
NP_078881                                                              15    9605
NP_002971                                                              15    9605
NP_001012421                                                           15    9605
NP_872412                                                              15    9605
NP_001012419                                                           15    9605
NP_055381                                                              15    9605
XP_006722388                                                           15    9605
XP_006717590                                                           15    9605
XP_005272589                                                           15    9605
XP_005272582                                                           15    9605
XP_005272576                                                           15    9605
XP_006715137                                                           15    9605
XP_005263273                                                           15    9605
XP_005263272                                                           15    9605
XP_005263271                                                           15    9605
XP_006714269                                                           15    9605
XP_005262797                                                           15    9605
XP_005262794                                                           15    9605
XP_005263787                                                           15    9605
XP_006712747                                                           15    9605
XP_006712746                                                           15    9605
XP_005270847                                                           15    9605
NP_002539                                                              15    9605
NP_001516                                                              15    9605
NP_115626                                                              15    9605
>NP_004351
          Length = 882

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   QIHFLVYA 9
           QIHFLVYA
Sbjct: 95  QIHFLVYA 102
>NP_001106995
          Length = 678

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   QIHFLVY 8
           ++HFLVY
Sbjct: 243 EVHFLVY 249
>XP_005247216
          Length = 609

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   QIHFLVY 8
           ++HFLVY
Sbjct: 243 EVHFLVY 249
>NP_004791
          Length = 663

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TQIHFLVYA 9
           T ++FL+YA
Sbjct: 599 TAVYFLIYA 607
>NP_060625
          Length = 310

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TQIHFLVY 8
           T IHF++Y
Sbjct: 190 TVIHFVIY 197
>XP_006713748
          Length = 188

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  TQIHFLVY 8
          T IHF++Y
Sbjct: 67 TVIHFVIY 74
>XP_005247632
          Length = 204

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  TQIHFLVY 8
          T IHF++Y
Sbjct: 83 TVIHFVIY 90
>NP_001098117
          Length = 311

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TQIHFLVY 8
           T IHF++Y
Sbjct: 190 TVIHFVIY 197
>NP_056414
          Length = 542

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   QIHFLVY 8
           Q+H++VY
Sbjct: 161 QLHYMVY 167
>NP_001186846
          Length = 570

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   QIHFLVY 8
           Q+H++VY
Sbjct: 189 QLHYMVY 195
>NP_001186848
          Length = 566

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   QIHFLVY 8
           Q+H++VY
Sbjct: 161 QLHYMVY 167
>XP_005248785
          Length = 461

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  QIHFLVY 8
          Q+H++VY
Sbjct: 80 QLHYMVY 86
>XP_006715567
          Length = 570

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   QIHFLVY 8
           Q+H++VY
Sbjct: 189 QLHYMVY 195
>NP_001186847
          Length = 441

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  QIHFLVY 8
          Q+H++VY
Sbjct: 80 QLHYMVY 86
>NP_056224
          Length = 3123

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    TQIHFLV 7
            T +HFLV
Sbjct: 1224 TMVHFLV 1230
>NP_056986
          Length = 2799

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1 TQIHFLVY 8
         T IHF+V+
Sbjct: 2 TSIHFVVH 9
>NP_001269802
          Length = 2798

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1 TQIHFLVY 8
         T IHF+V+
Sbjct: 2 TSIHFVVH 9
>XP_005251017
          Length = 2792

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1 TQIHFLVY 8
         T IHF+V+
Sbjct: 2 TSIHFVVH 9
>XP_005251016
          Length = 2795

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1 TQIHFLVY 8
         T IHF+V+
Sbjct: 2 TSIHFVVH 9
>XP_005251014
          Length = 2800

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1 TQIHFLVY 8
         T IHF+V+
Sbjct: 2 TSIHFVVH 9
>XP_005251013
          Length = 2801

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1 TQIHFLVY 8
         T IHF+V+
Sbjct: 2 TSIHFVVH 9
>NP_055318
          Length = 2785

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3    IHFLVY 8
            +HFL+Y
Sbjct: 1878 VHFLLY 1883
>NP_001431
          Length = 919

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   TQIHFLV 7
           T++HFL+
Sbjct: 491 TEVHFLL 497
>XP_005276395
          Length = 159

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   TQIHFLVYA 9
           T +H+ VY+
Sbjct: 140 TAVHYAVYS 148
>XP_006726551
          Length = 159

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   TQIHFLVYA 9
           T +H+ VY+
Sbjct: 140 TAVHYAVYS 148
>XP_005256701
          Length = 1062

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  TQIHFL 6
          TQ+HFL
Sbjct: 79 TQMHFL 84
>XP_005256700
          Length = 1063

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  TQIHFL 6
          TQ+HFL
Sbjct: 79 TQMHFL 84
>XP_006719406
          Length = 2380

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3    IHFLVY 8
            +HFL+Y
Sbjct: 1878 VHFLLY 1883
>XP_003403594
          Length = 159

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   TQIHFLVYA 9
           T +H+ VY+
Sbjct: 140 TAVHYAVYS 148
>XP_005273756
          Length = 351

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   TQIHFLVYA 9
           T +H+ VY+
Sbjct: 332 TAVHYAVYS 340
>XP_006716365
          Length = 919

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   TQIHFLV 7
           T++HFL+
Sbjct: 491 TEVHFLL 497
>NP_065908
          Length = 973

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   TQIHFLV 7
           TQ HFL+
Sbjct: 331 TQFHFLL 337
>NP_004131
          Length = 1064

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  TQIHFL 6
          TQ+HFL
Sbjct: 79 TQMHFL 84
>NP_443723
          Length = 1341

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  TQIHFLVYA 9
          T +H+ VY+
Sbjct: 85 TALHYAVYS 93
>NP_001517
          Length = 444

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   HFLVYA 9
           H+LVYA
Sbjct: 350 HWLVYA 355
>NP_001138501
          Length = 1392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   TQIHFLVYA 9
           T +H+ VY+
Sbjct: 141 TALHYAVYS 149
>NP_689612
          Length = 130

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   QIHFLV 7
           QIHFL+
Sbjct: 96  QIHFLL 101
>NP_001107859
          Length = 418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3  IHFLVY 8
          +HFLV+
Sbjct: 39 VHFLVF 44
>NP_001092275
          Length = 823

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   TQIHFLVYA 9
           T +H+ VY+
Sbjct: 135 TALHYAVYS 143
>NP_078881
          Length = 786

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   IHFLVY 8
           IHFLV+
Sbjct: 495 IHFLVH 500
>NP_002971
          Length = 440

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   IHFLVYA 9
           IH++V+A
Sbjct: 353 IHYIVFA 359
>NP_001012421
          Length = 823

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   TQIHFLVYA 9
           T +H+ VY+
Sbjct: 135 TALHYAVYS 143
>NP_872412
          Length = 421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3  IHFLVY 8
          +HFLV+
Sbjct: 39 VHFLVF 44
>NP_001012419
          Length = 823

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   TQIHFLVYA 9
           T +H+ VY+
Sbjct: 135 TALHYAVYS 143
>NP_055381
          Length = 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TQIHFLV 7
           TQ++FLV
Sbjct: 99  TQLYFLV 105
>XP_006722388
          Length = 1511

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   TQIHFLVYA 9
           T +H+ VY+
Sbjct: 141 TALHYAVYS 149
>XP_006717590
          Length = 1397

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   TQIHFLVYA 9
           T +H+ VY+
Sbjct: 141 TALHYAVYS 149
>XP_005272589
          Length = 822

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   TQIHFLVYA 9
           T +H+ VY+
Sbjct: 135 TALHYAVYS 143
>XP_005272582
          Length = 822

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   TQIHFLVYA 9
           T +H+ VY+
Sbjct: 135 TALHYAVYS 143
>XP_005272576
          Length = 822

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   TQIHFLVYA 9
           T +H+ VY+
Sbjct: 135 TALHYAVYS 143
>XP_006715137
          Length = 444

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   HFLVYA 9
           H+LVYA
Sbjct: 350 HWLVYA 355
>XP_005263273
          Length = 694

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   IHFLVY 8
           IHFLV+
Sbjct: 403 IHFLVH 408
>XP_005263272
          Length = 735

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   IHFLVY 8
           IHFLV+
Sbjct: 495 IHFLVH 500
>XP_005263271
          Length = 762

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   IHFLVY 8
           IHFLV+
Sbjct: 471 IHFLVH 476
>XP_006714269
          Length = 387

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3  IHFLVY 8
          +HFLV+
Sbjct: 21 VHFLVF 26
>XP_005262797
          Length = 130

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   QIHFLV 7
           QIHFL+
Sbjct: 96  QIHFLL 101
>XP_005262794
          Length = 130

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   QIHFLV 7
           QIHFL+
Sbjct: 96  QIHFLL 101
>XP_005263787
          Length = 262

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   IHFLVYA 9
           IH++V+A
Sbjct: 175 IHYIVFA 181
>XP_006712747
          Length = 290

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   IHFLVYA 9
           IH++V+A
Sbjct: 198 IHYIVFA 204
>XP_006712746
          Length = 445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   IHFLVYA 9
           IH++V+A
Sbjct: 353 IHYIVFA 359
>XP_005270847
          Length = 283

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   HFLVYA 9
           H+LVYA
Sbjct: 258 HWLVYA 263
>NP_002539
          Length = 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TQIHFLV 7
           TQ++FLV
Sbjct: 99  TQLYFLV 105
>NP_001516
          Length = 425

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   HFLVYA 9
           H+LVYA
Sbjct: 344 HWLVYA 349
>NP_115626
          Length = 823

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   TQIHFLVYA 9
           T +H+ VY+
Sbjct: 135 TALHYAVYS 143
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.343    0.146    0.452 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 525,513
Number of extensions: 908
Number of successful extensions: 64
Number of sequences better than 10000.0: 64
Number of HSP's gapped: 64
Number of HSP's successfully gapped: 64
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.6 bits)
S2: 28 (15.4 bits)

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