Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001933                                                              17    3301
NP_078966                                                              17    3301
NP_004925                                                              17    3301
NP_001161139                                                           17    3301
NP_997465                                                              17    3301
XP_006714500                                                           17    3301
XP_006714499                                                           17    3301
XP_006714498                                                           17    3301
XP_005248285                                                           17    3301
NP_776160                                                              17    4312
NP_001739                                                              17    4312
NP_001139540                                                           17    4312
NP_001091102                                                           17    4312
XP_006717115                                                           17    4312
XP_005247263                                                           17    4312
NP_001091105                                                           17    4312
NP_001481                                                              17    4312
NP_001091103                                                           17    4312
NP_001091104                                                           17    4312
NP_000544                                                              16    5631
NP_003283                                                              16    5631
NP_002798                                                              16    5631
NP_001177966                                                           16    5631
NP_001274433                                                           16    5631
NP_848642                                                              16    5631
XP_006718913                                                           16    5631
XP_005246870                                                           16    5631
XP_005246869                                                           16    5631
XP_005245528                                                           16    5631
XP_005270859                                                           16    5631
XP_005270858                                                           16    5631
XP_005270856                                                           16    5631
NP_001123917                                                           16    5631
NP_001274432                                                           16    5631
NP_006742                                                              16    5631
NP_002232                                                              16    7355
NP_055458                                                              16    7355
NP_054736                                                              16    7355
NP_001138736                                                           16    7355
NP_722451                                                              15    9605
NP_000211                                                              15    9605
NP_722448                                                              15    9605
NP_722449                                                              15    9605
NP_722450                                                              15    9605
NP_056040                                                              15    9605
NP_079245                                                              15    9605
NP_001165644                                                           15    9605
NP_001186512                                                           15    9605
NP_065855                                                              15    9605
NP_110436                                                              15    9605
NP_060127                                                              15    9605
XP_006719685                                                           15    9605
XP_006719684                                                           15    9605
XP_005251811                                                           15    9605
XP_005251810                                                           15    9605
XP_005251809                                                           15    9605
XP_005251808                                                           15    9605
XP_005251807                                                           15    9605
XP_005251805                                                           15    9605
XP_005251803                                                           15    9605
XP_006717050                                                           15    9605
XP_005251802                                                           15    9605
XP_006717049                                                           15    9605
XP_006717048                                                           15    9605
XP_006717047                                                           15    9605
XP_006717046                                                           15    9605
XP_006717045                                                           15    9605
XP_005246922                                                           15    9605
XP_005264437                                                           15    9605
NP_982261                                                              15    9605
NP_001002243                                                           15    9605
>NP_001933
          Length = 1049

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   TNTGTIEST 9
           TNTG  EST
Sbjct: 502 TNTGRQEST 510
>NP_078966
          Length = 14507

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TNTGTIEST 9
            T+TGTIE +
Sbjct: 1975 TSTGTIEQS 1983
>NP_004925
          Length = 790

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NTGTIEST 9
           NTGTI +T
Sbjct: 436 NTGTIRTT 443
>NP_001161139
          Length = 574

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NTGTIEST 9
           NTGTI +T
Sbjct: 436 NTGTIRTT 443
>NP_997465
          Length = 538

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TNTGTIEST 9
           TN GT+ ST
Sbjct: 135 TNVGTLPST 143
>XP_006714500
          Length = 575

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NTGTIEST 9
           NTGTI +T
Sbjct: 436 NTGTIRTT 443
>XP_006714499
          Length = 575

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NTGTIEST 9
           NTGTI +T
Sbjct: 436 NTGTIRTT 443
>XP_006714498
          Length = 790

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NTGTIEST 9
           NTGTI +T
Sbjct: 436 NTGTIRTT 443
>XP_005248285
          Length = 790

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NTGTIEST 9
           NTGTI +T
Sbjct: 436 NTGTIRTT 443
>NP_776160
          Length = 244

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  TGTIEST 9
          TGTIE+T
Sbjct: 24 TGTIETT 30
>NP_001739
          Length = 700

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   NTGTIE 7
           NTGTIE
Sbjct: 683 NTGTIE 688
>NP_001139540
          Length = 622

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   NTGTIE 7
           NTGTIE
Sbjct: 605 NTGTIE 610
>NP_001091102
          Length = 428

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TNTGTIE 7
           TNTGT++
Sbjct: 267 TNTGTVK 273
>XP_006717115
          Length = 428

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TNTGTIE 7
           TNTGT++
Sbjct: 267 TNTGTVK 273
>XP_005247263
          Length = 334

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  TGTIEST 9
          TGTIE+T
Sbjct: 91 TGTIETT 97
>NP_001091105
          Length = 428

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TNTGTIE 7
           TNTGT++
Sbjct: 267 TNTGTVK 273
>NP_001481
          Length = 428

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TNTGTIE 7
           TNTGT++
Sbjct: 267 TNTGTVK 273
>NP_001091103
          Length = 428

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TNTGTIE 7
           TNTGT++
Sbjct: 267 TNTGTVK 273
>NP_001091104
          Length = 428

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TNTGTIE 7
           TNTGT++
Sbjct: 267 TNTGTVK 273
>NP_000544
          Length = 1432

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   NTGTIEST 9
           N+GT+E T
Sbjct: 483 NSGTVEPT 490
>NP_003283
          Length = 2363

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    TNTGTIEST 9
            T+TGT+ +T
Sbjct: 2246 TSTGTLSTT 2254
>NP_002798
          Length = 953

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   TNTGTI 6
           TNTGT+
Sbjct: 282 TNTGTV 287
>NP_001177966
          Length = 922

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   TNTGTI 6
           TNTGT+
Sbjct: 282 TNTGTV 287
>NP_001274433
          Length = 1084

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NTGTIEST 9
           NTGT +ST
Sbjct: 451 NTGTKQST 458
>NP_848642
          Length = 179

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TNTGTIE 7
          T+TGT+E
Sbjct: 77 TDTGTVE 83
>XP_006718913
          Length = 553

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  TNTGTIEST 9
          T+ G+IEST
Sbjct: 6  TDLGSIEST 14
>XP_005246870
          Length = 1252

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NTGTIEST 9
           NTGT +ST
Sbjct: 604 NTGTKQST 611
>XP_005246869
          Length = 1255

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NTGTIEST 9
           NTGT +ST
Sbjct: 604 NTGTKQST 611
>XP_005245528
          Length = 2439

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    TNTGTIEST 9
            T+TGT+ +T
Sbjct: 2322 TSTGTLSTT 2330
>XP_005270859
          Length = 141

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TNTGTIE 7
          T+TGT+E
Sbjct: 70 TDTGTVE 76
>XP_005270858
          Length = 148

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TNTGTIE 7
          T+TGT+E
Sbjct: 77 TDTGTVE 83
>XP_005270856
          Length = 172

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  TNTGTIE 7
          T+TGT+E
Sbjct: 70 TDTGTVE 76
>NP_001123917
          Length = 1259

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NTGTIEST 9
           NTGT +ST
Sbjct: 604 NTGTKQST 611
>NP_001274432
          Length = 1237

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NTGTIEST 9
           NTGT +ST
Sbjct: 604 NTGTKQST 611
>NP_006742
          Length = 1256

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NTGTIEST 9
           NTGT +ST
Sbjct: 604 NTGTKQST 611
>NP_002232
          Length = 379

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   TGTIEST 9
           +GT+EST
Sbjct: 284 SGTVEST 290
>NP_055458
          Length = 1163

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    TNTGTIES 8
            +NTGT+++
Sbjct: 1149 SNTGTVQT 1156
>NP_054736
          Length = 125

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  NTGTIEST 9
          NTG ++ST
Sbjct: 15 NTGGVQST 22
>NP_001138736
          Length = 95

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  NTGTIEST 9
          NTG ++ST
Sbjct: 15 NTGGVQST 22
>NP_722451
          Length = 372

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   GTIEST 9
           GT+EST
Sbjct: 280 GTVEST 285
>NP_000211
          Length = 391

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   GTIEST 9
           GT+EST
Sbjct: 299 GTVEST 304
>NP_722448
          Length = 372

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   GTIEST 9
           GT+EST
Sbjct: 280 GTVEST 285
>NP_722449
          Length = 389

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   GTIEST 9
           GT+EST
Sbjct: 297 GTVEST 302
>NP_722450
          Length = 372

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   GTIEST 9
           GT+EST
Sbjct: 280 GTVEST 285
>NP_056040
          Length = 3088

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    TNTGTIE 7
            T+TGTI+
Sbjct: 2311 TSTGTID 2317
>NP_079245
          Length = 585

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   TNTGTIES 8
           T  GT+ES
Sbjct: 138 TKNGTVES 145
>NP_001165644
          Length = 585

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   TNTGTIES 8
           T  GT+ES
Sbjct: 138 TKNGTVES 145
>NP_001186512
          Length = 444

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   TGTIEST 9
           TG +EST
Sbjct: 332 TGAVEST 338
>NP_065855
          Length = 444

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   TGTIEST 9
           TG +EST
Sbjct: 332 TGAVEST 338
>NP_110436
          Length = 543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   TNTGTIES 8
           T  GT+ES
Sbjct: 139 TKNGTVES 146
>NP_060127
          Length = 909

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   NTGTIES 8
           N GT+ES
Sbjct: 143 NVGTLES 149
>XP_006719685
          Length = 272

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   TNTGTIES 8
           T  GT+ES
Sbjct: 139 TKNGTVES 146
>XP_006719684
          Length = 543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   TNTGTIES 8
           T  GT+ES
Sbjct: 139 TKNGTVES 146
>XP_005251811
          Length = 3060

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    TNTGTIE 7
            T+TGTI+
Sbjct: 2311 TSTGTID 2317
>XP_005251810
          Length = 3062

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    TNTGTIE 7
            T+TGTI+
Sbjct: 2311 TSTGTID 2317
>XP_005251809
          Length = 3063

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    TNTGTIE 7
            T+TGTI+
Sbjct: 2311 TSTGTID 2317
>XP_005251808
          Length = 3075

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    TNTGTIE 7
            T+TGTI+
Sbjct: 2311 TSTGTID 2317
>XP_005251807
          Length = 3088

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    TNTGTIE 7
            T+TGTI+
Sbjct: 2311 TSTGTID 2317
>XP_005251805
          Length = 3090

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    TNTGTIE 7
            T+TGTI+
Sbjct: 2311 TSTGTID 2317
>XP_005251803
          Length = 3091

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    TNTGTIE 7
            T+TGTI+
Sbjct: 2311 TSTGTID 2317
>XP_006717050
          Length = 3092

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    TNTGTIE 7
            T+TGTI+
Sbjct: 2311 TSTGTID 2317
>XP_005251802
          Length = 3092

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    TNTGTIE 7
            T+TGTI+
Sbjct: 2311 TSTGTID 2317
>XP_006717049
          Length = 3100

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    TNTGTIE 7
            T+TGTI+
Sbjct: 2311 TSTGTID 2317
>XP_006717048
          Length = 3101

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    TNTGTIE 7
            T+TGTI+
Sbjct: 2311 TSTGTID 2317
>XP_006717047
          Length = 3101

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    TNTGTIE 7
            T+TGTI+
Sbjct: 2311 TSTGTID 2317
>XP_006717046
          Length = 3103

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    TNTGTIE 7
            T+TGTI+
Sbjct: 2311 TSTGTID 2317
>XP_006717045
          Length = 3104

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    TNTGTIE 7
            T+TGTI+
Sbjct: 2311 TSTGTID 2317
>XP_005246922
          Length = 617

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   TNTGTIES 8
           T  GT+ES
Sbjct: 170 TKNGTVES 177
>XP_005264437
          Length = 937

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   NTGTIES 8
           N GT+ES
Sbjct: 143 NVGTLES 149
>NP_982261
          Length = 936

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   NTGTIES 8
           N GT+ES
Sbjct: 143 NVGTLES 149
>NP_001002243
          Length = 908

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   NTGTIES 8
           N GT+ES
Sbjct: 143 NVGTLES 149
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.286    0.105    0.257 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 555,821
Number of extensions: 986
Number of successful extensions: 71
Number of sequences better than 10000.0: 71
Number of HSP's gapped: 71
Number of HSP's successfully gapped: 71
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.8 bits)
S2: 28 (15.4 bits)

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