Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001121619                                                           20     390
NP_000258                                                              20     390
NP_001035957                                                           20     390
XP_006721991                                                           20     390
XP_006721990                                                           20     390
XP_006721989                                                           20     390
XP_005258041                                                           20     390
XP_006721988                                                           20     390
XP_006721987                                                           20     390
XP_006721986                                                           20     390
XP_005258040                                                           20     390
XP_006721985                                                           20     390
NP_004861                                                              17    3301
XP_006721662                                                           17    3301
XP_006721661                                                           17    3301
XP_006721660                                                           17    3301
NP_872303                                                              17    4312
NP_000128                                                              16    5631
XP_005263029                                                           16    5631
NP_443728                                                              16    7355
NP_001124435                                                           16    7355
NP_056072                                                              16    7355
XP_006713550                                                           16    7355
XP_006711606                                                           16    7355
XP_006711605                                                           16    7355
NP_005183                                                              15    9605
NP_001124323                                                           15    9605
NP_001276089                                                           15    9605
NP_005922                                                              15    9605
NP_000238                                                              15    9605
NP_073580                                                              15    9605
NP_001276081                                                           15    9605
NP_001161212                                                           15    9605
NP_001170990                                                           15    9605
NP_001276082                                                           15    9605
NP_004514                                                              15    9605
XP_006726158                                                           15    9605
XP_006726065                                                           15    9605
XP_005267315                                                           15    9605
XP_005264439                                                           15    9605
XP_005264438                                                           15    9605
XP_005273286                                                           15    9605
XP_005273285                                                           15    9605
NP_060197                                                              15    9605
>NP_001121619
          Length = 593

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TMLQELTVC 9
           T LQELTVC
Sbjct: 159 TRLQELTVC 167
>NP_000258
          Length = 2818

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TMLQELTVC 9
           T LQELTVC
Sbjct: 159 TRLQELTVC 167
>NP_001035957
          Length = 2839

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TMLQELTVC 9
           T LQELTVC
Sbjct: 159 TRLQELTVC 167
>XP_006721991
          Length = 1632

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TMLQELTVC 9
           T LQELTVC
Sbjct: 159 TRLQELTVC 167
>XP_006721990
          Length = 2823

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TMLQELTVC 9
           T LQELTVC
Sbjct: 159 TRLQELTVC 167
>XP_006721989
          Length = 2823

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TMLQELTVC 9
           T LQELTVC
Sbjct: 159 TRLQELTVC 167
>XP_005258041
          Length = 2836

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TMLQELTVC 9
           T LQELTVC
Sbjct: 159 TRLQELTVC 167
>XP_006721988
          Length = 2846

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TMLQELTVC 9
           T LQELTVC
Sbjct: 159 TRLQELTVC 167
>XP_006721987
          Length = 2849

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TMLQELTVC 9
           T LQELTVC
Sbjct: 159 TRLQELTVC 167
>XP_006721986
          Length = 2854

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TMLQELTVC 9
           T LQELTVC
Sbjct: 146 TRLQELTVC 154
>XP_005258040
          Length = 2857

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TMLQELTVC 9
           T LQELTVC
Sbjct: 159 TRLQELTVC 167
>XP_006721985
          Length = 2867

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   TMLQELTVC 9
           T LQELTVC
Sbjct: 159 TRLQELTVC 167
>NP_004861
          Length = 247

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MLQELTVC 9
           MLQ +T+C
Sbjct: 110 MLQTITIC 117
>XP_006721662
          Length = 192

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MLQELTVC 9
           MLQ +T+C
Sbjct: 110 MLQTITIC 117
>XP_006721661
          Length = 259

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MLQELTVC 9
           MLQ +T+C
Sbjct: 110 MLQTITIC 117
>XP_006721660
          Length = 260

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MLQELTVC 9
           MLQ +T+C
Sbjct: 110 MLQTITIC 117
>NP_872303
          Length = 431

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   MLQELTVC 9
           +L+ELT+C
Sbjct: 198 ILEELTLC 205
>NP_000128
          Length = 419

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TMLQELT 7
           TMLQ+LT
Sbjct: 325 TMLQQLT 331
>XP_005263029
          Length = 318

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  TMLQELTVC 9
          T LQ+L VC
Sbjct: 9  TTLQDLGVC 17
>NP_443728
          Length = 2145

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MLQELTVC 9
           MLQ +T+C
Sbjct: 367 MLQTVTLC 374
>NP_001124435
          Length = 444

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  MLQELTVC 9
          MLQE  VC
Sbjct: 51 MLQESQVC 58
>NP_056072
          Length = 371

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  MLQELTVC 9
          MLQE  VC
Sbjct: 51 MLQESQVC 58
>XP_006713550
          Length = 2180

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MLQELTVC 9
           MLQ +T+C
Sbjct: 367 MLQTVTLC 374
>XP_006711606
          Length = 506

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  MLQELTVC 9
          +L+EL VC
Sbjct: 22 VLEELAVC 29
>XP_006711605
          Length = 551

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  MLQELTVC 9
          +L+EL VC
Sbjct: 22 VLEELAVC 29
>NP_005183
          Length = 212

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   MLQELTVC 9
           +++ELT C
Sbjct: 122 IMEELTTC 129
>NP_001124323
          Length = 172

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  MLQELTVC 9
          +++ELT C
Sbjct: 82 IMEELTTC 89
>NP_001276089
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  LQELTVC 9
          LQE+ VC
Sbjct: 81 LQEIRVC 87
>NP_005922
          Length = 383

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LQELTVC 9
           LQE+ VC
Sbjct: 113 LQEIRVC 119
>NP_000238
          Length = 383

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LQELTVC 9
           LQE+ VC
Sbjct: 113 LQEIRVC 119
>NP_073580
          Length = 369

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   QELTVC 9
           +ELT+C
Sbjct: 174 EELTIC 179
>NP_001276081
          Length = 235

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  LQELTVC 9
          LQE+ VC
Sbjct: 16 LQEIRVC 22
>NP_001161212
          Length = 428

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   QELTVC 9
           +ELT+C
Sbjct: 233 EELTIC 238
>NP_001170990
          Length = 332

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LQELTVC 9
           LQE+ VC
Sbjct: 113 LQEIRVC 119
>NP_001276082
          Length = 235

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  LQELTVC 9
          LQE+ VC
Sbjct: 16 LQEIRVC 22
>NP_004514
          Length = 1056

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LQELTVC 9
           LQE T+C
Sbjct: 689 LQENTIC 695
>XP_006726158
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  LQELTVC 9
          LQE+ VC
Sbjct: 81 LQEIRVC 87
>XP_006726065
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  LQELTVC 9
          LQE+ VC
Sbjct: 81 LQEIRVC 87
>XP_005267315
          Length = 146

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   MLQELTVC 9
           +++ELT C
Sbjct: 122 IMEELTTC 129
>XP_005264439
          Length = 715

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TMLQEL 6
           TMLQEL
Sbjct: 203 TMLQEL 208
>XP_005264438
          Length = 753

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TMLQEL 6
           TMLQEL
Sbjct: 203 TMLQEL 208
>XP_005273286
          Length = 258

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4  QELTVC 9
          +ELT+C
Sbjct: 63 EELTIC 68
>XP_005273285
          Length = 359

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   QELTVC 9
           +ELT+C
Sbjct: 233 EELTIC 238
>NP_060197
          Length = 689

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   TMLQEL 6
           TMLQEL
Sbjct: 203 TMLQEL 208
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.330    0.131    0.386 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 578,868
Number of extensions: 963
Number of successful extensions: 44
Number of sequences better than 10000.0: 44
Number of HSP's gapped: 44
Number of HSP's successfully gapped: 44
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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