Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              18    1135
NP_671714                                                              18    1135
XP_006715890                                                           18    1135
XP_005250160                                                           18    1135
XP_005250159                                                           18    1135
NP_997639                                                              17    4312
NP_002017                                                              17    4312
NP_997643                                                              17    4312
NP_997647                                                              17    4312
NP_997641                                                              17    4312
NP_006827                                                              17    4312
XP_005246474                                                           17    4312
XP_005246473                                                           17    4312
XP_005246472                                                           17    4312
XP_005246471                                                           17    4312
XP_005246470                                                           17    4312
XP_005246469                                                           17    4312
XP_005246468                                                           17    4312
XP_005246467                                                           17    4312
XP_005246466                                                           17    4312
XP_005246465                                                           17    4312
XP_005246464                                                           17    4312
XP_005246463                                                           17    4312
XP_005246462                                                           17    4312
XP_005246461                                                           17    4312
XP_005246460                                                           17    4312
XP_005246459                                                           17    4312
XP_005246458                                                           17    4312
XP_005246457                                                           17    4312
XP_005246456                                                           17    4312
XP_005246455                                                           17    4312
XP_005246454                                                           17    4312
NP_006874                                                              16    5631
NP_000442                                                              16    5631
NP_078966                                                              16    7355
NP_001184060                                                           16    7355
NP_005520                                                              16    7355
NP_115287                                                              16    7355
NP_002472                                                              16    7355
NP_115286                                                              16    7355
XP_005245262                                                           16    7355
XP_005245259                                                           16    7355
XP_006711402                                                           16    7355
XP_005245258                                                           16    7355
XP_005245257                                                           16    7355
XP_005245256                                                           16    7355
XP_006710661                                                           16    7355
XP_005245920                                                           16    7355
XP_006710660                                                           16    7355
XP_006710659                                                           16    7355
XP_006710658                                                           16    7355
XP_006710657                                                           16    7355
NP_001073964                                                           15    9605
NP_001159635                                                           15    9605
NP_001159632                                                           15    9605
NP_001159634                                                           15    9605
NP_001159633                                                           15    9605
NP_001135760                                                           15    9605
NP_006058                                                              15    9605
XP_006716111                                                           15    9605
XP_006716110                                                           15    9605
XP_005250542                                                           15    9605
XP_006716109                                                           15    9605
XP_006715861                                                           15    9605
XP_006715860                                                           15    9605
NP_060120                                                              15    9605
>NP_005742
          Length = 3907

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TMTSRVAEG 9
            TMTSR AEG
Sbjct: 1025 TMTSRGAEG 1033
>NP_671714
          Length = 3899

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TMTSRVAEG 9
            TMTSR AEG
Sbjct: 1025 TMTSRGAEG 1033
>XP_006715890
          Length = 3860

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TMTSRVAEG 9
            TMTSR AEG
Sbjct: 1025 TMTSRGAEG 1033
>XP_005250160
          Length = 3939

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TMTSRVAEG 9
            TMTSR AEG
Sbjct: 1025 TMTSRGAEG 1033
>XP_005250159
          Length = 3952

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    TMTSRVAEG 9
            TMTSR AEG
Sbjct: 1025 TMTSRGAEG 1033
>NP_997639
          Length = 2176

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TMTSRVAEG 9
            T+TSR A+G
Sbjct: 1708 TLTSRPAQG 1716
>NP_002017
          Length = 2355

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TMTSRVAEG 9
            T+TSR A+G
Sbjct: 1798 TLTSRPAQG 1806
>NP_997643
          Length = 2330

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TMTSRVAEG 9
            T+TSR A+G
Sbjct: 1798 TLTSRPAQG 1806
>NP_997647
          Length = 2477

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TMTSRVAEG 9
            T+TSR A+G
Sbjct: 1889 TLTSRPAQG 1897
>NP_997641
          Length = 2296

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TMTSRVAEG 9
            T+TSR A+G
Sbjct: 1708 TLTSRPAQG 1716
>NP_006827
          Length = 2671

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   TMTSRVAEG 9
           T+TSRV +G
Sbjct: 958 TITSRVGKG 966
>XP_005246474
          Length = 2240

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TMTSRVAEG 9
            T+TSR A+G
Sbjct: 1708 TLTSRPAQG 1716
>XP_005246473
          Length = 2246

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TMTSRVAEG 9
            T+TSR A+G
Sbjct: 1708 TLTSRPAQG 1716
>XP_005246472
          Length = 2265

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TMTSRVAEG 9
            T+TSR A+G
Sbjct: 1708 TLTSRPAQG 1716
>XP_005246471
          Length = 2266

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TMTSRVAEG 9
            T+TSR A+G
Sbjct: 1798 TLTSRPAQG 1806
>XP_005246470
          Length = 2267

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TMTSRVAEG 9
            T+TSR A+G
Sbjct: 1799 TLTSRPAQG 1807
>XP_005246469
          Length = 2271

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TMTSRVAEG 9
            T+TSR A+G
Sbjct: 1708 TLTSRPAQG 1716
>XP_005246468
          Length = 2273

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TMTSRVAEG 9
            T+TSR A+G
Sbjct: 1799 TLTSRPAQG 1807
>XP_005246467
          Length = 2337

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TMTSRVAEG 9
            T+TSR A+G
Sbjct: 1799 TLTSRPAQG 1807
>XP_005246466
          Length = 2361

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TMTSRVAEG 9
            T+TSR A+G
Sbjct: 1798 TLTSRPAQG 1806
>XP_005246465
          Length = 2362

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TMTSRVAEG 9
            T+TSR A+G
Sbjct: 1799 TLTSRPAQG 1807
>XP_005246464
          Length = 2363

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TMTSRVAEG 9
            T+TSR A+G
Sbjct: 1889 TLTSRPAQG 1897
>XP_005246463
          Length = 2386

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TMTSRVAEG 9
            T+TSR A+G
Sbjct: 1798 TLTSRPAQG 1806
>XP_005246462
          Length = 2387

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TMTSRVAEG 9
            T+TSR A+G
Sbjct: 1799 TLTSRPAQG 1807
>XP_005246461
          Length = 2392

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TMTSRVAEG 9
            T+TSR A+G
Sbjct: 1798 TLTSRPAQG 1806
>XP_005246460
          Length = 2393

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TMTSRVAEG 9
            T+TSR A+G
Sbjct: 1799 TLTSRPAQG 1807
>XP_005246459
          Length = 2421

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TMTSRVAEG 9
            T+TSR A+G
Sbjct: 1889 TLTSRPAQG 1897
>XP_005246458
          Length = 2427

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TMTSRVAEG 9
            T+TSR A+G
Sbjct: 1889 TLTSRPAQG 1897
>XP_005246457
          Length = 2446

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TMTSRVAEG 9
            T+TSR A+G
Sbjct: 1889 TLTSRPAQG 1897
>XP_005246456
          Length = 2452

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TMTSRVAEG 9
            T+TSR A+G
Sbjct: 1889 TLTSRPAQG 1897
>XP_005246455
          Length = 2458

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TMTSRVAEG 9
            T+TSR A+G
Sbjct: 1889 TLTSRPAQG 1897
>XP_005246454
          Length = 2483

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    TMTSRVAEG 9
            T+TSR A+G
Sbjct: 1889 TLTSRPAQG 1897
>NP_006874
          Length = 225

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  TSRVAEG 9
          T+RVAEG
Sbjct: 87 TARVAEG 93
>NP_000442
          Length = 292

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  TSRVAEG 9
          T+RVAEG
Sbjct: 87 TARVAEG 93
>NP_078966
          Length = 14507

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    TMTSRVAE 8
            T+TSRV E
Sbjct: 6488 TLTSRVPE 6495
>NP_001184060
          Length = 186

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  TMTSRVAE 8
          T+TSRV E
Sbjct: 73 TLTSRVEE 80
>NP_005520
          Length = 4391

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    TSRVAEG 9
            +SRVAEG
Sbjct: 2835 SSRVAEG 2841
>NP_115287
          Length = 224

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TMTSRVAE 8
           T+TSRV E
Sbjct: 95  TLTSRVEE 102
>NP_002472
          Length = 982

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TMTSRVAE 8
           T+TSRV E
Sbjct: 869 TLTSRVEE 876
>NP_115286
          Length = 208

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TMTSRVAE 8
           T+TSRV E
Sbjct: 95  TLTSRVEE 102
>XP_005245262
          Length = 891

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TMTSRVAE 8
           T+TSRV E
Sbjct: 762 TLTSRVEE 769
>XP_005245259
          Length = 998

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TMTSRVAE 8
           T+TSRV E
Sbjct: 869 TLTSRVEE 876
>XP_006711402
          Length = 1042

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TMTSRVAE 8
           T+TSRV E
Sbjct: 930 TLTSRVEE 937
>XP_005245258
          Length = 1043

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TMTSRVAE 8
           T+TSRV E
Sbjct: 930 TLTSRVEE 937
>XP_005245257
          Length = 1058

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TMTSRVAE 8
           T+TSRV E
Sbjct: 930 TLTSRVEE 937
>XP_005245256
          Length = 1059

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   TMTSRVAE 8
           T+TSRV E
Sbjct: 930 TLTSRVEE 937
>XP_006710661
          Length = 4057

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    TSRVAEG 9
            +SRVAEG
Sbjct: 3018 SSRVAEG 3024
>XP_005245920
          Length = 4392

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    TSRVAEG 9
            +SRVAEG
Sbjct: 2836 SSRVAEG 2842
>XP_006710660
          Length = 4397

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    TSRVAEG 9
            +SRVAEG
Sbjct: 2835 SSRVAEG 2841
>XP_006710659
          Length = 4556

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    TSRVAEG 9
            +SRVAEG
Sbjct: 2994 SSRVAEG 3000
>XP_006710658
          Length = 4563

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    TSRVAEG 9
            +SRVAEG
Sbjct: 3001 SSRVAEG 3007
>XP_006710657
          Length = 4579

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    TSRVAEG 9
            +SRVAEG
Sbjct: 3017 SSRVAEG 3023
>NP_001073964
          Length = 2968

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TMTSRVAEG 9
            T TSR A+G
Sbjct: 2021 TKTSRCAKG 2029
>NP_001159635
          Length = 1090

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    MTSRVAEG 9
            MTS  AEG
Sbjct: 1079 MTSTTAEG 1086
>NP_001159632
          Length = 1374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    MTSRVAEG 9
            MTS  AEG
Sbjct: 1363 MTSTTAEG 1370
>NP_001159634
          Length = 1253

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    MTSRVAEG 9
            MTS  AEG
Sbjct: 1242 MTSTTAEG 1249
>NP_001159633
          Length = 1296

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    MTSRVAEG 9
            MTS  AEG
Sbjct: 1285 MTSTTAEG 1292
>NP_001135760
          Length = 126

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MTSRVAEG 9
           + SR+AEG
Sbjct: 111 VASRIAEG 118
>NP_006058
          Length = 210

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MTSRVAEG 9
           + SR+AEG
Sbjct: 111 VASRIAEG 118
>XP_006716111
          Length = 701

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   MTSRVAEG 9
           MTS  AEG
Sbjct: 690 MTSTTAEG 697
>XP_006716110
          Length = 1141

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    MTSRVAEG 9
            MTS  AEG
Sbjct: 1130 MTSTTAEG 1137
>XP_005250542
          Length = 1357

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    MTSRVAEG 9
            MTS  AEG
Sbjct: 1346 MTSTTAEG 1353
>XP_006716109
          Length = 1365

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    MTSRVAEG 9
            MTS  AEG
Sbjct: 1354 MTSTTAEG 1361
>XP_006715861
          Length = 2189

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TMTSRVAEG 9
            T TSR A+G
Sbjct: 2021 TKTSRCAKG 2029
>XP_006715860
          Length = 2968

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    TMTSRVAEG 9
            T TSR A+G
Sbjct: 2021 TKTSRCAKG 2029
>NP_060120
          Length = 1098

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    MTSRVAEG 9
            MTS  AEG
Sbjct: 1087 MTSTTAEG 1094
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.305    0.112    0.277 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 278,856
Number of extensions: 398
Number of successful extensions: 66
Number of sequences better than 10000.0: 66
Number of HSP's gapped: 66
Number of HSP's successfully gapped: 66
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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