Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001895                                                              20     390
NP_001091680                                                           20     390
NP_001091679                                                           20     390
XP_006713048                                                           20     390
XP_005264943                                                           20     390
NP_056082                                                              17    4312
NP_005015                                                              17    4312
XP_006719362                                                           17    4312
NP_001275950                                                           16    5631
NP_001275949                                                           16    5631
NP_056980                                                              16    5631
NP_659464                                                              16    5631
NP_002171                                                              16    5631
XP_005274034                                                           16    5631
XP_005274033                                                           16    5631
XP_005248961                                                           16    5631
XP_005265273                                                           16    5631
NP_001035203                                                           16    7355
NP_074035                                                              16    7355
NP_001035202                                                           16    7355
NP_002465                                                              16    7355
NP_001028774                                                           16    7355
NP_071353                                                              16    7355
XP_005257627                                                           16    7355
NP_006408                                                              16    7355
NP_056048                                                              16    7355
NP_660288                                                              15    9605
NP_005199                                                              15    9605
NP_036433                                                              15    9605
NP_116313                                                              15    9605
NP_005656                                                              15    9605
NP_001265219                                                           15    9605
NP_001265216                                                           15    9605
NP_001265213                                                           15    9605
NP_060185                                                              15    9605
NP_078920                                                              15    9605
NP_001153416                                                           15    9605
XP_005272515                                                           15    9605
XP_005250782                                                           15    9605
XP_006710953                                                           15    9605
XP_005271239                                                           15    9605
XP_006710952                                                           15    9605
XP_006710951                                                           15    9605
XP_006710950                                                           15    9605
XP_006710949                                                           15    9605
XP_006710948                                                           15    9605
XP_006710947                                                           15    9605
XP_005271237                                                           15    9605
XP_005271236                                                           15    9605
>NP_001895
          Length = 781

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  TQADLMELE 9
          TQADLMEL+
Sbjct: 3  TQADLMELD 11
>NP_001091680
          Length = 781

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  TQADLMELE 9
          TQADLMEL+
Sbjct: 3  TQADLMELD 11
>NP_001091679
          Length = 781

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  TQADLMELE 9
          TQADLMEL+
Sbjct: 3  TQADLMELD 11
>XP_006713048
          Length = 720

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  TQADLMELE 9
          TQADLMEL+
Sbjct: 3  TQADLMELD 11
>XP_005264943
          Length = 781

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  TQADLMELE 9
          TQADLMEL+
Sbjct: 3  TQADLMELD 11
>NP_056082
          Length = 1486

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   TQADLMEL 8
           TQA+L+EL
Sbjct: 217 TQAELLEL 224
>NP_005015
          Length = 397

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TQADLMEL 8
           T AD+MEL
Sbjct: 277 TSADMMEL 284
>XP_006719362
          Length = 1546

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   TQADLMEL 8
           TQA+L+EL
Sbjct: 277 TQAELLEL 284
>NP_001275950
          Length = 758

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TQADLMELE 9
           T+A+L++LE
Sbjct: 388 TEAELLQLE 396
>NP_001275949
          Length = 797

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TQADLMELE 9
           T+A+L++LE
Sbjct: 388 TEAELLQLE 396
>NP_056980
          Length = 440

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QADLMELE 9
           QA+LME E
Sbjct: 175 QAELMEFE 182
>NP_659464
          Length = 814

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TQADLMELE 9
           T+A+L++LE
Sbjct: 388 TEAELLQLE 396
>NP_002171
          Length = 993

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  QADLMELE 9
          Q DL+ELE
Sbjct: 13 QLDLLELE 20
>XP_005274034
          Length = 508

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  QADLMELE 9
          Q DL+ELE
Sbjct: 13 QLDLLELE 20
>XP_005274033
          Length = 540

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  QADLMELE 9
          Q DL+ELE
Sbjct: 13 QLDLLELE 20
>XP_005248961
          Length = 842

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   TQADLMELE 9
           T+A+L++LE
Sbjct: 388 TEAELLQLE 396
>XP_005265273
          Length = 361

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QADLMELE 9
           QA+LME E
Sbjct: 96  QAELMEFE 103
>NP_001035203
          Length = 1979

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    QADLMELE 9
            +ADLM+L+
Sbjct: 1693 EADLMQLQ 1700
>NP_074035
          Length = 1938

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    QADLMELE 9
            +ADLM+L+
Sbjct: 1686 EADLMQLQ 1693
>NP_001035202
          Length = 1945

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    QADLMELE 9
            +ADLM+L+
Sbjct: 1693 EADLMQLQ 1700
>NP_002465
          Length = 1972

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    QADLMELE 9
            +ADLM+L+
Sbjct: 1686 EADLMQLQ 1693
>NP_001028774
          Length = 1379

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    QADLMELE 9
            QA+L ELE
Sbjct: 1104 QAELQELE 1111
>NP_071353
          Length = 1181

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   TQADLMEL 8
           TQA LMEL
Sbjct: 706 TQAYLMEL 713
>XP_005257627
          Length = 1013

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   TQADLMEL 8
           TQA LMEL
Sbjct: 538 TQAYLMEL 545
>NP_006408
          Length = 444

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   TQADLMELE 9
           T+ DL+E+E
Sbjct: 355 TKGDLIEIE 363
>NP_056048
          Length = 348

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  QADLMELE 9
          QA+L ELE
Sbjct: 73 QAELQELE 80
>NP_660288
          Length = 794

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QADLMELE 9
           QA+LM+L+
Sbjct: 316 QAELMQLD 323
>NP_005199
          Length = 215

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  TQADLMELE 9
          TQA+  ELE
Sbjct: 3  TQAEQQELE 11
>NP_036433
          Length = 1455

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TQADLMEL 8
           TQA+LM L
Sbjct: 599 TQAELMTL 606
>NP_116313
          Length = 446

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  TQADLMELE 9
          TQADL+  E
Sbjct: 3  TQADLVSQE 11
>NP_005656
          Length = 810

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QADLMELE 9
           QA+LM+L+
Sbjct: 364 QAELMQLD 371
>NP_001265219
          Length = 446

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  TQADLMELE 9
          TQADL+  E
Sbjct: 3  TQADLVSQE 11
>NP_001265216
          Length = 446

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  TQADLMELE 9
          TQADL+  E
Sbjct: 3  TQADLVSQE 11
>NP_001265213
          Length = 446

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  TQADLMELE 9
          TQADL+  E
Sbjct: 3  TQADLVSQE 11
>NP_060185
          Length = 131

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  TQADLMELE 9
          TQADL+  E
Sbjct: 3  TQADLVSQE 11
>NP_078920
          Length = 641

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   QADLMEL 8
           QAD MEL
Sbjct: 591 QADAMEL 597
>NP_001153416
          Length = 805

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QADLMELE 9
           QA+LM+L+
Sbjct: 316 QAELMQLD 323
>XP_005272515
          Length = 805

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QADLMELE 9
           QA+LM+L+
Sbjct: 316 QAELMQLD 323
>XP_005250782
          Length = 1441

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TQADLMEL 8
           TQA+LM L
Sbjct: 599 TQAELMTL 606
>XP_006710953
          Length = 689

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QADLMELE 9
           QA+LM+L+
Sbjct: 183 QAELMQLD 190
>XP_005271239
          Length = 781

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QADLMELE 9
           QA+LM+L+
Sbjct: 275 QAELMQLD 282
>XP_006710952
          Length = 782

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QADLMELE 9
           QA+LM+L+
Sbjct: 361 QAELMQLD 368
>XP_006710951
          Length = 783

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QADLMELE 9
           QA+LM+L+
Sbjct: 361 QAELMQLD 368
>XP_006710950
          Length = 807

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QADLMELE 9
           QA+LM+L+
Sbjct: 361 QAELMQLD 368
>XP_006710949
          Length = 814

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QADLMELE 9
           QA+LM+L+
Sbjct: 361 QAELMQLD 368
>XP_006710948
          Length = 818

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QADLMELE 9
           QA+LM+L+
Sbjct: 361 QAELMQLD 368
>XP_006710947
          Length = 818

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QADLMELE 9
           QA+LM+L+
Sbjct: 361 QAELMQLD 368
>XP_005271237
          Length = 826

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QADLMELE 9
           QA+LM+L+
Sbjct: 320 QAELMQLD 327
>XP_005271236
          Length = 867

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QADLMELE 9
           QA+LM+L+
Sbjct: 361 QAELMQLD 368
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.306    0.121    0.287 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 479,262
Number of extensions: 950
Number of successful extensions: 49
Number of sequences better than 10000.0: 49
Number of HSP's gapped: 49
Number of HSP's successfully gapped: 49
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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