Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_919047                                                              20     509
XP_005250598                                                           20     509
NP_443086                                                              18    1935
NP_060862                                                              17    3301
NP_705833                                                              17    3301
XP_005263172                                                           17    3301
XP_005247174                                                           17    3301
XP_006718546                                                           17    4312
NP_055992                                                              17    4312
NP_055844                                                              16    5631
NP_001139332                                                           16    5631
NP_115766                                                              16    5631
NP_001363                                                              16    5631
XP_006721528                                                           16    5631
NP_001139333                                                           16    5631
NP_004653                                                              16    5631
NP_000024                                                              16    7355
NP_001265544                                                           16    7355
NP_115796                                                              16    7355
NP_001265542                                                           16    7355
NP_002578                                                              16    7355
XP_005268513                                                           16    7355
XP_005268512                                                           16    7355
XP_005268511                                                           16    7355
XP_005268510                                                           16    7355
XP_005268509                                                           16    7355
NP_060420                                                              15    9605
NP_612486                                                              15    9605
NP_001073932                                                           15    9605
NP_001368                                                              15    9605
NP_001157281                                                           15    9605
NP_653319                                                              15    9605
NP_001269524                                                           15    9605
NP_067004                                                              15    9605
NP_001269518                                                           15    9605
NP_001269519                                                           15    9605
NP_001230271                                                           15    9605
NP_001269523                                                           15    9605
NP_001269520                                                           15    9605
NP_542394                                                              15    9605
NP_001074008                                                           15    9605
NP_277045                                                              15    9605
NP_001271332                                                           15    9605
NP_079030                                                              15    9605
XP_006725317                                                           15    9605
XP_005257548                                                           15    9605
XP_005256511                                                           15    9605
XP_005254235                                                           15    9605
XP_005254233                                                           15    9605
XP_005254234                                                           15    9605
XP_006718966                                                           15    9605
XP_005248658                                                           15    9605
XP_006713578                                                           15    9605
XP_006712502                                                           15    9605
XP_006712501                                                           15    9605
XP_005245443                                                           15    9605
>NP_919047
          Length = 520

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TNRTLLQRL 9
           TNRTLLQ+L
Sbjct: 346 TNRTLLQQL 354
>XP_005250598
          Length = 457

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TNRTLLQRL 9
           TNRTLLQ+L
Sbjct: 283 TNRTLLQQL 291
>NP_443086
          Length = 519

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   NRTLLQRL 9
           NRTLLQ+L
Sbjct: 343 NRTLLQQL 350
>NP_060862
          Length = 2104

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1    TNRTLLQRL 9
            TNRTLL+++
Sbjct: 1775 TNRTLLKQV 1783
>NP_705833
          Length = 2970

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   TNRTLLQR 8
           +NRTL+QR
Sbjct: 416 SNRTLVQR 423
>XP_005263172
          Length = 2104

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1    TNRTLLQRL 9
            TNRTLL+++
Sbjct: 1775 TNRTLLKQV 1783
>XP_005247174
          Length = 2679

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   TNRTLLQR 8
           +NRTL+QR
Sbjct: 125 SNRTLVQR 132
>XP_006718546
          Length = 513

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   NRTLLQRL 9
           NRT LQRL
Sbjct: 187 NRTNLQRL 194
>NP_055992
          Length = 619

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   NRTLLQRL 9
           NRT LQRL
Sbjct: 293 NRTNLQRL 300
>NP_055844
          Length = 1024

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   TNRTLLQRL 9
           TNR LLQ L
Sbjct: 239 TNRCLLQDL 247
>NP_001139332
          Length = 1024

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   TNRTLLQRL 9
           TNR LLQ L
Sbjct: 239 TNRCLLQDL 247
>NP_115766
          Length = 293

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NRTLLQRL 9
           NRTL Q+L
Sbjct: 152 NRTLTQKL 159
>NP_001363
          Length = 4486

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    NRTLLQRL 9
            N+T LQRL
Sbjct: 3844 NKTALQRL 3851
>XP_006721528
          Length = 3869

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    NRTLLQRL 9
            N+T LQRL
Sbjct: 3844 NKTALQRL 3851
>NP_001139333
          Length = 1024

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   TNRTLLQRL 9
           TNR LLQ L
Sbjct: 239 TNRCLLQDL 247
>NP_004653
          Length = 798

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NRTLLQRL 9
           N+T LQRL
Sbjct: 156 NKTALQRL 163
>NP_000024
          Length = 745

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  NRTLLQRL 9
          NR  LQRL
Sbjct: 68 NRVFLQRL 75
>NP_001265544
          Length = 681

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NRTLLQRL 9
           NRTLL+ L
Sbjct: 439 NRTLLETL 446
>NP_115796
          Length = 1237

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NRTLLQRL 9
           NRTLL+ L
Sbjct: 818 NRTLLETL 825
>NP_001265542
          Length = 1076

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NRTLLQRL 9
           NRTLL+ L
Sbjct: 834 NRTLLETL 841
>NP_002578
          Length = 1060

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NRTLLQRL 9
           NRTLL+ L
Sbjct: 818 NRTLLETL 825
>XP_005268513
          Length = 858

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NRTLLQRL 9
           NRTLL+ L
Sbjct: 439 NRTLLETL 446
>XP_005268512
          Length = 858

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NRTLLQRL 9
           NRTLL+ L
Sbjct: 439 NRTLLETL 446
>XP_005268511
          Length = 1158

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NRTLLQRL 9
           NRTLL+ L
Sbjct: 862 NRTLLETL 869
>XP_005268510
          Length = 1215

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NRTLLQRL 9
           NRTLL+ L
Sbjct: 796 NRTLLETL 803
>XP_005268509
          Length = 1281

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NRTLLQRL 9
           NRTLL+ L
Sbjct: 862 NRTLLETL 869
>NP_060420
          Length = 1142

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TNRTLLQRL 9
           T  TLLQ+L
Sbjct: 560 TEATLLQKL 568
>NP_612486
          Length = 1227

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RTLLQR 8
           RTLLQR
Sbjct: 677 RTLLQR 682
>NP_001073932
          Length = 4314

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TNRTLLQRL 9
            T+R LLQ+L
Sbjct: 2323 TSRHLLQKL 2331
>NP_001368
          Length = 4307

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TNRTLLQRL 9
            T+R LLQ+L
Sbjct: 2323 TSRHLLQKL 2331
>NP_001157281
          Length = 1941

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  RTLLQR 8
          RTLLQR
Sbjct: 88 RTLLQR 93
>NP_653319
          Length = 855

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TNRTLLQR 8
           TN +L+QR
Sbjct: 658 TNESLIQR 665
>NP_001269524
          Length = 201

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TNRTLLQ 7
           TNRT+L+
Sbjct: 156 TNRTILK 162
>NP_067004
          Length = 335

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TNRTLLQ 7
           TNRT+L+
Sbjct: 290 TNRTILK 296
>NP_001269518
          Length = 204

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TNRTLLQ 7
           TNRT+L+
Sbjct: 159 TNRTILK 165
>NP_001269519
          Length = 228

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TNRTLLQ 7
           TNRT+L+
Sbjct: 183 TNRTILK 189
>NP_001230271
          Length = 1030

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TNRTLLQRL 9
           T  TLLQ+L
Sbjct: 560 TEATLLQKL 568
>NP_001269523
          Length = 241

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TNRTLLQ 7
           TNRT+L+
Sbjct: 196 TNRTILK 202
>NP_001269520
          Length = 188

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TNRTLLQ 7
           TNRT+L+
Sbjct: 143 TNRTILK 149
>NP_542394
          Length = 328

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TNRTLLQR 8
           T RTLLQ+
Sbjct: 275 TYRTLLQK 282
>NP_001074008
          Length = 1101

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TNRTLLQRL 9
           TNR L Q+L
Sbjct: 870 TNRELRQKL 878
>NP_277045
          Length = 1401

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TNRTLLQRL 9
           T+R L QRL
Sbjct: 686 TSRLLFQRL 694
>NP_001271332
          Length = 279

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  TNRTLLQRL 9
          +NR LLQ L
Sbjct: 13 SNRVLLQAL 21
>NP_079030
          Length = 388

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  TNRTLLQRL 9
          +NR LLQ L
Sbjct: 13 SNRVLLQAL 21
>XP_006725317
          Length = 1745

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  RTLLQR 8
          RTLLQR
Sbjct: 88 RTLLQR 93
>XP_005257548
          Length = 749

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TNRTLLQRL 9
           T  TLLQ+L
Sbjct: 167 TEATLLQKL 175
>XP_005256511
          Length = 1746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  RTLLQR 8
          RTLLQR
Sbjct: 88 RTLLQR 93
>XP_005254235
          Length = 1017

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RTLLQR 8
           RTLLQR
Sbjct: 678 RTLLQR 683
>XP_005254233
          Length = 1228

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RTLLQR 8
           RTLLQR
Sbjct: 678 RTLLQR 683
>XP_005254234
          Length = 1076

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RTLLQR 8
           RTLLQR
Sbjct: 678 RTLLQR 683
>XP_006718966
          Length = 4300

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TNRTLLQRL 9
            T+R LLQ+L
Sbjct: 2323 TSRHLLQKL 2331
>XP_005248658
          Length = 350

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  TNRTLLQRL 9
          +NR LLQ L
Sbjct: 13 SNRVLLQAL 21
>XP_006713578
          Length = 855

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TNRTLLQR 8
           TN +L+QR
Sbjct: 658 TNESLIQR 665
>XP_006712502
          Length = 588

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TNRTLLQRL 9
           TNR L Q+L
Sbjct: 357 TNRELRQKL 365
>XP_006712501
          Length = 1080

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   TNRTLLQRL 9
           TNR L Q+L
Sbjct: 849 TNRELRQKL 857
>XP_005245443
          Length = 295

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   TNRTLLQ 7
           TNRT+L+
Sbjct: 250 TNRTILK 256
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.328    0.136    0.348 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 438,174
Number of extensions: 837
Number of successful extensions: 56
Number of sequences better than 10000.0: 56
Number of HSP's gapped: 56
Number of HSP's successfully gapped: 56
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package