Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_115803                                                              20     299
NP_079484                                                              19     869
NP_149126                                                              19     869
NP_001073869                                                           18    1935
XP_006722933                                                           18    1935
XP_006722932                                                           18    1935
XP_006722931                                                           18    1935
XP_006722930                                                           18    1935
XP_005259697                                                           18    1935
XP_006722929                                                           18    1935
NP_003276                                                              17    2528
NP_064504                                                              17    4312
NP_689558                                                              17    4312
NP_078901                                                              17    4312
XP_006721756                                                           17    4312
XP_005257977                                                           17    4312
XP_005250558                                                           17    4312
NP_000612                                                              16    5631
NP_000634                                                              16    7355
NP_000635                                                              16    7355
NP_001007028                                                           16    7355
NP_000636                                                              16    7355
NP_000019                                                              16    7355
NP_000637                                                              16    7355
NP_076984                                                              16    7355
NP_000633                                                              16    7355
NP_653312                                                              16    7355
NP_000867                                                              16    7355
NP_001348                                                              16    7355
NP_001186219                                                           16    7355
NP_005549                                                              16    7355
XP_005274304                                                           16    7355
XP_005270614                                                           16    7355
NP_733831                                                              15    9605
NP_055087                                                              15    9605
NP_001231902                                                           15    9605
NP_001231901                                                           15    9605
NP_849196                                                              15    9605
NP_997237                                                              15    9605
NP_001185967                                                           15    9605
NP_061035                                                              15    9605
NP_001185966                                                           15    9605
NP_001185968                                                           15    9605
NP_775951                                                              15    9605
NP_003864                                                              15    9605
NP_997213                                                              15    9605
NP_057323                                                              15    9605
XP_006723723                                                           15    9605
XP_005259646                                                           15    9605
XP_005259643                                                           15    9605
XP_005256732                                                           15    9605
XP_005254195                                                           15    9605
XP_005254194                                                           15    9605
XP_006718594                                                           15    9605
XP_006717588                                                           15    9605
XP_006717587                                                           15    9605
XP_006717586                                                           15    9605
XP_006717585                                                           15    9605
XP_006717584                                                           15    9605
>NP_115803
          Length = 1156

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TNWSALTSS 9
           TNWSAL SS
Sbjct: 459 TNWSALPSS 467
>NP_079484
          Length = 370

 Score = 18.9 bits (37), Expect =   869
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TNWSALTSS 9
           TNW ++TSS
Sbjct: 181 TNWESVTSS 189
>NP_149126
          Length = 364

 Score = 18.9 bits (37), Expect =   869
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TNWSALTSS 9
           TNW ++TSS
Sbjct: 175 TNWESVTSS 183
>NP_001073869
          Length = 1357

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TNWSALTSS 9
            T+W  LTSS
Sbjct: 1048 TSWGGLTSS 1056
>XP_006722933
          Length = 1240

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TNWSALTSS 9
           T+W  LTSS
Sbjct: 931 TSWGGLTSS 939
>XP_006722932
          Length = 1306

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TNWSALTSS 9
            T+W  LTSS
Sbjct: 997  TSWGGLTSS 1005
>XP_006722931
          Length = 1371

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TNWSALTSS 9
            T+W  LTSS
Sbjct: 1062 TSWGGLTSS 1070
>XP_006722930
          Length = 1372

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TNWSALTSS 9
            T+W  LTSS
Sbjct: 1063 TSWGGLTSS 1071
>XP_005259697
          Length = 1372

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TNWSALTSS 9
            T+W  LTSS
Sbjct: 1063 TSWGGLTSS 1071
>XP_006722929
          Length = 1372

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TNWSALTSS 9
            T+W  LTSS
Sbjct: 1063 TSWGGLTSS 1071
>NP_003276
          Length = 1358

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    TNWSALTSS 9
            T WS++TS+
Sbjct: 1115 TTWSSITST 1123
>NP_064504
          Length = 902

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   NWSALTS 8
           NW +LTS
Sbjct: 358 NWKSLTS 364
>NP_689558
          Length = 626

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TNWSALTSS 9
           T W ALT+S
Sbjct: 527 TIWEALTNS 535
>NP_078901
          Length = 699

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   NWSALTS 8
           NW +LTS
Sbjct: 358 NWKSLTS 364
>XP_006721756
          Length = 505

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TNWSALTSS 9
           T W ALT+S
Sbjct: 406 TIWEALTNS 414
>XP_005257977
          Length = 637

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TNWSALTSS 9
           T W ALT+S
Sbjct: 538 TIWEALTNS 546
>XP_005250558
          Length = 1024

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   NWSALTS 8
           NW +LTS
Sbjct: 358 NWKSLTS 364
>NP_000612
          Length = 471

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  NWSALTSS 9
          NWSAL ++
Sbjct: 75 NWSALLTA 82
>NP_000634
          Length = 1532

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   NWSAL 6
           NWSAL
Sbjct: 927 NWSAL 931
>NP_000635
          Length = 1532

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   NWSAL 6
           NWSAL
Sbjct: 927 NWSAL 931
>NP_001007028
          Length = 467

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  NWSALTSS 9
          NW A+T S
Sbjct: 42 NWLAITHS 49
>NP_000636
          Length = 1515

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   NWSAL 6
           NWSAL
Sbjct: 910 NWSAL 914
>NP_000019
          Length = 1532

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   NWSAL 6
           NWSAL
Sbjct: 927 NWSAL 931
>NP_000637
          Length = 1516

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   NWSAL 6
           NWSAL
Sbjct: 911 NWSAL 915
>NP_076984
          Length = 526

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  NWSALTSS 9
          NW A+T S
Sbjct: 42 NWLAITHS 49
>NP_000633
          Length = 1532

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   NWSAL 6
           NWSAL
Sbjct: 927 NWSAL 931
>NP_653312
          Length = 558

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   WSALTSS 9
           WS +TSS
Sbjct: 446 WSLITSS 452
>NP_000867
          Length = 2491

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2    NWSALTSS 9
            NW A+T +
Sbjct: 1390 NWEAITGT 1397
>NP_001348
          Length = 1270

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TNWSALTSS 9
           +NW+  TSS
Sbjct: 337 SNWNPWTSS 345
>NP_001186219
          Length = 558

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   WSALTSS 9
           WS +TSS
Sbjct: 446 WSLITSS 452
>NP_005549
          Length = 517

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  NWSALTS 8
          +WSAL+S
Sbjct: 7  DWSALSS 13
>XP_005274304
          Length = 517

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  NWSALTSS 9
          NW A+T S
Sbjct: 33 NWLAITHS 40
>XP_005270614
          Length = 1532

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   NWSAL 6
           NWSAL
Sbjct: 927 NWSAL 931
>NP_733831
          Length = 270

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  WSALTSS 9
          WS+ TSS
Sbjct: 13 WSSTTSS 19
>NP_055087
          Length = 1686

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 2   NWSALTS 8
           NW  LTS
Sbjct: 775 NWENLTS 781
>NP_001231902
          Length = 916

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   WSALTS 8
           WS LTS
Sbjct: 666 WSVLTS 671
>NP_001231901
          Length = 917

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   WSALTS 8
           WS LTS
Sbjct: 666 WSVLTS 671
>NP_849196
          Length = 455

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   WSALTS 8
           WSAL+S
Sbjct: 283 WSALSS 288
>NP_997237
          Length = 605

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TNWSALTSS 9
           T W ALT++
Sbjct: 506 TVWEALTNT 514
>NP_001185967
          Length = 464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   WSALTS 8
           WSAL+S
Sbjct: 292 WSALSS 297
>NP_061035
          Length = 459

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   WSALTS 8
           WSAL+S
Sbjct: 287 WSALSS 292
>NP_001185966
          Length = 459

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   WSALTS 8
           WSAL+S
Sbjct: 287 WSALSS 292
>NP_001185968
          Length = 400

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   WSALTS 8
           WSAL+S
Sbjct: 228 WSALSS 233
>NP_775951
          Length = 537

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3   WSALT 7
           WSALT
Sbjct: 458 WSALT 462
>NP_003864
          Length = 923

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   WSALTS 8
           WS LTS
Sbjct: 673 WSVLTS 678
>NP_997213
          Length = 410

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   WSALTSS 9
           WS LTS+
Sbjct: 364 WSELTST 370
>NP_057323
          Length = 3530

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TNWSALTS 8
           ++WSAL S
Sbjct: 655 SHWSALLS 662
>XP_006723723
          Length = 394

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   NWSALTSS 9
           +W ALT+S
Sbjct: 386 SWIALTAS 393
>XP_005259646
          Length = 378

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  TNWSALTS 8
          T W A+TS
Sbjct: 15 TPWPAMTS 22
>XP_005259643
          Length = 567

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  TNWSALTS 8
          T W A+TS
Sbjct: 15 TPWPAMTS 22
>XP_005256732
          Length = 3531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TNWSALTS 8
           ++WSAL S
Sbjct: 655 SHWSALLS 662
>XP_005254195
          Length = 1155

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 2   NWSALTS 8
           NW  LTS
Sbjct: 241 NWENLTS 247
>XP_005254194
          Length = 1689

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 2   NWSALTS 8
           NW  LTS
Sbjct: 775 NWENLTS 781
>XP_006718594
          Length = 518

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   TNWSALTSS 9
           T W ALT++
Sbjct: 419 TVWEALTNT 427
>XP_006717588
          Length = 888

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   WSALTS 8
           WS LTS
Sbjct: 638 WSVLTS 643
>XP_006717587
          Length = 889

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   WSALTS 8
           WS LTS
Sbjct: 638 WSVLTS 643
>XP_006717586
          Length = 906

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   WSALTS 8
           WS LTS
Sbjct: 673 WSVLTS 678
>XP_006717585
          Length = 907

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   WSALTS 8
           WS LTS
Sbjct: 673 WSVLTS 678
>XP_006717584
          Length = 924

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   WSALTS 8
           WS LTS
Sbjct: 673 WSVLTS 678
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.296   0.0982    0.303 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 677,385
Number of extensions: 449
Number of successful extensions: 59
Number of sequences better than 10000.0: 59
Number of HSP's gapped: 59
Number of HSP's successfully gapped: 59
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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